10 episodes

Bryson is a beautiful, happy and loving boy. But a mysterious illness means he can’t walk, talk, or feed himself. After years without a diagnosis, even Bryson’s parents have come to accept that he may never be able to live independently. Then one day, everything changes. Scientists working at the cutting edge of genetics believe they know what’s causing Bryson’s disease — and think it could be reversed. Motivated by the hope for a cure, Bryson’s parents search for the miracle key that could unlock Bryson’s brain.

Unlocking Bryson's Brain CBC Podcasts

    • Science
    • 4.3 • 269 Ratings

Bryson is a beautiful, happy and loving boy. But a mysterious illness means he can’t walk, talk, or feed himself. After years without a diagnosis, even Bryson’s parents have come to accept that he may never be able to live independently. Then one day, everything changes. Scientists working at the cutting edge of genetics believe they know what’s causing Bryson’s disease — and think it could be reversed. Motivated by the hope for a cure, Bryson’s parents search for the miracle key that could unlock Bryson’s brain.

    Introducing: Sickboy

    Introducing: Sickboy

    The Sickboy podcast is determined to break down the stigma associated with illness and disease. Hosts and best friends Jeremie, Bryan, and Taylor tackle health taboos with people who have experienced those challenges firsthand and take their lead from Jeremie's life long battle with Cystic Fibrosis. Together they help us understand that sometimes the best way to deal with illness, disease, and life is simply to laugh. More episodes are available at smarturl.it/sickboycbc

    • 1 hr 17 min
    Episode 8: Two Futures

    Episode 8: Two Futures

    After months of waiting, the “Bryson mouse” is finally ready for lab tests that will provide new insights into treatments and cures. And Bryson’s parents explore two possible versions of Bryson’s future.

    • 58 min
    Episode 7: Pilgrimage to Boston

    Episode 7: Pilgrimage to Boston

    Bryson’s parents travel to Boston/Cambridge, the global capital for rare disease research. Their goal: to ask private biotech companies to help in their search for a cure. Scientists provide new clues, but also raise difficult questions.

    • 40 min
    Episode 6: The Ethics of Cure

    Episode 6: The Ethics of Cure

    Finding a cure for Bryson no longer seems impossible. And that raises new questions about the ethics of this journey. Bryson’s family seeks out new perspectives and learns why “cure” is a loaded term in the disability rights community.

    • 49 min
    Episode 5: Making a Mouse

    Episode 5: Making a Mouse

    Scientists in Toronto get to work building a mouse with Bryson’s precise genetic variant. Plus, the family travels to Atlanta to provide blood samples for a researcher to create DNA-based “mini-brains” in his lab. Could this cutting edge science provide clues to unlocking Bryson’s brain?

    • 43 min
    Episode 4: A New Hope

    Episode 4: A New Hope

    Bryson’s family travels to meet other GRIN1 patients, including Bryson’s GRIN-twin Olivia. And research on mice offers new hope for finding a cure. But a new illness means that the family now needs two medical miracles.

    • 53 min

Customer Reviews

4.3 out of 5
269 Ratings

269 Ratings

ontariogirl33 ,

Wonderful, sweet, eye opening must listen podcasts

Amazing podcast! Covers everything from how it feels to be a parent, sibling and caregiver of a kid with a rare disease to the ethics of cures for disabilities to how gene therapy works. Totally eye opening and thought provoking. Best podcast I’ve listened to in years! Like nothing I’ve heard before! Keep going Keith! I’m rooting for you!

Bobeh ,

Cheers to Hope

I sincerely enjoyed listening to this heartfelt podcast. It often brought tears to my eyes and introduced me to Scientific research that I was oblivious to. Rooting for this family & especially Bryson.

0874reviewer ,

More inclusively

While quite interesting in terms of scientific information, this series drips with white privilege.

The same episode that touches on ethics and the loaded meaning of a cure, ends in the formation of a foundation FOR finding a cure...

Hopefully the future of this podcast can feel more inclusive. Not only to the disability community but to the needs of other people with disabilities, not just Bryson.

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