73 episodes

Long-form science podcast about how drugs, ideas & biotechnology impact our bodies & minds. Learn directly from the best scientists & thinkers alive today. New episodes every week. Learn more at: www.nickjikomes.com

Mind & Matter Nick Jikomes

    • Science
    • 4.8 • 41 Ratings

Long-form science podcast about how drugs, ideas & biotechnology impact our bodies & minds. Learn directly from the best scientists & thinkers alive today. New episodes every week. Learn more at: www.nickjikomes.com

    Maayan Levy: Ketogenic Diet, Cancer, Microbiome, Nutrition & the Immune System | #72

    Maayan Levy: Ketogenic Diet, Cancer, Microbiome, Nutrition & the Immune System | #72

    Dr. Maayan Levy is an assistant professor of microbiology at the University of Pennsylvania, where her lab studies the communication between the microbiome and its host, with a focus on the gut microbiome and its relationship to diet, immune system function, and disease. We discuss: her recent study linking the ketogenic diet to lower risk of colon cancer; what the ketogenic diet is and what the metabolic state of ‘ketosis’ does in the body; molecules called ketone bodies, such as BHB, and the extent to which BHB supplementation can recapitulate some of the physiological effects of the ketogenic diet; how the microbiome influences the function and development of the immune system; and the hygiene hypothesis, the idea that modern human cultures may be too clean, or rely too heavily on antibiotics and other technology, and interfere with our microbiome in ways that may be detrimental to metabolic and immunological health.
    USEFUL LINKS
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    [https://mindandmatter.substack.com/?sort=top]
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    [https://linktr.ee/trikomes]

    Elysium Health, a life sciences company focused on aging research. Use code MIND for 10% off first purchase of any of their supplement products. Valid until 6/22/2022.
    [https://www.elysiumhealth.com/discount/MIND]

    DoubleBlind Magazine, a leading source of news, information, and education about psychedelics. Use code MINDMATTER for 20% site-wide.
    [https://www.doubleblindmag.com/mindmatter]
    Athletic Greens, comprehensive daily nutrition (Free 1-year supply Vitamin D w/ purchase)
    [https://www.athleticgreens.com/mindandmatter]
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    • 1 hr 17 min
    Andrew Chadeayne: Chemistry of Magic Mushrooms, DMT Analogues, Entourage Effects in Cannabis & Fungi, Novel Psychedelic Medicines, Psychedelic Startups | #71

    Andrew Chadeayne: Chemistry of Magic Mushrooms, DMT Analogues, Entourage Effects in Cannabis & Fungi, Novel Psychedelic Medicines, Psychedelic Startups | #71

    Nick talks to chemist & patent attorney Dr. Andrew Chadeayne, who is the CEO of the psychedelic startup CaaMTech. They discussed: the chemistry of magic mushrooms, including compounds beyond psilocybin, found in many species of psilocybin-containing mushrooms; the so-called entourage effect, the idea that multiple compounds found in plants and fungi might work together in a synergistic fashion to produce specific psychoactive or therapeutic effects; Cannabis and magic mushrooms; DMT, 5-MeO-DMT, and novel DMT analogues; how we went from academia, to patent law, to founding CaaMTech; the prospect of developing novel psychedelic drugs, non-hallucinogenic psychedelic drug analogues, and some of the details on how these various drugs differ in terms of their chemical structure.

    USEFUL LINKS
    Sign up for the weekly Mind & Matter newsletter
    [https://mindandmatter.substack.com/?sort=top]
    Follow Nick's work through Linktree:
    [https://linktr.ee/trikomes]

    Elysium Health, a life sciences company focused on aging research. Use code MIND for 10% off first purchase of any of their supplement products. Valid until 6/22/2022.
    [https://www.elysiumhealth.com/discount/MIND]

    DoubleBlind Magazine, a leading source of news, information, and education about psychedelics. Use code MINDMATTER for 20% site-wide.
    [https://www.doubleblindmag.com/mindmatter]
    Athletic Greens, comprehensive daily nutrition (Free 1-year supply Vitamin D w/ purchase)
    [https://www.athleticgreens.com/mindandmatter]
    Organize your digital highlights & notes w/ Readwise (2 months free w/ sub)[https://readwise.io/nickjikomes/]
    Download the podcast & follow Nick at his website
    [https://www.nickjikomes.com]

    Try Levels Health to monitor your blood sugar & optimize your diet
    [https://www.levelshealth.com/join?partner=MINDANDMATTER]
    Support the show

    • 1 hr 30 min
    Martin Picard | Mitochondria, Aging, Cellular Energy, Metabolism, Gray Hair Reversal & Brain-Body Communication | #70

    Martin Picard | Mitochondria, Aging, Cellular Energy, Metabolism, Gray Hair Reversal & Brain-Body Communication | #70

    Nick talks to Dr. Martin Picard, a biologist at Columbia University whose lab studies mitochondrial psychobiology, linking together molecular processes within mitochondria with human experience. They discussed; what mitochondria are and where they came from; their role in energy & metabolism; the mitochondrial genome; the importance of mitochondria in stress & aging; how exercise, diet, and genetics influence mitochondria biology; hair graying and whether it's reversible; the mind-mitochondria connection.

    USEFUL LINKS
    Sign up for the weekly Mind & Matter newsletter
    [https://mindandmatter.substack.com/?sort=top]
    Follow Nick's work through Linktree:
    [https://linktr.ee/trikomes]

    Elysium Health, a life sciences company focused on aging research. Use code MIND for 10% off first purchase of any of their supplement products. Valid until 6/22/2022.
    [https://www.elysiumhealth.com/discount/MIND]

    DoubleBlind Magazine, a leading source of news, information, and education about psychedelics. Use code MINDMATTER for 20% site-wide.
    [https://www.doubleblindmag.com/mindmatter]
    Athletic Greens, comprehensive daily nutrition (Free 1-year supply Vitamin D w/ purchase)
    [https://www.athleticgreens.com/mindandmatter]
    Organize your digital highlights & notes w/ Readwise (2 months free w/ sub)[https://readwise.io/nickjikomes/]
    Download the podcast & follow Nick at his website
    [https://www.nickjikomes.com]

    Try Levels Health to monitor your blood sugar & optimize your diet
    [https://www.levelshealth.com/join?partner=MINDANDMATTER]
    Support the show

    • 2 hr 12 min
    Leonard Guarente: Cellular Aging, Oxidative Stress, Antioxidants, Life Extension & Health Supplements | #69

    Leonard Guarente: Cellular Aging, Oxidative Stress, Antioxidants, Life Extension & Health Supplements | #69

    Nick talks to biologist Dr. Leonard Guarente about the biology of aging, life extension, health supplements, and related topics. Dr. Guarente is a Professor of Biology at MIT, where his lab has studied the molecular and cellular mechanisms of aging for many years. He is also the co-founder and Chief Scientist of Elysium Health, which uses the science of aging to develop health supplements to combat age-related decline and technologies to help consumers understand their rate of aging. 

    Nick and Dr. Guarente discussed many topics related to aging, including: how and why aging occurs; whether humans can achieve immortality; NAD and the core metabolic processes of cells; resveratrol, pterostilbene, and other anti-aging molecules; epigenetics and technology that can be used to calculate biological age vs. chronological age. 

    USEFUL LINKS
    Sign up for the weekly Mind & Matter newsletter
    [https://mindandmatter.substack.com/?sort=top]
    Follow Nick's work through Linktree:
    [https://linktr.ee/trikomes]

    Elysium Health, a life sciences company focused on aging research. Use code MIND for 10% off first purchase of any of their supplement products. Valid until 6/22/2022.
    [https://www.elysiumhealth.com/discount/MIND]
    Athletic Greens, comprehensive daily nutrition (Free 1-year supply Vitamin D w/ purchase)
    [https://www.athleticgreens.com/mindandmatter]
    Organize your digital highlights & notes w/ Readwise (2 months free w/ sub)[https://readwise.io/nickjikomes/]
    Download the podcast & follow Nick at his website
    [https://www.nickjikomes.com]

    Try Levels Health to monitor your blood sugar & optimize your diet
    [https://www.levelshealth.com/join?partner=MINDANDMATTER]
    Support the show

    • 1 hr 26 min
    Blanche Capel: Sex Determination, Sex Hormones & Chromosomes, Development & the Evolution of Sexual Reproduction | #68

    Blanche Capel: Sex Determination, Sex Hormones & Chromosomes, Development & the Evolution of Sexual Reproduction | #68

    Nick talks to cell & developmental biologist Dr. Blanche Capel. They discussed the nature of sexual reproduction and sexual dimorphism, including when these these things evolved, the evolutionary reasons for sexual reproduction, and the amazing diversity of mechanisms that determine the development of sexual traits across the animal kingdom; the contribution of genetic vs. environmental factors in sex determination, and how these vary across species; sex chromosomes, such as the X and Y chromosomes of humans and other mammals; sex hormones, such as testosterone and estrogen; as well as how gametes and gonads develop - these are the sex cells, such as sperm or egg, and the reproductive organs that produce them and the major sex hormones that shape sexual development; what we know, and don’t know, about the biology of puberty and sexual development after birth, as well as whether environmental factors, such as components of the diet an environmental contaminants, could be influencing sexual development.
    USEFUL LINKS
    Sign up for the weekly Mind & Matter newsletter
    [https://mindandmatter.substack.com/?sort=top]
    Follow Nick's work through Linktree:
    [https://linktr.ee/trikomes]

    Elysium Health, a life sciences company focused on aging research. Use code MIND for 10% off first purchase of any of their supplement products. Valid until 6/22/2022.
    [https://www.elysiumhealth.com/discount/MIND]
    Athletic Greens, comprehensive daily nutrition (Free 1-year supply Vitamin D w/ purchase)
    [https://www.athleticgreens.com/mindandmatter]
    Organize your digital highlights & notes w/ Readwise (2 months free w/ sub)[https://readwise.io/nickjikomes/]
    Download the podcast & follow Nick at his website
    [https://www.nickjikomes.com]

    Try Levels Health to monitor your blood sugar & optimize your diet
    [https://www.levelshealth.com/join?partner=MINDANDMATTER]
    Support the show (https://www.patreon.com/nickjikomes)

    • 1 hr 36 min
    Rachel Yehuda: Stress, PTSD, Intergenerational Trauma, Epigenetics & Psychedelic Medicine | #67

    Rachel Yehuda: Stress, PTSD, Intergenerational Trauma, Epigenetics & Psychedelic Medicine | #67

    Nick talks to neuroscientist & clinical researcher Dr. Rachel Yehuda, who is a professor of psychiatry & neuroscience at the Icahn School of Medicine at Mount Sinai, in New York. They discuss the biology and neuroscience of stress, PTSD (post-traumatic stress disorder), why people can be sensitive or resilient to stress, epigenetics, intergenerational trauma, and how MDMA and psychedelics are being explored for their ability to treat stress-related mental health conditions.

    USEFUL LINKS
    Sign up for the weekly Mind & Matter newsletter
    [https://mindandmatter.substack.com/?sort=top]
    Follow Nick's work through Linktree:
    [https://linktr.ee/trikomes]

    Elysium Health, a life sciences company focused on aging research. Use code MIND for 10% off first purchase of any of their supplement products. Valid until 6/22/2022.
    [https://www.elysiumhealth.com/discount/MIND]
    Athletic Greens, comprehensive daily nutrition (Free 1-year supply Vitamin D w/ purchase)
    [https://www.athleticgreens.com/mindandmatter]
    Organize your digital highlights & notes w/ Readwise (2 months free w/ sub)[https://readwise.io/nickjikomes/]
    Download the podcast & follow Nick at his website
    [https://www.nickjikomes.com]

    Try Levels Health to monitor your blood sugar & optimize your diet
    [https://www.levelshealth.com/join?partner=MINDANDMATTER]
    Support the show (https://www.patreon.com/nickjikomes)

    • 1 hr 37 min

Customer Reviews

4.8 out of 5
41 Ratings

41 Ratings

alannerd ,

informative and easily digestible

the topics covered can be complex in nature, but Nick asks appropriate clarifying questions and summarizes points in a way that aids with clarity for the listener. thanks for all the work you do, the consistency of your episodes, and all of the new knowledge nuggets!

Trevor Oldham ,

Awesome!

One of my new fav podcasts!

tamlers mistress ,

New favorite podcast

This podcast is a gem. If you’re interested in the mind/brain/behavior, then this is the best stuff out there. Nick also asks the great questions and has a knack for summarizing that makes the listening experience really complete

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