FoundMyFitness Rhonda Patrick, Ph.D.

Dr. Roger Seheult is the co-creator of MedCram Videos. In the early days of the COVID-19 pandemic, MedCram emerged as a beacon of insight, providing continuing coverage and perspectives in an environment almost defined by information scarcity.
What particularly excited me about the unique opportunity of this interview is that apart from Dr. Seheult being a unique voice of public scholarship during the early days of the pandemic, he's also a quadruple board-certified pulmonologist with deep experience working on the frontline of the COVID-19 pandemic.


In other words, when it comes to COVID-19 for Dr. Seheult... it's personal. He has worked tirelessly not just to help people find their way back to wellness as a critical care provider, but he broadcasts the insights he has gained realtime to the 1 million subscribers listening to his medical lecture platform he co-founded with physician assistant Kyle Allred.
Listen to this episode to hear Dr. Seheult's thoughts on:
00:06:20 - How MedCram Videos got started and the future of medical education from Dr. Seheult's standpoint. 00:09:37 - What to do when life is on the line and the usual hierarchy of evidence doesn't exist, as in early emergency COVID-19 treatment. 00:12:46 - The crucial differences in treating early vs. late-stage COVID-19 illness. 00:14:40 - How doctors would've treated COVID-19 one-hundred years ago. 00:18:13 - How increasing ventilation may powerfully impact COVID-19 disease transmission and why airplanes have surprisingly little disease transmission. 00:20:28 - How masks are virtually universally beneficial in the pandemic regardless of type. 00:21:32 - Vitamin D and COVID-19 00:22:22 - How the steroid chemical structure of vitamin D confers qualities on vitamin D that other vitamins ("vital amines") do not possess, such as membrane permeability that provides access to the nucleus and broad gene regulatory effects mediated by a specialized vitamin D receptor element. 00:23:24 - How calcium homeostasis, which was the early and exclusive focus for scientists and doctors that were trying to determine the ideal vitamin D levels, may have caused the RDA to be set too low since we now know vitamin D regulates around 5% of the protein-encoding genome and have much broader effects. 00:24:23 - How the hormonal role of vitamin D confers on it properties more similar to other hormones like testosterone and cortisol rather than those of ordinary vitamins. 00:26:21 - The surprising level of overlap between COVID-19 positivity and groups most affected by vitamin D deficiency and the surprise finding of how less than 50 ng/mL blood levels of vitamin D associated with greater likelihood of SARS-CoV-2 positivity in the hospital. 00:30:27 - How scientists are able to interrogate the effects of low vitamin D levels through genetic research, a type of study known as mendellian randomization. 00:34:20 - The gene regulatory effects of vitamin D and the implications for the scale of its biological impact. 00:35:49 - How Vitamin D's ACE2/renin-angiontensin-promoting effects may be mechanistically involved in the effects observed in vitamin D COVID-19 studies. 00:42:00 - Why ameliorating vitamin D deficiency in one large monthly bolus might be less effective than daily or weekly doses. 00:43:23 - How a prescription-only form of vitamin D known as Calcifediol might have an advantage in acute care for COVID-19. 00:47:06 - Why skin synthesis of vitamin D from UV B radiation can be extraordinarily unreliable when compared to supplementation. 00:53:43 - What the safest dose range for vitamin D is that should also address deficiency in most populations. 01:06:15 - The beneficial circadian effect of early morning sunlight. 01:07:38 - How sleep deprivation is meaningfully implicated in profound and immediate impairment of viral immunity. 01:12:08 - Dr. Seheult's suggestions for h

In this special two-hour Q&A episode with Dr. Jed Fahey, a world-leading expert on the science of chemoprotection and, in particular, sulforaphane, we discuss many of the listener-submitted questions from the hundreds of live event participants.
Get the full timeline and show notes.
Listen to learn Dr. Fahey's thoughts on…
00:07:19 - The minimum daily dose of sulforaphane that elicits beneficial health effects 00:12:04 - Why gauging the amount of sulforaphane in foods presents challenges 00:17:37 - Workarounds to enhance the sulforaphane in cooked foods 00:23:38 - How often to consume broccoli sprouts and how long their effects last 00:39:28 - The effects of sulforaphane on glutathione production in the brain 00:43:12 - The effects of sulforaphane on cancer 01:17:26 - Alternatives to sprouts, such as supplements (and which ones Dr. Fahey recommends) 01:33:08 - Safety concerns regarding sulforaphane In this episode, Dr. Fahey mentions the following companies, websites, and supplements:
Brassica Protection Products Cullman Chemoprotection Center Crucera SGS® (Thorne) Oncoplex® (Xymogen) Avmacol® Vision Defense® (Swanson) MaxN-Fuze® MitoCORE® (Ortho Molecular Products) Extra resources
Learn how to sprout at home safely by downloading the 15-page sprouting guide developed with Dr. Fahey.
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Giselle Petzinger, MD, an associate professor of Neurology at the University of Southern California and today’s guest, studies the extensive effects of how different types of exercise, in particular skill-based exercise, can affect the clinical outcome for people with Parkinson’s disease.
Dr. Petzinger's work focuses on understanding how to promote brain repair after injury, particularly in the context of Parkinson's disease. She is currently investigating ways to enhance neuroplasticity in a preclinical model of the disease. She has examined the role of exercise in Parkinson's disease, with emphasis on how different types of exercise affect distinct regions of the brain. Her work has implications for improving the quality of life of patients diagnosed with the neurological disorder — a condition for which there is no cure.
In this episode, we discuss...
00:06:57 - What is Parkinson’s disease? 00:11:57 - How symptoms of Parkinson’s disease generally only appear when ~50% of dopamine-secreting neurons in substantia nigra are lost. 1 00:14:57 - How other circuits in the brain can compensate for the loss of function of the substantia nigra. 00:18:37 - Prevalence and hereditary risk factors of Parkinson’s disease. 00:21:25 - How epidemiological studies have linked increased Parkinson’s disease risk with exposure to pesticides, herbicides, solvents, and certain heavy metals such as manganese. 1 00:26:57 - How exercise can lower the risk of developing Parkinson’s disease. 1 2 3 00:35:38 - How skill-based exercise, such as yoga, Tai chi, boxing, tango or skateboarding may play a special role in ameliorating some of the effects of the disease by driving circuit-specific effects, by creating top-down cognitive challenge for skills involved in a patient's movement through space. 00:47:49 - How serum BDNF significantly increases in Parkinson’s patients after 1 month of treadmill exercise and why this might mean better cognitive function. 1 2 00:58:33 - How treadmill exercise with heart rate 80-85% maximum for at least 3x per week slowed the progression of Parkinson’s disease symptoms. 1 01:01:31 - Why exercise may not fully replace the use of medications. 01:09:58 - How the omega-3 fatty acid DHA has some preclinical evidence suggesting it may reduce motor-symptoms and dyskinesia in Parkinson’s disease. 1 2 3 4 01:12:12 - How patients with Parkinson’s disease have higher levels of inflammatory biomarkers and how this might contribute to the disease. 1 Click here to get this episode's show notes and transcript
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Get a sample of our new premium member's content, known as Aliquots, by listening to this in-depth Q&A mashup on Fasting.
What's an aliquot, you may ask? Aliquots are special, curated segments prepared and distributed to premium members via the premium members podcast feed.
This collection of clips covers a range of topics related to fasting, including associated mechanisms of healthspan and longevity, purported health benefits, and when and how to break the fast.
Episode Highlights
00:01:36 - Fasting mimicking diet, the ketogenic diet and autoimmune diseases
00:13:42 - Spermidine is a fasting mimetic compound
00:16:51 - Aerobic exercises in a fasting state induces autophagy quicker than in a fed state.
00:25:15 - Intermittent fasting, prolonged fasting and healthspan. 00:28:02 - What we know about the minimal fasting time it takes to induce autophagy and apoptosis.
00:33:35 - Comparing and contrasting a ketogenic diet with prolonged fasting.
00:37:33 - Rhonda compares the rejuvenation effect of time-restricted eating vs prolonged fasting vs fasting mimicking diet.
00:41:16 - Rhonda's thoughts on coffee breaking a fast.
00:52:29 - Supplements and other medications outside of a time-restricted eating window.
01:01:28 - Differences between a fasting-mimicking diet vs a water-only fast. Learn more about our premium podcast feed The Aliquot by clicking here.
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Get a sample of our new premium member's content, known as Aliquots, by listening to this in-depth Q&A mashup on Sauna use.
What's an aliquot, you may ask? Aliquots are special, curated segments prepared and distributed to premium members via the premium members podcast feed.
This collection of clips covers some of the many health benefits associated with sauna use, including heat shock protein activation, cardiovascular health, muscle mass preservation, and more.
Episode Highlights
00:07:00 - What are the effects of sauna and hot baths on heat shock proteins and the immune system?
00:16:14 - What are your recommendations for infrared sauna temperature and time?
00:24:03 - At what temperature and how long do you need to stay in the sauna to activate heat shock proteins?
00:26:50 - Does sauna use promote excretion of heavy metals such as arsenic? 00:29:12 - Are there ways of mimicking sauna use without regular access to a sauna?
00:33:55 - If compounds such as metformin, resveratrol and vitamin E counteract exercise-induced hormesis, would this be true for other stressors such as the sauna, fasting, broccoli sprouts, polyphenols?
00:37:06 - How does fasting affect human growth hormone and IGF-1 in respect to muscle mass?
00:43:30 - Can saunas be used during fasting to preserve more muscle and increase fat burning?
00:45:50 - Can saunas be used to treat headaches? Learn more about our premium podcast feed The Aliquot by clicking here.
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Get a sample of our new premium member's content, known as Aliquots, by listening to this in-depth Q&A mashup on pregnancy and child development.
What's an aliquot, you may ask? Aliquots are special, curated segments prepared and distributed to premium members via the premium members podcast feed.
This particular collection of segments covers every single major discussion of pregnancy and child development spanning years of members-only Q&As.

Just for a few examples, it covers...
My pre-pregnancy regimen, including diet, exercise, vitamins and sleep Nutrition for babies and toddlers to maximize brain development and growth Extra precautions that I took during my pregnancy And much, much more! Learn more about our premium podcast feed The Aliquot by clicking here.
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