The most interesting people in the world of science and technology.
STEM-Talk is an interview podcast show produced by the Florida Institute for Human and Machine Cognition, a not-for-profit research lab pioneering ground-breaking technologies aimed at leveraging and extending human cognition, perception, locomotion and resilience. Twice a month, we talk to groundbreaking scientists, engineers and technologists. Our interviews focus on the science that our subjects are engaged with, as well as their careers, motivations, education, and passions. Think of them as “profiles in science.” Tune in every other Tuesday to our show—and if you like us, please write a review of STEM-talk on iTunes—and spread the word.
Episode 144: Jason Fung on how fasting and a low-carb diet improve insulin resistance and metabolic health
Our guest today is Dr. Jason Fung, a Toronto-based nephrologist, and the best-selling author of “The Obesity Code,” “The Diabetes Code,” and “The Cancer Code.” Jason is best known for his success in combining a low-carb diet with intermittent fasting to help thousands of overweight patients reverse their type 2 diabetes, lose weight, and improve their metabolic health.
Jason is the author of the blog “The Fasting Method” and the co-founder of the Intensive Dietary Management program, an initiative that provides low-carb dietary guidance and counseling on various fasting regimes. Jason is also the co-author with Jimmy Moore of “The Complete Guide to Fasting,” which looks at the history and culture of fasting and how it helps people improve their metabolic health.
In today’s episode, Ken is joined by Visiting IHMC research scientist Dr. Tommy Wood and together, they and Jason discuss:
* How in the beginning of his practice, Jason prescribed insulin for type 2 diabetes patients.
* How a series of landmark studies starting in 2008 changed Jason’s mind about using glucose-lowering medication for type 2 diabetes.
* Jason’s realization that type 2 diabetes is largely a dietary disease and therefore requires a dietary solution rather than a pharmaceutical one.
* The origins of Jason’s Dietary Management program, which counsels overweight and obese patients to follow a low-carbohydrate, high-fat diet to reduce insulin.
* A critique of the “eat less, move more” strategy acclaimed by many obesity experts.
* Mark Mattson’s research into the powerful impact of intermittent fasting on metabolic health and a recent paper that questioned the effectiveness of time-restricted eating when compared to daily calorie restriction.
* Recent research and evidence that fasting during chemotherapy may reduce the side effects of the treatment.
[00:02:25] Tommy opens the interview mentioning that Jason was born and raised in Toronto and asks what drew Jason to science as a kid.
[00:03:43] Tommy mentions the irony that Jason has written several best-selling books, yet Jason was not fond of English or writing when he was in school.
[00:04:53] Ken mentions that after graduating from high school, Jason stayed close to home and attended the University of Toronto, entering into medical school just after turning 19 to study internal medicine, eventually specializing in nephrology. Ken asks Jason what intrigued him about becoming a kidney specialist.
[00:06:36] Tommy asks Jason what led him to go to UCLA after medical school for his specialty training in kidney disease at Cedars-Sinai Medical Center.
[00:07:37] Tommy mentions that Jason has been practicing clinical nephrology in Toronto since 2001, and that in those early years of his practice, Jason saw patients with type 2 diabetes and prescribed medications to keep their blood glucose low. When that didn’t work, he would prescribe insulin, which is the standard medical practice. Tommy asks what Jason observed during these early years of his practice.
[00:09:28] Ken mentions that in 2008, two landmark studies were published, the ACCORD study and the a href="https://pubmed.ncbi.nlm.nih.
Episode 143: Ben Bikman on the roles of insulin and ketones in metabolic function
Today’s episode features the author of “Why We Get Sick,” Dr. Ben Bikman, a biomedical scientist at Brigham Young University.
Ben is known for his research into the contrasting roles of insulin and ketones as key drivers of metabolic function.
In “Why We Get Sick,” Ben takes a deep dive into insulin resistance and metabolic health. The book particularly focuses on the role that insulin resistance plays in many of today’s most common diseases: heart disease, diabetes, cancer, and Alzheimer’s.
Ben and his colleagues at the Bikman Lab investigate the molecular mechanisms behind the increased risks of disease that accompany obesity and excess visceral fat. Much of the research at the Bikman Lab particularly focuses on the etiology of insulin resistance and how it disrupts mitochondrial function.
In today’s interview, STEM-Talk cohosts Drs. Ken Ford and Dawn Kernagis talk to Ben about:
* How insulin resistance is tied to multiple chronic diseases.
* The relevance of ketones in mitochondrial function.
* How so many of our modern chronic diseases are self-inflicted and driven by insulin resistance.
* How many of the hallmarks of aging are a consequence of insulin resistance.
* The theory that the longest-lived people are likely the most insulin sensitive.
* The benefits that occur with carbohydrate reduction as a result of increasing insulin sensitivity.
* Ben’s thoughts about the degree of intermittent fasting needed to induce autophagy in humans.
[00:02:32] Dawn begins the interview asking Ben about his early life growing up in a small farm town in southern Alberta, Canada, as one of 13 children.
[00:02:48] Dawn asks Ben what he was like as a kid and what made him stand out from his 12 brothers and sisters.
[00:06:01] Dawn asks about Ben’s mother’s influence and how she wanted her sons to be Renaissance men.
[00:08:29] Ken asks about Ben’s experience as a Church of Jesus Christ of Latter-Day Saints Missionary in Samara, Russia.
[00:15:18] Dawn mentions that while Ben went into his undergrad majoring in exercise science, he wasn’t that interested in science at the time. It wasn’t until he began working on his master’s degree at BYU with Dr. Will Winder that he developed a true interest in science.
[00:19:49] Dawn asks Ben how he ended up at East Carolina University for his Ph.D. in bioenergetics.
[00:21:42] Ken mentions that Ben, after completing his Ph.D. moved to Singapore for his postdoc work at the Duke National University of Singapore. Ken asks how that came about.
[00:25:49] Dawn mentions that Ben is well-known for his work on insulin resistance, stemming from his time at East Carolina when he realized that insulin resistance is tied to many different chronic diseases. Dawn asks what was Ben’s ah-ha moment that led him to focus his research on insulin resistance.
[00:27:49] Dawn mentions that much of Ben’s work is focused on the role of elevated insulin in regulating obesity and diabetes, as well as the relevance of ketones in mitochondrial function. Dawn asks if it is correct that Ben has been on a sort of mission as a professor to teach a new generation of doctors and nurses how insulin resistance works, and why it is so relevant in terms of chronic disease.
[00:29:56] Ken mentions that Ben began to take his message about insulin resistance beyond the classroom, appearing on podcasts and making YouTube videos, and also giving a speech to the student body at BYU, titled “The Plagues of Prosperity” making the case that the human race is currently eating itself into metabolic disarray.
[00:32:31] Ben’s book a href="https://www.amazon.
Episode 142: Vyvyane Loh discusses weight management, ketogenic diet, and the treatment of metabolic diseases
Our interview today is with Dr. Vyvyane Loh, a board-certified physician in obesity and internal medicine. She is the founder and leader of Transform Alliance for Health, a Boston preventive-care practice that specializes in weight management and the treatment of chronic metabolic diseases such as diabetes, hypertension and dyslipidemia.
She and her staff are known for helping people lose 50 pounds or more and getting their type-2 diabetic patients off their many medications. Vyvyane has spent her medical career developing expertise in immunology, metabolic syndrome, fat metabolism, clinical nutrition, and preventive medicine.
In today’s interview, we discuss how abdominal, or visceral, fat is linked to a wide range of metabolic disorders. Vyvyane goes on to explain how there’s a clearcut association between obesity and decreased brain volume that rarely gets discussed. When her overweight patients complain about their behavior around food and how they consistently give in to snacks that patients know are bad for them, Vyvyane explains how the challenges they are facing is often a result of the brain struggling with decreased blood flow and the shrinkage of neurons.
Vyvyane also shares how a patient asked Vyvyane if she knew anything about the Atkins diet, and although she didn’t, Vyvyane ended up doing the diet along with her patient. This led Vyvyane to start seriously researching whether a ketogenic diet could help people not only lose weight, but also reverse chronic disease.
Toward the end of today’s interview, we explore Vyvyane’s interest in macrophages, which are specialized cells involved in the detection and destruction of bacteria and other harmful organisms.
We also have a nice discussion about how Vyvyane took some time off from practicing medicine to enroll in the writing program at Warren Wilson College in North Carolina in 1999. She spent the next two years writing a novel, “Breaking the Tongue.” Set in Singapore during World War II, her book was nominated for the prestigious International IMPAC Award in fiction and was selected by the New York Public Library as one of its top 25 books of 2004.
If you are interested in finding out more about Vyvyane, check out her website, vyvyanelohmd.com. Also, Vyvyane launched a podcast this week, which you also can find on her website. Episode one looks at “Metabolism: What It Is, And How It Affects Your Health.”
If you enjoy today’s interview with Vyvyane and the many other interviews we’ve had on STEM-Talk discussing the treatment and prevention of chronic metabolic diseases, you may want to check out the upcoming virtual conference on Targeting Metabesity.
Our cohost Dr. Ken Ford will be one of nearly 70 speakers, including many former guests on STEM-Talk, talking about the growing evidence that the major chronic diseases of the day share common metabolic roots and as a result may also share common solutions.
To find out more about the conference, follow this link to the Targeting Metabestiy home page where you find a program guide and list of speakers. If you would like a free ticket to the conference, click on this link where you will find instructions on how to receive a code for complimentary admission that is being offered to STEM-Talk listeners.
Ken will be moderating a session on emerging research related to endogenous and exogenous ketosis in health and disease as well as the role of keto...
Episode 141: Jeff Iliff on newly discovered system that clears waste from the brain
Our guest today is Dr. Jeffery Iliff, a professor of psychiatry and behavioral sciences in the Department of Neurology at the University of Washington. Much of Jeff’s research focuses on neurodegeneration and traumatic brain injury.
He is the associate director of research at the VA Puget Sound Health Care System and a co-leader for research at the University of Washington’s Alzheimer’s Disease Research Center.
In this episode, we talk about Jeff’s investigations into the glymphatic system, which is a newly discovered brain-wide network of perivascular spaces that facilitates the clearance of waste products from the brain during sleep. Jeff goes on to describe how he is exploring how the glymphatic system fails in the aging brain as well as in younger brains after traumatic brain injury.
Jeff and Dawn also have a conversation about their collaboration on a research project that’s focused on how extreme stressors impact the glymphatic system. Together they are investigating a potential approach to optimizing glymphatic clearance for individuals with acute or chronic sleep deprivation.
[00:02:55] Dawn opens the interview asking Jeff where he grew up.
[00:03:21] Dawn asks what Jeff what he was like as a kid.
[00:04:01] Ken mentions that it wasn’t until Jeff was working as a lifeguard at a boy scout camp that he first became interested in science. Ken asks Jeff what it was about his lifeguard experience that triggered the interest.
[00:05:06] Dawn asks what led Jeff to the University of Washington as an undergrad.
[00:06:02] Ken mentions that Jeff originally intended on going into pre-med. Ken explains that Jeff changed his mind and asks about a suggestion from a girlfriend that caused Jeff to have a change of heart.
[00:07:39] Dawn points out that in addition to working in the lab as an undergrad, Jeff also worked a 48-hour shift as an EMT over the weekends. Dawn asks Jeff why he kept such a busy schedule.
[00:09:35] Ken asks what led Jeff to the Oregon Health & Science University for his Ph.D.
[00:10:53] Dawn asks if it’s true that Jeff’s wife played a big role in his decision to travel across the country to New York for his post-doc at the University of Rochester.
[00:13:06] Dawn mentions that after the second year of Jeff’s post-doc, he was promoted to a junior faculty position because he was part of the team that discovered a brain cleaning system known as the glymphatic system. The team published a paper in 2012 in science translational medicine that was the first of about ten papers that later became known as the “glymphatic papers.” After a follow-up paper in 2013, Science Magazine cited the discovery that the glymphatic system cleans the brain during sleep as one of the “Top 10 Breakthroughs of 2013.” Dawn asks what this experience was like for Jeff as a young post-doc and junior faculty member.
[00:15:55] Dawn explains that the lymphatic system is a network of vessels extending throughout most of the body that transport excess fluid and waste from the interstitial spaces between cells to the blood. She goes on to explain that these vessels are notably not found in the brain leading to the question of how interstitial fluid is cleared in the brain. Jeff’s team discovered the glymphatic system, which serves the same function in the brain as the lymphatic system in the rest of the body. This discovery turned out to be a paradigm shift and led to numerous subsequent studies. Dawn asks Jeff how the initial 2012 study came about and how they identified a distinct clearing system in the brain that serves a lymphatic function.
Episode 140: Kaleen Lavin on the benefits of exercise on Parkinson’s and “inflammaging”
Today we would like to introduce you to one of our newest colleagues here at IHMC, Dr. Kaleen Lavin, a research scientist who investigates the molecular mechanisms by which the body adapts and reacts to stressors such as exercise, training and aging.
Kaleen came onboard at IHMC last year and is known for her use of computational biology techniques as a means to understand and improve human health, performance and resilience.
She also is interested in the use of exercise as a countermeasure for a range of disease conditions, including neurodegenerative diseases such as Parkinson’s disease. Today we will talk to her about some of her most recent work that examined the molecular effects of exercise training in skeletal muscle and in people with Parkinson’s.
We also talk to Kaleen about her recent paper that took a comprehensive look at the current literature surrounding the molecular and cellular processes underlying the molecular benefits that exercise induces in humans. The paper appeared earlier this year in Comprehensive Physiology and was titled, “State of Knowledge on Molecular Adaptations to Exercise in Humans.”
Kaleen is a graduate of Georgetown University, where she earned a bachelor’s degree in biology. She also earned a master’s in sports nutrition and exercise science from Marywood University in Pennsylvania and a Ph.D. in human bioenergetics from Ball State University in Indiana.
[00:03:02] Dawn opens the interview mentioning that Kaleen grew up in Scranton, Pennsylvania, and asks Kaleen about her passion for music as a youth.
[00:03:25] Ken asks Kaleen about her high school years and how she became a competitive swimmer.
[00:04:26] Dawn mentions that Kaleen was an excellent student growing up, but that it wasn’t until her junior year of high school that she became interested in science. Dawn asks if it were a teacher who inspired Kaleen.
[00:05:21] Dawn asks what led Kaleen to attend Georgetown University after graduating from high school.
[00:05:57] Dawn asks if Kaleen knew she wanted to major in biology when she first arrived on campus at Georgetown.
[00:06:45] Ken asks about Kaleen’s experience of becoming a part of the Howard Hughes Program at Georgetown, which led to her gaining experience working in lab.
[00:08:47] Dawn mentions that Kaleen transitioned from competitive swimming to running during her undergraduate years, running a marathon and half marathon. Dawn asks if Kaleen’s father, who is an avid marathoner, gave her the incentive to start signing up for marathons.
[00:13:19] Dawn asks Kaleen about a faculty advisor who noticed her passion for running and exercise and helped her decide what to pursue for her master’s degree.
[00:15:23] Ken asks Kaleen what led her to pursue her master’s at Marywood University, a small Catholic University in Scranton.
[00:16:56] Ken asks Kaleen what prompted her to pursue a Ph.D. in exercise science at Ball State University, which has one of the longest-standing human performance programs in the country.
[00:17:57] Dawn mentions Kaleen’s experience with no-breath laps as part of her training when she was in high school on the swim team. Dawn asks Kaleen to explain what no-breath laps are.
[00:19:00] Dawn asks Kaleen about a study she conducted for her master’s thesis at Marywood that examined the effects of controlled frequency breath swimming on pulmonary function.
[00:22:13] Ken asks about how Kaleen’s time at Ball State set her up for her post-doc work at Center for Exercise Medicine at the University of Alabama at Birmingham.
Episode 139: Matt Kaeberlein discusses healthspan, longevity, and rapamycin
In response to several requests from listeners, we have as our guest today, Dr. Matt Kaeberlein, a professor of pathology at the University of Washington. Matt is well-known for his investigations into the basic mechanisms of aging. Much of his research in this area is focused on identifying interventions that promote healthspan and lifespan.
In today’s interview, we talk to Matt about the biology of aging and what he has learned about slowing the aging process. In 1999, Matt and his colleague Mitch McVey discovered that overexpression of the SIR2 gene is sufficient to extend lifespan in yeast. SIR stands for silent information regulator, and we have an interesting discussion about how Matt’s research and 1999 discovery have elevated SIR2 to the forefront of aging research.
Also, some of Matt’s most recent and fascinating investigations have been into rapamycin, the only known pharmacological agent to extend lifespan. His research has shed new light on the role rapamycin plays in delaying age-related dysfunction in rodents, dogs, and humans.
We also have a fun discussion with Matt about his research showing that rapamycin may have the potential to reduce the mortality of companion dogs. The paper that came out of this research landed Matt on the front page of the New York Times and received prominent play in the national and overseas media.
Other topics we cover include:
* Matt’s attempts to uncover the molecular mechanism behind lifespan extension via calorie restriction.
* His research into mTOR, which is a protein in every cell, and how inhibiting mTOR has been shown to extend the lifespan of insects, rodents, and animals.
* Matt’s 2006 study that showed fasting extends lifespan in worms more than caloric restriction.
* And an article Matt published last year that summarized several of the most popular anti-aging diets, comparing them with classical caloric restriction.
In addition to his work in his Kaeberlein Lab, Matt is the co-director of the Nathan Shock Center of Excellence in the Basic Biology of Aging and the founding director of the Healthy Aging and Longevity Research Institute at the University of Washington. He also is the founder and co-director of the Dog Aging Project.
[00:02:53] Dawn asks Matt and his youth and where he grew up.
[00:03:06] Ken asks if it is true that Matt spent a good deal of his youth “up to no good.”
[00:04:20] Dawn mentions that while Matt got decent grades in school, it wasn’t until he went to college that he became studious. Dawn asks Matt if it true that he had originally decided to skip college.
[00:05:42] Dawn asks how Matt ended up in Bellingham at Western Washington.
[00:06:41] Dawn asks how in the world, despite not liking high school and working a morning shift at UPS for two years after graduating, Matt decided to head off for college and major in biochemistry of all things.
[00:08:01] Ken asks what led Matt to travel across the country to Boston and MIT’s biology program.
[00:09:57] Ken asks why Matt decided to focus his research on the biology of aging.
[00:11:57] Matt talks about what he did following his Ph.D.
[00:13:15] Dawn asks Matt what kind of research he did at the University of Washington Department of Genome Sciences for his post-doc, and how this research related to aging.
[00:15:10] Ken mentions that it was during Matt’s undergrad that he decided to focus on the question, “To what extent are the mechanisms of aging evolutionarily conserved?” Ken asks Matt what caused him to arrive at that for his central focus.
[00:19:36] Dawn mentions that the discovery by Matt, and Mitch McVey,
Fantastic Science Podcast!
I absolutely love STEM-Talk! Dr. Ford and Dawn are incredible guests and ask unbiased questions, that really help the listener understand both the science and the storyline of their guests. As a podcaster myself, I try to emulate what they do, as they always create amazing and unique episodes!
Intermittent fasting fascinating interview. I’m hooked after listening!
Thank you for a smart intriguing podcast.
Just wanted to thank you for the really timely episodes you’ve had recently. The Mark Mattson, Martin Kulldorff and Mike Griffin interviews were all such timely topics that dealt with topics that are on everyone’s minds because of current events and trends. Keep up the good work.