Your One Stop Shop For All Things Self-Improvement Related
Your One Stop Shop For All Things Self-Improvement Related
RAD140 Phase 1 HUMAN TRIAL Using 150 MG PER DAY Results
One Phase 1 study on the SARM RAD140 has been conducted [R].
The Phase 1 trials are the first stage of testing in human subjects designed to assess safety, side effects, best dosage, and formulation method for the drug.
In this podcast episode, I go over the recently published results of that trial.
Anadrol Dosage - 50 mg Vs. 100 mg Oxymetholone Results Comparison
In a study evaluating dose-response to a moderate and high Anadrol dosage, muscle and strength gains from 50 mg per day and 100 mg per day were compared.
By now you've probably heard me outline the "less is more" concept when it comes to steroid use.
On one side of the spectrum, the clinical data does show that the more steroids you use, the more muscle you will gain over the span of a cycle.
However, the same studies also reveal a dose-dependent decline in muscle growth response relative to increased drug load.
Basically, more works better, but there are diminishing returns the higher your dosages go, and how much muscle you net over the span of your life bodybuilding will likely differ based on how aggressively you approach your mass building phases.
50 mg Vs. 100 mg Anadrol Study Results In the following study, we can see changes in body weight, lean body mass (what we mainly care about), and fat loss in response to a moderate and high Anadrol dosage (50 mg vs. 100 mg) [R].
The placebo group didn't gain any lean body mass, nor did they lose any body fat.
The 50 mg Anadrol treated group gained 3.3 kilograms of lean body mass and lost 2.6 kg of fat.
The 100 mg Anadrol treated group gained 4.2 kilograms of lean body mass and lost 2.5 kg of fat.
Looking at lean body mass, we can see that when comparing the two dosage groups, the 100 mg group only gained 0.9 kg lean body mass more than the 50 mg group.
This is after three-month exposure to twice the amount of drug.
If we compare biomarkers between the two groups, we can see that the effect 100 mg of Anadrol had on ALT and AST levels was far more deleterious than the 50 mg group.
Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) are commonly used biomarkers for assessing liver damage.
Placebo 50 mg/day 100 mg/day PValue ALT, U/l 0 ± 2 21 ± 15 72 ± 67 0.001 AST, U/l 1 ± 2 14 ± 6 38 ± 29 Doubling the Anadrol dosage only yielded an additional 27% of muscle growth, but resulted in a 3.4x higher spike in ALT and a 2.7x higher spike in AST levels.
Those are just biomarkers in the blood too and aren't indicative of what deleterious impact doubling the dosage may have had on ventricular hypertrophy, or other commonly overlooked factors that should be used to evaluate cardiovascular health.
More Is Better, Until It's Not Yes, higher dosages will yield more muscle growth in the short-term.
This is established.
However, in the grand scheme of things, is it worth it to pursue that additional 20-30% of progress you can get out of a cycle by doubling your dosages?
Not only will you experience diminishing returns the higher your dosage climbs, but subjecting your body to a substantially greater toxic burden will ultimately shorten your bodybuilding career.
"The flame that burns twice as bright burns half as long."
- Lao Tzu
Cranking oxidative stress through the roof with higher dosages to yield fractional returns will just bring you towards a state of deteriorated health quicker, and will likely prevent you from even being healthy enough to pursue off-season cycles down the line that you would have otherwise been able to leverage to gain more muscle had you not pushed things so aggressively in your earlier years.
At some point, you are going to reach a stage where you have to choose between your health and bodybuilding, and your lifestyle practices will start to shift more in favor of longevity (if you're smart).
Pushing your body unnecessarily with high dosages just gets you to that point faster.
With that being said, how do you define what a "high dose" is and what a "safe dose" is?
There are no safe dosages when you're using anabolic steroids, but what you can do is take the hordes of clinical data and anecdotal reports we have available and form a health conscious approach to bodybuild
The Anabolic Steroid Family Tree - A Framework That Simplifies How Different Steroids Impact Muscle Building And Performance
The anabolic steroid family tree is a framework that simplifies how different steroids impact muscle building and performance.
In general, the most commonly used anabolic steroids fall into one of three different families/categories.
Testosterone and its derivatives, Dihydrotestosterone (DHT) and its derivatives, and Nandrolone (19-Nortestosterone) and its derivatives.
Expectedly, many of the anabolic steroids in each family have similar attributes to one another.
There are exceptions to this in each family, but in general breaking down anabolic steroids into the three families provides a simplified framework to identify the targeted action of each compound, as well as how they impact muscle building and overall performance.
Gorilla Mode Nitric Stimulant Free Pre-Workout Review | Comprehensive Supplement Breakdown
Gorilla Mode Nitric Pre-Workout is the most potent and comprehensive stimulant free pre-workout on the market in ALL aspects.
All angles of saturating the muscle with blood and hydration have been addressed in this formula and are quite literally maxed out.
Gorilla Mode Nitric Supplement Facts Per Full Daily Dose:
L-Citrulline – 10,000 mg Creatine Monohydrate – 5000 mg Betaine Anhydrous – 4000 mg GlycerPump™ (65% Glycerol Powder) – 4000 mg Malic Acid – 3000 mg Agmatine Sulfate – 1500 mg Nitrosigine® (inositol-stabilized arginine silicate) – 1500 mg Sodium Nitrate – 1500 mg VasoDrive-AP® (isoleucyl-prolyl-proline (IPP) and valyl-prolyl-proline (VPP) isolated from hydrolyzed milk casein) – 254 mg
Gorilla Mode Nitric Vs. Other Pre-Workouts On The Market This is the most maxed out stimulant free pre-workout formula on the market in all aspects.
It is also the most comprehensive formula that targets nitric oxide (NO), vasodilation and intracellular hyper-hydration from multiple angles, while maintaining top end dosages across all of those pathways.
We completely saturate the traditional Arginine–eNOS–nitric oxide (NO) pathway with a massive 10 gram dose of L-Citrulline, 1.5 grams of Nitrosigine and 1.5 grams of Agmatine Sulfate.
The often neglected nitrate–nitrite–nitric oxide (NO) pathway is also topped out with a 1500 mg dose of Sodium Nitrate.
A high level of intracellular hyper-hydration is achieved with 5 grams of Creatine Monohydrate, 4 grams of Glycerpump and 4 grams of Betaine Anhydrous.
We also addressed the enzyme angiotensin converting enzyme (ACE) with VasoDrive-AP®, which acts as an ACE inhibitor and significantly increases vasodilation.
Finally, we have 3 grams of Malic Acid added in on top of the 10 grams of pure L-Citrulline to act as a Krebs cycle intermediary and counter lactic acid buildup during training.
Some of these pathways are so maxed out that we could have easily just chosen one of them and sold the product for $39.99 and still had one of the most potent pre-workouts in the industry.
Instead, I packed it all into one absurd product that clocks in with over 30 grams of efficacious active ingredients per full dose.
It was incredibly expensive to create, but I am very happy with how it turned out, and I am not exaggerating when I say that this pre-workout is absolutely unmatched.
Basically, I just included exactly what I would want to see in a stimulant free pre-workout, even at the obvious detriment of our margins.
This product is even more potent than Gorilla Mode when it comes to pure pump and performance.
The full daily dose is 2 scoops.
Even a half dose (1 scoop) is still far more potent than the majority of other pre-workouts out there at their max dosages.
This is another product I wanted to be head and shoulders, clear as day, superior to everything else in the industry.
Just like in my description of how Gorilla Mode stacks up to other products in this industry, we can actually back up why our product is better than the rest.
When (insert fitness influencer name here) launches their own supplement line, they will regurgitate the same story about how their products are effectively dosed, only use the highest quality ingredients, blah blah blah.
They don't even know what they're selling half the time, let alone what combinations of ingredients work synergistically, or how to dose a product properly.
They employ others to manufacture their products, or use a pre-made formula their manufacturer uses for every company where they just slap a different label on it and sell it for a huge margin.
At the end of the day, most fitness influencers have no idea what goes into making an effective product.
They don't know how their products work, they probably wouldn’t even use them if they didn’t sell them, they didn't
How Different Anabolic Steroids Can Affect Your Immune System And Vulnerability To Viral Infections
Both Testosterone and anabolic androgenic steroids (AAS) adversely influence the immune system, affecting leucocyte growth or activity, and antibody and cytokine production, particularly when used at supraphysiological doses, mimicking a condition of secondary immunodeficiency [R, R].
Secondary immunodeficiency, much more common than primary immunodeficiency (that is to say those caused by genetic defects affecting the cells of the immune system), is characterized by various factors that affect a normal immune system, including infectious, iatrogenic, metabolic and environmental factors.
These immune deficiencies are manifested clinically with an increased frequency or unusual complications of common infections and occasionally with the onset of opportunistic pathogen infections.
Nandrolone And Anadrol Effects On The Immune System Nandrolone Decanoate and Anadrol directly induce the production of inflammatory cytokines Interleukin 1 Beta (IL-1β) and Tumor Necrosis Factor Alpha (TNF-α) in human peripheral blood leukocyte cultures [R].
Testosterone and DHEA had no direct cytokine inducing effect in the same model.
Nandrolone Decanoate also inhibits interferon production in NDV-infected mouse L-929 and human WISH cells.
Winstrol And Trenbolone Effects On The Immune System Winstrol and Trenbolone were found to be genotoxic and cytotoxic to human lymphocytes in a dose dependent manner [R].
Testosterone, Teslac, Anavar And Winstrol Effects On The Immune System To evaluate how anabolic steroids affect the immune system, five commercially available steroids with various types of structural differences were studied in a rodent model [R].
Animals were divided into five groups and treated with Testosterone (group 1), Testosterone Propionate (Group 2), the steroidal aromatase inhibitor Testolactone (Teslac) (Group 3), Anavar (Group 4), and Winstrol (Group 5).
Significant immunosuppression was observed with all groups.
However, by day 10, the Teslac, Anavar and Winstrol treated group showed immunostimulation and actually exceeded baseline immunity while the Testosterone treated groups maintained immunosuppressed.
To truly test the effects of endogenous androgens on the immune system a second experiment was then performed.
Ten animals maintained in a similar manner to the initial experiment were either treated intact or were castrated and then treated for 8 days, with Anavar (1.1 mg/kg/day), Testosterone (1.1 mg/kg/day) or Anavar combined with physiologic amounts of Testosterone (15 μg/day).
Anavar was selected because it has the greatest anabolic activity of all Testosterone analogues as compared to Testosterone (androgenic/anabolic activity = 1:13).
In the intact animals after 8 days of treatment with Anavar, serum Testosterone levels were measured by radioimmunoassay on tail vein blood.
Levels were either undetectable or very low, reflecting what would be significant HPTA suppression.
Immune function (DCH responses) measured at the same time revealed a 41% increase over baseline.
The Testosterone treated group experienced a 36% suppression of immune function.
Further treatment for 8 days with Anavar combined with physiologic amounts of Testosterone eliminated the immune system enhancement provided by Anavar monotherapy and returned the DCH responses to levels that were not significantly different from baseline.
The results were different in the castrated animals.
Castration, resulted in an increase in immune (DCH) responses.
The mean observed change was 90% greater than intact (pre-castration) baseline.
That means that castrated rats had a 90% improvement above and beyond rats that weren’t castrated.
Eight day administration of Anavar to these animals had an immunodepressive effect returning the DCH response to baseline.
Eight day treatment with Anavar combined with phy
Arnold Schwarzenegger’s Steroid Cycle - Dbol And Primobolan
Arnold Schwarzenegger's steroid cycle from the golden era of bodybuilding is a topic that is often heavily debated.
There's a lot of speculation around what kind of drug use the golden era bodybuilders deployed to get the physiques that are so sought after nowadays.
While Arnold himself never detailed exactly what he took, we have a handful of credible sources of information that all seem to overlap in their descriptions of his steroid use.
Despite this information being very accessible, it often goes overlooked because it is buried in the nooks and crannies of the internet.
There is such an overwhelming amount of content on the internet now that this information has become increasingly more difficult to find over the years.
While Arnold likely experimented a bit here and there, this article will detail what he built his physique on, and the staple anabolics he very likely used throughout his Mr. Olympia reign.
Arnold Schwarzenegger Briefly Touches On His First Steroid Cycle In Arnold Schwarzenegger's autobiography "Total Recall - My Unbelievably True Life Story" he gives some insight into what his first steroid cycle consisted of, and when he started it.
The first thing of note is that he discovered steroid use before the 1967 Mr. Universe competition while researching about the training methods of the East Germans and the Soviets.
There were rumors that they were using performance enhancing drugs to get superior results from their weightlifters, shot-putters, and swimmers and he soon found out that steroids were the drugs that they were using.
Arnold goes on to touch on how he went to a doctor to ask for a prescription of anabolic steroids.
He simply asked:
Can you let me try it?
The doctor agreed, and he was then prescribed an injection every two weeks and pills to take in between.
Keep in mind, this was Arnold's first steroid cycle ever.
His dosages may have titrated up in subsequent cycles, and he probably experimented with different anabolics at some point at least once or twice.
The more muscle you gain, the higher your requirements will become for increasingly high amounts of calories, training volume, and drug use to support additional hypertrophy above and beyond what you have already achieved.
While Arnold didn't state exactly what he was prescribed, we get some useful insight into the administration practice of each compound (oral and injectable) and what type of drugs would probably fall into these two categories at that time when considering all of the other information from other interviews we have compiled over the years.
At this point, we know he was using one injectable compound and one oral compound.
Arnold Schwarzenegger's Interview About Dianabol Use In another interview Arnold more or less implies that he used 3 Dianabol per day.
It is well-known in the community that Arnold was big on using Dianabol back in the day.
Obviously he's not actually straight up saying "this was what my cycle was", but we can put two and two together based on his prescription for pills and an injection from a doctor, Arnold talking about Dianabol himself, and the widespread information that's passed through the grapevine reinforcing his Dianabol use.
It all culminates to paint a pretty convincing picture that Dianabol was the oral steroid in question that Arnold used.
What the injectable compound was is mainly what is debated about.
After doing some digging, I uncovered some pretty convincing information suggesting that the injectable compound was Primobolan.
Steve Davis Outlines Golden Era Steroid Cycles In 2012, Ric Drasin interviewed Steve Davis to discuss steroid cycles from the golden era.
Both men trained at Gold's Gym with Arnold in the 70's and had personal insight into what golden era stacks consisted of, as they literall
Customer ReviewsSee All
Derek is easy to listen to and very knowledgeable. Doesn’t feel like some marketing scam.
Derek is always well informed and well spoken with his topics
Pretty much the most informative content creator within his niche
Love his youtube content now im gonna start on his podcasts