The Brainjo Channel

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04.10.2024

14.02.2023

5: What supplements are best for brain health?

To submit a question for us to answer on the podcast, go to brainjo.academy/question. To subscribe to The Brainjo Connection, a free, twice-monthly newsletter about the latest science of how to keep the brain fit and healthy, along with our recommended products, books, tools, and other resources for doing so, go to: brainjo.academy/connection To learn more about how you can boost brain fitness with neuroscience-based musical instruction, head to brainjo.academy. Intro and Outro music composed and produced by Julienne Ellen.
07.02.2023

4: How do we know if it's good for us?

Thanks to Rick B. for this week's questions. To submit a question for us to answer on the podcast, go to brainjo.academy/question. To subscribe to The Brainjo Connection, a free, twice-monthly newsletter about the latest science of how to keep the brain fit and healthy, along with our recommended products, books, tools, and other resources for doing so, go to: brainjo.academy/connection To learn more about how you can boost brain fitness with neuroscience-based musical instruction, head to brainjo.academy. Intro and Outro music composed and produced by Julienne Ellen.
21.02.2023

6: When is forgetfulness a cause for concern?

To submit a question for us to answer on the podcast, go to brainjo.academy/question. To subscribe to The Brainjo Connection, a free, twice-monthly newsletter about the latest science of how to keep the brain fit and healthy, along with our recommended products, books, tools, and other resources for doing so, go to: brainjo.academy/connection To learn more about how you can boost brain fitness with neuroscience-based musical instruction, head to brainjo.academy. Intro and Outro music composed and produced by Julienne Ellen.
10.12.2024

#63: Can You Learn More By Napping???

To submit a question for us to answer on the podcast, go to brainjo.academy/question. To subscribe to The Better Brain Fitness newsletter and get our Guide and Checklist to essential blood tests and nutrients, go to: betterbrain.fitness. To learn more about how you can boost brain fitness with neuroscience-based musical instruction, head to brainjo.academy. Intro and Outro music composed and produced by Julienne Ellen.
3. Juni

Preventing the Wrong Kind of Brain Plasticity, with Dr. Henry Mahncke

Henry Mahncke is the CEO of Posit Science and the creator of BrainHQ, the most researched brain training platform in the world. A neuroscientist who did his PhD with Michael Merzenich, considered the father of adult brain plasticity, Henry has spent two decades translating brain plasticity science into tools that actually improve brain health. In this conversation, we dig into why most brain training criticism misses the point, what the largest clinical trials really show, and why the future of brain health looks a lot like the evolution of physical fitness. In this episode: 00:00 — Introduction and Henry's background (PhD with Merzenich at UCSF, McKinsey, founding Posit Science) 07:00 — Brain training vs. cognitive training: why the distinction matters 09:00 — Brain plasticity as the driver of brain health, and why cognitive reserve is really just brain health 13:00 — Maladaptive brain plasticity: how aging actively degrades information processing through negative plasticity 18:00 — How BrainHQ exercises are designed: adaptive speed and accuracy training from psychophysics 24:00 — The transfer and generalization debate: does brain training improve real-world function? 28:00 — Clinical trial evidence: the Mayo/USC RCT, the ACTIVE study, and 300+ published papers 34:00 — The pharmaceutical analogy: why asking "does brain training work?" is the wrong question 37:00 — Who is brain training for? From post-concussive disorder to Tom Brady 44:00 — Brain training as physical exercise: the case for everyone at every age 46:00 — Real-world brain plasticity activities: racquet sports, musical instruments, foreign languages 51:00 — Josh's Brainjo origin story and what music training does for the brain 55:00 — The loss of skill learning in modern life and education 58:00 — The "dark ages" of brain health and where the field is headed To submit a question for us to answer on the podcast, go to brainjo.academy/question. To subscribe to the free Better Brain Fitness newsletter, join us when we record live, and get our Guide and Checklist to essential blood tests and nutrients, go to: betterbrain.fitness. Click here to order Dr. Wood's book, "The Stimulated Mind." Click here to pre-order Dr. Turknett's upcoming book, "The Genius and the Impostor" Intro and Outro music composed and produced by Julienne Ellen.
28. Feb.

An Existential Crisis for Alzheimer's Research?

In this episode, we discuss a study published in PLOS One that compared living brain tissue to post-mortem brain tissue and found dramatic molecular differences between the two. The findings raise serious questions about decades of Alzheimer's research built on post-mortem analysis and may help explain why pharmaceutical treatments for the disease have been so disappointing Study: A Study of RNA Splicing and Protein Expression in the Living Human Brain -------------- To submit a question for us to answer on the podcast, go to brainjo.academy/question. To subscribe to the free Better Brain Fitness newsletter, join us when we record live, and get our Guide and Checklist to essential blood tests and nutrients, go to: betterbrain.fitness. To learn more about how you can boost brain fitness with neuroscience-based musical instruction, head to brainjo.academy. Intro and Outro music composed and produced by Julienne Ellen.
01.05.2025

#73: Democratizing Health Optimization with AI: A conversation with Dr. Jared Pelo

Click here to learn more about Bionic Health. To submit a question for us to answer on the podcast, go to brainjo.academy/question. To subscribe to The Better Brain Fitness newsletter and get our Guide and Checklist to essential blood tests and nutrients, go to: betterbrain.fitness. To learn more about how you can boost brain fitness with neuroscience-based musical instruction, head to brainjo.academy. Intro and Outro music composed and produced by Julienne Ellen.
7. Mai

Can This Vaccine Help Prevent Alzheimer's?

Can a shingles vaccine cut your dementia risk by 20%? A series of landmark studies — published in Nature, Cell, and JAMA — say yes. In this episode, Tommy unpacks the research: how natural experiments in four countries produced one of the most compelling signals in dementia prevention, what might explain the effect beyond infection prevention, and what it means for your own vaccination decisions. In this episode: 00:00 — Introduction 00:52 — The new data on shingles vaccination and Alzheimer's risk 01:48 — The Stanford group and their regression discontinuity methodology 03:15 — How birthday-based eligibility creates a natural experiment (Wales, Canada, Australia) 05:28 — Results: a ~20% reduction in dementia diagnoses across all countries 06:52 — The Cell paper follow-up: benefits at every disease stage (unimpaired → MCI → dementia) 07:55 — Shingrix vs. Zostavax: the US natural experiment and a potentially larger effect 09:08 — Why does it work? Preventing illness, avoiding bed rest and disuse, immunomodulation 11:29 — Neuroinflammation and possible immune system "tuning" effects 12:27 — The sex difference: greater benefit in women in most (but not all) studies 15:52 — Summary of the evidence and what it means for dementia prevention strategy 17:36 — Josh's take: number needed to treat analysis 19:15 — Heterogeneous pathways to dementia and why vaccination fits the toolkit 21:13 — Practical advice: when to get vaccinated, repeat dosing, and personal risk assessment 25:36 — Wrap-up and how to submit questions Links & Resources: Shingles vaccine and dementia studies: Nature (Wales, 2025), Cell (Wales follow-up), JAMA/Lancet (Canada, Australia, US) Flu vaccine and dementia: Neurology (2026) Tommy's book: The Stimulated Mind To submit a question for us to answer on the podcast, go to brainjo.academy/question. To subscribe to the free Better Brain Fitness newsletter, join us when we record live, and get our Guide and Checklist to essential blood tests and nutrients, go to: betterbrain.fitness. To learn more about how you can boost brain fitness with neuroscience-based musical instruction, head to brainjo.academy. Intro and Outro music composed and produced by Julienne Ellen.
17.01.2023

1: What's the main driver of Alzheimer's and Age-Related Cognitive Decline?

In this episode, we go through the factors that drive age-related cognitive decline and dementia, which are also synonymous with the factors that promote peak brain health and fitness. Link to paper we discuss: "Demand Coupling Drives Neurodegeneration: A Model of Age-Related Cognitive Decline and Dementia" To submit a question for us to answer on the podcast, head to brainjo.academy/question To subscribe to The Brainjo Connection, a free, twice-monthly newsletter about the latest science of how to keep the brain fit and healthy, along with our recommended products, books, tools, and other resources for doing so, go to: brainjo.academy/connection To learn more about how you can boost brain fitness with neuroscience-based musical instruction, head to brainjo.academy. Intro and Outro music written and produced by Julienne Ellen.
16. Jan.

What's Wrong With The New Food Pyramid.

In this episode, we dive into guidelines to figure out what all the fuss is about, whether that fuss is warranted, and whether we should even be issuing dietary guidelines to begin with! Topics and Questions Covered The updates: A breakdown of the specific shifts regarding protein prioritization, full-fat dairy, and whole grain recommendations. The visual shift in nutrition: The transition from the "MyPlate" model to the inverted pyramid visual and the symbolism and subtext behind the change. Individualization vs. Population health: Why a "one-size-fits-all" approach to nutrition often fails to account for individual metabolic variation. The problem with food classification: Why our archaic food categories generate needless confusion and controversy. Internal contradictions: Identifying inconsistencies within the guidelines Subsidies and accessibility: The economic misalignment between government dietary advice and agricultural subsidies for ultra-processed food ingredients. Communication challenges: The difficulty of maintaining scientific nuance in a public health messaging environment. To submit a question for us to answer on the podcast, go to brainjo.academy/question. To subscribe to the free Better Brain Fitness newsletter, join us when we record live, and get our Guide and Checklist to essential blood tests and nutrients, go to: betterbrain.fitness. Click here to pre-order Dr. Wood's book, "The Stimulated Mind." Click here to grab Dr. Turknett's bestselling book, "Anyone Can Play Music" Intro and Outro music composed and produced by Julienne Ellen.

The Brainjo Channel brings you shows all about applying brain science to realize human potential.

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The Brainjo Channel

Top-Sendungen

5: What supplements are best for brain health?

4: How do we know if it's good for us?

6: When is forgetfulness a cause for concern?

#63: Can You Learn More By Napping???

Preventing the Wrong Kind of Brain Plasticity, with Dr. Henry Mahncke

An Existential Crisis for Alzheimer's Research?

#73: Democratizing Health Optimization with AI: A conversation with Dr. Jared Pelo

Can This Vaccine Help Prevent Alzheimer's?

1: What's the main driver of Alzheimer's and Age-Related Cognitive Decline?

What's Wrong With The New Food Pyramid.

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The Brainjo Channel

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