85 episodes

Pediapod is the pediatrics podcast from Pediatric Research, produced in association with Nature Publishing Group. Join us as we explore the etiologies of diseases of children and disorders of development, featuring interviews with top researchers and highlighted content from one of the premier journals in the field of pediatrics.

Pediatric Research Podcast Nature

    • Science
    • 4.0 • 3 Ratings

Pediapod is the pediatrics podcast from Pediatric Research, produced in association with Nature Publishing Group. Join us as we explore the etiologies of diseases of children and disorders of development, featuring interviews with top researchers and highlighted content from one of the premier journals in the field of pediatrics.

    Early Career Investigator Spotlight: Matthew W. Harer

    Early Career Investigator Spotlight: Matthew W. Harer

    Caffeine administration has been associated with reduced rates of Acute Kidney Injury (AKI) in preterm neonates but the effect of caffeine on renal oxygenation is unknown. 


    In this episode, we meet this month's highlighted Early Career Investigator, Dr. Matthew Harer from the University of Wisconsin School of Medicine and Public Health. He has been investigating the potential use of Near Infrared Spectroscopy (NIRS), a non-invasive means of continuously measuring tissue oxygenation to assess the effects of caffeine on renal oxygenation, in the hope that caffeine might one day be used to prevent and even treat AKI. 
     
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    • 11 min
    SARS-CoV-2 vaccine testing and trials in the pediatric population: biologic, ethical, research, and implementation challenges

    SARS-CoV-2 vaccine testing and trials in the pediatric population: biologic, ethical, research, and implementation challenges

    Early on in the SARS-CoV-2 pandemic, the majority of infected children were either asymptomatic or had mild COVID-19 disease, prompting many to demand a higher acceptable risk threshold for pediatric vaccines. More recently, as children begin to make up a larger proportion of the infected population and following evidence of the mental and physical toll exacted by the pandemic on children, a pediatric vaccine is now more pressing. But challenges to widespread vaccine uptake remain. In this episode meet Dr. Chulie Ulloa from the University of California Irvine about a recent commentary she wrote with fellow pediatric providers, physician scientists and advocates for children about these challenges and how they might be overcome. 
     
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    • 10 min
    Juvenile idiopathic arthritis: lymphocyte activation gene-3 is a central immune receptor in children with oligoarticular subtypes

    Juvenile idiopathic arthritis: lymphocyte activation gene-3 is a central immune receptor in children with oligoarticular subtypes

    Juvenile idiopathic arthritis (JIA) is one of the most common inflammatory joint diseases in children. Previous studies have shown that in the oligoarticular subtype of this disease, T cells play a central role in pathogenesis. T cell inhibitory receptors (IRs) seem to play an important role in the development of tolerance and recognition of self and non-self antigens. Ligands binding to these IRs inhibit T cell function and modulate the course of the immune response. In this episode, we meet this month's highlighted Early Career Investigator Erdal Sag, a paediatric rheumatologist at Ankara Training and Research Hospital in Turkey. He and his team designed an ex vivo disease model to examine the effects of different co-inhibitory receptors on the pathogenesis of oligoarticular JIA.
     
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    • 9 min
    Chorioamnionitis induces changes in ovine pulmonary endogenous epithelial stem/progenitor cells in utero

    Chorioamnionitis induces changes in ovine pulmonary endogenous epithelial stem/progenitor cells in utero

    Chorioamnionitis is an intrauterine infection of the placenta and fetal membranes. It is the leading cause of preterm delivery and is a common risk factor for adverse pulmonary outcomes such as bronchopulmonary dysplasia. There is evidence to suggest that the first negative impacts on pulmonary development occur in utero in the presence of chorioamnionitis. In this episode, we meet assistant professors Niki Reynaert and Tim Wolfs from Maastricht University in the Netherlands. Together they studied an ovine model of chorioamnionitis in order to study the effects of chronic and acute inflammation on the developing lungs. 
     
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    • 15 min
    Marc Beltempo – Early Career Investigator Highlight

    Marc Beltempo – Early Career Investigator Highlight

    Previous studies have shown an association between fluid retention during the early postnatal period and increased BPD. However, these studies were performed nearly two decades ago meaning their results may not apply to the contemporary NICU setting, with its widespread use of surfactants and modern incubators. In this episode we meet this month's featured Early Career Investigator Marc Beltempo from McGill University and the Montreal Children's Hospital in Canada, who has revisited this important question. 
     
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    • 11 min
    Calcium-sensing receptor and CPAP-induced neonatal airway hyper reactivity in mice

    Calcium-sensing receptor and CPAP-induced neonatal airway hyper reactivity in mice

    Respiratory support plays a crucial role in the care of preterm infants in the NICU, ensuring that they get enough oxygen during this critical period of development. But it is becoming increasingly clear that former preterm infants who have been exposed to ventilatory support are at an increased risk of developing asthma and other respiratory disorders. In this episode, we speak to Peter Macfarlane, an associate professor in the Department of Pediatrics at Rainbow Babies and Children's hospital. He and his team have developed a mouse model to study the effects of CPAP in combination with supplemental oxygen on lung function.
     
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    • 10 min

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