Histamine Well Podcast: Exploring Histamine, Methylation & Holistic Health

Joanne Kennedy
  • 5.0 (12)
  • ALTERNATIVE HEALTH
  • UPDATED WEEKLY

The Histamine Well is a podcast for health practitioners and patients alike, bridging the gap between complex science and practical understanding. With a focus on histamine, methylation, and related health topics, the show translates advanced concepts into actionable insights for practitioners while empowering patients with accessible, evidence-based knowledge.Your host, Joanne Kennedy, is a naturopath and expert in histamine intolerance, MTHFR, and methylation. She is also an author and runs an online group coaching program for practitioners and students on histamine and methylation. Jo loves breaking down complex science into clear, easy-to-understand language, offering practical tips and the latest insights to empower you to take charge of your health.

  1. 6 DAYS AGO

    46. High Homocysteine: Histamine, Methylation & Why You Might Not Tolerate Methylated B Vitamins

    Can methylated B vitamins make your symptoms worse instead of better? In this episode of The Histamine Well Podcast, Joanne explains the connection between high homocysteine, histamine intolerance, methylation, and why some people react poorly to methylated nutrients. High homocysteine is associated with cardiovascular disease, cognitive decline, inflammation, and neurological health concerns — yet lowering it isn’t always simple. Many people experience headaches, anxiety, insomnia, digestive issues, skin flare-ups, or worsening histamine symptoms when taking methylfolate or methyl B12. Joanne breaks down the methylation cycle in simple terms, explains the role of histamine in nutrient tolerance, and explores how genetics such as the MTHFR gene mutation and COMT enzyme activity may influence how your body responds to methylated supplements. In this episode, you’ll learn:  • What high homocysteine means and why it matters  • The connection between homocysteine and methylation  • Why methylated B vitamins can trigger symptoms  • Histamine intolerance and supplement sensitivity  • The role of MTHFR, COMT, and methylation pathways  • Overmethylation vs undermethylation explained  • Practical clinical insights for improving tolerance to methyl nutrients Whether you're a practitioner, student, or navigating your own health journey, this episode offers practical education on histamine, methylation, gut health, and root-cause healing. Subscribe to The Histamine Well Podcast for expert discussions on histamine intolerance, women’s hormones, functional medicine, gut health, methylation, and integrative wellness. ✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.  🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

    12 min

  2. 29 APR

    Q&A. Should I Take Calcium-D-Glucarate Whilst On HRT Oestrogen?

    Can you take Calcium-D-Glucarate while on HRT estrogen during menopause? In this short Q&A episode of The Histamine Well Podcast, Joanne explores the relationship between estrogen detoxification, hormone replacement therapy (HRT), menopause, gut health, and histamine-related symptoms. Many women are advised to take supplements that support estrogen detox, but is this always the right approach when using bioidentical hormones or estrogen therapy? Joanne explains why Calcium-D-Glucarate may not be beneficial for menopausal women on HRT, how estrogen balance works during menopause, and why understanding your hormone dose matters for symptom relief and long-term wellbeing. This episode also covers:  The role of estrogen during menopause and HRT  Why over-detoxifying estrogen may worsen symptoms  The connection between beta-glucuronidase, the estrobolome, and gut microbiome health  Histamine intolerance, hormone imbalance, and menopause symptoms  Natural considerations for estrogen metabolism and hormone support  Why gut health may be more important than estrogen detox supplements If you're navigating menopause, hormone replacement therapy, estrogen dominance symptoms, histamine intolerance, or gut-related hormone imbalance, this episode offers practical clarity backed by clinical naturopathic insight.  Subscribe to The Histamine Well Podcast for expert conversations on histamine intolerance, methylation, gut health, hormones, mold illness, MCAS, menopause, and functional medicine approaches to healing. ✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.  🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

    5 min

  3. 27 APR

    45. Case Study: SIBO, Histamine Intolerance & Hormonal Imbalance

    In this episode of The Histamine Well, Joanne shares a powerful clinical case study exploring the connection between SIBO (Small Intestinal Bacterial Overgrowth), histamine intolerance, hormonal imbalance, estrogen dominance, gut health, bloating, acne, fatigue, and PMS symptoms. This episode follows the journey of a 37-year-old woman who experienced rapid body changes over two years — including unexplained weight gain, chronic bloating, severe PMS, hormonal acne, headaches, fluid retention, breast tenderness, digestive discomfort, and low energy. Through functional testing and a naturopathic treatment approach, Joanne uncovers how gut dysfunction, histamine overload, and hormone imbalance can work together to drive chronic symptoms. You’ll discover how SIBO contributes to nutrient malabsorption, inflammation, estrogen dominance, histamine intolerance, and digestive dysfunction, along with why symptoms such as bloating, fatigue, skin issues, and menstrual changes are often connected. In this episode, Joanne discusses: The link between SIBO, histamine intolerance, and hormonal imbalanceWhy bloating, PMS, headaches, and acne may stem from gut dysfunctionThe difference between hydrogen and methane SIBOHow nutrient deficiencies affect hormones, mood, and energyWhy is bowel motility essential for successful SIBO treatmentThe role of biofilms in persistent gut symptomsFunctional medicine strategies for improving gut and hormone healthWhether you are a practitioner, student, or someone navigating digestive and hormone-related symptoms, this episode offers practical insight into the deep connection between gut health, histamine, hormones, and systemic inflammation. ✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.  🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

    17 min

  4. 22 APR ·  BONUS

    Q&A. How Do Epsom Salt Baths Work & Why Are They Good For Me?

    Can something as simple as an Epsom salt bath support detoxification, gut health, and nervous system regulation? In this Q&A episode of The Histamine Well Podcast, Joanne breaks down the clinical benefits behind Epsom salt baths (magnesium sulfate)—and why they’re often recommended for patients dealing with histamine intolerance, sulfur issues, chronic fatigue, and food sensitivities. You’ll learn how magnesium and sulfate work together in the body, how they’re absorbed through the skin, and why this gentle therapy can support everything from sleep and muscle relaxation to liver detox pathways and gut lining integrity. 🎧 In this episode, you’ll learn:  What Epsom salt (magnesium sulfate) actually is  How transdermal absorption supports magnesium levels  The role of sulfate in liver detoxification (sulfation pathway) Why sulfate is essential for gut lining, skin, and connective tissue health How Epsom salt baths support the nervous system and stress response Why they’re helpful for people with histamine intolerance, sulfur sensitivity, mold illness, and oxalate issues How to safely start Epsom salt baths (especially if sensitive) Epsom salt baths aren’t just about relaxation—they’re a powerful, low-cost tool to support detox pathways, reduce stress, and restore key nutrient levels without burdening the digestive system. This makes them especially beneficial for those who struggle to tolerate supplements or are dealing with complex chronic symptoms. If you’ve ever wondered whether Epsom salt baths actually “do anything”—this episode will give you a clear, science-backed answer and practical guidance. Tune in to learn how to use this simple therapy effectively and safely. ✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.  🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

    5 min

  5. 20 APR

    44. Sulfur Intolerace Explained: What Is It? Why Does It Happen? How Does It Increase Histamine?

    Are “healthy” foods like broccoli, garlic, eggs, or red meat making you feel worse instead of better? In this episode of The Histamine Well Podcast, Joanne breaks down one of the most overlooked root causes of food sensitivity, gut symptoms, and chronic fatigue: sulfur metabolism dysfunction. If you’ve been struggling with histamine intolerance, unexplained food reactions, bloating, brain fog, or fatigue, this episode will help you understand what may really be going on beneath the surface. 🎧 In this episode, you’ll learn: What “sulfur intolerance” actually is (and why that term is misleading)The difference between sulfide, sulfite, and sulfateHow disrupted sulfur metabolism impacts your gut, energy, skin, and brainThe connection between hydrogen sulfide gas and mitochondrial dysfunctionWhy sulfur issues can trigger or worsen histamine intoleranceHidden sources of sulfur in foods, supplements, and waterThe role of methylation, molybdenum, and gut bacteriaKey symptoms of sulfur imbalance (including bloating, fatigue, headaches, and food sensitivities)Many people are told to simply eliminate more and more foods—but what if the real issue isn’t the food itself? This episode offers a functional medicine perspective to help you understand the deeper biochemical pathways behind your symptoms and why your body may be reacting the way it is. Understanding sulfur metabolism can completely shift how you approach healing—and may explain why nothing else has worked. ✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.  🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

    24 min

  6. 15 APR

    Q&A. Why Does My Anxiety Get Worse at Night or Wake Me Up at 3am?

    Do you find your anxiety worsening at night—or waking you suddenly between 2AM and 4AM with a racing heart and intrusive thoughts? In this Clarity Session Q&A, Joanne explores one of the most common patterns seen in clinic: night-time anxiety and early morning wake-ups—and why this is often more than just a psychological issue. This episode explains the physiological root causes of anxiety at night, including the critical role of blood sugar regulation, liver glycogen stores, and stress hormones like cortisol and adrenaline. When blood sugar drops overnight, your body triggers a stress response—leading to symptoms that can feel like panic attacks.  You’ll learn:  Why anxiety often spikes between 2AM–4AM The connection between low blood sugar and night-time panic How cortisol and adrenaline disrupt sleep  Common triggers like skipping meals, low protein intake, and caffeine use Why this pattern is especially common in perimenopause Simple strategies to stabilize blood sugar and improve sleep qualityJoanne also shares practical tips, including how a protein-based evening snack may help prevent early morning wake-ups and reduce overnight anxiety. If you’ve been struggling with disrupted sleep, anxious thoughts at night, or waking at 3AM feeling wired, this episode offers a new perspective—and actionable steps to support your body. ✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.  🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

    3 min

  7. 13 APR

    43. Blood Sugar & Anxiety in Women: The Hidden Cause of Chronic Anxiety

    Are you struggling with anxiety, overwhelm, or constant nervous system dysregulation—despite normal lab results? In this episode of The Histamine Well Podcast, Joanne uncovers one of the most overlooked root causes of anxiety in women: blood sugar instability. Learn how blood sugar spikes and crashes can trigger cortisol and adrenaline, creating symptoms that feel exactly like anxiety disorders. Joanne breaks down why this often goes undiagnosed, even when glucose, insulin, and HbA1c levels appear normal. This episode explores the connection between blood sugar, hormones, histamine, gut health, and neurotransmitter production—and why women are particularly vulnerable, especially during high stress or perimenopause. You’ll also discover real-life patterns seen in clinical practice, including:  High-achieving women relying on coffee and insufficient protein intake, contributing to blood sugar instability Busy mothers under-eating and overwhelmedWomen using intermittent fasting in ways that disrupt hormonesHidden links between histamine intolerance and blood sugar imbalanceIf you’ve ever felt like your anxiety “doesn’t make sense,” this episode will help you understand what’s really happening in your body—and what to do about it. ✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.  🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

    16 min

  8. 8 APR ·  BONUS

    Q&A. Why Do I Still Have Inflammation When My CRP & ESR Are Normal?

    If your blood tests are “normal”… why do you still feel inflamed? In this Q&A Clarity Session of The Histamine Well Podcast, Joanne answers a deeply important and often overlooked question: why symptoms of inflammation can persist even when CRP and ESR markers come back normal. Many people are told everything is “fine” based on standard blood work—yet continue to experience fatigue, brain fog, skin issues, gut dysfunction, and hormonal imbalances. This episode explains why that disconnect happens and what may actually be driving your symptoms. CRP (C-reactive protein) and ESR (erythrocyte sedimentation rate) are commonly used markers for inflammation—but they primarily detect acute, systemic inflammation, not the chronic low-grade inflammation seen in many complex health conditions.  In this episode, you’ll learn:  Why CRP and ESR can be normal despite ongoing symptoms  The difference between acute vs chronic low-grade inflammation  Common drivers of hidden inflammation (gut issues, histamine, mold, blood sugar imbalance, stress)  How inflammation can show up as skin, neurological, hormonal, and digestive symptoms  Why patients are often dismissed despite real underlying issues If you’ve ever been told “your labs are normal” but still don’t feel well, this episode will give you the clarity and validation you’ve been looking for. This is essential listening for anyone dealing with:  Histamine intolerance  Chronic inflammation  Gut health issues (SIBO, candida, dysbiosis)  Hormonal imbalances  Unexplained symptoms despite normal blood tests 🎧 Subscribe to The Histamine Well Podcast for more expert insights on root-cause healing, inflammation, and complex chronic conditions. ✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.  🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

    3 min
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5
out of 5
12 Ratings

About

The Histamine Well is a podcast for health practitioners and patients alike, bridging the gap between complex science and practical understanding. With a focus on histamine, methylation, and related health topics, the show translates advanced concepts into actionable insights for practitioners while empowering patients with accessible, evidence-based knowledge.Your host, Joanne Kennedy, is a naturopath and expert in histamine intolerance, MTHFR, and methylation. She is also an author and runs an online group coaching program for practitioners and students on histamine and methylation. Jo loves breaking down complex science into clear, easy-to-understand language, offering practical tips and the latest insights to empower you to take charge of your health.

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