10 episodes

Physician focused on the science of metabolic health, aging, longevity, and athletic performance.

Nick Sterling, MD, PhD Nick Sterling, MD, PhD

    • Health & Fitness
    • 5.0 • 2 Ratings

Physician focused on the science of metabolic health, aging, longevity, and athletic performance.

    Metabolic Health, Insulin Resistance, & Mitochondrial Health | Nicolas Verhoeven (Physionic)

    Metabolic Health, Insulin Resistance, & Mitochondrial Health | Nicolas Verhoeven (Physionic)

    In this episode, I had the pleasure of sitting down with Nicolas Verhoeven of Physionic. We focus our attention on metabolic health and, specifically, the energy-related, cellular, and nutritional mechanisms of insulin resistance. Nicolas reviews evidence pertaining to the reversal of insulin resistance and dietary clinical trials demonstrating remission of type 2 diabetes. Nicolas also highlights the synergistic effects of physical activity and dietary habits on insulin resistance, expanding our discussion into mitochondrial health. Finally, we explore importance of a nuanced conversation around autophagy and its role in health and disease prevention.

    Physionic on YouTube:
    https://www.youtube.com/@Physionic

    Chapters:

    00:00:13 - Nicolas' Background & Inspiration
    00:05:34 - Misconceptions about Carbs & Fat Intake
    00:08:57 - Mechanisms of Insulin Resistance
    00:18:34 - Reversing Insulin Resistance & Diabetes
    00:23:08 - Measuring Insulin Resistance
    00:24:20 - Continuous Glucose Monitoring (CGM)
    00:30:25 - Insulin Resistance & Health
    00:37:33 - Mitochondrial Dysfunction
    00:49:14 - Mitochondrial Biogenesis
    00:56:05 - Improving Mitochondrial Health
    01:02:54 - Autophagy
    01:07:28 - Closing Remarks

    Social & Website:
    Instagram - https://www.instagram.com/sterlingmdphd
    Twitter - https://twitter.com/sterlingmdphd
    Facebook - https://www.facebook.com/sterlingmdphd
    TikTok - https://www.tiktok.com/@sterlingmdphd
    Newsletter - http://eepurl.com/hQpdqT

    Subscribe to the Podcast:
    Apple Podcasts: https://apple.co/3y438C9
    Spotify: https://open.spotify.com/show/5TDUK3F2sJXfnG63hSxJhT?si=40bb52e5b53f404c
    Google Podcasts: https://bit.ly/3Olanei

    References & Show Notes:
    http://www.nicksterling.com/

    The content of this podcast is not medical advice, is for general information purposes only, and does not constitute the practice of medicine or any other healthcare professional services. No doctor-patient relationship is formed. The content of this podcast is not a substitute for medical evaluation or treatment and does not take precedence over information provided to you by your healthcare provider or official public health sources. Please visit nicksterling.com/terms for full Terms of Use.

    • 1 hr 8 min
    How I Went from 5K to Ironman Triathlons & Ultra-Marathons. Building Speed & Endurance

    How I Went from 5K to Ironman Triathlons & Ultra-Marathons. Building Speed & Endurance

    In this episode, we discuss polarized training, which includes high-volume low intensity training and high-intensity training. We review the scientific literature pertaining to endurance performance, mechanisms of recovery debt, adaptations to various exercise modalities, and developing training programs around polarized training.

    MAF-180: https://philmaffetone.com/180-formula/

    #ultra #ironman #endurance #fitness #marathon

    Chapters:

    00:00 - Intro

    01:20 - Athletic Burnout

    02:36 - Endurance Training Distributions

    03:37 - Recovery Debt

    04:06 - Exercise-Induced Cardiac Fatigue

    04:34 - Nervous System Fatigue

    05:33 - Muscle Microtrauma

    07:01 - Fitness Adaptations

    08:56 - Maximum Aerobic Heart Rate

    10:30 - Lactate Threshold

    11:04 - High Intensity Exercise

    11:57 - Polarized Training Program

    13:05 - Outro

    Social & Website:

    Newsletter:  http://eepurl.com/hQpdqT

    Instagram: https://www.instagram.com/sterlingmdphd 

    Twitter: https://twitter.com/sterlingmdphd

    Facebook:  https://www.facebook.com/sterlingmdphd

    TikTok - https://www.tiktok.com/@sterlingmdphd

    Subscribe to the Podcast:

    Apple Podcasts: https://apple.co/3y438C9

    Spotify: https://open.spotify.com/show/5TDUK3F2sJXfnG63hSxJhT?si=40bb52e5b53f404c

    Google Podcasts: https://bit.ly/3Olanei

    References & Show Notes:

    http://www.nicksterling.com/

    • 13 min
    Muscle Loss & "Ozempic" - Prevention & What We Know | Nick Sterling, MD, PhD #8 | Nick Sterling, MD, PhD #8

    Muscle Loss & "Ozempic" - Prevention & What We Know | Nick Sterling, MD, PhD #8 | Nick Sterling, MD, PhD #8

    Does muscle loss occur in people taking GLP-1 receptor agonists such as semaglutide (marketed as "Ozempic" and "Wegovy") or combined GLP-1/GIP agonists like tirzepatide (marketed as "Mounjaro")? In this episode, we discuss current evidence regarding these next-generation weight loss drugs and muscle wasting, as well as principles of preventing muscle loss in weight loss programs.

    #healthspan, #ozempic, #fitness, #muscle, #science

    Chapters:

    00:00 - Intro
    00:30 - Importance of Muscle in Weight Loss
    01:19 - Muscle Loss During Weight Loss
    02:03 - What Affects Muscle Mass During Weight Loss?
    02:16 - Clinical Trials
    04:59 - Preserving Muscle During Weight Loss
    05:30 - Protein Intake
    06:28 - Strength Training
    06:59 - Monitoring Body Composition
    07:26 - Summary

    Social & Website:
    Instagram - https://www.instagram.com/sterlingmdphd
    Twitter - https://twitter.com/sterlingmdphd
    Facebook - https://www.facebook.com/sterlingmdphd
    TikTok - https://www.tiktok.com/@sterlingmdphd
    Newsletter - http://eepurl.com/hQpdqT

    Subscribe to the Podcast:
    Apple Podcasts: https://apple.co/3y438C9
    Spotify: https://open.spotify.com/show/5TDUK3F2sJXfnG63hSxJhT?si=40bb52e5b53f404c
    Google Podcasts: https://bit.ly/3Olanei

    References & Show Notes:
    http://www.nicksterling.com/

    The content of this video is for general information purposes only and does not constitute the practice of medicine or any other healthcare professional services. The content of this video is not medical advice. No doctor-patient relationship is formed. The content of this video should not take precedence over information provided to you by your healthcare provider or official public health sources. Please visit nicksterling.com/terms for full Terms of Use.

    • 8 min
    How “Ozempic” Works – Weight Loss, Weight Regain, & Neuroscience | Nick Sterling, MD, PhD #7

    How “Ozempic” Works – Weight Loss, Weight Regain, & Neuroscience | Nick Sterling, MD, PhD #7

    How do drugs like Ozempic (semaglutide) cause weight loss? In this episode, we discuss how these drugs (GLP-1 receptor agonists) target specific areas in the brain to suppress appetite and facilitate weight loss. We also discuss clinical trials data suggesting that these drugs and/or the weight loss that they facilitate may have cardioprotective effects. Lastly, we will also examine evidence regarding weight regain when coming off of these drugs and common side effects.

    Link to episode on neuroscience of appetite regulation:
    https://www.youtube.com/watch?v=i3RzV9vS_FA#healthspan, #semaglutide, #ozempic, #wegovy, #science, #weightloss

    Chapters:

    00:00 - Intro
    01:31 - What Does GLP-1 Do?
    02:08 - GLP-1 Receptors in the Brain
    02:52 - Activating the GLP-1 "Switch" (Receptors)
    04:13 - Clinical Trials - Semaglutide for Weight Loss
    05:29 - Semaglutide and Heart & Metabolic Health
    05:54 - For How Long Does Semaglutide Work?
    06:35 - Weight Regain After Stopping Semaglutide
    08:24 - Side Effects of GLP-1 Receptor Agonists
    09:37 - Take-Home Points
    10:20 - Outro

    Social & Website:
    Instagram - https://www.instagram.com/sterlingmdphd
    Twitter - https://twitter.com/sterlingmdphd
    Facebook - https://www.facebook.com/sterlingmdphd
    TikTok - https://www.tiktok.com/@sterlingmdphd
    Newsletter - http://eepurl.com/hQpdqT

    Subscribe to the Podcast:
    Apple Podcasts: https://apple.co/3y438C9
    Spotify: https://open.spotify.com/show/5TDUK3F2sJXfnG63hSxJhT?si=40bb52e5b53f404c
    Google Podcasts: https://bit.ly/3Olanei

    References & Show Notes:
    http://www.nicksterling.com/

    The content of this video is for general information purposes only and does not constitute the practice of medicine or any other healthcare professional services. The content of this video is not medical advice. No doctor-patient relationship is formed. The content of this podcast should not take precedence over information provided to you by your healthcare provider or official public health sources. Please visit nicksterling.com/terms for full Terms of Use.

    • 11 min
    How Fats & Carbs Drive Food Intake | Nick Sterling, MD, PhD #6

    How Fats & Carbs Drive Food Intake | Nick Sterling, MD, PhD #6

    Highly processed foods have been shown to lead to weight gain and are thought to drive intake through several mechanisms. Recent research suggests that the effect of combining fats and carbs on appetite might be more than the sum of their individual effects. Highly processed foods, accordingly, might simulate increased intake via the ratio of macronutrients.

    Link to episode on neuroscience of appetite regulation:
    https://www.youtube.com/watch?v=i3RzV9vS_FA

    Study Link: https://doi.org/10.1016/j.cmet.2018.06.010
    Errata: Hu et al. was published in 2018.

    #diet, #weightloss, #science, #fitness, #food

    Chapters:
    00:00 Intro to Ultra-Processed Foods
    00:51 Mouse Study on Macronutrients & Food Intake
    01:34 Fat-to-Carb Ratio May Affect Food Intake
    02:15 Brain Effects of Diet
    03:26 Key Points
    03:51 Study Limitations
    04:23 Outro

    Social & Website:
    Instagram - https://www.instagram.com/sterlingmdphd
    Twitter - https://twitter.com/sterlingmdphd
    Facebook - https://www.facebook.com/sterlingmdphd
    TikTok - https://www.tiktok.com/@sterlingmdphd
    Newsletter - http://eepurl.com/hQpdqT

    Subscribe to the Podcast:
    Apple Podcasts: https://apple.co/3y438C9
    Spotify: https://open.spotify.com/show/5TDUK3F2sJXfnG63hSxJhT?si=40bb52e5b53f404c
    Google Podcasts: https://bit.ly/3Olanei

    References & Show Notes:
    http://www.nicksterling.com/

    The content of this video is for general information purposes only and does not constitute the practice of medicine or any other healthcare professional services. The content of this video is not medical advice. No doctor-patient relationship is formed. The content of this podcast should not take precedence over information provided to you by your healthcare provider or official public health sources. Please visit nicksterling.com/terms for full Terms of Use.

    • 5 min
    How Ultra-Processed Foods Drive Weight Gain | Nick Sterling, MD, PhD #5

    How Ultra-Processed Foods Drive Weight Gain | Nick Sterling, MD, PhD #5

    Growing scientific evidence suggests that highly processed foods are associated with increased risk of disease. Until recently, scientists were unable to study directly the effects of highly processed foods on humans. In this episode, we review one of the first highly controlled scientific trials demonstrating that ultra-processed foods lead to weight gain. 

    Neuroscience of appetite regulation: https://youtu.be/i3RzV9vS_FA

    #diet, #weightloss, #science, #fitness, #food



    Chapters:

    00:00 - Intro to Ultra-Processed Foods

    00:55 - What are Ultra-Processed Foods?

    02:14 - Disease & Ultra-Processed Foods

    03:19 - Interventional Study

    04:24 - Ultra-Processed Foods & Weight Gain

    05:44 - Take-Home Points

    06:57 - Outro



    Social & Website:

    Instagram - https://www.instagram.com/sterlingmdphd

    Twitter - https://twitter.com/sterlingmdphd

    Facebook - https://www.facebook.com/sterlingmdphd

    TikTok - https://www.tiktok.com/@sterlingmdphd

    Newsletter - http://eepurl.com/hQpdqT

    Subscribe to the Podcast:

    Apple Podcasts: https://apple.co/3y438C9

    Spotify: https://open.spotify.com/show/5TDUK3F2sJXfnG63hSxJhT?si=40bb52e5b53f404c

    Google Podcasts: https://bit.ly/3Olanei



    References & Show Notes:

    http://www.nicksterling.com/

    • 8 min

Customer Reviews

5.0 out of 5
2 Ratings

2 Ratings

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