62 episodios

Promoting strategies to increase healthspan, well-being, cognitive and physical performance through deeper understandings of biology.

FoundMyFitness Rhonda Patrick, Ph.D.

    • Salud y forma física
    • 5,0 • 17 valoraciones

Promoting strategies to increase healthspan, well-being, cognitive and physical performance through deeper understandings of biology.

    Dr. Satchin Panda on Circadian Insights into Exercise Timing, Melatonin Biology, and Peak Cognition

    Dr. Satchin Panda on Circadian Insights into Exercise Timing, Melatonin Biology, and Peak Cognition

    Dr. Satchidananda (Satchin) Panda is a professor in the Regulatory Biology Laboratory at the Salk Institute for Biological Studies. His work focuses on chronobiology, the study of the day-night cycles that drive the multifaceted activities of the human body, using genetic, genomic, and biochemical approaches. He is an expert on circadian rhythms and a pioneer in the field of time-restricted eating. A priority for Dr. Panda when designing his studies is to identify strategies that positively impact public health.
    Circadian rhythms, the body’s 24-hour cycles of biological, hormonal, and behavioral patterns, modulate a wide array of physiological processes, including the body’s production of hormones that regulate sleep, hunger, and metabolism, ultimately influencing body weight, performance, and susceptibility to disease. Circadian rhythmicity may have profound implications for human healthspan.
    When and how much we sleep, eat, or exercise (and these activities’ effects on our health) are intrinsically linked to our circadian rhythms.
    In this episode, Dr. Panda and I discuss...
    05:31 - How circadian rhythms influence human health. 12:30 - How seeking bright light in the morning and avoiding it in the evening can help us sleep better. 20:40 - How the ability of supplemental melatonin to counteract evening bright light exposure varies. 26:16 - How understanding the relationship between melatonin and insulin secretion might help us decide when to eat. 33:15 - How shift work, jet lag, and modern lifestyles contribute to altered circadian rhythms and metabolic dysfunction. 45:10 - How naps might aid with afternoon sleepiness and sleep loss. 47:05 - How we can tailor our indoor lighting environment to promote healthy circadian rhythms. 51:20 - How time-restricted eating (eating within a narrow time range) can be beneficial. 01:02:13 - How Dr. Panda’s ongoing study uses a smartphone app to track when people eat. 01:03:41 - How most people are unaware of their eating patterns. 01:07:58 - How Dr. Panda incorporates his research findings into his own life. 01:16:21 - How our circadian rhythms dictate when we should exercise – and how caffeine provides a workaround. Read the full show notes to learn more: https://www.foundmyfitness.com/episodes/satchin-panda-3
    Sign up to receive Rhonda’s regular newsletter: https://www.foundmyfitness.com/newsletter
    Become a FMF Premium Member to receive exclusive podcasts, emails, and more: https://www.foundmyfitness.com/crowdsponsor

    • 1h 28 min
    Dr. Michael Snyder on Continuous Glucose Monitoring and Deep Profiling for Personalized Medicine

    Dr. Michael Snyder on Continuous Glucose Monitoring and Deep Profiling for Personalized Medicine

    Dr. Michael Snyder is the director for the Center for Genomics and Personalized Medicine at Stanford and a pioneer and advocate of "deep profiling." Deep profiling seeks to apply intelligent analysis to large data sets to yield specialized clinical insight, ranging from common consumer-grade wearables like Apple Watches to whole-body MRI, continuous glucose monitoring, and metabolomics.
    00:12:51 - Continuous glucose monitors 00:31:04 - Lyme disease 00:34:00 - Predicting illness with smartwatches 00:39:14 - Heart rate variability 00:40:41 - Exposome and airborne pollutants 00:51:04 - Discovering Ageotypes 00:58:05 - Exercise benefits 01:03:11 - Michael Snyder's lifestyle habits Get this show's notes, timeline, and transcript:
    Dr. Snyder's faculty bio page:
    Dr. Snyder on Twitter:

    COVID-19 Tracking Study:

    Free metabolism SNP report for consumer genetic data:

    • 1h 15 min
    Dr. Roger Seheult from MedCram on COVID-19 Vaccines, Vitamin D, and Heat Hydrotherapy

    Dr. Roger Seheult from MedCram on COVID-19 Vaccines, Vitamin D, and Heat Hydrotherapy

    Dr. Roger Seheult is the co-creator of MedCram Videos. In the early days of the COVID-19 pandemic, MedCram emerged as a beacon of insight, providing continuing coverage and perspectives in an environment almost defined by information scarcity.
    What particularly excited me about the unique opportunity of this interview is that apart from Dr. Seheult being a unique voice of public scholarship during the early days of the pandemic, he's also a quadruple board-certified pulmonologist with deep experience working on the frontline of the COVID-19 pandemic.

    In other words, when it comes to COVID-19 for Dr. Seheult... it's personal. He has worked tirelessly not just to help people find their way back to wellness as a critical care provider, but he broadcasts the insights he has gained realtime to the 1 million subscribers listening to his medical lecture platform he co-founded with physician assistant Kyle Allred.
    Listen to this episode to hear Dr. Seheult's thoughts on:
    00:06:20 - How MedCram Videos got started and the future of medical education from Dr. Seheult's standpoint. 00:09:37 - What to do when life is on the line and the usual hierarchy of evidence doesn't exist, as in early emergency COVID-19 treatment. 00:12:46 - The crucial differences in treating early vs. late-stage COVID-19 illness. 00:14:40 - How doctors would've treated COVID-19 one-hundred years ago. 00:18:13 - How increasing ventilation may powerfully impact COVID-19 disease transmission and why airplanes have surprisingly little disease transmission. 00:20:28 - How masks are virtually universally beneficial in the pandemic regardless of type. 00:21:32 - Vitamin D and COVID-19 00:22:22 - How the steroid chemical structure of vitamin D confers qualities on vitamin D that other vitamins ("vital amines") do not possess, such as membrane permeability that provides access to the nucleus and broad gene regulatory effects mediated by a specialized vitamin D receptor element. 00:23:24 - How calcium homeostasis, which was the early and exclusive focus for scientists and doctors that were trying to determine the ideal vitamin D levels, may have caused the RDA to be set too low since we now know vitamin D regulates around 5% of the protein-encoding genome and have much broader effects. 00:24:23 - How the hormonal role of vitamin D confers on it properties more similar to other hormones like testosterone and cortisol rather than those of ordinary vitamins. 00:26:21 - The surprising level of overlap between COVID-19 positivity and groups most affected by vitamin D deficiency and the surprise finding of how less than 50 ng/mL blood levels of vitamin D associated with greater likelihood of SARS-CoV-2 positivity in the hospital. 00:30:27 - How scientists are able to interrogate the effects of low vitamin D levels through genetic research, a type of study known as mendellian randomization. 00:34:20 - The gene regulatory effects of vitamin D and the implications for the scale of its biological impact. 00:35:49 - How Vitamin D's ACE2/renin-angiontensin-promoting effects may be mechanistically involved in the effects observed in vitamin D COVID-19 studies. 00:42:00 - Why ameliorating vitamin D deficiency in one large monthly bolus might be less effective than daily or weekly doses. 00:43:23 - How a prescription-only form of vitamin D known as Calcifediol might have an advantage in acute care for COVID-19. 00:47:06 - Why skin synthesis of vitamin D from UV B radiation can be extraordinarily unreliable when compared to supplementation. 00:53:43 - What the safest dose range for vitamin D is that should also address deficiency in most populations. 01:06:15 - The beneficial circadian effect of early morning sunlight. 01:07:38 - How sleep deprivation is meaningfully implicated in profound and immediate impairment of viral immunity. 01:12:08 - Dr. Seheult's suggestions for h

    • 2 horas 6 min
    Dr. Steve Horvath on epigenetic aging to predict healthspan: the DNA PhenoAge and GrimAge clocks

    Dr. Steve Horvath on epigenetic aging to predict healthspan: the DNA PhenoAge and GrimAge clocks

    Consistent patterns of age-based alterations in DNA methylation can be harnessed to estimate age, serving as a sort of "clock," the premise of which is truly remarkable: Predict a person's age (or even lifespan), based on chemical modifications to their DNA that reflect the biological life history of the organism. Dr. Steve Horvath has analyzed large data sets of DNA methylation profiles to derive an algorithm that accurately predicts a person's chronological age across multiple cells, tissues, and organs, and even mammalian species. He built on this algorithm to develop second-generation clocks that could predict time-to-death among people of the same chronological age, as well as lifespan and healthspan.
    In this episode, Dr. Steven Horvath describes epigenetic clocks and their role in predicting – and possibly slowing – aging.
    Get this show's notes, timeline, and transcript: https://www.foundmyfitness.com/episodes/steve-horvath
    Dr. Horvath's faculty bio page: https://ph.ucla.edu/faculty/horvath
    Dr. Horvath's Wikipedia page: https://en.wikipedia.org/wiki/Steve_Horvath
    Dr. Rhonda Patrick's 3-minute video crash course in epigenetics: https://www.foundmyfitness.com/episodes/epigenetic-clock
    The FoundMyFitness overview article of epigenetic clocks: https://www.foundmyfitness.com/topics/epigenetic-clocks

    • 1h 33 min
    Q&A with Dr. Jed Fahey on Sulforaphane, Moringa and Chemoprotection

    Q&A with Dr. Jed Fahey on Sulforaphane, Moringa and Chemoprotection

    In this special two-hour Q&A episode with Dr. Jed Fahey, a world-leading expert on the science of chemoprotection and, in particular, sulforaphane, we discuss many of the listener-submitted questions from the hundreds of live event participants.
    Get the full timeline and show notes.
    Listen to learn Dr. Fahey's thoughts on…
    00:07:19 - The minimum daily dose of sulforaphane that elicits beneficial health effects 00:12:04 - Why gauging the amount of sulforaphane in foods presents challenges 00:17:37 - Workarounds to enhance the sulforaphane in cooked foods 00:23:38 - How often to consume broccoli sprouts and how long their effects last 00:39:28 - The effects of sulforaphane on glutathione production in the brain 00:43:12 - The effects of sulforaphane on cancer 01:17:26 - Alternatives to sprouts, such as supplements (and which ones Dr. Fahey recommends) 01:33:08 - Safety concerns regarding sulforaphane In this episode, Dr. Fahey mentions the following companies, websites, and supplements:
    Brassica Protection Products Cullman Chemoprotection Center Crucera SGS® (Thorne) Oncoplex® (Xymogen) Avmacol® Vision Defense® (Swanson) MaxN-Fuze® MitoCORE® (Ortho Molecular Products) Extra resources
    Learn how to sprout at home safely by downloading the 15-page sprouting guide developed with Dr. Fahey.
    Sign-up to participate in the live every-single-month Q&A series by becoming a FoundMyFitness premium member.

    • 1h 56 min
    Dr. Giselle Petzinger on Exercise for Parkinson's Disease

    Dr. Giselle Petzinger on Exercise for Parkinson's Disease

    Giselle Petzinger, MD, an associate professor of Neurology at the University of Southern California and today’s guest, studies the extensive effects of how different types of exercise, in particular skill-based exercise, can affect the clinical outcome for people with Parkinson’s disease.
    Dr. Petzinger's work focuses on understanding how to promote brain repair after injury, particularly in the context of Parkinson's disease. She is currently investigating ways to enhance neuroplasticity in a preclinical model of the disease. She has examined the role of exercise in Parkinson's disease, with emphasis on how different types of exercise affect distinct regions of the brain. Her work has implications for improving the quality of life of patients diagnosed with the neurological disorder — a condition for which there is no cure.
    In this episode, we discuss...
    00:06:57 - What is Parkinson’s disease? 00:11:57 - How symptoms of Parkinson’s disease generally only appear when ~50% of dopamine-secreting neurons in substantia nigra are lost. 1 00:14:57 - How other circuits in the brain can compensate for the loss of function of the substantia nigra. 00:18:37 - Prevalence and hereditary risk factors of Parkinson’s disease. 00:21:25 - How epidemiological studies have linked increased Parkinson’s disease risk with exposure to pesticides, herbicides, solvents, and certain heavy metals such as manganese. 1 00:26:57 - How exercise can lower the risk of developing Parkinson’s disease. 1 2 3 00:35:38 - How skill-based exercise, such as yoga, Tai chi, boxing, tango or skateboarding may play a special role in ameliorating some of the effects of the disease by driving circuit-specific effects, by creating top-down cognitive challenge for skills involved in a patient's movement through space. 00:47:49 - How serum BDNF significantly increases in Parkinson’s patients after 1 month of treadmill exercise and why this might mean better cognitive function. 1 2 00:58:33 - How treadmill exercise with heart rate 80-85% maximum for at least 3x per week slowed the progression of Parkinson’s disease symptoms. 1 01:01:31 - Why exercise may not fully replace the use of medications. 01:09:58 - How the omega-3 fatty acid DHA has some preclinical evidence suggesting it may reduce motor-symptoms and dyskinesia in Parkinson’s disease. 1 2 3 4 01:12:12 - How patients with Parkinson’s disease have higher levels of inflammatory biomarkers and how this might contribute to the disease. 1 Click here to get this episode's show notes and transcript
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    • 1h 18 min

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