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In this episode of Psychedelics Weekly, Joe and Kyle are once again able to take advantage of Kyle's temporary Colorado residency and record together in Joe's office.
While last week focused on the numerous challenges facing a rapidly growing industry of psychedelic therapists, facilitators, and guides, the topic of therapy itself is put under the microscope this week, as they dissect a New York Times article titled, "Does Therapy Really Work? Let’s Unpack That." They discuss whether or not therapy is right for everyone, the efficacy of different types of therapy, the role of the therapeutic alliance in treatment outcomes, and how (if it's even possible) to measure all of these factors.
They also discuss:
-a study showing that ketamine was more effective than ECT (electroconvulsive therapy) for patients with treatment-resistant depression;
-the potential benefits of the LSD analog, Br-LSD, in treating people with major depressive disorders, cluster headaches, and more;
-Ireland's Health Service Executive launching the Safer Nightlife program, which will partner with music festivals this summer to establish on-site drug testing;
-the U.S. slowly beginning to legalize fentanyl test strips, which, for some reason, are illegal in many parts of the country;
And much more!
See you next week, and if you're in the NYC area, make sure to check out "Tales of Transformation," an in-person event Thursday, June 8 at the Athenæum, moderated by David, and featuring Ifetayo Harvey, Juliana Mulligan, and Raad Seraj.

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In this episode, Joe interviews the Co-Founders of Enosis Therapeutics: researcher and scientist, Agnieszka Sekula; and psychiatrist, clinical advisor to the Australian Psychedelic Society, and leading Australian advocate for psychedelic-assisted psychotherapy, Dr. Prash P. 
Enosis Therapeutics is a medtech startup that began with the question: how can we use VR – with or without psychedelics – to improve mental health outcomes? They feel that the biggest problem with powerful psychedelic experiences is that, once you’re back in reality, it’s oddly difficult to remember the insights and new ideas that were so clear during the experience, and even harder to make connections that lead to concrete change. They believe that the immersive nature of VR and the novelty of unique VR environments creates a sense of presence that can’t be recreated otherwise – a liminal, in-between state that’s just different enough to allow the patient to feel like they’re back in that non-ordinary state, and therefore more able to anchor their experience and begin to find connections and more clearly understand newfound insights. 
This all happens by the user essentially creating nonlinear, abstract, multi-sensory VR paintings while describing what they remembered; allowing them to revisit these worlds later, bring in therapists (or anyone else) to work inside these environments, and hear their own voice describing what happened, thereby creating a mental map that can be worked with in completely unique ways. 
They talk about the conflict between new technologies and traditionalists; the problems with moving away from psychoanalysis and not treating psychotherapy as a process; how VR could improve the efficacy of therapy (and improve therapists’ lives); how it could replace models of repeated dosage; how VR could generate analytics to actually quantify success in mental health treatment; and how (whether psychedelics are used or not) culture needs to bring the psychedelic way of thinking to mental health.
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In this episode of Psychedelics Weekly, Kyle and David meet up to talk news, but end up mostly having a discussion about the numerous challenges facing the rapidly growing industry of psychedelic therapists, guides, and facilitators.
That discussion comes from the article, “Psychedelic workers of the world, unite!”, which breaks down the shortcomings and risks of an industry many are flocking to without realizing what they’ll likely have to deal with: unprecedented legal and financial risks, burnout, misalignment with management, transference and countertransference, and what happens when one finds themselves in the middle of a genuine emergency? While these issues could be found in any industry, a big reason why they seem so prevalent and dangerous in the psychedelic world is our lack of elders and passed-down experience – and the faster this all grows, the more we need that guidance. 
And for news, they talk about Ohio State making history as the first U.S. University to receive a license to grow psilocybin mushrooms; a new study showing that LSD enhanced learning, exploratory thinking, and sensitivity to feedback; and the National Institute on Drug Abuse (NIDA) funding $1.5 million to research the efficacy of psychedelics for substance use disorder – which spurs a conversation about research, funding, and the idea that maybe we’re spending too much time and money on neuroscience.

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In this episode, Joe interviews Priyanka Wali, MD: board-certified practicing physician in Internal Medicine, MAPS-trained psychedelic facilitator, comedian, and co-host (with Sean Hayes of "Will & Grace" fame) of the HypochondriActor podcast, where they discuss interesting medical issues in a funny (and hopefully uplifting) way. 
She talks about recognizing and protecting the humanity of healthcare professionals, and how medical school is creating a cycle of hurt people trying to help other hurt people. She believes we need to become more holistic, especially in embracing Indigenous ways of thinking, as their frameworks may be the only way to explain phenomena with which Western science can’t come to terms.  
They talk a lot about ancient psychedelic use: the use of a soma described in the Rigveda; Egyptian culture and mushrooms observed in statues; Plato; the work of Brian Muraresku and Graham Hancock; and Vedic chants, Kashmiri Bhajans, and how singing (especially in a group) can be especially healing to the nervous system. And as Wali experienced first-hand the Kashmiri Pandit genocide of 1990, she discusses how much colonialism has changed cultures, and how much our cycles of oppression relate to our collective inability to experience pain and fear.  
They discuss the psychological impact of living through major catastrophes; the special and hard-to-describe feeling of returning to your home (especially in a world changed by colonization and constant conflict); the sad case of Ignaz Semmelweis and hand washing; ghosts of Japan’s 2011 tsunami, the concept of ‘future primitive,’ and more.

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In this episode of Psychedelics Weekly, Joe and Kyle are both on the road, so David and Alexa take the helm.
They cover news stories about: 
-a man in Colorado facing a Class 3 drug felony for giving people psilocybin mushrooms in exchange for monetary donations – pointing out the bold (or stupid?) stances some are taking to highlight the absurdity of legislation that allows possession and donation as long as no money changes hands; 
-a study showing what many of us have felt ourselves: that the day after psilocybin-assisted therapy, depressed patients had a stronger brain response to music and saw improvements in the ability to find pleasure in previously empty activities; 
-a trip report from a psychedelically-naive 50-year old, showing the power and beauty of MDMA-assisted therapy; 
-the New Hampshire state Senate continuing to be behind the times and voting down House Bill 639, which would have created a legal recreational cannabis framework for the state;
-a video where people on the street in Oregon were asked how much they thought psilocybin therapy would cost, showing a drastic misalignment between public perception and reality;
and a local TV news feature touring Rose City Laboratories, the first licensed psilocybin testing lab in Oregon.
And in conversation, they talk about some of the lesser-discussed (and often dismissed) tools like CBD, THC patches, and very low-dose edibles; the problem with drug dealers and harm reduction; the power of music in guiding a psychedelic experience (and in living a pleasurable life); and the importance of dosing and listening to your body to know what's right for you.
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In this episode, Joe interviews Nick Kadysh: Founder and CEO of PharmAla Biotech and member of the board of directors for The Canadian Psychedelic Businesses Association. 
PharmAla Biotech is a Toronto-based Life Sciences company with two focuses: contracting with manufacturers to provide researchers with GMP MDMA (created under Good Manufacturing Practice regulations), and creating and researching novel analogs of MDMA. And just today, they announced that Health Canada has authorized them (and their distribution partner, Shaman Pharma) to supply their LaNeo™ MDMA for the treatment of a patient under Canada’s Special Access Program – the first time this has happened in Canada. 
He discusses the creation of PharmAla and why their model changed from primarily researching analogs to manufacturing; why they’re operating out of Canada and using manufacturers instead of running the lab themselves; the excitement around Australia’s recent about-face on MDMA and psilocybin-assisted therapy; the bureaucracy of U.S. drug policy and how much a broken supply chain affects the whole industry; bad IP and companies filing rapid fire patents; why creating new analogs of MDMA is so important; and why the psychedelic space needs to bring culture along with us.
He also talks about Spravato, cannabis and risks of cancer, THC nasal sprays, and research he’s most excited about: that MDMA seems to alleviate dyskinesia caused from Parkinson’s disease, and that MDMA could improve social anxiety in people with autism. He’s aiming to run a clinical trial and believes they have developed a safe MDMA analog that the autistic community will respond to very well.
www.psychedelicstoday.com