Become Resilient with Jacob Gordon Jacob Gordon

This episode is also available at https://mybiohack.com/blog/solving-problems-with-jacob-gordon-episode-1-tammy-nick-motola-covid-19

Hello and WELCOME to Solving Problems With Jacob Gordon!

In this show we’ll be coving numerous aspects of science-based topics ranging from healthy living to chronic health conditions. We’ll be interviewing top scientists and doctors from around the globe and answering questions with seemingly unknown answers, and best yet, solving problems. 

To give you a little background about me, I personally have a forward thinking blog on epigenetics and neuroscience at mybiohack.com. 

This show is sponsored by a few good friends of mine and very smart doctors at rezilirhealth in hollywood florida. They are a team of world-class clinicians that are certified in the ReCODE and the Bredesen Protocol™, Shoemaker Protocol and Terry Wahls Protocol®. They focus on the revision of chronic disease, specializing in early-onset Alzheimer's, MS, autoimmunity , cognitive decline and Chronic Inflammatory Response Syndrome (CIRS) and personally have helped me overcome my chemical sensitivities as well as CIRS/SALI like problems. More information can be found out about them at rezilirheatlh.com.

On our first episode today I will be discussing the psychological effects of COVID-19 with Tammy Motola and her son Nick Motola. Tammy is a RN, PhD, as well as Co-Founder and President of Rezilir Health.

Brain Health and COVID by Craig P. Tanio, MD, FACP, IFMCP https://rezilirhealth.com/brain-health-and-covid/ 

"The Relationship between Basic Hope and Depression: Forgiveness as a Mediator" - https://link.springer.com/article/10.1007/s11126-020-09759-w 

Some links to Dr. Gersh:

http://www.felicelgershmd.com
http://integrativemgi.com/doctors

https://mybiohack.com/blog/felice-gersh-pcos-menopause-estrogen-receptors

Biotoxin Accumulation (bioaccumulation of toxins) is the basic concept of foreign and endogenous substances building up in the body.

This buildup can during any time in a person's life (from in utero womb development throughout your lifetime).

These "toxins" cause dysregulation of normal cell function and may contribute to many chronic illnesses and specifically neurological disorders.

As they can affect the central nervous system, this post is focusing mainly on how the body reacts to biotoxin accumulation.

Recent studies (e.g. by the CDC and Canada) have shown that most American adults and children of both genders have bioaccumulated numerous toxic pollutants in their body. https://mybiohack.com/blog/bioaccumulation-biotoxin-accumulation-detox. More here https://mybiohack.com/blog/jacob-explains-bioaccumulation

https://mybiohack.com/blog/jacob-explains-lipopolysaccharides-endotoxemia. How To Inhibit Lipopolysaccharides (LPS), Lipoglycans, And Endotoxins - https://mybiohack.com/blog/lipopolysaccharide-endotoxins-lps-tlr4

What is learning and memory?

Is amnesia really a loss of stored memories or something more?

In this interview, we will discuss where memory goes and if there is a way to retrieve them after trauma. Recent studies have shown that spatial memories are encoded as sparse populations of cells that are activated during learning and are necessary for the retrieval of specific memories.

We refer to these cells as "memory engram cells" and the focus of Tomás J Ryan and his team is to understand how engram cells are able to store specific memories as information. Here is a quick summary/breakdown of the video above.

The old storage theory of amnesia is WRONG.
The problem is the ability to retrieve the memory.
Short term memory lasts a few hours. It is very disruptable (long term is not).
Long term memory lasts your entire lifetime. It requires transcription and translation of many different genes.
We have many different genes that regulate memory.
They are different for short term and long term - playing roles at different stages.
Most popular was CREB (turns on other genes).
Engrams cells are structures in the brain where memories are stored. R
They used optigenetics to prove engram cells were important for memory.
Engram cells only account for 4-6% of the brain cells in the hippocampus (of mice). V
Consolidation idea - a short term memory (unstable) forms into a long term memory (stable), thus stabilizing the engram.
Optogenetics - let's us express photoactivatable opsins in whatever region of the brain we want.
The brain is electrically active.
They put certain opsins into brain cells and then stimulate them with light.
These opsins can conduct ions - putting positively charged cations from the external environment of the cell into the neuron.
This depolarizes the cell, which results in an action potential (creating neuronal activity).
What they did at MIT was integrate optogenetics and memory engram cells.
They tested parts of the brain using a transgenetics - they took immediate/early genes (genes that show activity as a function of neuronal spike) and used opsins to only activate those genes.
Amnesia and Memory
Learning is the enhancement of synaptic connections.
Memory is a stable thing in the brain and can last for your entire life.
Learning and recall are not "things", they are activities.
Learning = process of making a memory. Recall = process of retrieving a memory.
So the problem is not memory itself.
Amnesic engram cells have a loss of synaptic strength.
Increasing the synaptic strength helps get the memory (which is commonly seen in Alzheimer's (AD), Huntington's (HD)).
If you increase the synaptic potentiation (increasing the dendritic spine density), esp. of the amnesic engram cells, you can get natural access to those memories.
Neurotrophic factors (BDNF, NGF, CNTF, GDNF) do this, but are not localized nor memory specific.
Learning something new (about something you are amnesic about) will train your brain to those particular engram cells.
Once you activate the engram cells (with optogenetics), you can restore access to old information and add new information on those amnesic memories.
Without dealing with the cause, you probably won't be able to really restore memories (in diseases like AD, HD, etc.)
In late stages of neurodegeneration, you may actually lose memories.
Actions to take for prevention
Stay mentally active
Engage in physical exercise
Actions to take for amnesia (acute memory loss)
Do everything to remind yourself of those experiences
Retrain on the "forgotten" pieces
We briefly discussed gene expression and histone acetylation to enhance memory. https://mybiohack.com/blog/tomas-j-ryan-debunking-amnesia-and-stabilizing-engram-cells

Today Geoff Palmer and I talk about vegan diets, hormones, amino acids, healthy fats and more! https://mybiohack.com/blog/geoff-palmer-testosterone-dht-estrogen-fat-clean-machine