BioBits & Bytes

Arghya Ghosh
  • 0.0 (0)
  • LIFE SCIENCES

Welcome to BioBits & Bytes, your gateway to the world of science, technology, and the innovations shaping our future. Each week, we dive deep into groundbreaking discoveries, emerging technologies, and the minds behind them. Whether it's molecular biology, cellular biology, biotech, immunology, neuroscience breakthroughs or AI revolutions in biology — if it's cutting-edge, we’re talking about it. Designed for curious minds, students, professionals, and future thinkers, BioBits & Bytes where science meets imagination and tech meets tomorrow. Stay curious. Stay informed. Stay ahead.

  1. 3D AGO

    Spatial Connectomics: Barcodes, Sequencing, and Analysis

    What if we could map every neuron, every connection, and every signal pathway in the brain — not with a microscope, but with DNA barcodes and sequencing? In this podcast, we explore the groundbreaking field of spatial connectomics, where cutting-edge molecular tools reveal the brain’s wiring diagram at unprecedented resolution. Each episode uncovers how scientists use DNA barcoding, in situ sequencing, high-throughput imaging, and computational reconstruction to chart the trillions of connections that shape perception, memory, behavior, and disease. We break down major innovations: • Barcoded neurons that “tag” their connections • Molecular tracers that record synaptic events • Spatial sequencing that reconstructs circuits in 3D • Machine-learning models that assemble massive neural maps • Applications in Alzheimer’s, autism, neurodegeneration, and brain-inspired computing This is the story of how biology, genomics, and advanced computation come together to decode the most complex structure in the known universe — the human brain.

    39 min

  2. 6D AGO

    AI and Computational Methods in Drug Discovery

    How are today’s most advanced medicines created — not in the lab, but on a computer? In this podcast, we explore the rapidly evolving world of AI-driven and computational drug discovery, where algorithms, simulations, and machine intelligence accelerate what once took decades. Each episode uncovers how technologies like deep learning, AlphaFold, molecular docking, generative models, quantum computing, and virtual screening are transforming the search for life-saving drugs. We break down how scientists identify targets, design stable molecules, predict toxicity, repurpose existing drugs, and simulate entire biological systems — all before a single experiment is done. You’ll hear about real breakthroughs: AI-designed antibiotics, cancer therapeutics, RNA drugs, protein engineering, and personalized medicine powered by data. Whether you’re a biotech student, researcher, or just fascinated by the future of medicine, this podcast takes you inside the computational engines shaping the next era of healthcare — faster, smarter, and more precise than ever before.

    41 min

  3. 2025-12-25

    Neural Mechanisms of Psilocybin and Cortical Circuit Rewiring

    Recent neuroscience is revealing something extraordinary: psilocybin doesn’t just alter perception — it may temporarily reopen windows of neural plasticity in the adult brain. In this podcast, we explore the latest discoveries showing how psilocybin drives cortical circuit rewiring at the molecular, synaptic, and network levels. Drawing from cutting-edge animal studies, human neuroimaging, and molecular neuroscience, we break down how psilocybin: • activates 5-HT2A serotonin receptors on cortical pyramidal neurons • triggers rapid dendritic spine growth and synaptogenesis • reshapes functional connectivity across cortical networks • disrupts rigid neural patterns linked to depression and trauma • induces a “plasticity window” similar to early brain development • enables long-lasting circuit reorganization after short exposure We discuss groundbreaking findings showing that a single dose can produce sustained changes in cortical architecture, offering new explanations for psilocybin’s therapeutic effects in depression, PTSD, addiction, and end-of-life anxiety. Beyond therapy, this podcast examines the deeper implications: Is psilocybin a pharmacological tool for circuit reprogramming? Can transient psychedelic states lead to durable cognitive and emotional change? What does this teach us about consciousness, learning, and the brain’s capacity to rewire itself? Designed for neuroscience students, researchers, and curious minds, this series takes you inside the labs uncovering how psychedelics are redefining our understanding of plasticity and mental health.

    15 min

  4. 2025-12-23

    Synthetic Biology: DNA Recording and Computation

    What if we could see biology exactly where it happens — every gene, every molecule, every cell, in its true 3D environment? In this podcast, we journey into the transformative world of spatial and 3D omics, where advanced molecular technologies and powerful computational tools allow scientists to map tissues, organs, and entire organisms with unprecedented detail. Each episode explores cutting-edge innovations such as: • spatial transcriptomics and single-cell 3D atlases • volumetric DNA microscopy & in situ sequencing • advanced imaging + sequencing hybrid platforms • protein, chromatin, and metabolic spatial mapping • computational pipelines for high-dimensional spatial data • AI-driven reconstruction of tissues and cellular neighborhoods • applications in cancer biology, neuroscience, immunity, and regenerative medicine We break down both the technologies shaping the field and the computational challenges—including data integration, noise correction, multi-modal fusion, and building true 3D models of biological systems. Perfect for biotech students, researchers, and anyone fascinated by the future of molecular biology, this podcast reveals how spatial omics is transforming our understanding of disease, development, and the architecture of life itself.

    42 min

  5. 2025-12-19

    Bio-Interfacing and Wireless Implantable Sensors

    A deep dive into cutting-edge biotech: how scientists are using genetically engineered bacteria and dissolvable antennas to detect molecular signals from inside the body. We examine the science, the breakthroughs — and the promise (and caution) of living implants and real-time molecular tracking.

    38 min

  6. 2025-12-15

    Quantum Biology: Entanglement, Tunneling, and Biological Function

    What if the deepest secrets of life aren’t just biochemical — but quantum? In this podcast, we explore the mind-bending frontier of Quantum Biology, where the strange rules of quantum physics shape the machinery of living cells. Join us as we decode how phenomena like quantum tunneling, superposition, and entanglement may drive essential biological processes — from photosynthesis and enzyme catalysis to bird navigation, olfaction, and possibly even consciousness. Each episode dives into cutting-edge research, groundbreaking experiments, and conversations with leading scientists working at the intersection of physics, biology, and chemistry. Whether you’re a biology lover, a physics enthusiast, or simply curious about the mysteries of life, this podcast reveals how quantum effects may be the hidden operating system of nature — influencing everything from energy transfer and evolution to human health and future technologies. Step inside the quantum world within you. Life is stranger — and more beautiful — than we ever imagined.

    34 min

  7. 2025-12-14

    Microbial Strategies for PFAS Remediation and Biodegradation

    “Microbial Strategies for PFAS Remediation and Biodegradation” is a scientific podcast episode that explores how microorganisms can be used to break down and remove per- and polyfluoroalkyl substances (PFAS), often called “forever chemicals,” from contaminated soil and water. It focuses on the latest research into PFAS-degrading bacteria and microbial communities, discussing how they attack the strong carbon–fluorine bonds and what this means for practical clean‑up technologies. Main focus The episode typically explains why PFAS are so persistent in the environment, then introduces microbial and bioelectrochemical approaches that aim to not just capture but actually degrade these compounds. Listeners hear about lab and pilot studies, including specialized bacterial strains, designer microbiomes, and hybrid systems that combine microbes with advanced materials or electrodes to enhance defluorination. What you will learnThe podcast usually covers:How specific microbes and microbial consortia can transform or mineralize certain PFAS under aerobic and anaerobic conditions. Key challenges, such as slow degradation rates, incomplete breakdown, and the risk of forming mobile or toxic intermediates, and how researchers are trying to engineer better conditions and systems to overcome these issues.Overall, it is aimed at students, researchers, and practitioners interested in environmental biotechnology, giving an accessible overview of how microbiology and engineering are converging to tackle PFAS contamination.

    37 min

  8. 2025-12-12

    The Tubulin Code: Microtubule Post-Translational Modifications and Function

    This episode of Bio Bits and Bites explores how microtubules act as dynamic “highways” inside cells, storing mechanical energy and constantly remodeling as they grow and break down. It explains how specific post‑translational modifications of tubulin (the “tubulin code”)—such as detyrosination, acetylation, and polyglutamylation—control microtubule stability, motor protein traffic, and cargo transport, with a focus on neurons and how disruptions can lead to neurodegenerative disease.

    14 min
See All (57)

About

Welcome to BioBits & Bytes, your gateway to the world of science, technology, and the innovations shaping our future. Each week, we dive deep into groundbreaking discoveries, emerging technologies, and the minds behind them. Whether it's molecular biology, cellular biology, biotech, immunology, neuroscience breakthroughs or AI revolutions in biology — if it's cutting-edge, we’re talking about it. Designed for curious minds, students, professionals, and future thinkers, BioBits & Bytes where science meets imagination and tech meets tomorrow. Stay curious. Stay informed. Stay ahead.

Information

  • Creator
    Arghya Ghosh
  • Years Active
    2K
  • Episodes
    57
  • Rating
    Clean
  • Copyright
    © Arghya Ghosh
  • Show Website
    BioBits & Bytes