9 episodes

Bryson is a beautiful, happy and loving boy. But a mysterious illness means he can’t walk, talk, or feed himself. After years without a diagnosis, even Bryson’s parents have come to accept that he may never be able to live independently. Then one day, everything changes. Scientists working at the cutting edge of genetics believe they know what’s causing Bryson’s disease — and think it could be reversed. Motivated by the hope for a cure, Bryson’s parents search for the miracle key that could unlock Bryson’s brain.

Unlocking Bryson's Brain CBC Podcasts

    • Science
    • 4.4, 162 Ratings

Bryson is a beautiful, happy and loving boy. But a mysterious illness means he can’t walk, talk, or feed himself. After years without a diagnosis, even Bryson’s parents have come to accept that he may never be able to live independently. Then one day, everything changes. Scientists working at the cutting edge of genetics believe they know what’s causing Bryson’s disease — and think it could be reversed. Motivated by the hope for a cure, Bryson’s parents search for the miracle key that could unlock Bryson’s brain.

    Episode 8: Two Futures

    Episode 8: Two Futures

    After months of waiting, the “Bryson mouse” is finally ready for lab tests that will provide new insights into treatments and cures. And Bryson’s parents explore two possible versions of Bryson’s future.

    • 58 min
    Episode 7: Pilgrimage to Boston

    Episode 7: Pilgrimage to Boston

    Bryson’s parents travel to Boston/Cambridge, the global capital for rare disease research. Their goal: to ask private biotech companies to help in their search for a cure. Scientists provide new clues, but also raise difficult questions.

    • 40 min
    Episode 6: The Ethics of Cure

    Episode 6: The Ethics of Cure

    Finding a cure for Bryson no longer seems impossible. And that raises new questions about the ethics of this journey. Bryson’s family seeks out new perspectives and learns why “cure” is a loaded term in the disability rights community.

    • 49 min
    Episode 5: Making a Mouse

    Episode 5: Making a Mouse

    Scientists in Toronto get to work building a mouse with Bryson’s precise genetic variant. Plus, the family travels to Atlanta to provide blood samples for a researcher to create DNA-based “mini-brains” in his lab. Could this cutting edge science provide clues to unlocking Bryson’s brain?

    • 43 min
    Episode 4: A New Hope

    Episode 4: A New Hope

    Bryson’s family travels to meet other GRIN1 patients, including Bryson’s GRIN-twin Olivia. And research on mice offers new hope for finding a cure. But a new illness means that the family now needs two medical miracles.

    • 53 min
    Episode 3: The CRISPR Revolution

    Episode 3: The CRISPR Revolution

    Bryson’s parents explore CRISPR, a new technology with the potential to cure dozens of diseases once thought incurable. But gene editing comes with risks — not just for individual patients, but for the human race.

    • 33 min

Customer Reviews

4.4 out of 5
162 Ratings

162 Ratings

Nora the explora👍 ,

😉

I hope you end up finding a cure. I think Bryson deserves it!

DrKai09 ,

As a newly-graduating family doctor...

I’ve been enjoying this podcast immensely. I’m about to start my career as a rural family doctor, and this podcast has been so engrossing, inspiring, and thought-provoking. I especially like the touching on ethics of disability, and especially of prenatal diagnosis, which I as a family doctor am really a driver of. I commit myself to learning more about this in the future so I can guide my patients better. Thank you again!

debsuds ,

Bryson

When you look at Bryson you know that a lot is going on in that mind. Would love to see his brain unlocked to find out what he has to say! I am honoured to be a part of Bryson’s tribe. Bryson is so much more than a boy with a rare disease. He loves the Wiggles and the smile he has for Emma is definitely a crush. He is stubborn, he knows what he likes and what he doesn’t! I wore apple sauce trying to convince him to eat it...and the mischievous grin after kicking the applesauce in just the right way was enough to make me laugh with him.

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