Bloody Minded

Bloody Minded Crew
  • 5.0 (14)
  • MEDICINE
  • UPDATED WEEKLY

Baffled by blood? Confused by coags? Traumatised by TTP? Planning on quitting medical school because you've just finished haem block? Join the fellows of the Bloody Minded Crew as they tour the world of haematology one topic at at a time while procrastinating from their day jobs.  Your time is precious, so to maximise your return we look at each topic at a variety of levels so you can tailor your learning. Check out more at www.bloodyminded.com.au

  1. 4 DAYS AGO

    Episode 89 - What is this, disease for ants? | MRD in AML with Dr Jad Othman

    What happens when you take someone who is really really ridiculously good at haematology and also a really really ridiculously nice person as well? You get Dr Jad Othman, consultant Haematologist and Haematopathologist at Royal North Shore Hospital in Sydney who will be joining us today to discuss the use of measurable residual disease in acute myeloid leukaemia. Dr Othman is well suited to this topic, having written his doctoral thesis on molecular disease assessment in AML, sitting on the European LeukaemiaNet (ELN)-DAVID MRD Working Group as well as numerous ALLG AML and MDS working groups. We're delighted to have him field the Bloody Minded Crew's questions today.  Timestamps 01:00 - The boys making outdated millenial references 02:50 - Getting to know Dr Jad Othman 09:50 - The concept of MRD 11:55 - Lab techniques for MRD 17:59 - Why doesn't everyone have an MRD marker? 20:51 - What makes a good MRD assay? 24:14 - Patients without a molecular MRD marker 26:21 - Clinical case 30:30 - What we do with MRD results 31:47 - The NPM1/FLT3 PB/BM situation 35:31 - Why MRD is actually helpful 39:40 - Why single agent treatment in AML is challenging 44:33 - The 2025 ELN DAVID update 48:44 - Does doing MRD improve OS? 52:21 - The INTERCEPT study 55:41 - Wrap up and summary Support the show Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

    59 min

  2. 28 APR

    Episode 88 - 1-2-3-4-5-6 | Blastic Plasmacytoid Dendritic Cell Neoplasm

    Here’s a question, what do CD123, CD4 and CD56 have in common? Other than pleasing The Count on Sesame Street. Sorry, another question perhaps - what happens if you cross a plasma cell and a dendritic cell? The answers to these questions can be found on a most enigmatic myeloid cell - the plasmacytoid dendritic cell. And what happens when these rare beasts become neoplastic - why BPDCN of course. Embark on a journey into this weird and not so wonderful (but highly examinable) neoplasm with the Bloody Minded Crew  TIMESTAMPS  0:57 – A glimpse into Cale's psyche  2:39 – Intro to BPDCN  6:56 – What IS a plasmacytoid dendritic cell?  10:24 – Pathological PDCs in BPDCN  11:42 – Clinical presentation – lots of rash talk  15:23 – Morphology in BPDCN  17:48 – Immunophenotype  21:16 – Karyotypic and molecular features  22:44 – Treatment of BPDCN  24:00 – A bit on prognostic markers  25:03 – Transplant  25:28 – Tagraxofusp  29:15 – Other treatment options  31:33 – Take home messages  Support the show Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

    34 min

  3. 21 APR

    Episode 87 - Flitting About | In The Lab: FLT3 and NPM1

    “It’s pronounced nuc-ul-ophosmin” “Nucleophosmin”. “Noo-clee-o-phosmin”. FLT3-ITD got you In The Dumps? Have a Total Knowledge Deficit about TKD mutations? Struggling with the A-B-Cs of NPM1 mutations? Want to know how a cat sarcoma is somehow related to AML? Join the Bloody Minded Crew as they flit about the laboratory looking at the structure of FLT3 and NPM1, what these proteins usually do and how we test for mutations in the advanced myeloid episode. == Edit 6/5/26 = We've been made aware that strictly speaking the current MANE approved transcript for NPM1.1 has only 11 exons and therefore the mutations are best to be considered in Exon 11 as opposed to exon 12 - in contrast to what we said. == Timestamps 0:52 - Bloody Minded issues a formal apology 2:40 - Introducing molecular chaperones 5:05 - What even NPM1? 9:30 - Functions of NPM1 10:55 - Molecular biology of NPM1 in disease 15:42 - Why the subtypes are important 19:53 - NPM1 prognosis 21:35 - MRD testing in NPM1 25:52 - NPM1 summary 27:13 - Intro to FLT3 28:30 - Mandatory FLT3 history 36:28 - FLT3 pathogenesis 37:37 - FLT3 structure, ITD vs TKD 41:16 - The juxtamembrane domain 42:53 - Prognostic features in FLT3 44:17 - TKD mutations 46:26 - FLT3 in the lab 50:30 - Take home messages Support the show Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

    52 min

  4. 14 APR

    Episode 86 - You Ugly | In The Lab: Bone Marrow Dysplasia

    U-G-L-Y, you ain't got no alibi, you dysplastic yeah yeah you dysplastic. Apologies to all the ring sideroblasts out there, but this week the Bloody Minded crew is doing a Mean Girls and judging cells by their morphology. For now we’re deciding to ignore those that would argue that it’s what’s on the inside that counts (i.e. judging by NGS… that’ll come later). TIMESTAMPS 2:28 - For some reason, an audio podcast on visual dysplasia  5:05 - Normal erythroid morphology  7:17 - Dysplastic erythroid morphology  17:32 - Normal granulocyte morphology  20:00 - Dysplastic granulocyte morphology  28:33 - Monocyte morphology - dysplastic at baseline  30:33 - Normal megakaryocyte morphology  32:24 - Dysplastic megakaryocyte morphology  35:02 - Take Home Messages Support the show Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

    37 min

  5. 7 APR

    Episode 85 - Wake Me Up! | Acute Promyelocytic Leukaemia (APML)

    What do arsenic, acne tablets and Jodi Picoult have in common? Why, it must be a deep dive with Nick, Bashar and Cale on acute promyelocytic leukaemia. From buzzwords to brain bleeds, the sweetest of translocations to the cruellest of coagulopathies... The yield is almost as high as the survival rates. TIMESTAMPS 00:57 - Bloody Minded Poetry Jam & Jodi Picoult 06:25 - APML Starts Here 08:02 - APML - Where does it fit in AML? 10:02 - Morphology & Flow 12:12 - PML::RARA - t(15;17) and rare variants 16:58 - Lab Summary 17:50 - Clinical Presentation 21:02 - APML Coagulopathy 26:46 - Treatment and Risk Stratification 33:53 - High Risk Aside 36:58 - Differentiation Syndrome 41:04 - Treatment SEs 44:18 - Microgranular Variant 47:00 - Summary and Takehomes Support the show Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

    50 min

  6. 31 MAR

    Episode 84 - Chemotherapeutic Boogaloo | AML Part 2

    After our initial intro to AML back in ep 79, we are back to dig deeper into AML this week, from pathophysiology through to treatment overview. The boys are joined by final year registrar Dr Georgina Calov who is here to cut through our nonsense and deliver some actual high yield content. And thank goodness for that, otherwise it'd be an hour of us making bad April Fool's day jokes. Timestamps 2:09 - Introducing Dr Georgina Calov 3:34 - AML Refresher 7:12 - AML defined by recurrent genetic abnormalities 15:39 - AML defined by differentiation (aka whats with the M numbers) 18:14 - MN-pCT 19:03 - Prognostication - ELN Classification 21:58 - Diagnosing AML - Clinical 24:16 - Diagnosing AML - Lab 31:39 - New AML Workup 35:50 - Intro to Treatment - Induction in "Fit" patients 41:40 - Treatment - Consolidation & MRD 45:15 - Treatment - "Unfit" 48:02 - Treatment - Supportive 50:16 - Treatment - Relapse/Refractory 55:19 - Summary Support the show Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

    58 min

  7. 24 MAR

    Episode 83 - On The Wards: The NBM Transplant Patient

    Cat got your tongue? Or in this case - mucositis? Does converting the acute allogeneic transplant patient who can no longer eat's medications to IV fill you with dread? In this practical for once episode join consultant haematologist Dr Alison Chandler as well as haematology pharmacists Andriana Colic & Ariana McCauley as they take us through the how to of this challenging, but very common, clinical scenario.  Timestamps 0:58 - Nick's literal nightmare 2:18 - Today's outline 3:38 - Let's meet the A-team! 11:14 - What do you wish the haem doctors knew? 13:38 - Introducing the NBM transplant patient 15:18 - Tacrolimus 17:37 - Mycophenolate 19:51 - Ciclosporine (or cyclosporine or CsA or CyA, whatevs) 22:20 - Hot tip on TDM 23:47 - Antifungals 24:23 - Posaconazole 26:06 - Voriconazole 27:29 - Isavuconazole 28:45 - Echinocandins - mica/anidula 30:52 - Antivirals 33:27 - CMV treatment 37:41 - Antibacterials - PJP prophylaxis 39:22 - The NBM APML patient  43:35 - Antiepileptics 46:24 - TLS prophylaxis 47:53 - Wrap up time! 50:18 - Episode summary Support the show Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

    55 min

  8. 17 MAR

    Episode 82 - MDS 102 | Much More on Myelodysplastic Syndrome

    Was episode 79 too light on MDS for you? “Amateurs” you said, adjusting your sellotaped glasses. If so, you’re in the right place today as we prepare to look at classification, risk stratification and treatment of myelodysplastic syndrome. You also should seek out psychiatric attention, or perhaps just go outside. But in the meantime, enjoy this episode where we’ll dig deeper into the nitty gritty of MDS! We’ve got a lot to cover so we float about between intermediate and advanced for this episode. TIMESTAMPS 1:11 - A Very Unhinged Intro   3:34 - Actual Content Starts Here   5:52 - Differentials for dysplasia   7:54 - Presentations of MDS   12:36 - MDS Subtypes   14:23 - MDS with del(5q)   18:29 - Lenalidomide in del(5q)   25:03 - MDS with SF3B1   29:05 - MDS with biallelic TP53 inactivation   30:26 - Bonus cytogenetic abnormalities that pop up   31:43 - Germline mutations that predispose to MDS and AML   37:14 - MDS with low blasts   38:08 - Ogata Score   39:26 - Hypoplastic MDS   44:03 - MDS with increased blasts   44:58 - MDS with increased blasts and fibrosis   46:22 - Breaking News - Blasts Should Now Be Counted By Flow   48:30 - Prognostic models for MDS   53:36 - Treatments for MDS   1:04:39 - Take Home Messages Support the show Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

    1hr 8min
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Ratings & Reviews

5
out of 5
14 Ratings

About

Baffled by blood? Confused by coags? Traumatised by TTP? Planning on quitting medical school because you've just finished haem block? Join the fellows of the Bloody Minded Crew as they tour the world of haematology one topic at at a time while procrastinating from their day jobs.  Your time is precious, so to maximise your return we look at each topic at a variety of levels so you can tailor your learning. Check out more at www.bloodyminded.com.au

Information

  • Creator
    Bloody Minded Crew
  • Years Active
    2024 - 2026
  • Episodes
    90
  • Rating
    Explicit
  • Copyright
    © 2026 Bloody Minded
  • Show Website
    Bloody Minded

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