The Hunter Williams Podcast

Hunter Williams

Average health is a choice. And it's the wrong one. The Hunter Williams Podcast goes where mainstream medicine won't — deep into the science of peptides, hormone optimization, metabolic health, and biohacking protocols that actually move the needle. Every week, I sit down with elite researchers, doctors, and high-performers to cut through the noise and hand you biological leverage most people will never have access to. This isn't wellness. This is optimization. Subscribe. Take control of your biology.

  1. 1 DAY AGO

    Retatrutide Masterclass | Dosing, Side Effects, and the Framework Most People Get Wrong

    All links here: https://hunterwilliamshealth.com/links 00:00 — Intro and why I'm doing these masterclasses 02:42 — What we're covering and the regulatory timeline 04:04 — The two users: weight loss vs longevity 05:30 — What Retatrutide actually does (the three receptors) 06:50 — Why the glucagon receptor makes Retatrutide different 07:54 — Weight loss trial data (1mg to 12mg) 10:50 — The longevity data: liver fat, ApoB, blood pressure 13:14 — Who the lean biohacker user is 13:50 — The titration playbook 15:32 — Once weekly vs split dosing 19:50 — Morning vs night injections 21:02 — How far to push the dose (why 8mg is the ceiling) 22:50 — How long to stay on and the regain problem 25:44 — Longevity maintenance protocol 26:34 — Lean user protocol 27:24 — Protein and training are non-negotiable 29:06 — Side effects and how to manage them 30:20 — The heart rate question and why I use taurine 32:00 — The weird skin sensitivity issue 33:48 — Pairing Retatrutide with testosterone 35:56 — Drug interactions (blood pressure, thyroid, insulin) 37:02 — Metrics that matter 38:42 — How to cycle off correctly 39:54 — The most common mistakes 40:42 — How to start, what to do if you plateau 43:04 — Should you switch from Tirzepatide? 45:28 — Combining Retatrutide with other peptides 46:50 — The Ten Commandments of Retatrutide use 47:50 — The bottom line Today's episode is the first in a new format I'm rolling out. I'm working on a book where I cover one peptide at a time, one chapter at a time. Alongside that, I wanted to do a masterclass on each peptide and condense down everything I know into one place. First up is Retatrutide. I cover what it actually does in your body, the two very different users that should be on it, and the dosing strategies that get debated to death online. We go through the weight loss data, the longevity data, and why I think 8 milligrams is the real ceiling for most people. I also break down once weekly versus split dosing, the heart rate question, the skin sensitivity issue, and why testosterone optimization has to come first. If you want a definitive guide on Retatrutide, this is it. My goal is that you walk away with a framework you can actually use, whether it's on yourself, your coaching clients, or your patients. Let me know what you think. I plan on doing many more of these on every peptide that matters. ⚠️ For research and entertainment purposes only. ⚠️

    51 min

  2. 4 DAYS AGO

    Saturday Morning Coffee Talk 5/16/26

    All Links Here: https://hunterwilliamshealth.com/links

    1hr 59min

  3. 5 DAYS AGO

    Episode 4 — Why the 49ers Can't Stay Healthy | Peter Cowan on EMF, Substations, and Your Hormones

    If you do everything right and still feel off, this episode is for you. I sat down with Peter Cowan, a quantum biology practitioner and environmental health investigator who got chronically sick from EMF exposure, walked away from Silicon Valley, and spent years figuring out why on his own. Peter's Substack series on the San Francisco 49ers, who practice and play right next to a power substation, is some of the most compelling EMF research I've seen anywhere. We covered the EMF checklist anyone can run at home, the mitochondrial mechanism behind oxidative stress from magnetic fields, how EMF disrupts the cortisol and melatonin cycle that drives your testosterone, why pre-sunrise workouts under fluorescent lights are doing more damage than most people realize, and the three-pronged light protocol that took Peter's testosterone from 437 to over 800. Follow Peter: https://peteranthonycowan.substack.com/ For research and entertainment purposes only. 👇 ALL MY LINKS IN ONE PLACE https://hunterwilliamshealth.com/links

    1hr 6min

  4. 12 MAY

    This Peptide Works 10X Faster Than SSRIs (Here's How)

    👇 ALL MY LINKS IN ONE PLACE https://hunterwilliamshealth.com/links PE-22-28 is one of those peptides almost nobody is talking about, and I think that's a shame. In this episode I walk you through what it is, how it works, and why I'd put it in the antidepressant category before I'd call it a true nootropic. I get into the background as an optimized analogue of spadin, the TREK-1 channel inhibition that drives the effect, and the downstream impact on BDNF, synaptogenesis, and neuroinflammation. I also cover the part most people care about: the rapid antidepressant onset, usually around four days, versus the three to four weeks you wait on a typical SSRI. From there I share the dosing protocol I've been using on myself, including a four-on, three-off cycle to keep tolerance low, plus what I've noticed in terms of mood, mental energy, and the lack of any real come-down or withdrawal. I'm not saying this is a cure for depression. Depression is multifaceted and deserves a multifaceted approach. But if you need something to help get you out of the hole and back into the habits that actually move the needle, PE-22-28 is worth knowing about.

    17 min

  5. 9 MAY

    Reader Mailbag 3 — Traveling, Glutathione, Sleep & More | Hunter & Taylor Williams

    Hunter and Taylor are back for another deep dive Reader Mailbag. Real questions, real answers, no shortcuts. This week: traveling with peptides and TRT through customs, fixing glutathione injection pain, melanatan 1 vs 2 and skin cancer risk, severe female insomnia and perimenopause sleep protocols, retatrutide plateaus and GLP-1 desensitization, and how to actually build a peptide stack using the bleeding neck framework. Whether you're new to peptides or deep in your optimization journey this one has something for everyone. Submit your questions for the next episode at the link below. For research and entertainment purposes only. 👇 EVERYTHING IN ONE PLACEhttps://hunterwilliamshealth.com/links

    1hr 7min

  6. 5 MAY

    20 Fat Loss Compounds Ranked Worst to Best (No GLP-1s)

    👇 ALL MY LINKS IN ONE PLACE https://hunterwilliamshealth.com/links GLP-1s like retatrutide are the kings of fat loss. No argument there. But what do you actually do when you're cycling off, when GLP-1s aren't on the table, or when you want to stack something alongside your GLP-1 so you don't have to escalate the dose? In this video I rank 20 non-GLP-1 fat loss compounds from F-tier to S-tier. Most are peptides. A few are small molecules. Some I use all the time. Some I would never touch. I cover the mechanisms, the dosing protocols I actually run, the side effects I've personally experienced, and where each one fits in a real fat loss program. You'll get my honest take on adipotide, AOD-9604, sermorelin, setmelanotide, tesofensine, SS-31, cagrilintide, IGF-1 LR3, cardarine, CJC/ipamorelin, MOTS-c, 5-amino-1MQ, BAM15, SLU-PP-332, ATX-304, mirabegron, albuterol, HGH, and tesamorelin. Hormones and lifestyle come first. Always. But once those are dialed in, these are the tools worth knowing about. If you want my peptide cheat sheet and links to everything I use, check the description  below. And if you want to ask me questions directly, come hang out in the Axion Collective.

    47 min

  7. 2 MAY

    Saturday Morning Coffee Talk 5/2/26

    All links here: https://hunterwilliamshealth.com/links

    2h 15m

  8. 1 MAY

    LDN | The Force Multiplier for Peptides and HRT

    👇 ALL MY LINKS IN ONE PLACE https://hunterwilliamshealth.com/links Low-dose naltrexone is one of my favorite compounds out there, and in this updated 2026 episode I'm breaking down why it deserves a spot in your protocol. I cover the four mechanisms that make LDN work: the endorphin rebound, the OGF/OGFR axis, TLR4 antagonism, and broad anti-inflammatory signaling. Then I get into where LDN actually shines clinically. Autoimmune conditions like Hashimoto's and Crohn's. Chronic pain and fibromyalgia. Depression. PCOS and fertility. Even skin issues like acne, which I've personally dealt with for years. But the part I'm most excited about is how LDN stacks with hormones and peptides. I walk through why it pairs so well with TRT, estrogen, and thyroid optimization, and then I get into specific peptide combos including BPC-157, TB-500, thymosin alpha-1, KPV, SS-31, and GLP-1 agonists. I also share why LDN might let you stay at lower GLP-1 doses for longer. I cover dosing, titration, side effects, and my own experience cycling versus staying on continuously. If you're already optimizing with peptides and hormones, LDN might be that last five to ten percent that makes everything else work better. 00:00 – Intro and why LDN deserves an updated episode 02:22 – Why LDN belongs in your protocol (40-year safety record, broad benefits) 03:44 – The history of LDN and Dr. Bernard Bihari's HIV discovery 05:42 – The four mechanisms of action explained 06:30 – The OGF/OGFR axis and cancer applications 07:30 – TLR4 antagonism and the immune benefits 09:24 – Where LDN shines: autoimmune, pain, gut, depression, PCOS, skin 13:14 – Dosing, titration, and timing (night vs morning) 15:06 – Side effects, contraindications, and safety 16:14 – LDN and hormone replacement therapy synergy 18:34 – LDN for men on TRT, sexual function, and cortisol 20:48 – LDN stacked with peptides (BPC-157, TB-500, KPV, SS-31, GLP-1s, TA-1) 28:38 – My personal take on cycling vs daily use 30:16 – Closing thoughts Timestamps

    31 min
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Hosts & Guests

About

Average health is a choice. And it's the wrong one. The Hunter Williams Podcast goes where mainstream medicine won't — deep into the science of peptides, hormone optimization, metabolic health, and biohacking protocols that actually move the needle. Every week, I sit down with elite researchers, doctors, and high-performers to cut through the noise and hand you biological leverage most people will never have access to. This isn't wellness. This is optimization. Subscribe. Take control of your biology.

Information

  • Creator
    Hunter Williams
  • Years Active
    2020 - 2026
  • Episodes
    456
  • Rating
    Clean
  • Copyright
    © Hunter Williams
  • Show Website
    The Hunter Williams Podcast

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