This podcast's purpose is to bring together the field of neuroprosthetics / brain machine interfaces / brain implants in an understandable conversation about the current topics and breakthroughs. We hope to complement scientific papers on new neural research in an easy, digestable way. Innovators and professionals can share thoughts or ideas to facilitate 'idea sex' to make the field of brain implants a smaller and more personal space.
Scott Kim Discusses How Neofect Technology is Assisting Stroke Victims
Scott Kim is the Co-Founder and CEO at Neofect. Neofect provides technologies that work to provide stroke victims with rehabilitation devices that can increase their range of motion. These devices include smart gloves and ankle braces. In this episode, Scott Kim discusses how Neofect technology is assisting stroke victims.
Top three takeaways:
The user receives a smart-glove and a tablet with the Neofect App. Each therapeutic session consists of eight different “training games” that allow users to regain mobility lost from a stroke injury. This technology allows users to achieve rehabilitation results from their own homes.
[0:00] Ladan introduces the episode and the guest, Scott Kim.
[2:40] Scott Kim describes the beginnings of Neofect and their devices.
[5:40] The smart glove works by measuring six targets of motion guided by the therapist coach.
[7:50] An initial range of motion for each activity is captured as a baseline, then progress is determined over time through improved performance.
[10:55] The therapists at Neofect report a 10% improvement in the range of motion of users.
[15:00] While the main target with the device is stroke victims, the technology can be applied to other injuries in the future.
[18:00] The company recently launched Neofect Connect, which gives users daily reading and training games.
Lloyd Diamond Discusses How Pixium Vision is Creating a Solution for Dry Age-Related Macular Degeneration
Lloyd Diamond is the CEO of Pixium Vision. Dry age-related macular degeneration affects millions of people globally. Using an insertable implant in the eye in combination with lenses, central vision focus can be regained. In this episode, Lloyd Diamond discusses how Pixium Vision is creating a solution to dry age-related macular degeneration.
Top three takeaways:
There is a dry and wet form of age-related macular degeneration. The dry form makes up 80% of all cases. The degeneration begins in the center of the eye and then migrates to the periphery at the age of 60-65. The implant is no thicker than a human hair and contains 378 independent electrodes on it, activated by light.
[0:00] Ladan introduces the episode and the guest, Lloyd Diamond.
[1:50] Diamond explains the need for a device like the PRIMA system.
[4:00] The macular degeneration (AMD) targets the central vision portion of the retina, making it difficult to read or recognize faces.
[7:00] The retinal surgery recovery time is four weeks. After this, the activation and rehabilitation process begins.
[9:30] A pair of lenses that houses a camera are used in combination with the implant.
[11:45] The entire event of observance to signal processing occurs in microseconds, so the user is unaware of the reaction time of the device.
[16:00] Their new data proves that using clear glasses and the implant, it is possible to read as small as size eight font. This demonstrates seven lines of improvement on an ETDRS chart.
[19:00] Diamond discusses the history of Pixium.
[21:30] Due to the difficulty in regulatory approval for these types of implants, AMD research is not as common as retinitis pigmentosa.
[25:00] The ability to be independent and recognize family members’ faces makes the rehabilitation time and procedure appealing to the aged population.
[27:20] The future goal is to sell in Europe first and then bring devices to the US using FDA approval.
Renee Ryan and Dr. Kate Rosenbluth Discuss How the Cala Trio Controls Tremors
Renee Ryan is the CEO and Dr. Kate Roosenbluth is the founder, CSO, and member of the board of directors for Cala Health. The company creates bioelectronic neuromodulation devices to mitigate the effects of chronic diseases. In this episode, Renee Ryan and Dr. Kate Rosenbluth discuss how the Cala Trio device controls essential tremors.
Top three takeaways:
The Cala Trio device uses the nerve circuitry of the body to calm tremors by stimulating a part of the brain through the wrist. Accelerometer sensors in each of the devices assess the efficacy of each use. There is a digital screen on the watch that displays time, length of session, and tasks.
[0:00] Ladan introduces the episode and the guests, Renee Ryan and Dr. Kate Rosenbluth.
[4:50] Dr. Kate Rosenbluth explains the history of the company and its goals.
[7:00] The wearable device goes on the user’s wrist to stimulate the ventral intermediate nucleus in the brain.
[9:00] The essential tremors are characterized by action tremors in the hands, which makes daily tasks incredibly difficult.
[13:40] Cala Health plans to accomplish more wrist-based projects to help mitigate other chronic diseases.
[16:30] Renee Ryan explains her transition from investor to CEO at Cala Health.
[19:30] The demand for the Cala Trio device was so great that the clinical trials were fully enrolled within 6 weeks.
[22:30] Due to the wristband having dry electrodes, the band needs to be replaced every 90 days.
[25:20] A new device trial has started that includes a new band technology.
Iain McIntyre Discusses How the Humm Bioelectric Memory Patch Provides a Brain Boost
Iain McIntyre is the CEO and co-founder of Humm. Humm creates devices such as the Bioelectric Memory Patch that use electricity to stimulate the brain. The disposable forehead device has shown to cause an increase in brain functionality and memory.
In this episode, Iain McIntyre discusses how the Humm Bioelectric Memory Patch provides a brain-boost.
Top three takeaways:
When this device improves your working memory, it is improving your capabilities to focus, multitask, and acquire new skills. The Humm Bioelectric Memory Patch brings neuromodulation to a cheaper and smaller design compared to traditional devices. The benefits of use compound over time; even in the beginning stages, 15 minutes of use could provide up to two hours of mental performance improvement.
[0:00] Ladan introduces the episode and the guest, Iain McIntyre.
[2:50] The Bioelectric Memory Patch device works by delivering tACS to stimulate the prefrontal cortex and improve working memory.
[5:00] The research studies done at Berkeley showed that users of the patch had a 20% increase in working memory effectiveness.
[8:20] McIntyre describes it as a compound interest transaction, the more the patch is used, the greater the benefits each time.
[11:10] Humm can provide results in a safe manner where there are rarely side effects due to the low amount of current.
[14:00] While trials and data collection currently assess healthy users; in the future, the project will be used to help with neurological diseases.
[17:00] Interestingly, the test groups that were found to have the most need for such a device are college students and the elderly.
[21:10] With a 15-minute session, you can achieve an hour and a half of noticeable brain activity improvement.
Dr. Sangeeta Chavan Discusses the Fourth Annual Bioelectronic Medicine Summit
Dr. Sangeeta Chavan is a professor at the Feinstein Institutes for Medical Research. In September of 2020, the Feinstein Institutes hosted its fourth annual Bioelectronic Medicine Summit located in New York. In this episode, Dr. Sangeeta Chavan discusses the key takeaways of the summit.
Top three takeaways:
Bioelectronic medicine uses modulation and stimulation of neural activity for the benefit of those with diseases as an alternative to drugs. Various advances are being made in clinical trials dealing with problems such as Crohn’s disease, neural plasticity disorders, and vision loss. Vagus nerve stimulation has opened a gateway to many bioelectronic medicine applications.
[0:00] Ladan introduces the episode and the guest, Dr. Sangeeta Chavan.
[3:40] Dr. Chavan discusses Dr. Kevin Tracey’s background in neuromodulation.
[5:10] Bioelectronic medicine takes into account molecular mechanisms and neural circuits that contribute to diseases, to be able to modulate them.
[7:20] At the summit, Dr. Chris Puleo discussed non-invasive neuromodulation using ultrasound as a form of therapy.
[9:30] The speakers that inspired Dr. Chavan the most were Dr. Molly Stevens and Dr. Chris Collier for their cutting-edge projects.
[11:50] The keynote speaker for the second day was Dr. Lawrence Steinman, whose research focuses on the role of amyloid proteins in inflammatory disease models.
[13:40] Dr. Larry Miller spoke about the uses of bioelectronic medicine in regulating sphincter function.
[15:00] Targeting nerves to treat diseases has been proven to work for many patients and is continuing to grow.
To learn more about the Feinstein Institutes, listen to these episodes: Dr. Stavros Zanos, Dr. Kevin Tracey, Jojo Platt, Dr. Harbi Sohal
Dr. Owen Phillips Discusses How BrainKey Develops 3-D MRI Visualizations
Dr. Owen Phillips is the co-founder and CEO of Brainkey. Their mission is to “revolutionize brain health care by helping people access, understand, and benefit from advances in our understanding of the human brain”. Brainkey’s work allows patients to view their own MRI scans in 3-D while teaching them about the regions of the brain through an online platform. In this episode, Dr. Owen Phillips discusses how BrainKey develops 3-D MRI visualizations.
Top three takeaways:
An MRI consists of photographic slices of your brain put together to produce an image. Brainkey takes these images and makes a 3-D model. 3-D imaging allows for biometric data to be collected that could provide more information about neurological diseases. Your brain age can be calculated through the MRI scans, giving patients data to track brain health.
[0:00] Ladan introduces the episode and the guest, Dr. Owen Phillips.
[2:30] Dr. Owen Phillips explains how Brainkey makes medical imaging friendly for the patient.
[4:00] By developing relationships with MRI centers, Brainkey can provide affordable MRI scans.
[6:20] Repeated Brainkey MRI scans can allow patients to view how their brain has changed over time and check on their brain health.
[8:30] As a HIPAA compliant company, they ensure that patient data is secure.
[10:20] Aside from getting a 3-D visualization, you can also get a life-size 3-D print of your brain.
[13:25] While many are still able to upload their MRI into Brainkey, COVID has made it difficult to provide MRI scans as easily.
Customer ReviewsSee All
Great and Informative Channel!
This channel provides wonderful in-depth perspectives to the developing field of neural technologies. I highly recommend the Dan Rizzuto episode—really made me ponder the possibilities for patients suffering from traumatic brain injury. Awesome job!
Best source of neural interface and brain implant info on the web today
Ladan is an amazing podcaster who has managed to snag some of the best and most important people in this space and ask great questions for 30+ minutes at a time. Very on topic, insightful, and I've learned so many things about companies and research that I could not have anywhere else. If you're into brain-computer interfaces, this is perhaps THE most information-dense way to learn.
Helpful and insightful
I really enjoy the different guests in this podcast. I'm a 1st year engineering student and just started as a research student assistant at my university. I still have not gotten to the upper level courses so I feel rather behind in terms of knowledge during lab meetings, but this podcasts helps me shorten that gap between what I know and want to know in terms of neuroprostheses. Definitely recommend!