311 episodes

Throughout my training and practice as a physician I have come to one very disappointing conclusion: Western medicine isn’t helping people lead better lives. Now that I’ve realized this, I’ve become obsessed with understanding what makes us healthy or ill. I want to live the best life I can and I want to be able to share this knowledge with others so that they can do the same. This podcast is the result of my relentless search to understand the roots of chronic disease. I hope you’ll join me on this journey.

Paul Saladino MD podcast Paul Saladino, MD

    • Health & Fitness
    • 4.8 • 2.4K Ratings

Throughout my training and practice as a physician I have come to one very disappointing conclusion: Western medicine isn’t helping people lead better lives. Now that I’ve realized this, I’ve become obsessed with understanding what makes us healthy or ill. I want to live the best life I can and I want to be able to share this knowledge with others so that they can do the same. This podcast is the result of my relentless search to understand the roots of chronic disease. I hope you’ll join me on this journey.

    246. Some things I'm experimenting with lately...

    246. Some things I'm experimenting with lately...

    On today’s podcast, Paul shares some new things he’s been experimenting with lately including eating more heart, supplementing with creatine, attempting to incorporate white rice as a carb source, and most excitingly, the launch of his new company: Lineage.

    00:00:00 The importance of heart & riboflavin

    00:08:30 Pauls new company: Lineage

    00:10:50 Thoughts on creatine

    00:19:10 Paul’s experience with white rice & potatoes

    00:24:45 Paul experimenting with supplements for methylation

    Check out Lineage Meat Sticks: https://lineageprovisions.com/password

    References:
    Riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677C-T polymorphism: https://pubmed.ncbi.nlm.nih.gov/16380544/

    • 30 min
    245. Debunking Sugar Claims: What Dr. Lustig Got Wrong On The Huberman Lab Podcast

    245. Debunking Sugar Claims: What Dr. Lustig Got Wrong On The Huberman Lab Podcast

    This week, Paul talks to Mike Fave, critical care RN, about all things sugar & fructose. They share their thoughts on a recent podcast with Andrew Huberman and Alex Lustig, and why they disagree with certain points made about insulin, fruit juice, and fructose.

    00:00:00 Podcast begins
    00:04:00 Mike’s background
    00:05:15 Diving into fructose
    00:13:00 Thoughts on honey and other carb sources
    00:27:30 Robert Lustig rebuttal: is fructose addictive?
    00:37:40 Fructose & fiber
    00:47:00 How fructose affects the mitochondria
    00:51:00 Clarifying hyperglycemia vs. a postprandial hyperglycemia
    00:56:17 Is insulin the bad guy?
    01:12:20 How insulin relates to diabetes, obesity, and insulin resistance
    01:23:30 Balancing protein, fat and carbohydrates
    01:30:00 Is fructose making us fat?
    01:46:00 Final thoughts


    Connect with Mike:
    Mikefave.com
    https://m.youtube.com/@MikeFaveSimplified


    References:
    Review article: fructose malabsorption and the bigger picture: https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2006.03186.x

    A Relationship between Reduced Nucleus Accumbens Shell and Enhanced Lateral Hypothalamic Orexin Neuronal Activation in Long-Term Fructose Bingeing Behavior: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988143/

    A High-Fat Meal, or Intraperitoneal Administration of a Fat Emulsion, Increases Extracellular Dopamine in the Nucleus Accumbens: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061790/

    A Relationship between Reduced Nucleus Accumbens Shell and Enhanced Lateral Hypothalamic Orexin Neuronal Activation in Long-Term Fructose Bingeing Behavior: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988143/

    The regulation of glucose metabolism: implications and considerations for the assessment of glucose homeostasis in rodents: https://journals.physiology.org/doi/full/10.1152/ajpendo.00165.2014?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org

    Consumption of Raw Orange, 100% Fresh Orange Juice, and Nectar- Sweetened Orange Juice—Effects on Blood Glucose and Insulin Levels on Healthy Subjects: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770506/

    The Effects of Soluble Dietary Fibers on Glycemic Response: An Overview and Futures Perspectives: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736284/#B37-foods-11-03934

    The Effects of Soluble Dietary Fibers on Glycemic Response: An Overview and Futures Perspectives: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736284/#B37-foods-11-03934

    Formation of Fructose-Mediated Advanced Glycation End Products and Their Roles in Metabolic and Inflammatory Diseases: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5227984/

    Altered glycolytic and oxidative capacities of skeletal muscle contribute to insulin resistance in NIDDM: https://pubmed.ncbi.nlm.nih.gov/9216960/

    Glucagon and type 2 diabetes: the return of the alpha cell: https://pubmed.ncbi.nlm.nih.gov/25344790/

    Insulin, growth hormone and sport: https://pubmed.ncbi.nlm.nih.gov/11431133/

    Effect of Mild Physiologic Hyperglycemia on Insulin Secretion, Insulin Clearance, and Insulin Sensitivity in Healthy Glucose-Tolerant Subjects: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881846/

    Fructose metabolism in humans – what isotopic tracer studies tell us: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533803/

    Absorption capacity of fructose in healthy adults. Comparison with sucrose and its constituent monosaccharides: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1433856/

    Review article: fructose malabsorption and the bigger picture: https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2006.03186.x

    Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice: https://pubmed.ncbi.nlm.nih.gov/19637282/

    Fructose Promotes Leaky Gut, Endotoxemia and Liver Fibrosis through CYP2E1-Mediated Oxidative and Nitrative Stress: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783321/

    • 1 hr 54 min
    244. Longevity Alert: The Dark Side of Olive Oil Revealed with Brad Marshall

    244. Longevity Alert: The Dark Side of Olive Oil Revealed with Brad Marshall

    On this week's podcast, Brad Marshall, evolutionary biologist, talks with Paul about how signaling to our body that winter is coming is not advantageous for humans and why humans may want to stop consuming olive oil. They do a deep dive into the human metabolism, what European diets are truly like, and touch on other kinds of oils & fats as well.



    00:00:00 Podcast begins

    00:02:50 Brad’s weight loss journey

    00:10:50 The human metabolism

    00:15:10 How olive oil makes us fat

    00:34:24 Deep dive into European diets

    00:48:50 PREDIMED trial comparing different types of olive oil

    00:51:05 De novo lipogenesis (DNL)

    00:53:50 What happens when humans eat canola oil

    00:59:20 A story about the Inuit & long-term ketosis

    01:07:20 Takeaways about olive oil



    Connect with Brad:

    https://www.youtube.com/@fireinabottle3410



    References:

    Diabetes prevalence, 2021: https://ourworldindata.org/grapher/diabetes-prevalence



    Trends of overweight, obesity and anthropometric measurements among the adult population in Italy: The CUORE Project health examination surveys 1998, 2008, and 2018: https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0264778.g004



    OBESITY AMONG CHILDREN IN EUROPE: https://landgeist.com/2023/02/18/obesity-among-children-in-europe/



    Modeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016-2030: https://pubmed.ncbi.nlm.nih.gov/29886156/



    Effects of free omega-3 carboxylic acids and fenofibrate on liver fat content in patients with hypertriglyceridemia and non-alcoholic fatty liver disease: A double-blind, randomized, placebo-controlled study: https://www.lipidjournal.com/article/S1933-2874(18)30362-3/fulltext



    Quality of Dietary Fat Intake and Body Weight and Obesity in a Mediterranean Population: Secondary Analyses within the PREDIMED Trial: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315420/

    • 1 hr 17 min
    243. Responding to Layne Norton on SEED OILS

    243. Responding to Layne Norton on SEED OILS

    This episode is my response to Layne’s video about seed oils. Due to the pervasive mainstream support for seed oils, I believe it’s extremely important to shed some light on the hidden truth behind these oils. There is a lot of conflicting evidence on seed oils out there. Looking at the totality of the evidence can be very misleading, so we must look at the details. By thoroughly breaking down each trial from Layne’s video, we can see massive flaws in the methods and designs of each study. Trans fat consumption by the control group and multifactorial interventions in the experimental group were the primary confounding variables.

    In this video, Paul references several studies suggesting different ways in which seed oils are harmful to humans. He always appreciate differing views and these discussions because it’s how we all learn. He has hope that a respectful debate will happen in the future so that we can dive deeper into this important subject. He strongly believe that seed oils are evolutionarily inconsistent, these are not the fats that humans have evolved on. In fact, we have evolved by consuming ample amounts of animal fats, rich in saturated fats. Saturated fats have been shown to lower markers of heart disease and they are an amazing source of essential vitamins like A, D3, K2, E.

    It's always meat / organs / fruit / honey / raw dairy. This is an ANIMAL-BASED diet, and I believe this is the most optimal diet for humans on the planet.

    Check out my ANIMAL-BASED CALCULATOR here: https://www.paulsaladinomd.co/ab-guide



    Listen on YouTube: https://www.youtube.com/watch?v=8QhWNBXamCM&t=1s



    Sign-up for Animal Based 30: https://heartandsoil.co/animalbased30/

    00:00 Intro
    02:57 Randomized controlled trials in humans
    03:47 Flaws found in the studies
    04:42 Reviewing each trial
    16:10 What’s the takeaway
    19:45 Studies against seed oils
    26:30 Toxic compounds in seed oils
    27:32 Responding to Layne’s claims
    36:10 Closing thoughts


    References:

    Meta-analysis of RCT by C. Ramsden - https://www.ncbi.nlm.nih.gov/pmc/arti...

    Meta-analysis of RCT by S. Hamley - https://www.ncbi.nlm.nih.gov/pmc/arti...

    PUFA increases lipid peroxidation - https://www.ncbi.nlm.nih.gov/pmc/arti...

    Linoleic acid metabolites in metabolic syndromes - https://www.ncbi.nlm.nih.gov/pmc/arti...

    Lower saturated fat increases oxidized LDL - https://pubmed.ncbi.nlm.nih.gov/14739...

    More linoleic acid increases oxidized LDL - https://pubmed.ncbi.nlm.nih.gov/9488997/

    OXLAMs in atherosclerosis - https://www.ncbi.nlm.nih.gov/pmc/arti...

    Oxidized LDL and metabolic syndrome - https://pubmed.ncbi.nlm.nih.gov/19802...

    De novo lipogenis through oxidized LDL and linoleic acid - https://pubmed.ncbi.nlm.nih.gov/27020...

    Lower linoleic acid reduces oxidized metabolites - https://www.ncbi.nlm.nih.gov/pmc/arti...

    Soybean oil increase Lp-PLA2 and oxidized LDL - https://pubmed.ncbi.nlm.nih.gov/28503...

    Saturated fat lowers Lp(a) - https://pubmed.ncbi.nlm.nih.gov/9327759/

    Benzene in seed oils - https://pubmed.ncbi.nlm.nih.gov/11064...

    Heavy metals in seed oils - https://www.mdpi.com/2076-3417/13/5/3020

    Phthalates in seed oils - https://pubmed.ncbi.nlm.nih.gov/37726...

    • 36 min
    242. Debunking Cholesterol Myths: New Study Reveals Surprising Findings! With Dave Feldman

    242. Debunking Cholesterol Myths: New Study Reveals Surprising Findings! With Dave Feldman

    Today, Paul has Dave Feldman on the podcast to discuss, in depth, a recent study that he conducted about LDL and cardiovascular risk and what this may mean for the future of medicine.



    *Produced by Mountain Valley Media



    00:03:30 The genesis of Dave’s most recent study

    00:07:00 is FH a phenotype or genotype polygenetic vs monogenetic

    00:22:30 Dave’s overall perspective while conducting studies

    0:24:00 Diving into Dave Feldman’s most recent study: Does APOE-B cause atherosclerosis

    00:42:30 How the medical community has received this study

    00:46:30 Do credentials matter?

    00:58:30 Thoughts on Statins

    01:04:45 What alters lipid levels

    01:13:30 Connect with Dave



    References:

    Twitter: @realdavefeldman

    Instagram: @realdavefeldman

    Youtube: youtube.com/@realdavefeldman

    https://citizensciencefoundation.org/

    • 1 hr 13 min
    241. Coke’s secret playbook to keep you addicted to sugar with Calley Means

    241. Coke’s secret playbook to keep you addicted to sugar with Calley Means

    Paul sits down in person with Calley Means to talk about the ins and outs of food industry corruption. Calley shares his firsthand experience as a previous consultant for Coca Cola, and unearths their strategies in keeping Americans addicted to sugar.



    *Produced by Mountain Valley Media



    00:02:00 The truth about Ozempic

    00:08:15 Calley’s experience working for Big Pharma

    00:27:45 When is Western medicine necessary?00:32:00 Addiction & targeting children

    00:42:00 The infertility crisis

    00:46:00 How Big Pharma manipulates the narrative

    01:06:10 Food Compass & Dariush Mazaffarian

    01:12:00 The path forward for medical professionals

    01:35:20 Politics & disrupting the nutritional space

    01:40:40 Ideas

    01:45:40 Seed oils in infant formula

    01:52:00 Conclusion & how to connect with

    Calley



    References:

    https://www.truemed.com/

    • 1 hr 55 min

Customer Reviews

4.8 out of 5
2.4K Ratings

2.4K Ratings

idahowapiti ,

Awesome, But……

Great podcast but maybe a little less pimping of the supplements

kellyoyoy ,

Paul Saladino MD Podcast

I absolutely appreciate the raw knowledge Paul and his guests share with us. Real true information that truly gives us realistic changes we can make. The referrals he offers, the testimony stories, the connections he gives us, really does help us make these dreams to change a reality. I appreciate all the different topics he talks about and learning all the benefits there is out there. Thanks Paul

jstev171 ,

Calley Means

Fantastic interview and discussion. Thank you so much!!

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