Paper Talk

淼淼Elva

Sharing research articles, tracking the latest developments

  1. VOR 19 STD.

    496-Vascularized Human Retinal Organoids

    Researchers developed vascularized human retinal organoids using a novel bioengineered platform. By integrating endothelial cells, the model reduces hypoxia and enhances RGC survival. These organoids exhibit mature light-driven responses, serving as a tool for vision research.References: Sharma K, Habibey R, Ribeiro M M, et al. Retinal ganglion cell survival and functional maturation in transiently vascularized human retinal organoids[J]. Cell Stem Cell, 2026.

    19 Min.

  2. VOR 20 STD.

    495-Vitamin B6 Enhances Antitumor Immunity

    Vitamin B6 and its active form PLP promote tumor regression by preserving CD8+ T cell stemness and antitumor function. PLP directly inhibits p70S6K, preventing the phosphorylation and nuclear exclusion of BACH2. This axis sustains stemness genes and enhances immunotherapy efficacy.References: Wu J, Li G, Zhou J, et al. Vitamin B6 preserves the stemness-like phenotypes and antitumor ability of CD8+ T cells[J]. Developmental Cell, 2025.

    15 Min.

  3. VOR 20 STD.

    494-Cell Atlas of Human Gonadal Lineage Specification

    This single-cell atlas of 128,000 cells maps human gonad development from 5 to 12 weeks. It identifies coelomic-epithelium-derived progenitors that branch into supporting and steroidogenic lineages. The study also reveals GnRHR signaling's role in testis differentiation.References: Lardenois A, Suglia A, Moore C L, et al. Single-cell exploration of gonadal somatic cell lineage specification during human sex determination[J]. Developmental Cell, 2025.

    16 Min.

  4. VOR 1 TAG

    493-Commensal TMCM Lipids Protect the Ocular Surface

    Research shows the commensal bacterium Corynebacterium mastitidis uses the lipid TMCM to trigger protective ocular immunity. TMCM activates IL-17+ γδ T cells through TCR and IL-1R1 signaling. This microbial factor strengthens barrier defenses and prevents bacterial infections.References: Xu X, Rigas Y E, Mattapallil M J, et al. Commensal-derived trehalose monocorynomycolate triggers γδ T cell-driven protective ocular barrier immunity[J]. Immunity, 2025.

    13 Min.

  5. VOR 1 TAG

    492-ECS-dependent polytubey block in Arabidopsis

    In Arabidopsis, egg-cell proteins SDN1–3 prevent polyspermy by degrading specific miRNAs (miR833a, miR395a/f, miR827). This turnover ensures the expression of ECS1/2 endopeptidases, which establish a polytubey block post-fertilization to maintain genomic integrity.References: Shen K, Qu M, Zhou X, et al. Degradation of detrimental microRNAs safeguards the fertilized egg cells to establish an ECS-dependent polytubey block in Arabidopsis[J]. Developmental cell, 2025.

    17 Min.

  6. VOR 1 TAG

    491-Enhanced Stem Cell Differentiation

    Yu et al. mapped human pancreatic gene co-expression networks (GCNs) to improve stem cell-derived β cell induction. Existing protocols fail to mimic in vivo GCNs, but a new 19-day strategy restores this architecture. This approach yields 70% functional β cells that reverse diabetes.References: Yu X X, Wang X, Yang L, et al. Reconstructing human pancreatic gene networks enhances stem cell-derived β cell induction[J]. Developmental Cell, 2025.

    17 Min.

  7. VOR 2 TAGEN

    490-Peroxisome-Mediated Intestinal Repair in Long COVID

    SARS-CoV-2 reservoirs in the gut cause long COVID gastrointestinal issues by disrupting the VLCFA-PPAR-peroxisome axis. This impairment halts intestinal stem cell differentiation and epithelial repair. Treatments like fenofibrate restore regeneration and alleviate symptoms.References: Wang M, Chen Y, Guo M, et al. Impaired VLCFA-peroxisome-mediated intestinal epithelial repair causes gastrointestinal sequelae of long COVID[J]. Developmental Cell, 2026.

    17 Min.

  8. VOR 2 TAGEN

    489-MYRF: Regulator of Lung Mesothelium Fate and Plasticity

    Luna et al. found that Myrf is essential for mesothelium function and lung development. Deleting Myrf causes lung hypoplasia and congenital diaphragmatic hernia (CDH). Without Myrf and Yap/Taz, mesothelial cells transform into ectopic smooth muscle, mimicking adult PPFE.References: Luna G, Verheyden J M, Tan C, et al. MYRF controls mesothelium specification, signaling, and plasticity in lung development[J]. Developmental Cell, 2026.

    15 Min.
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