Physionic

Nicolas Verhoeven
  • 0,0 (0)
  • Medicina
  • Dvaput tjedno

I translate health studies for the public - from 'the macro to the micro'.

  1. prije 1 d

    Dr. Rhonda Patrick: ‘Scientists discovered a Supplement that Repairs Aging Mitochondria!’

    *JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with BiorenderDr. Patrick's Video: https://www.youtube.com/shorts/1Du-MKJOjk80:00 - Introduction1:05 - It Clears out Old Mitochondria!4:30 - It Rejuvenates the Immune System!6:54 - VO2 Boost, Anti-Aging Benefits11:52 - A Huge Caveat!13:22 - Main PointsReferences [Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][1] Singh A, D'Amico D, Andreux PA, et al. Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population. Eur J Clin Nutr. 2022;76(2):297-308. doi:10.1038/s41430-021-00950-1 [2] Alpert A, Pickman Y, Leipold M, et al. A clinically meaningful metric of immune age derived from high-dimensional longitudinal monitoring. Nat Med. 2019;25(3):487-495. doi:10.1038/s41591-019-0381-y [3] Imboden MT, Harber MP, Whaley MH, Finch WH, Bishop DL, Kaminsky LA. Cardiorespiratory fitness and mortality in healthy men and women. J Am Coll Cardiol. 2018;72(19):2283-2292. doi:10.1016/j.jacc.2018.08.2166. [6] Bailey SJ, Winyard P, Vanhatalo A, et al. Dietary nitrate supplementation reduces the O2 cost of low-intensity exercise and enhances tolerance to high-intensity exercise in humans. J Appl Physiol (1985). 2009;107(4):1144-1155. doi:10.1152/japplphysiol.00722.2009[7] Lansley KE, Winyard PG, Bailey SJ, et al. Acute dietary nitrate supplementation improves cycling time trial performance. Med Sci Sports Exerc. 2011;43(6):1125-1131. doi:10.1249/MSS.0b013e31821597b4[8] Cuenca E, Jodra P, Pérez-López A, et al. Effects of Beetroot Juice Supplementation on Performance and Fatigue in a 30-s All-Out Sprint Exercise: A Randomized, Double-Blind Cross-Over Study. Nutrients. 2018;10(9):1222. Published 2018 Sep 4. doi:10.3390/nu10091222[Study 230] D'Amico D, Olmer M, Fouassier AM, et al. Urolithin A improves mitochondrial health, reduces cartilage degeneration, and alleviates pain in osteoarthritis. Aging Cell. 2022;21(8):e13662. doi:10.1111/acel.13662[Study 232] Singh A, D'Amico D, Andreux PA, et al. Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults. Cell Rep Med. 2022;3(5):100633. doi:10.1016/j.xcrm.2022.100633[Study 549] Denk D, Singh A, Kasler HG, et al. Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial. Nat Aging. 2025;5(11):2309-2322. doi:10.1038/s43587-025-00996-xPlease use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

  2. prije 3 d

    Why is Cheese immune to raising Cardiovascular Disease risk?

    *JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with BiorenderMain Analysis: https://www.youtube.com/watch?v=9i121BcPYlk&t=231s0:00 - Introduction1:03 - Assumptions make an Ass out of You and Me4:33 - The Matrix: Not the Movie6:57 - Keep this in mind...References [Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][Study 1100] Feeney EL, Barron R, Dible V, et al. Dairy matrix effects: response to consumption of dairy fat differs when eaten within the cheese matrix—a randomized controlled trial. American Journal of Clinical Nutrition. 2018;108(4):667–674. doi:10.1093/ajcn/nqy146[Study 1101] Soerensen KV, Thorning TK, Astrup A, Kristensen M, Lorenzen JK. Effect of dairy calcium from cheese and milk on fecal fat excretion, blood lipids, and appetite in young men. American Journal of Clinical Nutrition. 2014;99(5):984–991. doi:10.3945/ajcn.113.077735[Study 1102] Rosqvist F, Smedman A, Lindmark-Månsson H, et al. Potential role of milk fat globule membrane in modulating plasma lipoproteins, gene expression, and cholesterol metabolism in humans: a randomized study. American Journal of Clinical Nutrition. 2015;102(1):20–30. doi:10.3945/ajcn.115.107045Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

  3. prije 6 d

    TUDCA: A New Way of Addressing Insulin Resistance

    *JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with Biorender0:00 - Introduction1:50 - TUDCA2:59 - Mechanisms of Intrigue4:18 - TUDCA Results7:50 - Dosing & ConsiderationsReferences [Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][1] She J, Tuerhongjiang G, Guo M, et al. Statins aggravate insulin resistance through reduced blood glucagon-like peptide-1 levels in a microbiota-dependent manner. Cell Metab. 2024;36(2):408–421.e5. doi:10.1016/j.cmet.2023.12.027.[2] Crosignani A, Battezzati PM, Cestari C, et al. Tauroursodeoxycholic acid for the treatment of chronic hepatitis: a multicentre dose-response study. Hepatol Res. 1998;13:10–19.[3] Ma H, Zeng M, Han Y, et al. A multicenter, randomized, double-blind trial comparing the efficacy and safety of TUDCA and UDCA in Chinese patients with primary biliary cholangitis. Medicine (Baltimore). 2016;95(47). doi:10.1097/MD.0000000000005391.[4] Pan XL, Zhao L, Li L, et al. Efficacy and safety of tauroursodeoxycholic acid in the treatment of liver cirrhosis: a double-blind randomized controlled trial. J Huazhong Univ Sci Technolog Med Sci. 2013;33(2):189–194. doi:10.1007/s11596-013-1095-x.[5] Poupon RE, Poupon R, Balkau B; UDCA-PBC Study Group. Ursodiol for the long-term treatment of primary biliary cirrhosis. N Engl J Med. 1994;330(19):1342–1347.[Study 1078] Kars M, Yang L, Gregor MF, et al. Tauroursodeoxycholic acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women. Diabetes. 2010;59(8):1899–1905. doi:10.2337/db10-0308.[Study 1079] Walsh LK, Restaino RM, Neuringer M, Manrique C, Padilla J. Administration of tauroursodeoxycholic acid prevents endothelial dysfunction caused by an oral glucose load. Clin Sci (Lond). 2016;130(21):1881–1888. doi:10.1042/CS20160501.[Study 1080] Panzhinskiy E, Hua Y, Culver B, Ren J, Nair S. Endoplasmic reticulum stress upregulates protein tyrosine phosphatase 1B and impairs glucose uptake in cultured myotubes. Diabetologia. 2013;56(3):598–607. doi:10.1007/s00125-012-2782-z.Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

  4. 15. lis

    The ‘Berberine Signature’: A New Heart Disease Protection Uncovered!

    *JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with Biorender0:00 - IntroductionYou talkin’ to me, ApoB?A Berberine Story: Genes, Associations, and TrialsReferences [Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][1] Yin J, Xing H, Ye J. Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism. 2008;57(5):712–717. doi:10.1016/j.metabol.2008.01.013[Study 1076] Zhao JV, Sarsani V, Chen B, Yun H, Hu J, Liang L. Berberine signature and cardiometabolic diseases using randomized controlled trial, cohort study and Mendelian randomization. npj Cardiovasc Health. 2026;3(1):15. doi:10.1038/s44325-026-00113-w[Study 1077] Zhao JV, Chen B, Chan YH, et al. Sex-specific lipid, apolipoprotein B, and lipoprotein(a) responses to berberine based on 2 randomized placebo-controlled trials. JACC Asia. Published online July 11, 2026. doi:10.1016/j.jacasi.2026.06.011Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

  5. 12. lis

    15 Studies Later: Investigating Omega-3 Fats promoting Cancer

    *JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with Biorender0:00 - Introduction1:25 - The Study in Question2:05 - Worries Multiplied5:50 - A Counter-PunchReferences [Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][Study 1061] Aronson et al. J Clin Oncol. 2025. doi:10.1200/JCO.24.00608[Study 1062] Brasky et al. J Natl Cancer Inst. 2013. doi:10.1093/jnci/djt174[Study 1063] Brasky et al. Am J Epidemiol. 2011. doi:10.1093/aje/kwr027[Study 1064] Park et al. Cancer Causes Control. 2009. doi:10.1007/s10552-008-9236-4[Study 1065] Crowe et al. Am J Clin Nutr. 2008. doi:10.3945/ajcn.2008.26369[Study 1066] Chavarro et al. Cancer Epidemiol Biomarkers Prev. 2007. doi:10.1158/1055-9965.EPI-06-1033[Study 1067] Männistö et al. Cancer Epidemiol Biomarkers Prev. 2003. DOI not provided.[Study 1068] Harvei et al. Int J Cancer. 1997. doi:10.1002/(SICI)1097-0215(19970516)71:4%3C545::AID-IJC7%3E3.0.CO;2-U[Study 1069] Augustsson et al. Cancer Epidemiol Biomarkers Prev. 2003. DOI not provided.[Study 1070] Leitzmann et al. Am J Clin Nutr. 2004. doi:10.1093/ajcn/80.1.204[Study 1071] Chavarro et al. Am J Clin Nutr. 2008. doi:10.3945/ajcn.2008.26419[Study 1072] Brasky et al. Nutr Cancer. 2011. doi:10.1080/01635581.2011.553022[Study 1073] Torfadottir et al. PLoS One. 2013. doi:10.1371/journal.pone.0059799[Study 1074] Moreel et al. Cancer Prev Res (Phila). 2014. doi:10.1158/1940-6207.CAPR-13-0349[Study 1075] Outzen et al. Eur J Cancer Prev. 2018. doi:10.1097/CEJ.0000000000000330Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

  6. 8. lis

    Bombshell Study Upends Low Carb Nutrition Science!

    *JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with BiorenderOriginal Prediction on Ketone Mechanism: https://www.youtube.com/watch?v=q-uG5lMwHlU&t=228s0:00 - Introduction1:20 - Finally!2:59 - Agreement across Studies?4:50 - The Carbohydrate Twist5:15 - Protein Inequality6:06 - Time Matters?7:18 - Revisiting my PredictionReferences [Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][Study 518] Queathem ED, Stagg DB, Nelson AB, et al. Ketogenesis mitigates metabolic dysfunction–associated steatotic liver disease through mechanisms that extend beyond fat oxidation. J Clin Invest. 2025;135(12). doi:10.1172/JCI191021.[Study 1056] Petersen MC, Smith GI, Farabi SS, et al. Effect of diet macronutrient content on the cardiometabolic response to weight loss: a randomized clinical trial. Cell Metab. 2026;38:1–12. doi:10.1016/j.cmet.2026.07.020.[Study 1057] Qadri SF, Porthan K, Dufour S, et al. Distinct effects of ketogenic and non-ketogenic weight-loss diets on hepatic steatosis and mitochondrial metabolism in MASLD. J Hepatol. 2026;85:26–36. doi:10.1016/j.jhep.2026.02.001.[Study 1058] London A, Richter MM, Sjøberg KA, et al. The impact of short-term eucaloric low- and high-carbohydrate diets on liver triacylglycerol content in males with overweight and obesity: a randomized crossover study. Am J Clin Nutr. 2024;120:283–293. doi:10.1016/j.ajcnut.2024.06.006.[Study 1059] Kirk E, Reeds DN, Finck BN, et al. Dietary fat and carbohydrates differentially alter insulin sensitivity during caloric restriction. Gastroenterology. 2009;136(5):1552–1560. doi:10.1053/j.gastro.2009.01.048.[Study 1060] Haufe S, Engeli S, Kast P, et al. Randomized comparison of reduced fat and reduced carbohydrate hypocaloric diets on intrahepatic fat in overweight and obese human subjects. Hepatology. 2011;53(5):1504–1514. doi:10.1002/hep.24242.Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

  7. 5. lis

    Oats, Heart Disease, and the Molecules within Oats

    *JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with BiorenderMain Analysis: https://www.youtube.com/watch?v=c0Hm9tQ9zuc&t=1s0:00 - Introduction0:43 - Oats: Eat ‘em or Leave ‘em?1:52 - The Traditional3:10 - Something Suspicious about Oats…References[Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][1] Zhang J, Li L, Song P, et al. Randomized controlled trial of oatmeal consumption versus noodle consumption on blood lipids of urban Chinese adults with hypercholesterolemia. Nutrition Journal. 2012;11:54. doi:10.1186/1475-2891-11-54.[2] Thongoun P, Pavadhgul P, Bumrungpert A, Satitvipawee P, Harjani Y, Kurilich A. Effect of oat consumption on lipid profiles in hypercholesterolemic adults. Journal of the Medical Association of Thailand. 2013;96 Suppl 5–S32.[Study 1002] Klümpen L, Mantri A, Philipps M, et al. Cholesterol-lowering effects of oats induced by microbially produced phenolic metabolites in metabolic syndrome: a randomized controlled trial. Nature Communications. 2026;17:598. doi:10.1038/s41467-026-68303-9.[Study 1003] Xu D, Feng M, Chu Y, et al. The prebiotic effects of oats on blood lipids, gut microbiota, and short-chain fatty acids in mildly hypercholesterolemic subjects compared with rice: a randomized, controlled trial. Frontiers in Immunology. 2021;12:787797. doi:10.3389/fimmu.2021.787797.[Study 1004] Hu Y, Willett WC, Manson JE, et al. Intake of whole grain foods and risk of coronary heart disease in US men and women. BMC Medicine. 2022;20:192. doi:10.1186/s12916-022-02396-z.[Study 1005] Helnæs A, Kyrø C, Andersen I, et al. Intake of whole grains is associated with lower risk of myocardial infarction: the Danish Diet, Cancer and Health Cohort. American Journal of Clinical Nutrition. 2016;103:999–1007. doi:10.3945/ajcn.115.124271.Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

  8. 28. ruj

    4 Ways to Melt Visceral Fat!

    JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 HEALTH AUTONOMY [COURSE]Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy JOIN THE COMMUNITYJoin my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2 EMAIL LIST1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6 HIRE ME FOR CONSULTING:Consulting: https://bit.ly/3dmUl2H Created with Biorender 0:00 - Introduction1:22 - Option 12:20 - Option 23:55 - Option 35:55 - Option 4 References[1] Kadowaki T, et al. Obes Res Clin Pract. 2025;19(2):146-153. doi:10.1016/j.orcp.2025.03.003. [2] Wilding JPH, et al. J Endocr Soc. 2021;5(Suppl 1):A16-A17. doi:10.1210/jendso/bvab048.030. [3] Arciero PJ, et al. Obesity. 2023;31(Suppl 1):139-149. doi:10.1002/oby.23660. [4] Zuo L, et al. Front Physiol. 2016;7:350. doi:10.3389/fphys.2016.00350. [Study 396] Zelicha H, et al. BMC Med. 2022;20:327. doi:10.1186/s12916-022-02525-8. [Study 427] Kaplan A, et al. Am J Clin Nutr. 2022;115(5):1270-1281. doi:10.1093/ajcn/nqac001. [Study 780] Look M, et al. Diabetes Obes Metab. 2025;27(5):2720-2729. doi:10.1111/dom.16275. [Study 790] Falutz J, et al. J Clin Endocrinol Metab. 2010;95(9):4291-4304. doi:10.1210/jc.2010-0490. [Study 793] Makimura H, et al. J Clin Endocrinol Metab. 2012;97(12):4769-4779. doi:10.1210/jc.2012-2794. [Study 509] Di Tano M, et al. Nat Commun. 2020;11:2332. doi:10.1038/s41467-020-16243-3. [Study 510] Vernieri C, et al. Cancer Discov. 2022;12(1):90-107. doi:10.1158/2159-8290.CD-21-0030. [Study 511] Ligorio F, et al. Int J Cancer. 2024;154(1):114-123. doi:10.1002/ijc.34701. [Study 512] Vernieri C, et al. Cell Metab. 2024;36(8):1644-1667. doi:10.1016/j.cmet.2024.06.014. [Study 606] Ni Y, et al. Cell Metab. 2023;35(9):1530-1547. doi:10.1016/j.cmet.2023.08.002. [Study 607] Long X, et al. Cell Metab. 2025;37:2342-2361. doi:10.1016/j.cmet.2025.10.017. [Study 608] Li H, et al. Nat Metab. 2024;6(3):578-597. doi:10.1038/s42255-024-00988-y. Please use the following link to submit your critique: https://bit.ly/PhysionicCritique Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

Pogledajte sve (497)

Opis

I translate health studies for the public - from 'the macro to the micro'.

Informacije

  • Autor
    Nicolas Verhoeven
  • Aktivne godine
    2018. - 2026.
  • Epizode
    497
  • Ocjena
    Korektno
  • Copyright
    © Nicolas Verhoeven
  • Web‑stranica emisije
    Physionic

Također bi vam se moglo svidjeti