The sign of a good podcast is when it tackles a topic you're interested in and covers it well. The sign of a GREAT podcast is when it tackles a topic you couldn't care less about, and still makes it essential listening.
I couldn't care less about any form of reality TV and usually stop paying attention whenever anyone threatens to mention it, but the show's comparison the two 2012 diet programs The Biggest Loser with Excess Baggage was both entertaining and well-informed.
Nothing is off limits. Shows such as Games of Thrones and Mad Men, reality TV, European dramas, sports coverage, advertising, gender politics in HBO's Girls, an episode devoted to whether or not The Newsroom works... it's broad, smart and consistently funny. Hit subscribe and never look back.