The Doctor's Farmacy with Mark Hyman, M.D‪.‬ Dr. Hyman+

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Every year, we celebrate our birthdays, marking another year of growing older and, hopefully, wiser. But what if we flipped the script and celebrated getting younger instead? 

With groundbreaking advancements in longevity science and technology, this idea is becoming more than just a dream. We now have the tools, diet, lifestyle, and supplement regimens to reverse our biological clock.

In today’s episode, we’ll dive into the science behind what ages us, the latest research breakthroughs in eating and aging, and we’ll uncover how our diet and lifestyle impact our bodies at the genetic level, influencing DNA expression and potentially switching off our aging genes. Stay tuned until the end for my six-step actionable protocol to start aging in reverse!

This episode is brought to you by Rupa Health, Essentia, and House of Macadamias. 

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We live in a time with more money, medical interventions, and knowledge than ever before—so why are we getting sicker? While this might seem depressing, there are actually many exciting discoveries changing the future of wellness, like our increased understanding of the microbiome and how it interacts with the brain. This dynamic has profound implications for mental health, reducing the risk of neurodegenerative diseases, and even supporting positive behavior in our children. I’m excited to talk to board-certified internal medicine physician, bestselling author, and published researcher Dr. Austin Perlmutter about all this and more on this episode of the podcast. 
We explore:

Why don’t we try to prevent brain dysfunction the same way we do cardiovascular disease and other illnesses?

Neuroinflammation and how to modulate it to improve mood, behavior, and neurodegenerative diseases

Having an “adult in the room” versus our lizard brain

The inundation of Big Food and Big Pharma marketing we’re up against

Psychobiotics: The future of probiotics for brain health 

I know you’ll love this conversation as much as I did. I hope you’ll tune in wherever you listen to podcasts!
This episode is brought to you by Rupa Health, Magnesium Breakthrough, LMNT, and Pique. 
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Lifestyle and dietary factors are widely accepted as key drivers of disease among cardiologists, oncologists, and endocrinologists, however the impact of diet and lifestyle on our brain health still remains largely on the margins. And, while there are certainly other factors, creating healthy daily habits can make a significant difference.
In this episode, Dr. Hyman speaks with Dr. Marwan Sabbagh, Dr. Richard Isaacson, and Dr. Jay Lombard about the role of genetics in brain disorders, lifestyle habits you can start right now to reduce your risk or reverse symptoms, and why we need to look at bacteria as a cause of neurodegenerative disease.
This episode is brought to you by Rupa Health and AG1.
Streamline your lab orders with Rupa Health. Access more than 3,000 specialty lab tests and register for a FREE live demo at RupaHealth.com.
Get your daily serving of vitamins, minerals, adaptogens, and more with AG1. Head to DrinkAG1.com/Hyman and get a year's worth of D3 and five Travel Packs for FREE with your first order.

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There’s a common misconception that getting older means getting weaker, but what if you could improve your fitness level at any age? The truth is, you can. 
In today’s Health Bites episode, I’m joined by my dear friend and colleague, Dr. George Papanicolaou, a highly sought-after Functional Medicine practitioner on my team at the Ultra Wellness Center. Together, we explore the incredible benefits of exercise—a free, universally accessible powerhouse drug—from a functional medicine perspective. 
We discuss the crucial, often-overlooked aspects of fitness for enhancing longevity, such as VO2 max, how to optimize our levels, and the role our mitochondria play. We also dive into the importance of resistance training and nutrition for enhancing body composition, strength, and muscle mass, vital for metabolic health, recovery from illness, and so much more.
If you’re looking to leverage your exercise routine to enhance your overall health and quality of life, no matter your age, this episode is for you. 
This episode is brought to you by AG1, Neurohacker, and Cymbiotika
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One of the many reasons I was drawn to Functional Medicine is that it’s the medicine of asking “why?” and looking beyond the status quo to reimagine health. When we use this practice to assess the metabolic diseases we see today, we can see we’re in an energy crisis. We’re wrapped up in a web of physiologic root causes, but also a web of policies, industries, and economic incentives impacting our health from the ground up. I loved discussing all this and more on this episode of the podcast with Dr. Casey Means. 
We take a deep dive into:

Why we need to reimagine the healthcare system and how to use Functional Medicine as a framework for asking “why?”

Using metabolic health as a barometer for our challenges as a society 

A stark reality: Every institution related to our health makes money off of sickness

Combining advanced technology with our own awareness to take back control of our health

Five affordable biomarkers of metabolic syndrome to start with 

And so much more!

I hope you’ll tune in to learn how to dramatically improve your metabolic health and support foundational societal shifts, all at once.
This episode is brought to you by Rupa Health, ARMRA Colostrum, Pendulum, Live Momentous, and House of Macadamias.
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Head over to LiveMomentous.com/Mark for 20% off creatine, collagen, and all of their best-in-class products.
Enjoy the highest quality macadamia nuts today. Get 15% off my custom House of Macadamias bundle or 10% off your entire order at HouseOfMacadamias.com/Hyman.

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Our brain has the ability to adapt, change, and grow new neurons through a concept known as neuroplasticity. Compounds in psychedelics are finally being recognized as powerful tools to change the wiring of the brain which means we’re not doomed to become a statistic and lose our minds as we get older or carry destructive trauma in our bodies for the rest of our lives. 
In this episode, Dr. Hyman speaks with Dr. Andrew Huberman, Dr. Sara Gottfried, and Paul Stamets about what exactly neuroplasticity is and how psychedelics like ketamine and psilocybin may be a helpful treatment for depression, trauma, addiction, and more.
This episode is brought to you by Rupa Health, Cozy Earth, and Cymbiotika.
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Upgrade your supplement routine with Cymbiotika. Get 20% off with free shipping on all orders. Head to Cymbiotika.com and use code HYMAN.