Real Life Pharmacology - Pharmacology Education for Health Care Professionals Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist

On this episode, I discuss risperidone pharmacology, adverse effects, monitoring, and common indications.







There are numerous drug interactions that I discuss in this podcast episode. CYP2D6 inhibitors may increase drug concentrations.







Risperidone increases prolactin more than most 2nd generation antipsychotics. This can lead to sexual adverse effects.







QTC prolongation is a concern with all antipsychotics like risperidone. We can monitor EKG to monitor for this risk.

On this podcast episode, I discuss vortioxetine pharmacology, adverse effects, drug interactions, and much more.







Because of vortioxetine's long half-life, antidepressant discontinuation syndrome is going to be less prominent compared to ADPs with shorter half-lives.







Vortioxetine is metabolized by CYP2D6. Drugs that inhibit this enzyme will likely raise concentrations and place the patient more at risk for adverse effects.







I discuss rare vortioxetine adverse effects like hyponatremia and bleeding in this podcast episode.

On this episode, I discuss isosorbide mononitrate pharmacology, adverse effects, and important drug interactions.







Isosorbide mononitrate is a vasodilator that works by relaxing and widening the blood vessels (primarily veins) through nitric oxide action. This reduces the preload and oxygen demand on the heart.







The primary use for isosorbide mononitrate is angina prevention. It is important to remember that it is NOT meant for acute relief of chest pain.







Headache is a major adverse effect of isosorbide mononitrate and can be very bothersome for patients. Vasodilation is primarily responsible for this adverse effect.







PDE-5 inhibitors are notorious for causing drug interactions with any nitrate medication. I discuss management strategies in this podcast episode.

On this episode of the RLP podcast, I discuss azelastine nasal spray pharmacology, adverse effects, administration, and much more!







While most nasal sprays for allergic rhinitis are corticosteroids, azelastine is classified as an antihistamine.







Systemic absorption of azelastine is about 40%, so while not common, systemic adverse effects like sedation can happen.







On this podcast episode, I use azelastine to remind you about important education points regarding the use of nasal sprays.

On this episode of the Real Life Pharmacology Podcast, I discuss amlodipine pharmacology, adverse effects, and important drug interactions.







I break down why edema occurs with amlodipine on this episode of the Real Life Pharmacology podcast.







While beta-blockers are typically the first-line agent for the prevention of chronic angina symptoms, CCBs like amlodipine can be used as an alternative.







There are some potential CYP3A4 interactions with amlodipine. I discuss the severity of these interactions and how to monitor patients.

On this episode, I discuss pyridoxine pharmacology, adverse effects, and important clinical uses.







Pyridoxine is most well known for its potential to reduce the likelihood of isoniazid-induced neuropathy.







Another common indication of pyridoxine is its use for nausea and vomiting associated with pregnancy.







Pyridoxine plays an important role in the production of heme, so deficiency will increase the risk for anemia.