The Metabolic Edge

CMBH Lifestyle Medicine

Take ownership of your long-term health and fitness with Metabolic Edge. Hosted by Dr. Andrew Appleton- distinguished Internal Medicine Specialist and Assistant Professor at Western University, and Tommy Caldwell, bestselling author & high-performance coach, this podcast uncovers the root causes of lifestyle-driven diseases that plague our communities. From heart disease to cancer to neurological disorders , our health is intricately linked to our cardiometabolic health. Learn how to optimize yours so you can live long and strong.

  1. Jun 30

    Ep.59- Metabolic Health and Human Enhancement

    Key Topics Covered The Next Frontier in Weight Loss: GLP-1s & Myostatin Inhibitors The Muscle Loss Problem: While GLP-1 receptor agonists (like Tirzepatide) are highly effective for weight loss, roughly 25% to 30% of the weight lost is actually lean body mass (muscle). The Pharmaceutical Solution: A recent Phase II clinical trial paired a GLP-1 drug with a myostatin inhibitor (which blocks the protein that caps muscle growth), successfully promoting lean mass development while shedding fat. The Practical Alternative: The hosts emphasize that resistance training and adequate protein intake achieve these exact same muscle-preserving results naturally, though large-scale studies on this are rarely funded because "you can't package and sell" exercise. The "Enhanced Games" & Tech-Bro Gladiators A critique of the upcoming "Enhanced Games"—an Olympic-style event where performance-enhancing drugs are openly allowed. Using baseball's historic steroid era (e.g., Mark McGwire and Sammy Sosa) as an example, they discuss how performance enhancers amplify raw power margins without actually replacing foundational athletic coordination. A humorous look at the logical extreme of this trend: transitioning from myostatin inhibitors to full-blown CRISPR genetic engineering, drawing parallels to the movie Gattaca. The Rise of "Wellness Burnout" Wellness Maxing: The multi-billion-dollar wellness industry has created a exhausting "firehose" of protocols, leaving people overwhelmed by red-light masks, cold plunges, complex morning supplement "stacks," and hyper-optimized mattress coolers. The Power of Subtraction: The hosts advocate for simplifying your health routine rather than adding to it. They recommend automating simple meal choices, hitting a baseline of 20 minutes of daily exercise, and finding community-based, accountable activities like pickleball to naturally reduce stress and fight social isolation.

5
out of 5
13 Ratings

About

Take ownership of your long-term health and fitness with Metabolic Edge. Hosted by Dr. Andrew Appleton- distinguished Internal Medicine Specialist and Assistant Professor at Western University, and Tommy Caldwell, bestselling author & high-performance coach, this podcast uncovers the root causes of lifestyle-driven diseases that plague our communities. From heart disease to cancer to neurological disorders , our health is intricately linked to our cardiometabolic health. Learn how to optimize yours so you can live long and strong.

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