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Let's dive into the results of industrial biotechnology at acib. This short podcast episodes shortly summarize our scientific publications and give a quick hint about the main findings.

  1. 10.10.2025

    Rhamnose Biosynthesis in Synechocystis: Unexpected Gene Roles and Industrial Implications

    We investigated fucose and rhamnose biosynthesis in Synechocystis sp. PCC 6803, crucial for biotechnologically valuable EPS. Deleting fucS impaired both sugars. Surprisingly, deleting putative rfbC genes did not impair rhamnose, despite affecting EPS production, suggesting misannotation and complex pathways. Further elucidation is vital.

    9 Min.

  2. 08.10.2025

    Decoding CHO Cell Survival: CRISPR Reveals Essential Genomic "Dark Matter"

    We performed a genome-scale CRISPR screen in CHO cells using paired guide RNAs, identifying 427 essential genomic regions, including unannotated "dark matter." Deleting these regions impairs cell survival, revealing critical regulatory functions and enabling advanced bioprocess engineering.

    8 Min.

  3. 06.10.2025

    Unlocking Yeast's Secretory Potential: Innovations in MFa Signal Sequences

    The MFa signal sequence is key for recombinant protein secretion in yeast. This review details its evolution, processing, and challenges like missorting and aggregation. Innovations include optimized MFa variants, hybrid sequences, and cell engineering, significantly boosting protein yield and quality for biotechnological and therapeutic applications.

    9 Min.

  4. 01.10.2025

    Enzymatic Engineering of Bio-polyester Degradation for a Circular Economy

    This study investigates enzymatic hydrolysis of bio-based poly(butylene succinate) (PBS) and poly(pentamethylene 2,5-furanoate) (PPeF), their blends, and block copolymers. *Humicola insolens* cutinase achieved 100% degradation. Blends degraded faster than copolymers, offering routes for tailored sustainable recycling.

    12 Min.

  5. 23.09.2025

    Unlocking Bio-Vanillin: A Novel Enzymatic Pathway from Renewable Feedstocks

    This study identifies MapADO, a novel alkene cleaving dioxygenase, offering unprecedented efficiency in synthesizing aldehydes like vanillin from renewable resources. It's co-enzyme-free, operates under mild conditions, and enables sustainable valorization of waste streams.

    8 Min.

  6. 18.09.2025

    Boosting Baculovirus Production Efficiency

    A Conversation on Resource-Saving Strategies for Biotech Manufacturing

    7 Min.

  7. 13.09.2025

    Rapid IgG Quantification in Plasma

    This study validates a rapid affinity chromatography method for quantifying immunoglobulin G from human plasma. Utilizing POROS CaptureSelect FcXP resin, it achieves a 2.5-minute cycle time, excellent precision, and high accuracy. This efficient method is ideal for high-throughput applications in biopharmaceutical production, offering a superior alternative to nephelometry.

    11 Min.

  8. 01.09.2025

    Unraveling Yeast Flocculation: A pH-Driven Secret to Bioprocess Control

    This study investigates pH-dependent flocculation in Komagataella phaffii. We found it peaks at pH 4.0 and is reversible. Flo5-1 critically affects this process, and Nrg1 negatively regulates it. Our findings offer vital insights for optimizing bioprocesses using this yeast host.

    7 Min.
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Let's dive into the results of industrial biotechnology at acib. This short podcast episodes shortly summarize our scientific publications and give a quick hint about the main findings.

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    2025
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