The Collaborative Group of the Americas on Inherited Gastrointestinal Cancer (CGA-IGC) was established in 1995 to improve understanding of the basic science of inherited colorectal cancer and the clinical management of affected families, with an emphasis on the particular aspects of caring for families living in the Americas.
The Expert Approach to Hereditary Gastrointestinal Cancers podcast series (seasons 1 and 2), and more recently, the Journal Club podcast series (season 3), are presented by the CGA-IGC Education Committee.
S.3 Ep. 5 Cancer prevention with aspirin in hereditary colorectal cancer (Lynch Syndrome), 10-year follow-up and registry-based 20-year data in the CAPP2 study: a double-blind, randomised, placebo-controlled trial
The fifth episode, hosted by CGA-IGC Council Member Dr. Swati Patel, features Sir John Burn, who is a professor of clinical genetics at Newcastle University, and Dr. Toni Seppälä, who is a GI surgeon from University of Helsinki currently conducting a research fellowship at Johns Hopkins University. They discuss recently updated data from the CAPP2 study of aspirin chemoprevention in individuals with Lynch syndrome that was published in Lancet this summer, found here: https://pubmed.ncbi.nlm.nih.gov/32534647/.
This episode was recorded on September 22, 2020, and reflects expert opinion at the time of the recording.
S.3 Ep. 4 Highlights from the 2020 ASCO Annual Meeting
This episode is hosted by Dr. Leah Biller and features Dr. Zsofia Stadler, a medical oncologist at Memorial Sloan Kettering Cancer Center and CGA council member, and Dr. Michael Hall, a medical oncologist at Fox Chase Cancer Center and CGA past president. They discuss data from Abstract 1500 (https://meetinglibrary.asco.org/record/185963/abstract), which reports on targeted therapy based on germline analysis of tumor-normal sequencing in a pan-cancer population, as well as data from the plenary presentation about the clinical trial KEYNOTE-177 (https://meetinglibrary.asco.org/record/186928/abstract), a study of pembrolizumab versus standard therapy for treatment of MSI-H metastatic colorectal cancer.
This episode was recorded on August 28, 2020 and reflects expert opinion at the time of the recording.
S.3 Ep.3: Updates in the Evaluation and Management of Serrated Polyposis Syndrome (SPS)
The third episode, hosted by CGA-IGC Council Member Dr. Swati Patel, features Dr. Arne Bleijenberg, who is a research fellow at Amsterdam University Medical Center, and Dr. Evelien Dekker, who is a professor in the Department of Gastroenterology & Hepatology and Gastrointestinal Oncology and the head of the Hereditary Cancer Center at the Amsterdam University Medical Center. They discuss the recently updated World Health Organization Guidelines on diagnosis of Serrated Polyposis Syndrome (SPS) (summarized here https://pubmed.ncbi.nlm.nih.gov/31982410/). Dr. Bleijenberg and Dr. Dekker also discuss their recent publications that shed light on a personalized approach to surveillance in SPS (https://pubmed.ncbi.nlm.nih.gov/30981990/) and long-term outcomes and natural disease course in those with SPS undergoing colonoscopic surveillance (https://pubmed.ncbi.nlm.nih.gov/32360902/). This episode was recorded on July 9, 2020 and reflects expert opinion at the time of the recording.
S.3 Ep.2: A Multi-Institutional Cohort of Therapy-Associated Polyposis in Childhood and Young Adulthood Cancer Survivors
The second episode features Dr. Leah Biller, CGA education committee member, who is interviewed by fellow CGA education committee member TJ Slavin. They discuss "A Multi-Institutional Cohort of Therapy-Associated Polyposis in Childhood and Young Adulthood Cancer Survivors", recently published online in Cancer Prevention Research. You can find the article here: https://www.ncbi.nlm.nih.gov/pubmed/32051178
This episode was recorded May 5, 2020 and reflects expert opinion at the time of the recording.
S3. Ep.1: Collaborative Group of the Americas on Inherited Gastrointestinal Cancer Position statement on multigene panel testing for patients with colorectal cancer and/or polyposis
Each episode of the 2020 season of the CGA-IGC podcast series will be a short journal club featuring a recently published article of interest to our membership.
The first episode features Brandie Heald Leach, former CGA president, who is interviewed by CGA education committee member TJ Slavin. They discuss the CGA-IGC position statement on multi-gene panel testing for hereditary colorectal cancer and polyposis, published online in Familial Cancer on March 14, 2020.
You can find the article here: https://www.ncbi.nlm.nih.gov/pubmed/32172433
This episode was recorded April 8, 2020 and reflects expert opinion at the time of the recording.
S2 Ep.6: Transitioning from Pediatric to Adult Care for Patients with FAP
The 2019 season of the CGA-IGC podcast series, Expert Approach to Hereditary Gastrointestinal Cancers, will focus on the management of extra-colonic features of Familial Adenomatous Polyposis, or FAP. FAP is an inherited condition that is primarily characterized by the development of many colon polyps and an increased risk for colon cancer, but there are other aspects of FAP that are also important to be aware of and manage appropriately.
The sixth and final episode features Kristin Zajo, a genetic counselor at Nationwide Children’s Hospital in Columbus Ohio. In this episode, we focus on children and young adults with FAP and special considerations regarding management and transitioning from pediatric to adult care.
Note: This episode was recorded on April 23, 2019, and reflects expert opinion at the time of recording. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.