Nick Sterling, MD, PhD

Nick Sterling, MD, PhD
Nick Sterling, MD, PhD

Physician focused on the science of metabolic health, aging, longevity, and athletic performance.

Episodes

  1. Can we Slow the Speed of Aging? Biological Age & Epigenetics - Varun Dwaraka, PhD

    AUG 29

    Can we Slow the Speed of Aging? Biological Age & Epigenetics - Varun Dwaraka, PhD

    Can we slow the speed of aging? In this episode, Dr. Varun Dwaraka, Head of Bioinformatics at TruDiagnostic, walks us through through the science of measuring "biological age" using epigenetic markers, such as DNA methylation. We discuss how epigenetics (i.e. DNA methylation), may provide biomarkers of biological age, the rate at which aging occurs, and potentially early markers of disease. Dr. Dwaraka explains the distinctions between chronological and biological age, the development and refinement of epigenetic clocks, and the potential applications of these tools in aging interventions. The conversation also addresses the mechanisms of epigenetic regulation, the influence of lifestyle factors on biological age, and the future role of epigenetics in predicting and managing age-related diseases. Additionally, we examine the data science that underpins these clocks, their targeted outcomes, and a recent study published by Dr. Dwaraka and colleagues comparing aging biomarker outcomes in a vegan vs. omnivore diet intervention among twins. Chapters: 00:00 - Biological Age & Epigenetics 01:07 - What is Biological Age? 03:34 - Rate of Aging (aka. Speed of Aging) 05:28 - Epigenetics and Aging 11:14 - How the Epigenome Changes Over Time 18:26 - The Evolution of Epigenetic Clocks 24:49 - Understanding the Horvath Clock 30:03 - New Generations of Aging Clocks 34:07 - The Impact of Lifestyle on Biological Age 42:13 - The Future of Epigenetics in Predicting Disease 50:34 - Practical Applications of Epigenetic Testing 57:43 - The Role of Multi-Omics in Understanding Aging 01:07:34 - The Rejuvenation Olympics and the Future of Anti-Aging Social & Website: Instagram - / sterlingmdphd Twitter - / sterlingmdphd Facebook - / sterlingmdphd TikTok - / sterlingmdphd Newsletter - http://eepurl.com/hQpdqT Subscribe to the Podcast: Apple Podcasts: https://apple.co/3y438C9 Spotify: https://open.spotify.com/show/5TDUK3F... Google Podcasts: https://bit.ly/3Olanei References & Show Notes: http://www.nicksterling.com/ The content of this podcast is not medical advice, is for general information purposes only, and does not constitute the practice of medicine or any other healthcare professional services. No doctor-patient relationship is formed. The content of this podcast is not a substitute for medical evaluation or treatment and does not take precedence over information provided to you by your healthcare provider or official public health sources. Please visit nicksterling.com/terms for full Terms of Use.

    1h 24m
  2. Preventing Atherosclerosis & Heart Disease (ApoB, Cholesterol, and Lipids) | Tom Dayspring, MD

    JUL 16

    Preventing Atherosclerosis & Heart Disease (ApoB, Cholesterol, and Lipids) | Tom Dayspring, MD

    Why do humans get cardiovascular disease and how can we prevent it? These are critical processes to understand for anyone who is interested in living a longer and healthier life. I'm very honored to talk with Dr. Tom Dayspring, a world-renowned clinical lipidologist and physician whose topic expertise is unparalleled. We discuss the underlying process of atherosclerosis & the formation of plaques, ApoB, methods to stabilize plaque, metabolic syndrome and insulin resistance, markers and the risk of atherosclerosis, LP-PLA2 & atherosclerosis, homocysteine and cardiac risk, genetic therapies for lipid disorders. We also discuss lifestyle interventions, including exercise, in managing lipid disorders and reducing cardiovascular risk. Dr. Dayspring Twitter: https://x.com/Drlipid Chapters: 01:07 Introduction 07:44 ApoB & Atherosclerosis 13:25 How Plaques Form 26:32 Stabilizing Plaque & Preventing Rupture 31:46 Metabolic Syndrome & Insulin Resistance 37:57 Markers & Risk of Atherosclerosis 40:42 LP-PLA2 & Atherosclerosis 47:00 Homocysteine & Cardiac Risk 57:14 Genet Therapies for Lipid Disorders 01:09:50 The Role of Exercise Social & Website: Instagram - / sterlingmdphd Twitter - / sterlingmdphd Facebook - / sterlingmdphd TikTok - / sterlingmdphd Newsletter - http://eepurl.com/hQpdqT Subscribe to the Podcast: Apple Podcasts: https://apple.co/3y438C9 Spotify: https://open.spotify.com/show/5TDUK3F... Google Podcasts: https://bit.ly/3Olanei References & Show Notes: http://www.nicksterling.com/ The content of this podcast is not medical advice, is for general information purposes only, and does not constitute the practice of medicine or any other healthcare professional services. No doctor-patient relationship is formed. The content of this podcast is not a substitute for medical evaluation or treatment and does not take precedence over information provided to you by your healthcare provider or official public health sources. Please visit nicksterling.com/terms for full Terms of Use.

    1h 16m
  3. Metabolic Health, Insulin Resistance, & Mitochondrial Health | Nicolas Verhoeven (Physionic)

    APR 15

    Metabolic Health, Insulin Resistance, & Mitochondrial Health | Nicolas Verhoeven (Physionic)

    In this episode, I had the pleasure of sitting down with Nicolas Verhoeven of Physionic. We focus our attention on metabolic health and, specifically, the energy-related, cellular, and nutritional mechanisms of insulin resistance. Nicolas reviews evidence pertaining to the reversal of insulin resistance and dietary clinical trials demonstrating remission of type 2 diabetes. Nicolas also highlights the synergistic effects of physical activity and dietary habits on insulin resistance, expanding our discussion into mitochondrial health. Finally, we explore importance of a nuanced conversation around autophagy and its role in health and disease prevention. Physionic on YouTube: https://www.youtube.com/@Physionic Chapters: 00:00:13 - Nicolas' Background & Inspiration 00:05:34 - Misconceptions about Carbs & Fat Intake 00:08:57 - Mechanisms of Insulin Resistance 00:18:34 - Reversing Insulin Resistance & Diabetes 00:23:08 - Measuring Insulin Resistance 00:24:20 - Continuous Glucose Monitoring (CGM) 00:30:25 - Insulin Resistance & Health 00:37:33 - Mitochondrial Dysfunction 00:49:14 - Mitochondrial Biogenesis 00:56:05 - Improving Mitochondrial Health 01:02:54 - Autophagy 01:07:28 - Closing Remarks Social & Website: Instagram - https://www.instagram.com/sterlingmdphd Twitter - https://twitter.com/sterlingmdphd Facebook - https://www.facebook.com/sterlingmdphd TikTok - https://www.tiktok.com/@sterlingmdphd Newsletter - http://eepurl.com/hQpdqT Subscribe to the Podcast: Apple Podcasts: https://apple.co/3y438C9 Spotify: https://open.spotify.com/show/5TDUK3F2sJXfnG63hSxJhT?si=40bb52e5b53f404c Google Podcasts: https://bit.ly/3Olanei References & Show Notes: http://www.nicksterling.com/ The content of this podcast is not medical advice, is for general information purposes only, and does not constitute the practice of medicine or any other healthcare professional services. No doctor-patient relationship is formed. The content of this podcast is not a substitute for medical evaluation or treatment and does not take precedence over information provided to you by your healthcare provider or official public health sources. Please visit nicksterling.com/terms for full Terms of Use.

    1h 9m
  4. Muscle Loss & "Ozempic" - Prevention & What We Know | Nick Sterling, MD, PhD #8 | Nick Sterling, MD, PhD #8

    11/22/2023

    Muscle Loss & "Ozempic" - Prevention & What We Know | Nick Sterling, MD, PhD #8 | Nick Sterling, MD, PhD #8

    Does muscle loss occur in people taking GLP-1 receptor agonists such as semaglutide (marketed as "Ozempic" and "Wegovy") or combined GLP-1/GIP agonists like tirzepatide (marketed as "Mounjaro")? In this episode, we discuss current evidence regarding these next-generation weight loss drugs and muscle wasting, as well as principles of preventing muscle loss in weight loss programs. #healthspan, #ozempic, #fitness, #muscle, #science Chapters: 00:00 - Intro 00:30 - Importance of Muscle in Weight Loss 01:19 - Muscle Loss During Weight Loss 02:03 - What Affects Muscle Mass During Weight Loss? 02:16 - Clinical Trials 04:59 - Preserving Muscle During Weight Loss 05:30 - Protein Intake 06:28 - Strength Training 06:59 - Monitoring Body Composition 07:26 - Summary Social & Website: Instagram - https://www.instagram.com/sterlingmdphd Twitter - https://twitter.com/sterlingmdphd Facebook - https://www.facebook.com/sterlingmdphd TikTok - https://www.tiktok.com/@sterlingmdphd Newsletter - http://eepurl.com/hQpdqT Subscribe to the Podcast: Apple Podcasts: https://apple.co/3y438C9 Spotify: https://open.spotify.com/show/5TDUK3F2sJXfnG63hSxJhT?si=40bb52e5b53f404c Google Podcasts: https://bit.ly/3Olanei References & Show Notes: http://www.nicksterling.com/ The content of this video is for general information purposes only and does not constitute the practice of medicine or any other healthcare professional services. The content of this video is not medical advice. No doctor-patient relationship is formed. The content of this video should not take precedence over information provided to you by your healthcare provider or official public health sources. Please visit nicksterling.com/terms for full Terms of Use.

    9 min
  5. How “Ozempic” Works – Weight Loss, Weight Regain, & Neuroscience | Nick Sterling, MD, PhD #7

    07/30/2023

    How “Ozempic” Works – Weight Loss, Weight Regain, & Neuroscience | Nick Sterling, MD, PhD #7

    How do drugs like Ozempic (semaglutide) cause weight loss? In this episode, we discuss how these drugs (GLP-1 receptor agonists) target specific areas in the brain to suppress appetite and facilitate weight loss. We also discuss clinical trials data suggesting that these drugs and/or the weight loss that they facilitate may have cardioprotective effects. Lastly, we will also examine evidence regarding weight regain when coming off of these drugs and common side effects. Link to episode on neuroscience of appetite regulation: https://www.youtube.com/watch?v=i3RzV9vS_FA#healthspan, #semaglutide, #ozempic, #wegovy, #science, #weightloss Chapters: 00:00 - Intro 01:31 - What Does GLP-1 Do? 02:08 - GLP-1 Receptors in the Brain 02:52 - Activating the GLP-1 "Switch" (Receptors) 04:13 - Clinical Trials - Semaglutide for Weight Loss 05:29 - Semaglutide and Heart & Metabolic Health 05:54 - For How Long Does Semaglutide Work? 06:35 - Weight Regain After Stopping Semaglutide 08:24 - Side Effects of GLP-1 Receptor Agonists 09:37 - Take-Home Points 10:20 - Outro Social & Website: Instagram - https://www.instagram.com/sterlingmdphd Twitter - https://twitter.com/sterlingmdphd Facebook - https://www.facebook.com/sterlingmdphd TikTok - https://www.tiktok.com/@sterlingmdphd Newsletter - http://eepurl.com/hQpdqT Subscribe to the Podcast: Apple Podcasts: https://apple.co/3y438C9 Spotify: https://open.spotify.com/show/5TDUK3F2sJXfnG63hSxJhT?si=40bb52e5b53f404c Google Podcasts: https://bit.ly/3Olanei References & Show Notes: http://www.nicksterling.com/ The content of this video is for general information purposes only and does not constitute the practice of medicine or any other healthcare professional services. The content of this video is not medical advice. No doctor-patient relationship is formed. The content of this podcast should not take precedence over information provided to you by your healthcare provider or official public health sources. Please visit nicksterling.com/terms for full Terms of Use.

    11 min
  6. How Fats & Carbs Drive Food Intake | Nick Sterling, MD, PhD #6

    07/30/2023

    How Fats & Carbs Drive Food Intake | Nick Sterling, MD, PhD #6

    Highly processed foods have been shown to lead to weight gain and are thought to drive intake through several mechanisms. Recent research suggests that the effect of combining fats and carbs on appetite might be more than the sum of their individual effects. Highly processed foods, accordingly, might simulate increased intake via the ratio of macronutrients. Link to episode on neuroscience of appetite regulation: https://www.youtube.com/watch?v=i3RzV9vS_FA Study Link: https://doi.org/10.1016/j.cmet.2018.06.010 Errata: Hu et al. was published in 2018. #diet, #weightloss, #science, #fitness, #food Chapters: 00:00 Intro to Ultra-Processed Foods 00:51 Mouse Study on Macronutrients & Food Intake 01:34 Fat-to-Carb Ratio May Affect Food Intake 02:15 Brain Effects of Diet 03:26 Key Points 03:51 Study Limitations 04:23 Outro Social & Website: Instagram - https://www.instagram.com/sterlingmdphd Twitter - https://twitter.com/sterlingmdphd Facebook - https://www.facebook.com/sterlingmdphd TikTok - https://www.tiktok.com/@sterlingmdphd Newsletter - http://eepurl.com/hQpdqT Subscribe to the Podcast: Apple Podcasts: https://apple.co/3y438C9 Spotify: https://open.spotify.com/show/5TDUK3F2sJXfnG63hSxJhT?si=40bb52e5b53f404c Google Podcasts: https://bit.ly/3Olanei References & Show Notes: http://www.nicksterling.com/ The content of this video is for general information purposes only and does not constitute the practice of medicine or any other healthcare professional services. The content of this video is not medical advice. No doctor-patient relationship is formed. The content of this podcast should not take precedence over information provided to you by your healthcare provider or official public health sources. Please visit nicksterling.com/terms for full Terms of Use.

    5 min
  7. How Overeating Rewires Our Brains – Neuroscience of Weight Gain & Loss | Nick Sterling, MD, PhD #4

    12/28/2022

    How Overeating Rewires Our Brains – Neuroscience of Weight Gain & Loss | Nick Sterling, MD, PhD #4

    In this episode, we discuss how overeating can lead to inflammation and neuron dysfunction in specific parts of the brain that control appetite and energy regulation. We review the neuroscience of appetite regulation, energy expenditure, and body fat regulation. Topics include hypothalamic dysfunction of body fat regulation, leptin resistance, neuro-inflammation, and physical changes in the hypothalamus involving microglia (the immune cells of the brain). We also review what is known about avoiding and reversing these changes. Chapters: 00:00:00 - Introduction 00:00:37 - Brain Changes in Obesity 00:01:20 - Leptin Deficiency & Obesity 00:03:25 - Leptin Replacement 00:04:43 - Hypothalamic Obesity 00:05:42 - What is the Hypothalamus? 00:06:51 - Food Intake, Appetite, & VMH 00:08:50 - Ob Gene 00:09:34 - The Satiety Factor 00:11:11 - Leptin Paradox 00:11:51 - Leptin Resistance 00:13:41 - Leptin Physiology 00:15:03 - Leptin Resistance 00:18:11 - Effects of Leptin Resistance 00:18:29 - Improving Leptin Resistance 00:20:24 - Hypothalamic Inflammation 00:24:08 - Triggers of Hypothalamic Inflammation 00:25:45 - Fatty Acids & Hypothalamic Inflammation 00:26:24 - Advanced Glycation End Products (AGEs) 00:27:05 - Current Knowledge on Hypothalamic Inflammation 00:28:17 - Summary 00:30:16 - Outro Social & Website: Instagram - https://www.instagram.com/sterlingmdphd  Twitter - https://twitter.com/sterlingmdphd Facebook - https://www.facebook.com/sterlingmdphd TikTok - https://www.tiktok.com/@sterlingmdphd Newsletter - http://eepurl.com/hQpdqT Subscribe to the Podcast: Apple Podcasts: https://apple.co/3y438C9 Spotify: https://open.spotify.com/show/5TDUK3F2sJXfnG63hSxJhT?si=40bb52e5b53f404c Google Podcasts: https://bit.ly/3Olanei References & Show Notes: http://www.nicksterling.com/

    32 min
  8. Is it Possible to be Healthy and Obese? | Nick Sterling, M.D., Ph.D. #3

    12/28/2022

    Is it Possible to be Healthy and Obese? | Nick Sterling, M.D., Ph.D. #3

    Is it possible to be metabolically healthy and overweight or obese? In this episode, we discuss the science of what makes fat healthy or unhealthy. We discuss how metabolic dysfunction in fat tissue can affect the rest of the body. We also review evidence pertaining to the "obesity paradox" and explore explanations for the associations of body mass index (BMI) and changes in the risk of disease complications and mortality. We discuss how metrics of central obesity can be used to obtain a better picture of an individual's metabolic health. Lastly, we discuss the critical link between exercise capacity and future health, as well as how to begin to transform our existing fat stores into a healthier state. Chapters: 00:00 - Introduction 00:50 - Healthy Obesity as an Idea 02:36 - Concepts of Healthy vs. Unhealthy Fat 02:59 - Subcutaneous, Visceral, and Ectopic Fat 05:22 - Adipocyte Hypertrophy 06:36 - Fat Cell Insulin Resistance 08:19 - The Obesity Paradox 12:23 - BMI & Age 13:53 - Bariatric Surgery 15:51 - Limitations of BMI 16:26 - Lifetime Maximal BMI 16:37 - Metrics of Central Adiposity 18:30 - Metabolically Healthy Obesity 21:38 - Exercise & Metabolically Healthy Obesity 22:36 - Improving the Health of Fat 24:03 - Exercise Capacity & Risk of Death 25:29 - Zone 2 Training 26:51 - The Effects of Weight Loss (Fat Loss) 27:55 - Summary Social & Website: Instagram - https://www.instagram.com/sterlingmdphd  Twitter - https://twitter.com/sterlingmdphd Facebook - https://www.facebook.com/sterlingmdphd TikTok - https://www.tiktok.com/@sterlingmdphd Newsletter - http://eepurl.com/hQpdqT Subscribe to the Podcast: Apple Podcasts: https://apple.co/3y438C9 Spotify: https://spoti.fi/3mZDvMv Google Podcasts: https://bit.ly/3Olanei References & Show Notes: http://www.nicksterling.com/ Maffetone Method: https://philmaffetone.com/180-formula/

    31 min
  9. How the Best Athletes "Burn" Fat for Fuel - Endurance Metabolism | Nick Sterling, M.D., Ph.D. #2

    12/28/2022

    How the Best Athletes "Burn" Fat for Fuel - Endurance Metabolism | Nick Sterling, M.D., Ph.D. #2

    In this episode, we discuss fat through the lens of performance and survival, and what happens when we push our energy systems to their limits. We also talk about how our bodies make adaptations via exercise to improve our ability to "burn" fat for fuel, and how our bodies conserve fuel during times of negative energy balance. Lastly, we preview the role of fat as an endocrine organ and the importance of its communication with the brain, as well as the critical role of exercise capacity for our future health. Chapters: 00:00 - Introduction 01:49 - Extreme Endurance 02:54 - Fuel Source & Effort 03:12 - Glycogen 05:16 - Using Fat for Fuel 08:48 - Known Limits of Prolonged Energy Expenditure 10:21 - Metabolic Rate & Endurance Duration 14:00 - Physiology of Fat 16:18 - Insulin & Catecholamines in Fat Metabolism 19:10 - Fat as an Endocrine Organ 21:05 - Exercise & Maximal Fat Oxidation 22:02 - Exercise & Future Health 22:55 - Summary Social & Website: Instagram - https://www.instagram.com/sterlingmdphd  Twitter - https://twitter.com/sterlingmdphd Facebook - https://www.facebook.com/sterlingmdphd TikTok - https://www.tiktok.com/@sterlingmdphd Newsletter - http://eepurl.com/hQpdqT Subscribe to the Podcast: Apple Podcasts: https://apple.co/3y438C9 Spotify: https://spoti.fi/3mZDvMv Google Podcasts: https://bit.ly/3Olanei References & Show Notes: http://www.nicksterling.com/

    26 min
  10. How Our Food Environment Drives Weight Gain | Nick Sterling, M.D., Ph.D. #1

    12/28/2022

    How Our Food Environment Drives Weight Gain | Nick Sterling, M.D., Ph.D. #1

    This is our first episode on weight gain and weight loss. In this episode, we describe how, as an industrialized nation, our food supply and environment have changed in a way that, in many cases, is mismatched with our biology as humans. We explore how these changes can lead to disease and metabolic dysfunction. We discuss how the replacement of whole foods with processed foods, as well as the addition of caloric sweeteners to most of the food items within grocery stores across the nation has preceded a rapid rise in obesity and metabolic dysfunction. In this episode, we begin to discuss some of the pathophysiology related to the consumption of ultra-processed and hyper-palatable foods as well as concerns surrounding the consumption of fructose- and glucose- containing sugary drinks. We also discussed the timelines of weight gain and loss as they typically occur over the lifespan and vary according to season. This episode sets the stage for the next episodes, which will focus on the normal fat metabolism and how it may become dysregulated in metabolic dysfunction.  Chapters: 00:00 - Introduction 01:21 - Metabolic health as a continuum 03:57 - Obesity as an epidemic 05:12 - Heritability and genetics of obesity 06:45 - Where obesity starts in the body 07:26 - History of weight gain in the U.S. 11:32 - High fructose corn syrup vs. table sugar 13:40 - Glycemic index and load 14:45 - What happens to your liver with sugary drinks 16:24 - Sugary drinks may be associated with cancerous changes 17:35 - The calories from sugary drinks are not automatically offset 20:24 - Obesity as a disease 23:10 - Obesity and kids 24:24 - How obesity develops across the lifespan 26:55 - The impacts of weight loss attempts 30:12 - Summary and upcoming content Social & Website: Instagram - https://www.instagram.com/sterlingmdphd  Twitter - https://twitter.com/sterlingmdphd Facebook - https://www.facebook.com/sterlingmdphd TikTok - https://www.tiktok.com/@sterlingmdphd Newsletter - http://eepurl.com/hQpdqT Subscribe to the Podcast: Apple Podcasts: https://apple.co/3y438C9 Spotify: https://spoti.fi/3mZDvMv Google Podcasts: https://bit.ly/3Olanei References & Show Notes: http://www.nicksterling.com/

    34 min

Ratings & Reviews

5
out of 5
2 Ratings

About

Physician focused on the science of metabolic health, aging, longevity, and athletic performance.

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