Informed Dissent

LGB Courage Coalition

You Have Permission to Question, Scrutinize, Push Back, and Dissent! Jamie Reed, Cori Cohn, and Lauren Leggieri report on their adventures and misadventures trying to explain and mitigate the gender culture wars. We will publish most weeks, focusing some on the news and some on important topics from social transition to lawsuits to what the heck the word “gender” means. informeddissentpodcast.substack.com

  1. 2 days ago

    Puberty Blockers, Round Two?

    James Esses — psychotherapist, former criminal barrister, founder of Just Therapy, co-founder of Thoughtful Therapists, founder/coordinator of the Declaration for Biological Reality, Honorary Fellow at the Centre for Heterodox Social Science, University of Buckingham. Jamie, Lauren, and Cori are joined by James Esses ahead of the July 26th High Court judicial review of the PATHWAYS puberty blocker trial. James — alongside Keira Bell and the Bayswater Support Group — is a claimant in the case challenging the Health Research Authority and MHRA’s decision to approve the trial. This conversation covers the trial’s history, the regulatory reversal that let it proceed, and what’s legally at stake this weekend for the children already enrolled. PATHWAYS Trial: - 2024:UK bans puberty blockers for pediatric gender dysphoria outside of clinical research, following the Cass Review. - PATHWAYS approved as the sanctioned research exception — a King’s College London / South London and Maudsley NHS Trust study of GnRH analogues in patients under 16, commissioned by NHS England and the National Institute for Health and Care Research. - February 11, 2026: MHRA writes to trial sponsors raising safety concerns. - February 23, 2026: Health Secretary Wes Streeting confirms to Parliament that the trial has been paused. - Early 2026: Bell, Bayswater Support Group, and Esses file for judicial review against the HRA and MHRA, arguing the regulators failed to properly weigh foreseeable risk to cognition, bone density, and fertility against anticipated benefit. - June 2026: MHRA approves a modified protocol — minimum age requirement, updated patient information — clearing PATHWAYS to proceed, subject to the outcome of the judicial review. - Recruitment date: Originally set for August 1, 2026, pending the court’s decision. - July 26, 2026: High Court hears the judicial review. Further Reading: - Sex Matters coverage of the trial pause and judicial review - Transgender Trend on the modified protocol - The Free Press on the trial’s approval to enroll 11-year-olds - James Esses’s Substack and Just Therapy directory This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit informeddissentpodcast.substack.com/subscribe

    Puberty Blockers, Round Two?
  2. 11 Jul

    The Odd Girls Out

    Closing out Pride month, Cori Cohn and Lauren Leggieri sit down with pseudonymous writer Jack of Shadows — a cancelled public health professional, gay man, and contributor to our Substack — for a real conversation from inside the LGB about what happens when trans and queer politics collide with gay life. The conversation centers on “Odd Girls Out: Trans-Identified Women in Gay Male Spaces (Part 3: The White Knight and the Wallflower),” the final piece in Jack’s three-part series. Drawing on a firsthand account from a gay men’s retreat, Jack argues that gay male affinity spaces are built on shared orientation — and that well-meaning efforts to include trans-identified women in those spaces, however kindly intended, don’t resolve the underlying mismatch so much as paper over it. It’s a meditation on chivalry, honesty, and what’s lost when spaces built around one thing are asked to become something else. We’ll also touch on his earlier piece, “How a Private Conversation about Gender Got Me Fired from My Dream Job” — our most-read piece to date — about the professional cost of dissent in public health. * * If you liked this episode, like, subscribe, and share Informed Dissent — it genuinely helps more people find us. And check out our merch, available now, if you want to rep the show. Got a story from inside our community that isn’t getting told? Send it to us through lgbcourage.org. Know someone we should be talking to? Send that our way too. Informed Dissent is a reader-supported publication. To receive new posts and support our work, consider becoming a free or paid subscriber. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit informeddissentpodcast.substack.com/subscribe

  3. 4 Jul

    The Assumed Monopoly

    On today’s episode, Jamie Reed moderates a roundtable discussing the Supreme Court’s ruling in West Virginia v. B.P.J. and Little v. Hecox. At the table: Cori Cohn — co-host of Informed Dissent, who has testified in many states on this exact issue. Kara Dansky — attorney and author of The Abolition of Sex and The Reckoning: How the Democrats and the Left Betrayed Women and Girls. She’s a former ACLU senior counsel on criminal justice policy, a former president of the U.S. chapter of Women’s Declaration International, and a former board member of the Women’s Liberation Front. She describes herself as a lifelong Democrat. Kim Jones — co-founder of the Independent Council on Women’s Sports, or ICONS, the organization funding litigation against the NCAA over transgender eligibility policy. She’s a former All-American tennis player at Stanford; she got involved after watching young women compete against Lia Thomas in 2022. Leyland Streiff — co-founder and lead organizer of Maine Girl Dads, and principal officer of the Protect Girls Sports in Maine ballot committee. A father of three who relocated his family to Maine after decades in the New York area, he led the citizen-initiative signature drive that gathered more than 76,000 signatures. Decided 6-3. Majority opinion by Justice Kavanaugh, joined by Roberts, Thomas, Alito, Gorsuch, and Barrett. The majority held that neither Title IX nor the Equal Protection Clause prevents states from reserving girls’ and women’s school sports for biological females. Thomas and Gorsuch each wrote separate concurrences. Justice Sotomayor wrote an opinion concurring in part and dissenting in part, joined by Kagan and Jackson; Jackson also wrote a separate opinion concurring in part and dissenting in part. Notably, all nine justices agreed the states hadn’t violated Title IX — the three liberals only dissented on the Equal Protection question, arguing the case should have gone back to a lower court to develop the factual record on competitive advantage. Chief Justice John Roberts Male · Age 71 · Appointed by President George W. Bush (R), 2005 * Obergefell v. Hodges (2015) — Dissented from the majority’s recognition of a constitutional right to same-sex marriage, arguing the decision should have been left to the democratic process rather than decided by the Court. * Bostock v. Clayton County (2020) — Joined Justice Gorsuch’s majority opinion holding that Title VII’s ban on sex discrimination in employment extends to discrimination based on sexual orientation and gender identity. * United States v. Skrmetti (2025) — Authored the majority opinion upholding Tennessee’s ban on certain gender-affirming medical treatments for minors, applying rational-basis review. * This ruling — Joined Kavanaugh’s majority opinion. Justice Clarence Thomas Male · Age 78 · Appointed by President George H.W. Bush (R), 1991 * Obergefell — Dissented, joined Scalia’s and wrote his own dissent arguing the majority’s reasoning had no basis in the Constitution’s text or history. * Bostock — Dissented, joining Alito’s opinion arguing the majority rewrote the statute rather than interpreting it. * Skrmetti — Joined the majority. * This ruling — Wrote a concurrence arguing biological sex is an immutable characteristic and that a man does not have a legal right to compete against women based on gender identity. Justice Samuel Alito Male · Age 76 · Appointed by President George W. Bush (R), 2006 * Obergefell — Dissented, warning the ruling would be used to brand traditional marriage views as bigotry. * Bostock — Wrote the primary dissent (joined by Thomas), arguing the majority’s textualism was a pretext for judicially imposed policy change that only Congress had authority to make. * Skrmetti — Joined the majority. * This ruling — Joined the majority. Justice Sonia Sotomayor Female · Age 72 · Appointed by President Barack Obama (D), 2009 * Obergefell — Joined the majority recognizing a right to same-sex marriage. * Bostock — Joined the majority extending Title VII protections. * Skrmetti — Dissented from the majority upholding Tennessee’s minor gender-care ban. * This ruling — Wrote the lead dissent, arguing the majority resolved factual questions about competitive advantage that should have gone to a lower court first, and read a summary of her dissent aloud from the bench — a signal of unusually strong disagreement. Justice Elena Kagan Female · Age 66 · Appointed by President Barack Obama (D), 2010 * Obergefell — Joined the majority. * Bostock — Joined the majority. * Skrmetti — Dissented. * This ruling — Joined Sotomayor’s dissent. Justice Neil Gorsuch Male · Age 58 · Appointed by President Donald Trump (R), 2017 * Bostock — Authored the majority opinion himself, reasoning as a textualist that firing someone for being gay or transgender necessarily involves treating them differently because of sex — one of the most consequential LGBT-rights opinions ever written by a conservative justice. * Skrmetti — Joined the majority. * This ruling — Joined the majority and wrote his own concurrence. * (Gorsuch was not yet on the Court for Obergefell in 2015.) Justice Brett Kavanaugh Male · Age 61 · Appointed by President Donald Trump (R), 2018 * Bostock — Dissented, arguing the Court overstepped its role and that any expansion of Title VII protections should come from Congress. * Skrmetti — Joined the majority. * This ruling — Authored the majority opinion, framing it as declining to require “an overhaul of women’s and girls’ sports throughout America,” while stating that transgender girls and women who want to play sports deserve “respect” and should not be “ostracized or vilified.” * (Kavanaugh was not yet on the Court for Obergefell.) Justice Amy Coney Barrett Female · Age 54 · Appointed by President Donald Trump (R), 2020 * Skrmetti — Joined the majority. * This ruling — Joined the majority. * (Barrett joined the Court in 2020, after both Obergefell and Bostock.) Justice Ketanji Brown Jackson Female · Age 55 · Appointed by President Joe Biden (D), 2022 * Skrmetti — Dissented. * This ruling — Joined Sotomayor’s dissent and additionally wrote her own separate opinion concurring in part and dissenting in part. * (Jackson joined the Court in 2022, after both Obergefell and Bostock.) Shop our Merch Store: We have mugs, t-shirts, and tote bags for sale! Stay Informed and Ready to Dissent! This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit informeddissentpodcast.substack.com/subscribe

  4. 20 Jun

    ROGD: A 'New' Clinical Phenomenon

    Episode Summary In Part Two of our conversation with Dr. Kenneth Zucker, we continue exploring what decades of clinical research actually shows about gender dysphoria in children and adolescents — and what gets lost when ideology replaces evidence. Dr. Zucker is a certified psychologist based in Toronto, Editor-in-Chief of Archives of Sexual Behavior, and one of the most cited researchers in this field. If you missed Part One, start there — this conversation builds on it. Topics Covered * ROGD as a distinct clinical phenomenon: what the evidence does and doesn’t show * The shift in sex ratios among clinic-referred adolescents and what it signals * Desistance, persistence, and why longitudinal data matters * Is there a “true” transgender? Dr. Zucker makes the case for a genuine gender dysphoria diagnosis — and what distinguishes it from the current wave of adolescent presentations From Dr. Zucker’s Research Dr. Zucker has a new paper under review asking the core question directly: Is “rapid-onset” gender dysphoria in adolescence a new clinical phenomenon? The manuscript was submitted for publication in January 2026. You can track his work and find the paper when it publishes at his research page: 🔗 kenzuckerphd.com/research His full CV is also available there as a PDF for listeners who want the complete publication record. Earlier relevant work: * “Adolescents with Gender Dysphoria: Reflections on Some Contemporary Clinical and Research Issues” — Archives of Sexual Behavior, 2019 * “The Myth of Persistence” — International Journal of Transgenderism, 2018 Coming Up Next Week 🎙️ Pride Discussion — Lauren and Cori sit down to talk about Lauren trip to Chicago for the Endocrine Conference and her visit to a Pride Festival. 🎙️ Interview: Dr. Leonard Sax — Author, physician, and researcher. Dr. Sax joins Jamie to discuss intersex conditions, how prevalence claims get distorted, and what accurate terminology actually requires. As always, Stay Informed and Ready to Dissent. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit informeddissentpodcast.substack.com/subscribe

    ROGD: A 'New' Clinical Phenomenon
  5. 13 Jun

    A Conversation with Bioethicist Arthur Caplan

    This week it’s just Jamie Reed — this weekend is the Endocrine Society’s annual conference in Chicago, so Headlines and the usual roundtable are off, and we’ll be back at full strength next week. In the meantime, you can stay current with our weekly news: every week the LGB Courage Coalition publishes a roundup of the stories that matter in gender medicine, science, and policy — the headlines you won’t see covered honestly anywhere else. Subscribe on our Substack so you never miss it. For this episode, Jamie sits down with Arthur Caplan, PhD, one of the most influential figures in American bioethics. Dr. Caplan is the Drs. William F. and Virginia Connolly Mitty Professor and founding head of the Division of Medical Ethics at NYU School of Medicine. Before NYU, he created the Center for Bioethics and the Department of Medical Ethics at the University of Pennsylvania, and founded the Center for Biomedical Ethics at the University of Minnesota. He is the author or editor of thirty-five books and over 890 peer-reviewed papers, and has chaired or served on national and international committees spanning the United Nations, the World Health Organization, the National Institutes of Mental Health panel on human experimentation on vulnerable subjects, and the FDA’s Reagan/Udall Foundation. Since 2015 he has co-chaired the Compassionate Use Advisory Committee advising Janssen Pharmaceuticals. He has been named one of the most influential people in American health care, science, and biotechnology by outlets including Discover, Modern Healthcare, and Scientific American. Jamie and Dr. Caplan discuss the foundational frameworks of bioethics — where they came from, why they exist, and how they apply to medicine today. About our guest: Arthur Caplan, PhD, is the Mitty Professor of Bioethics and founding head of the Division of Medical Ethics at NYU School of Medicine. He holds eight honorary degrees and received the National Science Foundation’s Public Service Award for contributions to public understanding of science. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit informeddissentpodcast.substack.com/subscribe

  6. 19 May

    Drescher and His Traveling Road Show at the APA: The Full Audio

    About This Episode This episode contains audio recorded inside Session 1240 at the 2026 American Psychiatric Association Annual Meeting in San Francisco, held Saturday, May 16, 2026. The session was a Continuing Medical Education offering titled Transgender Psychiatrists Speak: Reflections From Training, Patient Care and Professional Practice. It ran from 1:30 to 3:00 PM Pacific Time in Room 202 of the Moscone Center. The session was designated in-person only and was not offered as a hybrid event. CME credit was available to attending psychiatrists. The session was chaired by Dr. Jack Drescher and presented by Dr. Lana Irons, Dr. Jack Pula, Dr. Tobias Murphy, and Dr. Jami Woods. We received the audio, verified its authenticity, and are releasing it in full. The only alterations made were to audio quality. The Conference The American Psychiatric Association Annual Meeting is the largest gathering of psychiatrists in the United States. The 2026 meeting took place May 16–19 at the Moscone Center in San Francisco. CME sessions at the meeting offer accredited continuing education credit to licensed psychiatrists and other mental health providers. The Chair Dr. Jack Drescher, MD is a Clinical Professor of Psychiatry at Columbia University and a Distinguished Life Fellow of the American Psychiatric Association. He served on the APA’s DSM-5 Workgroup on Sexual and Gender Identity Disorders, was Section Editor of the Gender Dysphoria chapter in the DSM-5-TR, and served on the WHO Working Group that revised gender diagnoses in the ICD-11. At the 2025 APA Annual Meeting in Los Angeles, Dr. Drescher presented alongside Dr. Scott Leibowitz in a session on pediatric gender medicine that the APA sought to keep from public view. LGB CC livestreamed the session on X; it was also covered by journalist Benjamin Ryan on his Substack, Hazard Ratio. Thanks for reading Informed Dissent! This post is public so feel free to share it. The Presenters Dr. Lana Irons, MD is a trans-identified male psychiatrist and Clinical Assistant Professor of Psychiatry at SUNY Downstate Health Sciences University. He earned his MD from Eastern Virginia Medical School and completed his Adult Psychiatry Residency and Chief Residency at SUNY Downstate, where he received a certification in psychodynamic psychotherapy through the Psychoanalytic Association of New York. He currently serves as a full-time attending psychiatrist with the NYC Health + Hospitals Domestic Violence Shelter Mental Health Initiative. Dr. Jack Pula, MD is a trans-identified female psychiatrist in private practice in New York City and is affiliated with New York-Presbyterian Hospital. She completed her medical degree at SUNY Downstate Medical Center and her psychoanalytic training at the Columbia Center for Psychoanalytic Training and Research. She has published on transgender mental health in peer-reviewed literature and has served in leadership roles focused on expanding transgender psychiatry training in residency programs. Dr. Tobias Murphy, MD is a trans-identified female psychiatrist licensed in New York, Ohio, and West Virginia. She completed medical school and psychiatry residency at Marshall University’s School of Medicine and has additional training in neuropsychiatry and geriatric psychiatry. She is a member of the American Psychiatric Association and the World Professional Association for Transgender Health. Dr. Jami Woods, MD, DPh is a trans-identified male psychiatrist and board-certified psychopharmacologist, formerly Associate Professor of Psychiatry and Vice Chair for Diversity and Inclusion at the University of California, Riverside School of Medicine. He holds subspecialty certification from the American Society of Clinical Psychopharmacology and has delivered CME presentations on pediatric gender medicine to national audiences of prescribers. Stay Informed and Ready to Dissent. lgbcourage.org This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit informeddissentpodcast.substack.com/subscribe

    Drescher and His Traveling Road Show at the APA: The Full Audio
  7. 18 May

    Turban and Karasic at the APA: The Full Audio

    INFORMED DISSENT — Special Edition Monday, May 19, 2026 About This Episode This episode contains audio recorded inside Session 1193 at the 2026 American Psychiatric Association Annual Meeting in San Francisco, held Saturday, May 16, 2026. The session was a Continuing Medical Education offering titled Transgender Care: Update on Evidence Base and Clinical Practice of Primary Care Child and Adolescent Psychiatry and Adult Psychiatry. It ran from 8:30 to 10:00 AM Pacific Time in Room 201 of the Moscone Center. CME credit was available to attending psychiatrists. The session was chaired by Dr. Dan Karasic and presented by Dr. Jack Turban. We received the audio, verified its authenticity, and are releasing it in full. The only alterations made were to audio quality. A PDF of Dr. Karasic’s slide deck is available below. Audio note: Dr. Karasic’s presentation opens with embedded video clips, including a clip of Robert F. Kennedy Jr. and a clip of Dr. Karasic in a news segment. The audio quality on those clips is limited by recording conditions and is harder to hear than the rest of the session. It improves once those clips have played. The Conference The American Psychiatric Association Annual Meeting is the largest gathering of psychiatrists in the United States. The 2026 meeting took place May 16–19 at the Moscone Center in San Francisco. CME sessions at the meeting offer accredited continuing education credit to licensed psychiatrists and other mental health providers. The Presenters Dr. Dan Karasic, MD is Professor Emeritus of Psychiatry at UCSF. He received his MD from Yale University and trained at the UCLA Neuropsychiatric Institute. He is the lead author of the Mental Health chapter of the WPATH Standards of Care, Version 8, and serves as Chair of the APA Workgroup on Gender Dysphoria. He is a Distinguished Fellow of the American Psychiatric Association. In May 2023, audio from a presentation Karasic delivered at the San Francisco Trans Health Summit, titled “Managing Patients with Co-Occurring Mental Health Diagnoses,” was published by The Post Millennial and subsequently released in full by the Transparency podcast (Gender Dysphoria Alliance). In that presentation, Karasic addressed the treatment of verbally impaired autistic patients and discussed drawing as a mode of communicating gender identity. The remarks generated significant public attention. In Saturday’s session, Dr. Karasic returned to that controversy directly, including a screenshot of a tweet about it in his slide deck. (2023 audio sources: Mia Ashton, The Post Millennial, May 10, 2023; “Special Series – National Transgender Health Summit – Ep. 2 – Dr. Karasic,” Transparency, Gender Dysphoria Alliance, June 4, 2023 — Apple Podcasts / Spotify ) Dr. Jack Turban, MD, MHS is an Assistant Professor of Child and Adolescent Psychiatry and Health Policy at UCSF and Founding Director of the UCSF Gender Psychiatry Program. He trained at Harvard (BA, neurobiology), completed his psychiatry residency at McLean Hospital/Harvard Medical School, and his child and adolescent psychiatry fellowship at Stanford. He is the author of Free to Be: Understanding Kids & Gender Identity (Simon & Schuster, 2024). His research on pediatric gender medicine has been cited in legislative debates and federal court proceedings. He has served as a paid expert witness for the ACLU in legal challenges to state restrictions on pediatric gender medicine. Coming Soon: We will release audio from Transgender Psychiatrists Speak: Reflections From Training, Patient Care and Professional Practice, chaired by Dr. Jack Drescher also from the APA Conference. Stay Informed and Ready to Dissent. lgbcourage.org This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit informeddissentpodcast.substack.com/subscribe

    Turban and Karasic at the APA: The Full Audio

About

You Have Permission to Question, Scrutinize, Push Back, and Dissent! Jamie Reed, Cori Cohn, and Lauren Leggieri report on their adventures and misadventures trying to explain and mitigate the gender culture wars. We will publish most weeks, focusing some on the news and some on important topics from social transition to lawsuits to what the heck the word “gender” means. informeddissentpodcast.substack.com

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