a16z Podcast a16z

At the end of 2022, our team at a16z asked dozens of partners across the firm to spotlight one big idea that startups in their fields could tackle in 2023.

Emerging from this exercise came 40+ builder-worthy pursuits for the year, ranging from entertainment franchise games to precision delivery of medicine to small modular reactors, and of course loads of AI applications.

In our 2-part series, we’ll be covering 12 of these big ideas with the partners that shared them.

Here in part 2, we’ll cover Fintech, American Dynamism, and Bio & Health. Listen in as we chat with Anish Acharya, Angela Strange, Michelle Volz, Ryan McEntush, Vijay Pande, and Julie Yoo.

And for the full list of 40+ ideas, check out the full article: https://a16z.com/2022/12/15/big-ideas-in-tech-2023/

Topics Covered:

(0:59) GPT Unlocks Credit Counseling - Anish Acharya
(9:53) Compliance as a Competitive Advantage - Angela Strange
(23:31) Small Modular Reactors Advance the Nuclear Renaissance - Michelle Volz
(33:48) Overhauling the Space Supply Chain - Ryan McEntush
(44:40) The Biggest Company in the World - Vijay Pande
(51:17) The Value-Based Care Stack - Julie Yoo

At the end of 2022, our team at a16z asked dozens of partners across the firm to spotlight one big idea that startups in their fields could tackle in 2023.

Emerging from this exercise came 40+ builder-worthy pursuits for the year, ranging from entertainment franchise games to precision delivery of medicine to small modular reactors, and of course loads of AI applications.

In our 2-part series, we’ll be covering 12 of these big ideas with the partners that shared them.

Here in part 1, we’ll cover Consumer, Games, and Enterprise, with a little Fintech sprinkled in. Listen in as we chat with Connie Chan, Anne Lee Skates, Jack Soslow, Doug McCracken, Sarah Wang, and Sumeet Singh.

And look out for part 2 dropping soon, covering Fintech, American Dynamism, and Bio & Health!

And for the full list of 40+ ideas, check out the full article: https://a16z.com/2022/12/15/big-ideas-in-tech-2023/

Topics Covered:

(1:30) Breakthroughs in Buying (Finally!) - Connie Chan
(16:40) Unlocking the “Third Place” - Anne Lee Skates
(30:14) Games as a Neverending Turing Test - Jack Soslow
(46:09) The Metaverse Goes Fashion Forward - Doug McCracken
(59:24) Generative AI Advances Beyond “Text to Image” to Complex Workflows - Sarah Wang
(1:12:23) Embracing Large Language Models and Maintaining Trust - Sumeet Singh

In this special episode, we share never heard before footage from Steve Wozniak alongside his cofounder and best man, Alex Fielding.

Listeners get an inside look into what drove Woz to building a computer, but also how Steve’s zest for life was applied beyond computers – from the rare opportunity to play Tetris on the side of a building or throw a concert across borders.

New year, new you! Right?

Well, as much as we’d all like to believe that we embrace the new… the reality is that we often resist change.

That’s why we’ve brought in someone who has studied how humans respond to and adapt to change – or sometimes how we fail to. That person is Jason Feifer – long-time editor in chief at Entrepreneur Magazine, host of two popular podcasts, and recent author of his book Build for Tomorrow.

Today, Jason shares 6 specific frameworks around the very natural human responses to change, which he’s developed through interviewing and studying some of the most influential people in the world – past and present. We also play a fun game at the end, where Jason comments on current technologies encountering pushback, and assesses where they might fit into his framework.

In this episode, Marc Andreessen and Vijay Pande discuss expert AI and its role in healthcare, bio, and more.

with @robertiger @cdixon @smc90


A wide-ranging conversation with Bob Iger on the interplay between technology, content, and distribution; as well as Bob’s journey -- and that of various creators! -- especially as the industry evolved from TV and cable to the advent of the internet/ web 1.0 to 2.0 to briefly touching on web3 and other emerging technologies. As well as topics top of mind for all company and community builders: from build vs. buy and the innovator's dilemma, to managing creativity, decentralization, remote work, and much more.