52 episodes

Promoting strategies to increase healthspan, well-being, cognitive and physical performance through deeper understandings of biology.

FoundMyFitness Rhonda Patrick, Ph.D.

    • Medicine
    • 4.8, 659 Ratings

Promoting strategies to increase healthspan, well-being, cognitive and physical performance through deeper understandings of biology.

    COVID-19 Q&A #2 - Antibody-Dependent Enhancement, Cross-Immunity, Immunity Duration & More

    COVID-19 Q&A #2 - Antibody-Dependent Enhancement, Cross-Immunity, Immunity Duration & More

    This is a continuation of the last episode where Dr. Patrick took questions from newsletter subscribers around the on-going pandemic and tried to add value by talking about some of the recent research, among other things.
    Some of the topics that came up as a result of the questions submitted include:
    00:04:03 - Data surrounding SARS-CoV-2 duration 00:06:37 - SARS-CoV-2 and potential immunity 00:11:35 - Some of the main factors known to play a role in immune variation 00:12:05 - What role genetics may play in immune function 00:14:27 - How previous viral exposure regulates immunity 00:15:05 - What cross immunity is and how it may be relevant for SARS-CoV-2 00:19:46 - Antibody-dependent enhancement and SARS-CoV-2 relevance 00:21:50 - How sleep is a key regulator of immune function 00:23:44 - Microbiome composition and immune function 00:28:31 - The differential effects of exercise intensity and duration on immune regulation 00:35:00 - How specific micronutrient inadequacies may promote immune dysregulation 00:47:20 - The effect of sex hormones on immune function 00:48:55 - How biological age age may play a role in immune regulation 00:49:46 - Controversy surrounding hypertension drugs such as ACE inhibitors and COVID-19 00:53:15 - ARDS and long-term lung damage Get our detailed summary, timeline, references and more on the FoundMyFitness episode page.
    This episode mentions a number of genetic polymorphisms that affect viral entry into the host cell, viral replication, host immune response ranging from cytokine production to viral-induced inflammation, SNPs that affect vitamin D levels and more. If you have used any consumer-based genetic testing services like 23andMe or Ancestry DNA we have a free viral report with these SNPs that you can check out.
    Learn more about this free report by clicking here. If you enjoy this content or any of the associated content, I can promise you that not only does the premium membership help bring MORE of it into the world in a broadly accessible format, that membership also comes with some really great benefits just for members. Members enjoy extra science emails twice per month, my monthly Question & Answer sessions, and a whole lot more. Support the show and get cool perks, that's the bottom line.
    Click here to learn more about premium membership.

    • 55 min
    Vitamin C: Oral vs. Intravenous, Immune Effects, Cancer, Exercise Adaptation & More

    Vitamin C: Oral vs. Intravenous, Immune Effects, Cancer, Exercise Adaptation & More

    In this episode, Dr. Rhonda Patrick discuss all things vitamin C. This episode covers oral bioavailability, intravenous vitamin C bioavailability, immune cell function, common cold and other viral infections, lung function, sepsis, pneumonia, inflammation, intravenous vitamin C and cancer, role in exercise, safety concerns, and so, so much more!
    Episode Timeline (abridged)
    00:07:33 - Background on vitamin C 00:17:09 - Bioavailability of vitamin C [including dosing frequency] 00:22:53 - Vitamin C in the context of the common cold 00:28:09 - Vitamin C and lung function 00:35:54 - Vitamin C in the context of exercise [includes discussion of blunting of exercise adaptation] 00:45:51 - Vitamin C and fatty acid oxidation, including relevance in obesity 00:48:44 - Vitamin C and the brain 00:51:15 - Intravenous Vitamin C and its use for the treatment of certain kinds of infection 00:55:33 - Intravenous Vitamin C and cancer 00:57:40 - Effect of Vitamin C on fertility and reproduction 00:58:36 - Intravenous vitamin C and cardiovascular health 01:00:42 - Vitamin C and inflammation 01:02:38 - Vitamin C’s mechanisms of action 01:08:34 - Intravenous and Oral vitamin C safety 01:10:20 - Vitamin C intake and kidney stone risk 01:13:57 - Conclusions Get the full timeline, show summary, and all references for this episode by clicking here.
    View our new 28-page vitamin C overview article with over 190 references by clicking here.
    Premium membership: Members enjoy extra science emails twice per month, my monthly Question & Answer sessions, and a whole lot more. Support the show and get cool perks, that's the bottom line. Click here to learn more about premium membership.

    • 1 hr 19 min
    COVID-19 Q&A #1 with Rhonda Patrick, Ph.D.

    COVID-19 Q&A #1 with Rhonda Patrick, Ph.D.

    This episode features Dr. Rhonda Patrick answering some of the most popular questions related to COVID-19. Look for another COVID-19-focused Q&A, coming soon.
    Some of the questions we selected from the batch to cover in this episode include:
    00:02:36 - Are children and infants susceptible to COVID-19? Are some more susceptible to a more severe form of the disease? Are they carriers of it and possibly spreading transmission? 00:11:00 - Can you explain a little about hydroxychloroquine as possibly treating COVID-19? How does it work? Does it have to do with it being a zinc ionophore? 00:17:58 - Can you talk about quercetin's role as a zinc ionophore? 00:20:51 - Is there any indication blood type influences COVID-19 risk? 00:24:52 - Would you shed light on the conversation regarding vitamin D upregulating ACE2 receptors and vitamin D's influence on susceptibility to COVID19 infection? 00:43:45 - Can you discuss whether sauna use might help prevent COVID19? 00:52:55 - Is it true that high dose intravenous vitamin C might help treat COVID-19? 01:04:35 - What are your thoughts on melatonin being a potential factor for impacting the severity of the virus via its effects on inflammation and oxidative stress? To supplement this podcast Q&A, we’ve also made a video, summary, timeline, and references. You can view all of these on the episodes page on my website at foundmyfitness.com/episodes/covid-19-qa-1.

    If you enjoy this question & answer format, consider joining my premium membership community! Non-COVID-19 related Q&As happen monthly, you get access to an an exclusive bi-weekly science digest email, and much more more! Click here to learn about premium.

    • 1 hr 14 min
    New Omega-3, sulforaphane research, and more! [Kevin Rose Show]

    New Omega-3, sulforaphane research, and more! [Kevin Rose Show]

    This episode was originally recorded for The Kevin Rose Show. Given some of the unique discussions we had, I had no choice but to ask the great Kevin Rose if he would let me re-post it over here on the FoundMyFitness podcast feed. A request which he graciously obliged.
    In this episode, we discuss...
    00:08:00 - Omega-3 00:27:23 - Metformin 00:50:05 - Sulforaphane 01:06:57 - Magnesium L-Threonate 01:13:44 - Sauna 01:23:48 - New FMF Membership Learn more about the new premium membership.
    Learn more about sauna on our overview page.
    Learn more about metformin on our overview page.
    Learn more about Kevin Rose at his website or on his Twitter @kevinrose. You can also subscribe to either of his two podcasts:
    Kevin Rose Show Foundation by True Ventures

    • 1 hr 36 min
    Is Resveratrol a Longevity Compound?

    Is Resveratrol a Longevity Compound?

    In this episode, Rhonda gives a summary of the science of resveratrol including its effects in animals and humans, mechanisms, and the bottom line on resveratrol supplementation and safety.
    Learn more about resveratrol at our comprehensive overview
    Relevant timepoints...
    00:03:39 - Clinical effects of resveratrol in humans 00:04:10 - Effects on cardiovascular health biomarkers in humans 00:06:54 - Reduction of inflammatory biomarkers in humans 00:08:11 - Improved cognition and memory in clinical studies 00:11:23 - Healthspan improvements in animals 00:12:28 - Induction of longevity genes via xenohormesis 00:16:19 - Contradictory effects on exercise-associated benefits 00:20:34 - Various factors that affect resveratrol bioavailability 00:23:09 - Unintentional effects on drug metabolism Get earlier access with the premium members early access podcast feed, monthly Q&A sessions, an exclusive bi-weekly science digest email, and more! Click here to learn about premium.
    Click here to sign-up for a three issue trial of the bi-monthly science digest.

    • 28 min
    NAD+, Nicotinamide Riboside, and Nicotinamide Mononucleotide with Rhonda Patrick

    NAD+, Nicotinamide Riboside, and Nicotinamide Mononucleotide with Rhonda Patrick

    In this episode, Rhonda describes NAD+ (perhaps one of the most important molecules in the human body), why it is so important for aging, and why it declines with age. She discusses some of the popular NAD+ boosters like nicotinamide riboside and nicotinamide mononucleotide, explains what the animal and human data say, discusses some of the concerns associated with using these boosters, and provides some concluding thoughts.
    Learn more about NAD+ Learn more about nicotinamide riboside Learn more about nicotinamide mononucleotide Learn more about sirtuins Get earlier access with the premium members early access podcast feed, monthly Q&A sessions, an exclusive bi-weekly science digest email, and more! Click here to get started.

    • 35 min

Customer Reviews

4.8 out of 5
659 Ratings

659 Ratings

Alvycity ,

Simply the best drug to my brain

I discovered Foundmyfitness in early 2019 and I think it is brillant because Dr Rhonda is outstanding and can articulate very well so that people with non scientific backgrounds can understand the value bombs she give every time. And for that I thank you.

llllllainy ,

Easy to digest information

This podcast is recommended by my Naturopath doctor. Although there’s not as much content as the other podcasts I follow, I found that she really digs deep into research literature and is very good at breaking down some of the technical backgrounds to easy-to-digest pieces. I found it especially helpful for people who have some scientific background (us the “health nerds”) but maybe “too much information” for others.

LovestoSpooge13 ,

Totally disagree with the one star review

The information here is very useful. I found Dr. Patrick to be a skilled and knowledgeable interviewer who intimately knows a lot of the literature. I didn’t find her self-aggrandizing I the least. A very worthwhile and informative podcast, if a bit scientific at times. The terms are, however, clarified in Dr. Patrick’s videos on YouTube.

Thank you Dr. Patrick

Top Podcasts In Medicine

Listeners Also Subscribed To