One Thing with Dr. Adam Rinde Dr. Adam Rinde

Episode 85: In this episode, I welcome on Dr. Dawn Ipsen who is a pharmacist that is out of the Seattle area. She is a professor of pharmacology at the University of Washington and at Bastyr University and also an owner of two very successful compound pharmacies; Kussler's Pharmacy In Snohomish, Washington and Clark's Pharmacy in Bellevue, Washington. Dawn was a previous guest on our podcast and speaking to us about low dose naltrexone. Today she's coming back
to help us connect some dots and find out some solutions for long covid. We also had a previous episode with researcher Amy Proal, PhD which really broke down the underlying drivers of Long Covid and I encourage everyone to listen to that one as a companion to this episode.

In this episode we cover:


(00:00:00) Opening and Intro


(00:03:07) Dr. Ipsen's Early Response to Covid-19


(00:09:21) Current state of Covid-19 ; March , 2023


(00:11:19) Similarities between Long-Covid and other chronic illnesses


(00:14:00) Neuroinflammation and how it plays a role in Long-Covid


(00:22:58) Is Low Dose Naltrexone an effective therapy for Long Covid?


(00:27:35) Is Methylene Blue a safe and effective therapy for Long Covid?


(00:42:02) Synapsin (B12, NAD) for Long Covid


(00:44:01) Ivermectin and its role in Covid-19


(00:46:15) Why its difficult to research Covid-19 therapies


(00:48:16) About Compounding Pharmacy


(00:51:16) Parting Words and encouragement.




Dawn Ipsen, PharmD is owner and pharmacist of Clarks Compounding Pharmacy in Bellevue, WA and Kuslers Compounding Pharmacy in Snohomish, WA. Dawn graduated from the University of Washington with a Doctorate of Pharmacy in 2001 where she received the Deans Outstanding Service Award. She holds memberships with International Academy of Compounding Pharmacists and Washington State Pharmacy Association. She is a Clinical Instructor for the University of Washington School of Pharmacy and an Affiliate Faculty Member for Bastyr University. She is a Pharmacist Preceptor for Washington State and teaches Doctorate of Pharmacy students. Dawn also serves on the Professional Compounding Centers of America (PCCA) Advisory Counsel. She was named PCCA Pharmacist of the Month in 2016 and Washington State Distinguished Young Pharmacist of the Year in 2011. Dawn has presented on the topic of pharmaceutical compounding to physician, patient, and peer groups. She is dedicated to helping her community find solutions to medication problems through personalized medication therapies.





















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In episode #84 we welcome back a familiar name to our audience: Dr. Jill Crista.    Dr. Crista is back to discuss another area of her expertise Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections(PANDAS) and  Pediatric Acute Onset Neuropsychiatric Syndromes (PANS) She recently authored a new book called  



 A Light in the Dark for PANDAS & PANS  which highlights integrative and root cause strategies and treatments for patients and their families who are struggling with this disorders The list of symptoms of PANDAS & PANS is exhaustive but the most telling symptoms are Tics, Obsessive Compulsive Disorder behavior, and Separation Anxiety.  

There are many other subsets of symptoms that can arise such as oppositional behavior, changes in handwriting, and Tourette's syndrome In many of these kids these symptoms will happen abruptly.

 In this episode we go into so many aspects of PANDAS and PANS including: 


Diagnosis Challenges 
The overwhelm of the experience for parents 
Chronic infections and Mold as being an underlying cause Neuroinflammation and Autoimmunity in the brain.
 Dopamine, Glutamate,  Microglial Cells, Mast Cells 
The gut microbiome
 Treatment philosophy 

We are dedicating this episode to the organization  The Neuroimmune Foundation in honor of Dr. Crista. And we will make $100 contribution in her honor once this episode reaches 100 downloads. We hope that you will join us in that effort. 

About Dr. Jill Dr. Jill Crista is a pioneering naturopathic doctor, best-selling author, devoted educator, and creative innovator. Her superpower is to make complex medical concepts simple and digestible for the average person. Dr. Jill’s passion is to elevate the well-being of the planet via the well-being of her inhabitants. Her books, memberships, and online courses support those wanting concrete steps to conquer health challenges. Dr. Jill focuses on conditions that cause injury to the brain and nervous system, including mold, PANS and PANDAS, Lyme disease, and concussion. She has practitioner course and parent course and otherwise amazing set of offerings found at www.drcrista.com  #pandaspans #panspandas #autoimmuneencephalitis #pandassyndrome #pandasawareness #pans #pansawareness #pandas #basalgangliaencephalitis #pandaspansawareness #ocd #autoimmunedisease #tics #panssyndrome #panspandaswarriors #healingpansandpandas #pandastreatment #autoimmunewarrior #encephalitis #brainonfire #pansandpandas #functionalmedicine #immunedeficiency #autoimmunity #thepandasdocs #autoimmuneawareness #ivig #lyme #ae #strep


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Episode 83:  Neurostabilization with Amber Walker. Link in Profile and below, or Scan QR code on picture. The worlds of Mast Cell Activation Disorder, Postural Orthostatic Tachycardia Syndrome, and Hypermobility Ehlers Danlos Syndrome have many threads in common and many shared experiences. The common thread in these conditions expands to the fact that the symptoms, causes, and triggers are unpredictable, undefined, and this experience is largely disruptive to the nervous system. Further the nervous system disruption makes the symptoms worsen. How serious should we take neurostabilization in these conditions? To help answer this question, I welcomed on Amber Walker, PT, DPT, CFMP, CNPT.  Her unique personal and clinical journey provides a most comprehensive look at this area: We cover many things such as: Where to start when complex health conditions present. How the immune system and environmental triggers effect the Vagus nerve and limbic system Polyvagal theory Nervous system balancing Mast Cells and much more This episode is dedicated to Projectmercy.org an organization committed to education, healthcare, food security, adult skills and infrastructure in Ethiopia.  For each of the first 100 listens we will donate $1.  You too can donate here BIO- Amber Walker, PT, DPT, CFMP, CNPT is a doctor of physical therapy with advanced training in functional medicine, nutrition and natural healing. She specializes in working with patients who suffer from mast cell activation issues, Chronic Inflammatory Response Syndrome from mold exposure, dysautonomia, hypermobility spectrum disorders, hereditary angioedema, PASC (post-acute sequelae of Covid-19) and other chronic conditions. As the owner of Origin Wellness, she encourages a “root issue” approach to patient care. Amber is the author of “Mast Cells United: A Holistic Approach to Mast Cell Activation Syndrome” (2019) and “The Trifecta Passport: Tools for Mast Cell Activation Syndrome, Postural Orthostatic Tachycardia Syndrome and Ehlers-Danlos Syndrome” (2021). Her 2022 course "Conquering CIRS" focuses on healing from mold exposure. Amber utilizes the Safe & Sound Protocol to help foster healing for autonomic nervous system regulation and is trained in CranioBiotic Technique, a natural method of addressing health stressors and improving immune function. She utilizes a hands-on approach to physical therapy through dry needling, manual therapy and chronic illness-conscious exercise strategies. Career highlights include the role as a public health volunteer in Peru, and Amber continues to be passionate about working toward creative community health solutions. She’s also enjoyed the roles of swimming coach, paddleboarding company owner, faculty with two universities in Colorado and is a member of the Ehlers-Danlos Society International Consortium: Allergy & Immunology Working Group. In her spare time, you can find Amber on a surfboard, mountain trail or somewhere in Latin America. Learn more: www.originwellnesscolorado.com https://originwellness.teachable.com/p/conquering-cirs www.mastcellsunited.com


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Current studies estimate that 2.7% to 6.5% of women in the United States have symptoms consistent with a diagnosis of interstitial cystitis/bladder pain syndrome (IC/BPS). The broad range in prevalence depends on whether a high-sensitivity definition (6.53%) is used versus a highly specific definition (2.7%)
And that is really an underestimate, because most people complaining of painful, urinary discomfort,  urgency, and frequent urination; in the absence of an infection are just brushed off by their health care provider and sent home with no solutions. Meanwhile they suffer, with constant urging to urinate and pain sometimes to the point that urinating feels like peeing chards of glass.  It is not something that is over in a few days. This is a chronic and intermittent condition  In previous episodes of the one thing podcast we spoke about IC and got a nice view of the microbial  and also biofilm component; however there was more to the story that I wanted to explore. So I reached out to Dr. Mandy LaGrega who is known as the IC healer.  I was intrigued by her work in this area especially when it comes to her knowledge of the Oxalate component of IC/PBS and her understanding of the gut, fungal, mycotoxin, and psychoemotional role of these disorders.  We had a great conversation on this episode about how IC/PBS develops, how oxalates play a role,  the risk factors for IC/PBS, and overall approaches to healing this disorder from a nutritional approach.  Enjoy!

About Dr. Mandy

Dr. Mandy LaGreca is a Root Cause Investigator and founder of IC Healer. She uses cutting edge science to help guide clients in investigating the root cause of their ailments. Dr. Mandy is a Doctor in Clinical Nutrition (DCN) and a Certified Nutrition Specialist (CNS).  She also has attained the following certifications: Clinical Certification Nutrition (CCN), Functional Diagnostic Practitioner (FDN-P), Masters in Biology (MS), and Certified Personal Trainer (CPT). She is recognized across the world as one of the leading experts in Interstitial Cystitis and Painful Bladder Syndrome.  She has dedicated her life to helping people find relief and remission from Interstitial Cystitis and Painful Bladder Syndrome.

Dr. Mandy LaGreca, DCN, CNS, FDN-P, CCN, LN

IC Healer

Believe and you WILL Heal!

www.ichealer.com



Articles:

How to reduce oxalates without reducing plants: https://deannaminich.com/do-you-need-to-stop-eating-plants-because-of-oxalates/



#interstitialcystitisawareness #interstitialcystitis #chronicpain #chronicillnesswarrior #chronicillness #pain #interstitialcystitiswarrior #chronicillnessawareness #bladderproblems #bladder #painfulbladdersyndrome #bladderhealth #pelvicpain #chronicallyill #invisibleillness #icwarrior #ic #bladderpain


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In this episode I welcome on one of my hero's in medicine, Dr. Mark Pimentel.   Without hesitation, he changed my career trajectory for the better when I first came across his work in 2007. Since then he has been a mentor, adviser, and educator of me as I have dedicated myself to helping patients dealing with Irritable Bowel syndrome, Small Intestinal Bacterial Overgrowth, and Intestinal Methanogen Overgrowth.

We covered so many amazing topics in this episode including:


Highlights from the last 5 years of Dr. Pimentel's research
His career trajectory from IBS starting as a psychosomatic disorder to know a disorder with a defined pathophysiology\
The latest 2021-22 research that identified the key microbes involved with hydrogen overgrowth sibo, intestinal methanogen overgrowth, and hydrogen sulfide overgrowth
The role of bile acids in Irritable bowel syndrome
The role of stomach acid in IBS/SIBO/IMO
The role of the migrating motor complex in IBS
Post-infectious Irritable bowel syndrome
What makes a good GI Doctor
the Medically Associated Science and Technology Program (MAST) at Cedar Sinai
and more.

about Dr. Pimentel:

Mark Pimentel, MD, FRCP (Fellows of the Royal College of Physicians – Canada) Mark Pimentel, MD, is a Professor of Medicine at Cedars-Sinai. Dr. Pimentel is also the Executive Director of the Medically Associated Science and Technology (MAST) program at Cedars-Sinai, an enterprise of physicians and researchers dedicated to the study of the gut microbiome in order to develop effective diagnostic tools and therapies to improve patient care. Dr. Pimentel is also a Professor of Medicine at the Geffen School of Medicine, University of California, Los Angeles (UCLA.) As a physician and researcher, Dr. Pimentel has served as a principal investigator or co-investigator for numerous basic science, translational and clinical investigations of irritable bowel syndrome (IBS) and the relationship between gut flora composition and human disease. This research led to the first ever blood tests for IBS, ibs-smart™, the only licensed and patented serologic diagnostic for irritable bowel syndrome. The test measures the levels of two validated IBS biomarkers, anti-CdtB and anti-vinculin. A pioneering expert in IBS, Dr. Pimentel’s work has been published in the New England Journal of Medicine, Annals of Internal Medicine, American Journal of Physiology, American Journal of Medicine, American Journal of Gastroenterology and Digestive Diseases and Sciences, among others. Dr. Pimentel has presented at national and international medical conferences and advisory boards. He is a diplomate of the American Board of Internal Medicine (Gastroenterology,) a fellow of the Royal College of Physicians and Surgeons of Canada and a member of the American Gastroenterological Association, the American College of Gastroenterology, and the American Neurogastroenterology and Motility Society. Dr. Pimentel completed 3 years of an undergraduate degree in honors microbiology and biochemistry at the University of Manitoba, Canada. This was followed by his medical degree, and his BSc (Med) from the University of Manitoba Health Sciences Center in Winnipeg, Manitoba, Canada, where he also completed a residency in internal medicine. His medical training includes a fellowship in gastroenterology at the UCLA Affiliated Training Program.



papers referenced

https://journals.lww.com/ajg/pages/articleviewer.aspx?year=2022&issue=12000&article=00029&type=Fulltext

https://pubmed.ncbi.nlm.nih.gov/33534012/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145321/

#ibs #sibo #imo #irritablebowelsyndrome #dysbiosis


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Heart Rate Variability (HRV)  is a key metric in the overall homeostatic balance of the body.
HRV is simply a measure of the variation in time between each heartbeat. This variation is controlled by a primitive part of the nervous system called the autonomic nervous system (ANS).  It is largely an indicator of how well the body is handling the Allostatic Load (stress load).

I didn't truly grasp HRV until I was exposed to the work of Dr. Marco Altini; so I decided to ask him to come on and help educate my listeners.

In this episode we talk about:


Overview of Heart Rate Variability (HRV
The Autonomic Nervous Systems as an informant of health and homeostasis.
Daily HRV fluctuation vs. Baseline changes over time. Factors, value of data, and implications
Different tools to measure HRV
Can HRV fluctuations predict chronic or acute flareups (ie  Autoimmune Disease Flare?)
The impact of  breathing practices  and lifestyle changes on HRV?

About Dr. Altini

Marco holds a PhD cum laude in applied machine learning, a M.Sc. cum laude in computer science engineering, and a M.Sc. cum laude in human movement sciences and high-performance coaching. He has published more than 50 papers and patents at the intersection between physiology, health, technology and human performance. He is the co-founder of HRV4Training, advisor at Oura, guest lecturer at VU Amsterdam, and editor of the Wearables department of IEEE Pervasive Computing. He loves running.

References

Social media
Twitter: @altini_marco

Website: https://www.hrv4training.com/



Medium reference: https://medium.com/@altini_marco

#hrv #autonomicnervoussystem #vagalnerve @heartratevariability #homeostasis #stressresponse #resiliency #allostaticload


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