In Search of Insight Nootropics Depot

Tribugen | How We Took Tribulus To The Next Level

This month, Emiel and Erika discuss the benefits of Tribulus Terrestris for energy, motivation, focus, and hormonal health. Making an effective stack takes more than just scientific research - this podcast episode focuses on the human element of stack creation, and why we spent so much time refining Tribugen until we got the effects profile just right.

On this month’s podcast, learn more about:

Tribulus Terrestris, Fenugreek, Dioscorea nipponica, and Cordyceps
Monoamine oxidase A and B inhibitors
Megadosing Tribugen
How Nootropics Depot creates synergistic stacks

Each ingredient in Tribugen was selected to compliment the stimulating and motivating effects of Tribulus, and in this episode Emiel discusses the mechanisms of action that are responsible for these effects.

Before Tribugen made it’s debut, the team at Nootropics Depot tried a variety of Tribulus Terrestris extracts to find the most motivating but smooth extract that would shine as a stand-alone product. When making Tribugen, we wanted to increase the motivation benefits of Tribulus, but to smooth out the stimulation and edginess of Tribulus when taken on its own. After a year of bioassaying Tribugen, adjusting the dosages of the synergistic ingredients, and sharing the pre-released stack with friends, family and colleagues, we arrived at the finished product. If you are interested in learning more about this process, and the ingredients that make up the Tribugen stack, tune into this podcast episode!

Podcast Chapters

0:00 Introduction
3:06 Mega-Dosing Tribugen
6:07 Making A Next-Level Tribulus Terrestris Extract
8:45 Why Do People Reach for Tribulus?
17:00 Where Do We Source Our Tribulus Terrestris?
18:40 β-carbolines - Monoamine Oxidase Inhibitors
21:00 Connecting Pharmacodynamics with Perceptible Benefits
24:00 Creating the Tribugen Stack
32:00 Taking Tribulus with Vignatex
34:00 How Cordyceps Interacts Within the Tribugen Stack
35:29 Cordyceps + Caffeine Connection
40:30 Choosing Synergistic Compounds + Dosages
58:30 Protodioscin + Diosgenin
1:05:19 DHEA
1:08:00 Focus Enhancing Effects of Tribugen
1:09:00 Stimulation Effects of Tribugen
1:21:00 Conclusion

March Mushroom Magic | Energy, Focus and Motivation From Your Daily Dose of Adaptogenic Mushrooms 

Have you experienced the mood lifting, physically relaxing, cognition enhancing benefits of adaptogenic mushrooms? Listen to our new podcast episode as we review Nootropics Depot's new Mushroom Magic drink mixes! Emiel and Erika disucss how Nootropics Depot sources coffee, matcha and cocoa for the most delicious drinking experience, and why Mushroom Magic drinks are great to share with friends and family! Learn more about why we chose Lions Mane, Cordyceps, Tiger Milk and Poria mushroom for our blend of gut health boosting, energizing, and immune supporting drink mixes. 

Are you interested in making adaptogenic mushrooms a part of your everyday supplement stack? Mushroom Magic drink mixes are the easiest and tastiest way to get full servings of four highly-effective, non-extracted mushrooms, proven for their cognition and immune health benefits. Tune into the podcast to learn more about each mushroom, and why we chose to include Lions Mane, Cordyceps, Poria and Tiger Milk in our first ever drink mix. 

On this month’s podcast, learn more about:


How we make mushroom magic matcha, coffee, cocoa, and lattes at home


Why we chose Poria, Tiger Milk, Cordyceps and Lions Mane mushroom in our mixes


How mushrooms benefit our gut health, cognition, focus, and energy


Which Mushroom Magic drink mix is right for you



Buy Mushroom Magic Drinks Here

https://nootropicsdepot.com/mushroom-magic-coffee/

https://nootropicsdepot.com/mushroom-magic-matcha-latte/

https://nootropicsdepot.com/mushroom-magic-coffee-latte/

https://nootropicsdepot.com/mushroom-magic-matcha-powder-blend/

https://nootropicsdepot.com/mushroom-magic-cocoa/

Learn More About Lions Mane and Tiger Milk Mushrooms

Follow Us on Instagram

Podcast Chapters

00:00 Introduction

00:40 Introducing Mushroom Magic Drink Mixes

1:02 Gut Function and Microbiome

1:45 Beta Glucans and Polysaccharides Benefit Our Gut

3:45 Follow Us On Instagram @insearchofinsight 

5:20 Poria Mushroom Sclerotium

6:25 Check Out Emiel’s Updated Stack on Reddit

8:15 Unextracted Mushrooms Contain More Beta Glucans

9:00 500 Milligrams of Poria, Lion’s Mane, Cordyceps, and 150 mg Tiger Milk

11:20 Why Mushroom Magic Drinks Contain SCOOPS

19:35 Drinking Mushroom Magic Matcha - iced latte with milk

25:20 Stevia - Why We Sourced a Higher Quality Stevia

28:00 Perceptible Effects of Mushroom Magic Matcha

31:50 Our Matcha vs. Traditional Matcha Teas

34:50 Ceremonial Grade Matcha

38:05 Effects of Poria and Tiger Milk sclerotium

49:25 Checking in On the Perceptible Benefits

56:39 The Difference Between Caffeine and Mushrooms in Isolation vs. Mushroom Magic mixes

58:05 Beta Testing Mushroom Magic drinks with friends, family and coworkers

1:07:30 Drinking Mushroom Magic Coffee

1:20:43 Non-Perceptible Benefits of Adaptogenic Mushrooms

1:26:29 Drinking Mushroom Magic Cocoa

1:39:38 Cordyceps Mushroom Health Benefits

2:08:30 Drinking Mushroom Magic Coffee Latte

2:12:40 Mushroom Magic with your Daily Supplement Stack

2:14:20 Be Moderate When Taking Multiple Doses of PreBiotics - Digestion

2:19:00 Coffee Approved By Coffee Nerds (Emiel and Erika)

2:20:30 Closing Remarks on Perceptible Benefits of Mushroom Magic DrinksLion’s Mane Mushroom | The Journey To Connect Modern Science With Traditional Chinese MedicineTiger Milk | Could It Be The New Lion's Mane? | This Rare Malaysian Mushroom Is Finally On The Prowl

Your Body’s Amazing Immune System | Is It Better To Take A Natural Approach When You Get Sick?



Our immune system is our body’s defense against sickness and infection. In this month’s podcast episode, Emiel and Erika discuss inflammation, oxidation, immune supporting supplements, fermented foods, and gut health, and explore ways to stay healthy all year round.

Tune into the new podcast episode to learn more about:

How inflammation and oxidation are tools that the immune system uses to attack pathogens and help us recover from illness
Why fermented foods and carbohydrates are essential for a healthy immune system
Vitamins, minerals, and supplements that support a healthy immune system
The connection between the gut and the immune system
Why symptom management during illness can work against us, and what to do instead

This episode is focused on why inflammation and oxidation are essential for helping us fight off pathogens, and therefore, why taking a natural approach when getting sick may help us recover faster. Sometimes, it can be advantageous to lean into the inflammation and oxidation caused by our immune system, though this can be uncomfortable. Dampening inflammation and oxidation can prolong illness, and work against our immune system’s natural response to pathogens.

Follow In Search of Insight on Instagram
https://www.instagram.com/insearchofinsight?igsh=ZGNjOWZkYTE3MQ%3D%3D&utm_source=qr

Buy Immune Supporting Supplements from Nootropics Depot
Infini C
https://nootropicsdepot.com/infini-c-capsules/

Vitamin D
https://nootropicsdepot.com/vitamin-d3-k2-with-vitamin-c-tablets/
https://nootropicsdepot.com/vitamin-d3-k2-c-supplement/

Vitamin B
https://nootropicsdepot.com/infini-b-capsules/

Zinc
https://nootropicsdepot.com/microzinc-capsules-zinc-supplement/

N-Acetyl Cysteine
https://nootropicsdepot.com/n-acetyl-l-cysteine-500mg-capsules/

Micromag
https://nootropicsdepot.com/micromag-capsules-optimized-magnesium/

Andrographis paniculata
https://nootropicsdepot.com/andrographis-paniculata-capsules-50-andrographolides/

Reduced Glutathione
https://nootropicsdepot.com/reduced-glutathione-tablets/


Recommended Podcasts on the Immune System
Using Your Nervous System to Enhance Your Immune System - Huberman Labs Podcast
https://www.youtube.com/watch?v=poOf8b2WE2g&t=3604s

The Ultimate Cold Prevention Protocol: Strengthening The Immune System with Chris Masterjohn
https://www.youtube.com/watch?v=ygeJSE2Xz4w&t=3510s

Podcast Chapters

00:00 Introduction - Immune System
01:15 How Does Our Environment Affect Our Immune System?
05:30 Inflammation and Oxidation are Tools of the Immune System
06:45 Taking GABA for Immune Function
17:20 The Impact of Gut Health on the Immune System - Why Kombucha?
18:50 How Lindsay Lohan Ruined The Kombucha Industry
23:40 Stomach Acid is the First Line of Defence Against Viruses and Bacteria
26:44 How Fermentation and Food Preservation Supports Our Immune Function
30:44 Sauerkraut - Low PH Means Bad Bacteria Die, Good Bacteria Live
36:25 Short Chain Fatty Acids - Fibers, prebiotics, and biotics
42:45 How the Immune System Functions Beyond Our Gut
46:05 We Have Microbiomes Everywhere
47:55 Innate vs. Adaptive Immune System
57:30 How Genetics Factor Into Our Immune System Response
1:00:00 Leaning Into the Immune Response
1:09:43 Why Do We Get Fevers When We Get Sick?
1:30:16 Sickness Behavior
1:34:34 How To Boost Immune System When You’re Not Sick
1:54:00 Behavior, Micronutrients, and Mushrooms
2:14:00 How to Take Supplements When Getting Sick
2:18:47 Supplements to Support Your Immune System
2:33:39 GABA for the Gut, Mood, and Immune System
2:36:14 Conclusion

Video Episode | Kanna | Can This South African Succulent Make You a Better Dancer?



Kanna is a unique succulent plant, originating from South Africa. It has been used as a mood and energy boosting botanical for thousands of years by the KhoiSan people of South Africa, for dancing ceremonies and as a hunting aid.



In this month's podcast episode, Emiel (Nootropics Depot Product Specialist) and Erika discuss the history of Kanna, its pharmacokinetics and mechanisms of action, and how Kanna provides a distinctly uplifting effect from its serotonergic activity.



Tune in to learn about dosing Kanna, taking Kanna at night clubs in Amsterdam, mesembrine, mesembrenone, and Delta 7 mesembrenone, and why you should try Kanna for its pro-social benefits.

Follow In Search of Insight on Instagram
https://www.instagram.com/insearchofinsight?igsh=ZGNjOWZkYTE3MQ%3D%3D&utm_source=qr

Buy Full Spectrum Kanna Tablets from Nootropics Depot
https://nootropicsdepot.com/full-spectrum-kanna-extract-quick-dissolve-tablets/

Read Nootropics Depot's Blog on Kanna
https://nootropicsdepot.com/kanna-lift-mood-and-lower-stress

Podcast Chapters
00:00 Introduction
04:10 Dosing Kanna
09:40 Stimulating Effects of Kanna
11:50 Fat or Water Soluble? Bioavailbility of Kanna
17:30 Oral & Sublingual Administration
18:53 Pharmacokinetics - T Max and C Max
34:00 Caffeine Usage and Concentration
36:00 Dynamax Pharmicokinetics
38:45 Mood, Focus, Energizing, Pro-Social Effects of Kanna
43:00 Traditional Uses of Kanna, Amanita Muscaria, Kava
50:00 Neuroscience of Kanna - Neurotransmitter Releaser
53:07 Mesembrine acts as a VMAT2 Upregulator
1:03:40 Testing Mesembrine Content of Kanna Extracts
1:14:10 Cultivars of Kanna - Sceletium tortuosum
1:14:54 What Sets Nootropics Depot’s Kanna Extract Apart
1:18:22 Beta Testing and Initial Bio-assaying
1:25:31 Kanna as a Subtle Appetite Suppresant
1:33:11 Emiel & Erika’s Current Occasional Supplements
1:47:07 Emiel & Erika’s Daily Supplement Stack
1:57:24 Conclusion

Isoliquiritigenin | Candy For Your Brain



This month, learn all about neurotransmitters and the powerful mechanisms of action behind Nootropics Depot’s mood-boosting licorice root extract, Isoliquiritigenin. Erika and Emiel take you on a journey through the traditional uses of licorice, what makes it such a soothing remedy for inflammation, and where licorice candy originates from.



Buy Isoliquiritigenin from Nootropics Depot

https://nootropicsdepot.com/isoliquiritigenin-controlled-dissolve-tablets/



Follow In Search of Insight on Instagram

https://instagram.com/insearchofinsight?igshid=MzMyNGUyNmU2YQ%3D%3D&utm_source=qr



Podcast Chapters

00:00 Introduction

00:18 Licorice Root

03:53 Isoliquiritigenin

06:07 Mega-Dosing Isoliquiritigenin

10:27 Traditional Uses of Licorice Root

14:23 Why Is Licorice Candy Black?

15:28 Where The Classic Licorice Flavor Came From

24:32 Slight Detour - The Use of Quinine in Tonic Water

28:58 The Medicinal Background of Vermouth, Absinthe, Coca Cola

32:00 Tasting Dutch Licorice

35:12 Ammonium Chloride as a Cough and Mucus Remedy

43:00 Laws Against Licorice

44:54 Tasting Mild Salt Licorice

48:02 Benefits of Licorice Root and Isoliquiritigenin

54:12 The Pharmacology of Isoliquiritigenin

57:36 Neurotransmitter Basics

1:00:38 What Effects are Produced When Norepinephrine, Serotonin, and Dopamine Build Up?

1:02:34 GABA-A and GABA-B Activation

1:06:20 GABA, Amino Acid Neurotransmitter vs. Norepinephrine, Serotonin, and Dopamine Monoamine Neurotransmitter

1:08:19 Why We Typically Try to Dampen Glutamatergic Activity

1:09:40 Glycine, a Neurotransmitter

1:16:17 Dopamine D3 Agonist Effects of Isoliquiritigenin

1:18:38 Isoliquiritigenin For Pain Management

1:20:21 Isoliquiritigenin For Long Term Potentiation

1:22:47 Tonic Water - Traditional and Modern Uses

1:26:32 New Products From Nootropics Depot - Mushroom Magic Matcha

1:31:57 Why Not Ceremonial Grade Matcha?

1:36:55 The Mushroom Blend of Mushroom Magic Matcha

1:46:08 The First Scoop for Nootropics Depot

1:48:48 Full Spectrum Kanna Tablets

1:55:21 Taking Kanna at the Club

1:57:27 Conclusion

An Unexpected Journey Through The Past & Future Of Supplements With Lucas Of Boost Your Biology

This month on In Search of Insight, we welcome Lucas Aoun from Boost Your Biology and embark on an unexpected, stimulating journey through the past and future of supplements.

Learn More About Lucas Aoun of Boost Your Biology https://www.youtube.com/@UC4O8s5Eir3A0ULQ-0HOJr8Q https://www.youtube.com/@UCG-Da6bw7vNJ4oEkhs-D_KQ

Meet Lucas and learn about his background as a biohacker, Naturopath, and supplement enthusiast. In this episode, Emiel, Lucas, and Erika share the beginnings of their journeys with supplements. They discuss what products they’ve loved and hated, new frontiers in the supplement world, and why quality and safety are the most essential elements in supplementation.

Podcast Chapters

0:00 Introduction

1:15 Beta Testing Unreleased Cistanche Stack + Tribugen

5:00 Meet Lucas Aoun

6:45 Extraction Technique for Cognance - Producing a Non-Drowsy Bacopa Extract 14:00 Glycosides in Botanicals

17:21 Extraction Techniques of Cognance, Erinamax

21:47 Lucas’ Journey in Nootropics Begins

23:28 Acetyl L-Carnitine, an Early Adopted Nootropic

26:33 Emiel’s Journey in Nootropics Begins

28:41 Bioassaying Tribugen

31:59 Pre-Workout Formulations

34:15 Ginkgo Biloba

38:31 Clinical Trials vs. Empirical Evidence

39:49 Approaches to Research

42:18 Asking Questions, Asking the Right Questions

46:18 How Reddit Inspired Nootropics Depot 49:08 Benefits of Community Bioassaying

51:41 Staying Close to the Source When Researching

56:19 When Research Studies Can’t be Verified

59:02 The Origins of Acetylcholinesterase inhibitors

1:01:25 Plant Defence Systems

1:04:38 Beta Ecdysterone

1:06:39 Being Critical of Research

1:09:34 Erika’s Journey with Nootropics Begins

1:14:34 Safety Concerns of Fadogia Agrestis

1:17:21 Fadogia Agrestis Toxicology

1:20:45 The Future of Nootropic Supplements from Africa

1:21:20 Kanna and its Traditional Uses

1:38:00 Naturopathy and Nootropics

1:40:00 Criteria for Nootropics - Gurgia

1:47:40 How Traditional Chinese Medicine Informs Modern Nootropics

1:51:00 Shizandra Chinensis

1:52:20 Eria Jarensis

1:54:40 Dynamine

2:02:16 The Benefits of Progesterone

2:08:25 Enhancing Insulin Sensitivity

2:09:20 Conclusion