The Evidence Based Rheumatology Podcast

Michael Putman
  • 5.0 (5)
  • MEDICINE
  • UPDATED TWICE MONTHLY

A weekly podcast for physicians interested in evidence based medicine and rheumatology. Find the papers at ebrheum.com

  1. 30 APR

    E135: IL17 and a GLP1?

    Really interesting study this week comparing the IL17 inhibitor ixekizumab WITH the GLP1 inhibitor tirzepatide to ixekizumab alone. Raises some interesting questions about what worked here and whether or not it matters how it worked.    Paper: https://acrjournals.onlinelibrary.wiley.com/doi/10.1002/art.70134 Newsletter: http://autoimmunedevreport.com/

    11 min

  2. 17 APR

    E134: Brepocitinib in Dermatomyositis (VALOR)

    Great trial this week looking at brepocitinib in dermatomyositis. Looks like a winner, expect it will be approved. Where it fits in our approach to IIM is an open question, but nice to have another option.  Study: https://www.nejm.org/doi/10.1056/NEJMoa2503531 JC Companion: https://autoimmunedevreport.substack.com/

    15 min

  3. 19 MAR

    E133: Obinutuzumab for SLE (ALLEGORY)

    Good RCT this week, investigating the CD20 B cell inhibitor obinutuzumab for SLE. Sign up for my newsletter if you would like to have a read-along companion piece!    Paper: https://www.nejm.org/doi/full/10.1056/NEJMoa2516150 Landing Page: https://ebrheum.com/ Substack: https://autoimmunedevreport.substack.com/

    15 min

  4. 5 MAR

    E132: Romosozumab vs teriparatide for osteoproosis (STRUCTURE)

    Quick podcast this week about a nifty head to head study that I had previously missed. Worth reading if - like me - you're still trying to figure out how the heck to manage osteoporosis.  Paper: https://pubmed.ncbi.nlm.nih.gov/28755782/

    14 min

  5. 21 JAN

    E131: A Sham-Controlled Sham of a Trial: RESET-RA

    Today I cover the recent publication of the RESET-RA study, which evaluated vagal nerve stimulation to treat rheumatoid arthritis. Have a listen in full, but let me be clear upfront: I do not think this works and will not be referring any patients to receive it. This will forever be my pivotal example of the effect of unblinding, but would love to hear if you think different!    Paper: https://www.nature.com/articles/s41591-025-04114-7 Supplement (see S4): https://www.nature.com/articles/s41591-025-04114-7#Sec27

    15 min

  6. 22/12/2025

    E130: Telitacicept for SLE

    Surprisingly (unbelievably?) impressive RCT evaluating the Blys/APRIL inhibitor "telitacicept" for patients with SLE (mixed SLE and SLE-LN). Very curious to see where the FDA goes with this one.    Paper: https://www.nejm.org/doi/full/10.1056/NEJMoa2414719

    13 min

  7. 04/12/2025

    E129: Long Term Routine Laboratory Monitoring in RA

    Ever wonder how often you really need to check "monitoring" labs? If so then this is the podcast for you! Bryant England mentioned this during his excellent Year in Review session at ACR Convergence 2025. I've been meaning to cover it and finally got around to doing so. Have a listen and share with friends!   Paper: https://pubmed.ncbi.nlm.nih.gov/40854212/

    15 min

  8. 12/11/2025

    E128: Nerandomilast for Autoimmune ILD (FIBRONEER-ILD)

    Covering a very interesting study this week, which investiaged the PDE4B inhibitor nerandomilast for patients with progressive pulmonary fibrosis (specifically including 325 patients with autoimmune ILD). Would have been yet another ho hum trial if not for the big reveal... have a listen to find out! Article: https://www.nejm.org/doi/full/10.1056/NEJMoa2503643

    19 min
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A weekly podcast for physicians interested in evidence based medicine and rheumatology. Find the papers at ebrheum.com

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