Health Mysteries Solved: Thyroid and Hashimoto's Revealed Inna Topiler

The Case:  Laura has thyroid issues causing her to feel overweight and her constantly dry skin made her feel like she was aging too fast.   She suspected that her issues might be genetic so she did a DNA test which revealed that she had the MTHFR gene.  She tried biohacking; taking high doses of B vitamins and a cocktail of other supplements but nothing got her the results she was looking for.  Investigation My suspicions were that her various supplements might not be right for her. I also wanted to take a closer look at her diet and lifestyle. 
Because I suspected that the answers were going to be found at the intersection of genetics, diet, and lifestyle I knew that Dr. Kara Fitzgerald would be the perfect person to consult with since she is an expert in epigenetics, nutrition, and aging. She is the author of two incredible books, Younger You: Reduce Your Bio Age and Live Longer, Better and Better Broths & Healing Tonics: 75 Bone Broth and Vegetarian Broth-Based Recipes for Everyone. 
Unveiling the Power of Epigenetics We often associate our health, thyroid function, and immune system with genetics and autoimmunity. However, as Dr. Kara explains, it is not our genes alone that determine our level of health, immune system function, or even our age. Instead, it is our epigenetics that play a significant role. I know there's a lot of confusion surrounding this topic, and in this episode, Dr. Kara shed some light on it.
She explains that in the early 2000s, scientists successfully deciphered the human genome. They discovered that we possess a little over 23,000 genes, and many believed that this knowledge would provide a clear roadmap to understanding and treating diseases. However, the reality turned out to be quite different. In over 90% of cases, genes alone do not determine our health outcomes. For most of us, the key lies in how our genes are being turned on and off—a fascinating field known as epigenetics that we’ve covered before in episode 143.
Unleashing the Potential of Epigenetic Expression Epigenetics emerged as a prominent field of study after the completion of the Human Genome Project. It explores the factors that influence gene expression, such as our diet, exposure to toxins, stress levels, social connections, and exercise habits. Simply put, we have the power to determine which genes are activated and which ones remain dormant. Ideally, we want to activate the genes associated with health, longevity, and overall well-being while silencing those that contribute to disease progression.
This realization is particularly empowering for individuals like Laura, who believed that her family history of Hashimoto's meant she was destined to follow the same path. However, epigenetics shows us that we are not bound by our genetic heritage alone. 
Lifestyle and Nutrition: The Epigenetic Keys Dr. Kara dives into the exciting realm of lifestyle and nutrition, revealing some of the most significant factors that influence gene expression. Understanding these keys can help us unlock the potential for anti-aging, detoxification, and disease prevention.
1. Diet Program: Dr. Kara shares insights from a groundbreaking study on biological aging, which focused on DNA methylation—a marker of aging and gene expression changes. The study participants followed a specific diet program designed to optimize gene expression. The key elements of this diet program include:
Veggies and Greens: Emphasizing a plant-rich diet with an abundance of greens and cruciferous vegetables, cooked to support thyroid health. Low-Glycemic and Fruit-Dense: Opting for low-glycemic vegetables and incorporating dark berries rich in polyphenols. Smart Protein Choices: Eggs and liver (if open to consuming them) are excellent gene whispering foods, while seeds, nuts, and fatty fish provide essential nutrients. Healthy Oils: Including extra virgin olive oil and coconut oil in cooking. Vitamin D and Mushrooms: Ensuring sufficient vitamin D

The Case:  Mindy has Hashimoto’s and hypothyroidism and experiences low energy and anxiety She’s worried genetics may be making it worse because her mother also has Hashimoto’s She’s feeling like the genetic cards are stacked against her and there’s nothing she can do to feel healthy again.   
The Investigation When I first met Mindy, I noted the stock she was placing on her genetics, missing things under her control. Genetics are important but they only account for 15% of our wellness picture. I knew that there were a myriad of things we could do to shift the impact of her genetics on her health. However, I also knew that a bigger shift might be needed at the epigenetic level.  
The Epigenetic Expert - Anat Peri To look further into what might be going on for Mindy, I invited Anat Peri back to the show. Longtime listeners may remember her from episode 55 of Health Mysteries Solved when she shared her insights on emotional resilience. I highly recommend going back and listening to (or relistening to) that episode. Anat is an inner child expert and the founder of Training Camp for the Soul. She has 18 years of experience as a trauma-informed coach using a variety of tools including mindset, somatic healing, safety connection, nervous system regulation, and inner child reparenting. Through her work, she has learned a great deal about epigenetics and how our upbringing can manifest physically in our adult minds and our health.  
What is Epigenetics? Epigenetics refers to the biology of our beliefs and how we view the world. It's about how our reactions to life impact our nervous system and whether we operate in a parasympathetic state or a stressful (sympathetic) state. This can have a huge impact on our health, as stress and trauma can lead to a range of health issues and can be a major trigger for Hashimoto’s. 
Anat explains that everything we learn as children is learned from our caretakers, and if they were absent or dysfunctional, we may have learned unhealthy patterns that can impact our health as adults. Anat explains that we learn so much at a young age because as children we are like sponges; soaking up what we see, hear, and feel energetically from our caretakers. Our beliefs and the way we view the world are formed at a young age, and they can have a huge impact on our health later on. Often, we are completely unaware of the role epigenetics is playing in our health.
The good news is that we can turn our epigenetics on and off, just like gene expressions. Our ability to control our epigenetics depends on our beliefs, how we regulate our nervous system, and how we speak to ourselves. 
Inflammation and its Impact on Health Inflammation is a natural response of the immune system to injury or infection. However, chronic inflammation can contribute to a wide range of health issues, including autoimmune diseases such as Hashimoto's and thyroid issues. In my practice, I’ve seen how specific beliefs and behaviors can contribute to inflammation in the body.
Beliefs and Behaviors that Impact Inflammation and Hashimoto’s One of the beliefs that can increase inflammation is shame. Anat explains that shame is a powerful enough emotion that it can cause us to close in on ourselves and hide our true selves. When we feel ashamed, we may try to suppress our emotions and our needs, which can lead to chronic stress and inflammation.
Fear is another powerful emotion that can contribute to inflammation, says Anat. When we are in a state of fear, our bodies release stress hormones, such as cortisol and adrenaline. Over time, chronic stress can lead to inflammation in the body.
Our parents may have ingrained shame and fear responses into us at a very young age without realizing it. Growing up in a chaotic or turbulent environment can also contribute to inflammation. When our nervous system is constantly activated by stress and fear, our bodies release stress hormones, which can lead to inflammation over

The Investigation Those of you who have been listening to the show for a while might remember the challenges I had with coloring my hair during the pandemic. This upset to my regular routine led me to seek out a healthy, at home option. I was particularly curious about how dying my hair may have impacted the management of my Hashimoto’s. You can hear more about that in Episode 121. 
Well, it’s been a year since then and I wanted to give you an update. In this episode, I deep dive into the problem with hair dye for people with autoimmunity, Hashimoto’s and thyroid issues. Plus, I share my review of Hairprint after one year of continuous use. 
 
The Problem with Traditional Hair Dyes for Autoimmunity and Hypothyroidism Chemicals in hair dye act as immune triggers. This can be a big issue for anyone with an autoimmune disease like Hashimoto’s because the immune system is already confused and attacking the thyroid. More confusion means more attacks which can result in a flare up or subtle symptom shifts.
If you have hypothyroidism, you may already be dealing with:
Hair loss Thinning hair Dry brittle hair Frizzy hair Unfortunately, using traditional hair dye can make it worse. 
Traditional hair dyes use harsh chemicals like ammonia or nanolumens to break apart the layers of the hair protein to give the dye access to the hair shaft. Even ammonia-free dyes use chemicals like Paraphenylenediamine (PPD) that are potentially harmful (they’re even banned in Canada and the EU). Moreover, chemicals in hair dyes seep into the bloodstream during the dying process, causing harm to the immune system, respiratory system, liver, kidneys, and can trigger serious allergic reactions, hair loss, and hair breakage.
 
Why You May Want to Avoid the ‘Organic Hair Dyes’ The term ‘organic’ is not defined, recognized, or regulated by the FDA in the personal care industry. Companies can add natural ingredients and call their hair dyes organic or natural, but it doesn't mean that they're chemical-free. 
Often, the added botanical or organic elements have nothing to do with the dyeing process and are there in addition to all the usual chemicals that are in conventional hair dye. It might just be a marketing gimmick.
 
Hairprint: A Safer Alternative to Traditional Hair Dye? I was thrilled to find Hairprint last year for all of the reasons I listed above. Before I share more about the product, I want to clarify that this is not a sponsored post - I genuinely use the product and love the product. And, in the past year of using it, I’ve learned a lot about how to get the best results. 
First, let me share a bit about Hairprint (in case you missed episode 121). It’s a unique product that doesn't break up the hair follicle and degrade it in any way, unlike traditional hair dyes. This makes it a safer alternative for everyone but especially for those with thyroid issues or autoimmune diseases. It actually restores the natural pigment in hair without using harsh chemicals. 



How to Apply Hairprint (and Get the Most Out of It) If you've been using Hairprint or plan to use it, it's important to note that it can have a slight drying effect on your hair, even though protein is great for hair. To combat this, I highly recommend hair oiling. You can use moisturizing oils such as amla oil, argan oil, or jojoba oil. You can apply the oil to the full length of your hair or just the ends depending on where you need it and if you want to avoid adding oil to an oily scalp. Now, if you have a dry scalp, you can apply it there as well. Apply the oil 15-20 minutes before shampooing, or even better, leave it in overnight and wash your hair in the morning. 
I have noticed a significant improvement in my hair's manageability and moisture since starting this practice. I apply the oils right after I do my Hairprint application and then once a week, or sometimes twice a week if I have time. This has made such a difference for my hai

The Case:  Hadley has been struggling with weight loss for years and is now in perimenopause.
She’s tried many diets but the results were temporary.
She eats mindfully avoiding gluten, processed foods, and sugar.
She was intrigued by the hype around Ozempic (semaglutide) but wanted to make sure it was safe and that there weren’t other issues at play in her weight mystery.
 
Weight Loss Struggles and Hormone Changes in Perimenopause Hadley’s struggle is so common. Perhaps it’s familiar to you too? You hear about the latest trend in weight loss and wonder (hope) that it’s going to be what helps you get your metabolism working in your favor so you can drop those last few pounds and keep them off. Ozempic has put semaglutide in the news with so many people talking about its popular side effect of weight loss with ease. But, like Hadley, you may have wondered - is it safe and does semaglutide really work for weight loss? 
The Functional Medicine View of Ozempic for Weight Loss Emily Sadri is a long-time friend of the show. She joined us on episode 107 to share all kinds of eye-opening information about birth control pills and thyroid. 
Because of that informative episode, I knew she was just the person to talk to about Hadley’s case and this trend of using semaglutide for weight loss purposes.
Emily is a board-certified Women's Health Nurse Practitioner, and hormone and weight loss expert. She owns and operates a boutique women’s functional medicine practice in Cleveland, Ohio, and helps women everywhere live more balanced, healthier lives.
What is Semaglutide (originally marketed as Ozempic)? Semaglutide is a peptide drug that was initially marketed as a medication for diabetes. Developed by Novo Nordisk in 2012, semaglutide was later found to have the potential for weight loss. The drug is now available under the commercial name Wegovy and is prescribed for obesity.
How does Semaglutide Work? One of the most impressive things about semaglutide is its multi-faceted approach to weight loss. Unlike many weight loss medications that rely on appetite suppression or stimulants, semaglutide works by slowing down digestion and promoting a feeling of fullness.
In this episode, Emily explains that by slowing gastric emptying, semaglutide delays the movement of food from the stomach into the small intestines, which helps to control appetite and reduce food intake. The drug also acts on the hypothalamus, a part of the brain that regulates signaling for many different functions.
The hypothalamus controls sympathetic nervous system signaling, and semaglutide modulates and increases sympathetic output just enough to stimulate lipolysis or fat breakdown. This action raises people's basal metabolic rate slightly, which over time results in weight loss.
What did the Clinical Studies on Semaglutide Find? Clinical studies have shown that people treated with semaglutide for weight loss have an average of 15% body weight loss, which is a remarkable achievement. This weight loss was achieved without significant lifestyle or diet counseling, making semaglutide seem like exactly what the weight loss market has been waiting for. 
But…
As a practitioner who primarily works with women aged 35 to 55 who often have a thyroid issue or Hashimoto’s, I'm sensitive to anything that stimulates stress pathways. Emily agrees with my caution but says semaglutide is an appealing option for women who are looking to lose weight but want to avoid the side effects of stimulant-based medications. Unlike stimulants, semaglutide doesn't suppress appetite in the same way, which is better for metabolism in the long term. However, sustainable weight loss isn’t just about eating less. 
Exploring the Emotional Component of Weight Loss In this episode, we also discussed the emotional component of weight loss and how important it is to acknowledge and address it. We talked about how people need reassurance to feel confident ab

The Case:  In the last episode, we met Liana and heard all about her issues with fatigue, digestion, hair loss, joint pain, and lack of concentration. As a person living with Hashimoto’s, she knows many of these symptoms are related but was struggling to stick to the healthy routines that could make a difference. 
That’s why I decided to discuss her case with Hypnotherapy expert, Grace Smith. 
In episode 139 of Health Mysteries Solved: Thyroid and Hashimoto’s Revealed, Grace busted the misconceptions surrounding hypnotherapy and explained so clearly how it works. I encourage you to jump back and listen to that episode before proceeding to learn how hypnotherapy can specifically help those with Hashimoto’s and how it helped Liana with her issues.
Stress as a Trigger for Hashimoto’s There are four main triggers for Hashimoto’s:
Food Infection  Toxins (environmental and food) Stress  
Of these, stress is so often overlooked. And one of the causes of stress that is easy to overlook because we may not be fully aware of is past trauma. This is where hypnosis can play a big role. 
Sometimes it could be big T trauma (a specific event that is easily identifiable as the source of trauma), but for others, it could even be smaller things. For example, it could be that they may have been rejected from something, or that they struggle with self-worth because of their upbringing. There's also a really big connection between shame and Hashimoto’s and inflammation in general. These small t traumas or limiting beliefs can be the stress trigger for Hashimoto’s without people realizing it.
Grace explains that many of these issues develop in the subconscious before the age of 7. What’s significant about this is that the brain has not yet started to produce beta waves. And so, from seven and under, we're almost completely in the hypnotic state. This is why kids learn so quickly - our brains can easily absorb new information and make new neural pathways in the hypnotic state. However, those neural pathways and ideas we are taught at an early age, tend to stick. This is why it can be hard to change our way of thinking - especially if our brains are stuck in a beta brain state. 
Rewriting Childhood Neural Pathways Since many of our beliefs (limiting and otherwise) are created before the age of 7, hypnosis can help to take us back to that time and allow us to understand where these ideas come from and rewrite those neural pathways. 
Grace shares a great example of this in our conversation where she’s talking about a kindergarten teacher picking on someone’s drawing and how that can lead to them feeling shame, unworthiness, or even fear of being the center of attention. 
As kids, we have a reaction to that and it’s hard to believe that a single event can affect us years later but Grace says it can be the cause. The good news, she says, is that through hypnosis, you can go back and rewrite that script. And, by doing that, you shift those long-held beliefs and feelings. 
Subconscious Self-Sabotage When we looked at Liana’s case, we discovered that she had this subconscious belief that she was not worthy of good health. As a result, she couldn’t trust that feeling good would last or that it was really how she felt. That’s why she couldn’t stick with a routine - she never believed it would work, and when it started to, she couldn’t believe it would last. She didn’t think she deserved to be healthy. 
Grace says this is so common and something that can absolutely be addressed through hypnosis.
She shares a great story about a grandmother in her late 70s who was dealing with chronic pain. Doctors and their tests could find no cause. Through hypnosis, Grace was able to get the patient into the theta brainwave state and have a conversation with the woman’s subconscious. It was here that the real cause of the pain was revealed - the woman was afraid to heal because she believed that her family vi

The Case:  Liana is dealing with fatigue, digestive issues, hair loss, joint pain, and lack of concentration She’s been diagnosed with Hashimoto’s and has been trying to eat right and take supplements to support it but can’t seem to stick with the routine.  She’s struggling to find a balance that includes feeling good.  The Investigation One of the things I noticed when I met with Liana was she had some limiting beliefs about her ability to feel good again and, I suspected that she was subconsciously self-sabotaging. I knew then that if we were dealing with issues on a subconscious level, we needed to start there - and more specifically with Hypnosis.
Understanding Hypnosis Grace Smith is one of the world's leading hypnotherapists and I knew she was the perfect person to have on the show to address how hypnotherapy can help chronic illnesses, like Hashimoto’s, from all angles, including beliefs, fears, stressors, and traumas. 
Before we could dive into how it can help, we had to address the elephant in the room - the perception of hypnotherapy as a party trick that leaves people barking like a dog or strutting like a chicken. 
Grace has heard this all before and admits that she was skeptical herself before hypnosis helped her quit smoking. 
The first thing she does is dispel the myth that hypnosis is mind control. Next, she reveals the real secrets behind those hypnotist shows. Spoiler - it’s all a show!
She goes on to explain that hypnotherapy is just meditation with a goal or a purpose. 
How Hypnosis Works Our brain waves fluctuate between several different states based on our level of consciousness. The beta state is where we spend most of our waking lives - it's the state of normal waking consciousness where we experience stress, fight or flight mode, and survival mode. Unfortunately, many people live in this state perpetually, which can be really corrosive to our physical, emotional, and mental health, as well as our relationships.
There are three other brain wave states that we can access with a bit of effort. The alpha state is where we go when we're daydreaming or doing something rote like washing our hair in the shower. It's a slightly more relaxed state where we can access inspiration and intuition. The delta state is where we go when we're sleeping and our brains are essentially offline. But the most interesting state, and the one that Grace works with, is the theta state. This is where hypnotherapy takes place, and it's a state of deep relaxation where we're still consciously aware of our surroundings. In this state, we have the surplus energy required to create new neural pathways in our brain extremely rapidly, which is why hypnotherapy can be so effective. It's all about telling your brain a better story and focusing on what you want, rather than staying stuck in the same old thought patterns.
How Hypnotherapy can Help with Hashimoto’s, Inflammation, and other Autoimmune Issues Through hypnotherapy, Grace Smith suggests that people can learn how to visualize their bodies healing and healthy, as well as learn how to communicate with their bodies to promote healing. By changing the way the person perceives their symptoms, they can reduce the inflammation in their body and improve their overall health. Additionally, she emphasizes the importance of identifying and addressing any emotional or mental factors that may be contributing to the inflammation and autoimmune response in the body. By helping the person relax and release emotional tension, hypnotherapy can promote a healthier immune response and reduce inflammation.
In this way, hypnotherapy can help with Hashimoto's and inflammation by:
Opening up access to a deep state of relaxation where rest and repair happen Weakening the neural pathways of limiting beliefs and creating new pathways for positive change Helping promote healing through visualization of the body's healing Addressing emotional and mental factors that may b