The Human Upgrade: Biohacking for Longevity & Performance

Dave Asprey

For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization. Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more. This isn’t just self-improvement - it’s human enhancement backed by data. Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life. Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.

  1. 13 hr ago

    Change Your Morning, Change Your Life! Hal Elrod

    Starting your weekend off right, with the king of mindset. We had to replay this one because it's too goo not to! Meet a man who makes miracles happen. Today, I’m joined in the studio by Hal Elrod, author of the international bestseller The Miracle Morning and his newest book, The Miracle Equation. After overcoming multiple near-death experiences and financial hardships, Hal channeled his adversity into helping others overcome their own challenges. His Miracle Morning approach has impacted millions of lives. On today’s episode, Hal tells us all about his updated version of The Miracle Morning. He explains SAVERS, the six foundational practices that will transform your morning and change your life. We also talk about tips for hacking your sleep, productivity, and relationships.  Hal shares the stories of his devastating car accident and rare cancer diagnosis—and the superpowers he gained from coming back to life. We explore how these near-death experiences changed his perspective on life and what he values most. He also tackles some tough questions… Should we try to help everyone? What does it mean to be a “man”? And what does it take to truly serve others? There’s so much to take away from Hal’s refreshing and optimistic perspective.  (00:03:20) Creative Ways To Hold Yourself Accountable (00:13:57) Ditching Veganism (00:21:08) Hal’s Near-Death Experiences (00:27:35) Taking Your Health in Your Hands (00:29:37) Did Hal Come Back With Superpowers? (00:31:55) Are You Supposed To Help Everyone? (00:40:51) How the Miracle Morning Changed Hal’s LIfe (00:43:42) What Does It Mean To Be a “Man”? (00:51:25) Customizing Your Morning To Meet Your Needs (00:54:05) The Six Savers for Success (00:56:53) Tips To Save Your Sleep (01:01:51) The MVP of Personal Development Practices (01:06:14) Nourishing Our Connections Sponsors -Download Dave’s Free Peptide Guide at daveasprey.com/peptide-guide. -The One Device | Use code DAVE for $10 off at theonedevice.com/dave -iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestore.com/DAVE Resources Dave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books  Read: The Miracle Morning and The Miracle Equation Website: halelrod.com Facebook: Hal Elrod X: @HalElrod YouTube: @HalElrod See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    Change Your Morning, Change Your Life! Hal Elrod
  2. 1 day ago

    Learn THIS And You’ll Become Impossible To Trigger

    Jonny Miller on Nervous System Mastery, Grief, and Why High Performers Can't Afford to Stay Stuck in Their Heads    Your nervous system is running every decision, relationship, and reaction in your life, and you won't notice how much it's costing you until something breaks. This episode gives you the exact framework for building real nervous system mastery instead of running on autopilot until it fails.  Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR  Host Dave Asprey sits down with Jonny Miller, host of the Inner Frontier Podcast and founder of Nervous System Mastery, who has taught more than 1,000 people how to build the skills of interoception, self-regulation, and emotional fluidity. A former Silicon Valley founder turned nervous system expert, Jonny brings a rare mix of rational, data-driven thinking and deep somatic work to a field most high performers avoid entirely.  They break down why interoception, self-regulation, and emotional fluidity are the three learnable skills behind every major shift in performance, relationships, and decision-making, and why most high achievers have spent their whole lives disconnected from what's happening below the neck. Jonny introduces the half-life of reactivity, his framework for measuring how quickly someone can move from triggered back to calm, and explains how free diving became his gateway into surrender, breath work, and pressure equalization as a form of high-stakes meditation. Dave shares his own parallel journey through nervous system work, including lessons from running 40 Years of Zen and a costly business betrayal that reshaped how he reads people. Dave and Jonny also open up about grief, including Jonny's experience losing his fiancée and later his mother, and how community and co-regulation shape how fast someone actually heals.  You'll Learn:  Why interoception, self-regulation, and emotional fluidity are the three core skills behind nervous system mastery What the half-life of reactivity is and how to use it to measure real emotional progress How free diving works as a form of high-stakes meditation and a direct feedback loop for unclenching Why congruence between your inner and outer state matters more than staying composed under pressure How team intuition can be used as a practical filter in high-stakes hiring decisions Why co-regulation with friends and community can dramatically shorten the grieving process What Jonny's Breath Buddy device is designed to teach kids and families about nervous system regulation   Thank you to our sponsors!       - MOD | Visit mod.com for a consultation and get 10% off your first order plus free shipping with promo code DAVE.  - ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount.  - BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle.  - Timeline | Visit timeline.com/dave to learn more about Mitopure and get 20% off your first order for a limited time.  Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.  New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.  Keywords: Jonny Miller, Inner Frontier Podcast, Nervous System Mastery, interoception, self-regulation, emotional fluidity, half-life of reactivity, free diving, breathwork, nervous system regulation, somatic healing, grief processing, co-regulation, congruence, trauma response, boundary setting, narcissism, hiring intuition, cold plunge, surrender, NSDR, yoga nidra, Breath Buddy, biohacking, high performance, 40 Years of Zen, psychedelic integration, Silicon Valley founder, emotional resilience  Resources:    • Nervous System Mastery Course: https://www.nsmastery.com/  • Listen To Jonny’s Podcast ‘The Inner Frontier’ at: https://open.spotify.com/show/1lGD5wIfhnE4bepja42C9S  • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/   • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.    • Danger Coffee: https://dangercoffee.com/discount/dave15?  • My Daily Supplements: SuppGrade Labs (15% Off)     • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)     • Dave Asprey’s BEYOND Conference: https://beyondconference.com     • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated    • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/   • Upgrade Labs: https://upgradelabs.com     Timestamps:   00:00 – Trailer  01:10 – Losing His Fiancée  04:28 – Nervous System Mastery  11:52 – Community & Co-Regulation  17:37 – From Head to Body  22:52 – Surrender & Free Diving  28:54 – Half-Life of Reactivity  35:33 – Congruence & the $100M Lesson  38:58 – Stupidity, Narcissism & Intuition  50:22 – Biohacking Trojan Horses  59:11 – Breath Buddy & Outro  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    Learn THIS And You’ll Become Impossible To Trigger
  3. 3 days ago

    Jim Kwik: If You're Using AI Like This, You're Killing Your Brain

    Jim Kwik on Memory, AI, and Why Natural Intelligence Beats Artificial Intelligence    Your brain is quietly outsourcing itself to AI, and you won't notice until it's gone. This episode gives you the exact framework to use artificial intelligence as a tool for brain optimization instead of a crutch that erodes your memory, focus, and critical thinking.  Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR  Host Dave Asprey sits down with Jim Kwik, one of the world's leading experts in memory improvement, brain optimization, and accelerated learning. For more than 30 years, Jim has served as the brain coach to professional athletes, political leaders, business magnates, and Hollywood icons, with corporate clients including Google, Nike, SpaceX, and Harvard. He hosts the Kwik Brain podcast with over 100 million downloads, reaches 200,000 people annually through live keynotes, and just wrapped his 14th annual Beyond Biohacking Conference with 5,000 attendees in Austin. Jim overcame a childhood brain injury that left him labeled "learning disabled," and turned that struggle into a mission he calls "no brain left behind."  They break down the MIT study showing that people who use AI to write and think score worse on memory and comprehension than those who rely on their own brains, and why that matters for anyone serious about longevity, human performance, and anti-aging. Jim introduces the concept of digital dementia and cognitive sovereignty, explaining how nootropics, neuroplasticity, and functional medicine can support your biology while AI still requires you to keep your own hardware sharp. They cover the MEDS Rx framework for brain optimization: meditation, exercise, diet, sleep optimization, and relationships, plus why mitochondria, metabolism, and inflammation from processed food directly impact your cognitive output. Jim also shares how his own kids use AI as a tutor rather than a replacement for thinking, and why sleep inertia and the first few minutes after waking set the tone for your entire day.  This is essential listening for anyone serious about biohacking, hacking their own brain, longevity, neuroplasticity, brain optimization, supplements, and building a Smarter Not Harder approach to human performance in the age of AI.  You'll Learn:  Why the MIT study found AI users had weaker memory and comprehension than people who did the work themselves What digital dementia and digital deduction are, and how they quietly erode your cognitive muscles How to use AI as an augmented intelligence partner instead of a replacement for critical thinking The MEDS Rx framework for brain optimization: meditation, exercise, diet, sleep, and relationships Why the first few minutes after waking determine your focus and mood for the entire day How spaced repetition and AI-assisted learning can lock in new skills and behavior change faster The HUMAN framework for staying irreplaceable in a world run by algorithms   Thank you to our sponsors!       - KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/and use code DAVE for 20% off  - Neuronic | Go to www.neuronic.online Code DAVE for $100 off  - Our Place | Upgrade your kitchen with Our Place today. Visit fromourplace.com/DAVE and use code DAVE for 10% off sitewide.  - LMNT | Check it out at drinklmnt.com/DAVE. You'll get a free 8 count sample pack with any purchase.  Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.  New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.  Keywords: Jim Kwik, Limitless, Kwik Brain, digital dementia, cognitive sovereignty, human intelligence, artificial intelligence, MIT AI study, brain injury recovery, accelerated learning, memory improvement, speed reading, neuroplasticity, spaced repetition, memory palace, MEDS Rx framework, sleep inertia, attentional priming, metacognition, digital deduction, brain optimization, cognitive flexibility, cognitive anti-fragility, 40 Years of Zen, biohacking, Beyond Biohacking Conference, HUMAN framework, learning how to learn, GPS dependency, mental fatigue, burnout recovery, Limitless Daily  Resources:    • Learn More About Jim At: https://limitlessdaily.com/  • Follow Jim On Instagram At: https://www.instagram.com/jimkwik/  • Watch Jim On YouTube At: https://www.youtube.com/jimkwik  • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/   • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.    • Danger Coffee: https://dangercoffee.com/discount/dave15?  • My Daily Supplements: SuppGrade Labs (15% Off)     • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)     • Dave Asprey’s BEYOND Conference: https://beyondconference.com     • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated    • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/   • Upgrade Labs: https://upgradelabs.com     Timestamps:   00:00 – Trailer  00:55 – Intro  06:54 – AI as Tool, Not Crutch  13:00 – Protecting Cognitive Sovereignty  21:28 – Digital Dementia Explained  27:13 – AI-Enhanced Learning Techniques  32:18 – Speed Listening and Reading  40:38 – Rapid Tips by Age  46:59 – Building an AI Second Brain  53:04 – Burnout and Brain Optimization  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    Jim Kwik: If You're Using AI Like This, You're Killing Your Brain
  4. 5 days ago

    The Most Important Longevity Molecule I've Ever Found

    Try TrueDark glasses: https://truedark.com Try Danger Coffee: https://dangercoffee.com/discount/davetube Try Suppgrade Labs: https://shopsuppgradelabs.com/ Try Longevity Gummies: https://www.timeline.com/partners/dave-asprey Most people see the physical decline of aging as an inevitable process that can only be managed with medications, but this video cuts through that assumption by explaining that the smartest minds in science, including multiple Nobel Prize winners, have identified a single root cause of aging tied to a specific molecule called NAD+. You'll also learn: Why your body actively destroys NAD+ faster as you age, and why that's the real driver of fatigue and brain fogHow the gap between NAD+ production and destruction widens every year, quietly draining your cellular energyThe early signs your NAD+ levels are already too low, from slow-healing skin to workouts that take days to recover fromWhat actually flips your body's NAD+ production back on, and the exact order of diet, fasting, exercise, and supplementation that makes it work Try Danger Creatine: https://dangercoffee.com/products/danger-creatine Try TrueDark glasses: https://truedark.com Try Danger Coffee: https://dangercoffee.com/discount/davetube Try Suppgrade Labs: https://shopsuppgradelabs.com/ Thank you to our sponsors! ECHO Water | Go to http://echowater.com/daveand use code DAVE10 for 10% off your ECHO Flask.Viome | Check it out at viome.com and use code 10DAVE for 10% off. It’s time to stop guessing and start knowing your body.iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE Timestamps: 00:00 – The Aging Molecule 01:03 – The War Within Your Cells 03:28 – Builder vs. Demolition Crew 04:34 – NAD+ and Brain Function 06:00 – Root Cause Over Symptoms 08:31 – Fixing the Imbalance 10:10 – Fasting for NAD+ 11:30 – The REHIT Protocol 12:37 – The Supplementation Step Connect with Dave Asprey! Website: https://daveasprey.com TikTok: https://www.tiktok.com/@daveaspreyofficial Instagram: https://www.instagram.com/dave.asprey/ Facebook: https://www.facebook.com/Daveaspreyofficial/ X: https://x.com/daveasprey YouTube: https://www.youtube.com/c/daveaspreybpr The Human Upgrade Podcast: https://www.instagram.com/ TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/ Dave Asprey’s BEYOND Conference: https://beyondconference.com/ Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15 Upgrade Labs: https://upgradelabs.com 40 Years of Zen: https://40yearsofzen.com See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    The Most Important Longevity Molecule I've Ever Found
  5. 21 Aug

    The Scientist Monk: Gurudev Sri Sri Ravi Shankar

    This Friday, I had to play back an all-time favorite. I was honored and grateful to bring you a conversation that I recorded in person with Gurudev Sri Sri Ravi Shankar at the Art of Living Center in Los Angeles.  Gurudev Sri Sri Ravi Shankar is a leader of an international movement with more than 50 million followers who do breathwork every single morning. He has worked for 40 years as a global ambassador for peace at the highest levels.  I did his breathwork exercises every morning without fail for five years while fixing my mind, body and nervous system, and I have a huge amount of respect for his work in the world. It was a joy to chat with him in person and his childlike curiosity, enthusiasm for teaching, and deep understanding of the world are echoed in every word of this episode.  Gurudev is a true visionary, so I am grateful that he set aside time to talk with me so I could share his wisdom with you.  Thank you to our sponsors!       -Qualia | If you want to take the guesswork out of maintaining high NAD+ levels as you age, go to www.qualialife.com/daveNAD to get clinically proven Qualia NAD+ backed by a 100 day money back guarantee and code DAVENAD at checkout gets you an extra 15% off. -Essentia | Go to https://myessentia.com/dave and use code DAVE for $100 off The Dave Asprey Upgrade. -iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.  New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.  Keywords: Sri Sri Ravi Shankar, Dave Asprey, Art of Living, Sudarshan Kriya, breathwork, pranayama, meditation, non-dual consciousness, gut feeling intuition, biohacking, quantum physics consciousness, Nobel Prize physics, curiosity and childlike wonder, skepticism vs cynicism, scientific temper, dogmatism, veterans PTSD breathwork, SKY campus happiness program, violence prevention, community building, dating apps romance, Elon Musk Mars, computer chip brain implant, duality and consciousness, equanimity, ego and inner voice, spirituality and science, yoga philosophy, guru interview, positive energy radiation, transcending fear   Resources:    • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/   • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.    • Danger Coffee: https://dangercoffee.com/discount/dave15?  • My Daily Supplements: SuppGrade Labs (15% Off)     • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)     • Dave Asprey’s BEYOND Conference: https://beyondconference.com     • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated    • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/   • Upgrade Labs: https://upgradelabs.com        Timestamps:   00:00 - Trailer 01:11 - Curiosity & Skepticism 03:42 - Reality, Physics & Illusion 06:34 - Non-Dual Consciousness 08:37 - Origins of Breathwork 13:36 - Trusting Your Gut Feeling 14:28 - Violence, Peace & Veterans 19:54 - Romance & Dating Apps 23:44 - Science Behind Meditation 27:27 - Fear of the Unknown See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    The Scientist Monk: Gurudev Sri Sri Ravi Shankar
  6. 20 Aug

    The Wild New Theory of Cancer (It's GOOD For You?)

    Quantum Scientist Patrick Coles Reveals How Tumors Protect Your Mitochondria From Toxic Overload    Cancer might not be the enemy your doctor says it is. What if tumors are actually your body's emergency detox system, built on purpose to protect you from something far more dangerous?  Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR    Host Dave Asprey sits down with Patrick Coles, Ph.D., Chief Scientist at Normal Computing, where he develops novel computing hardware for AI applications. Previously a Staff Scientist at Los Alamos National Lab, Coles led their near-term quantum computing group and made significant contributions to quantum computing theory. He holds a Ph.D. in Chemical Engineering from UC Berkeley and a Master of Philosophy in Biochemistry from Cambridge, and he's currently developing a new theory for cancer and chronic disease, the subject of this conversation. His rare combination of hard physics and deep biochemistry gives him a radically different lens on one of medicine's most misunderstood diseases.  Coles lays out his Toxin Sequestration Theory, a framework that reframes cancer tumors not as malignant accidents but as intentional storage vaults the body builds to sequester toxins, heavy metals, seed oils, mold, and excess glucose, away from healthy tissue and mitochondria. He and Dave connect the dots between this theory and chronic disease, biohacking fundamentals, and why chemotherapy itself behaves as a toxin that can backfire. They dig into oxalates, deuterium, linoleic acid, circadian biology, and the detox protocols that support the body's natural ability to shrink these toxic reservoirs.  This conversation challenges the mainstream genetic theory of cancer, explores the metabolic theory popularized by Thomas Seyfried, and lands on a radical, functional medicine-aligned framework for anyone serious about longevity, anti-aging, and human performance. Dave and Coles also break down how sleep optimization, fasting, ketosis, and a carnivore approach to nutrition support the body's detox hierarchy, from fat tissue and the liver to moles, cysts, and eventually tumors themselves.  This is essential listening for anyone serious about biohacking, functional medicine, mitochondria health, brain optimization, nootropics, and taking full control of their metabolism and longevity.  You'll Learn:  Why toxins may be the root cause of Alzheimer's, Parkinson's, autism, and most chronic disease How Toxin Sequestration Theory reinterprets tumors as the body's backup detox organs Why chemotherapy ranks among the most tissue-damaging toxins, and what happens when a tumor bursts The role of oxalates, deuterium, heavy metals, and seed oils in cancer cell hoarding Why moles, cysts, lipomas, and nodules may be minor versions of the same detox response How circadian rhythm, sleep, and light exposure affect the body's toxin excretion cycles What spontaneous tumor regression reveals about lowering your toxic burden Why tracking tumor progression matters no matter which treatment path you choose   Thank you to our sponsors!       - Download Dave’s Free Peptide Guide at daveasprey.com/peptide-guide.  - ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount.  - Timeline | Visit timeline.com/dave to learn more about Mitopure and get 20% off your first order for a limited time.  - Just Thrive | Get a free 90-day supply of Digestive Bitters (a $90 value) when you start a 90-day Just Thrive Probiotic subscription at https://get.justthrivehealth.com/pages/asprey  Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.  New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.  Keywords: toxin sequestration theory, cancer theory, Patrick Coles, quantum computing scientist, thermodynamic computing, Normal Computing, Los Alamos National Lab, chemotherapy toxicity, oxalates cancer, deuterium toxin, Stephanie Seneff, heavy metal detox, mycotoxins tumors, seed oils cancer, linoleic acid, oleic acid oxidation, lipid peroxidation, glucose toxicity, mitochondria downregulation, genetic theory of cancer, metabolic theory of cancer, Thomas Seyfried, spontaneous tumor regression, backup detox organ, circadian rhythm cancer, mold toxins, forever chemicals, microplastics, bile flow, activated charcoal binders, cholestyramine    Resources:    • Follow Patrick’s Work At: https://www.instagram.com/patrickc_tst/  • Watch Gabby’s Podcast At: https://www.youtube.com/@GabbyReece  • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/   • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.    • Danger Coffee: https://dangercoffee.com/discount/dave15?  • My Daily Supplements: SuppGrade Labs (15% Off)     • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)     • Dave Asprey’s BEYOND Conference: https://beyondconference.com     • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated    • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/   • Upgrade Labs: https://upgradelabs.com        Timestamps:   00:00 – Trailer  00:58 – Introducing Patrick Coles  04:08 – Toxin Sequestration Theory  06:26 – Defining a Toxin  14:13 – Cancer as Backup Detox Organ  15:01 – History of the Theory  16:30 – Deuterium and Oxalates  21:31 – Cancer Theories Compared  28:06 – Chemotherapy and Toxic Overload  37:23 – Tiered Toxin Storage System  45:17 – Diet, Light, and Circadian Rhythm  50:39 – Detox Protocols and Binders  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    The Wild New Theory of Cancer (It's GOOD For You?)
  7. 18 Aug

    Scream Cream and Weekly Injections (Double Episode) | Gabby Reece

    Dave Asprey and Gabby Reece Talk Testosterone Therapy, Scream Cream, Autism as a Superpower, Cancer Protocols, and Surviving Fame in This Double Interview Episode    Mega-Episode time! Your hormones might be causing symptoms you've been blaming on aging, stress, or your heart. This double interview episode gives you a real look at biohacking from two different angles: cutting-edge longevity science and the lived experience of hormone optimization after 50.    Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR  Host Dave Asprey sits down with Gabby Reece, an American athletic icon, wellness entrepreneur, and one of the most influential voices in women's health, fitness, and performance. A former professional beach volleyball player who became Nike's first female spokesperson and shoe designer, Gabby set volleyball records at Florida State University that still stand today, and her signature Nike shoe line famously outsold Air Jordan during its release. She has since built a career at the intersection of performance and longevity, co-founding Hamilton House, Laird Superfood (NYSE: LSF), XPT, and HIGHX, and hosting both The Gabby Reece Show and the Proof of Practice podcast alongside leading voices in women's health and evidence-based performance. She is also a New York Times bestselling author. In this episode, Gabby turns the tables and interviews Dave herself, creating a rare two-way conversation between two people deeply immersed in human performance and biohacking.   Dave and Gabby dig into how mitochondria function as quantum systems that shape everything from cognitive performance to spiritual perception, why autism can come with genuine neurological superpowers, and what actually happens in the body when hormone levels shift after 40. Gabby shares her personal protocol, including weekly testosterone injections, an estradiol patch, and a compounded hormone cream that most people have never heard of, and explains how correcting her hormones, not her thyroid, resolved a heart arrhythmia doctors initially missed.  The conversation also covers Dave's approach to cancer protocols, why he avoids GLP-1 drugs despite their longevity benefits, the peptides he actually uses for mitochondrial renewal, and how cyclical ketosis, fasting, and a carnivore-leaning diet fit into a sustainable performance strategy. They also talk about AI's growing role in personalized longevity research, sleep optimization while traveling, and the supplement and functional medicine protocols Dave relies on daily.  You'll Learn:  Why Gabby's heart arrhythmia turned out to be a hormone problem, not a cardiac one, and how testosterone fixed it when nothing else worked What "scream cream" actually is, how it works through vasodilation, and why doctors quietly prescribe it during hormone replacement therapy How mitochondria function as quantum systems and why improving their function can sharpen intuition, focus, and perception Why Dave believes autism comes paired with real cognitive advantages once the physical burden of the condition is addressed What Dave would actually do if diagnosed with cancer, from antifungal protocols to high-power infrared light and early detection screening The peptides Dave uses for mitochondrial renewal, including SS31 and lesser-known Russian bioregulators like epitalon and pinealon Why Dave avoids GLP-1 drugs despite believing low doses carry real longevity benefits How cyclical ketosis, fasting windows, and a carnivore-leaning diet support sustainable long-term metabolism Why surrender, not control, was the hardest and most expensive lesson of Dave's career Gabby's advice for raising confident daughters and why she believes success is less about deserving it and more about how you steward it   Thank you to our sponsors!       - Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.com.  - Visit www.myvitalc.com/davesfav to unlock Dave’s discount  - Fatty15 | You can get an additional 15% off their 90-day subscription Starter Kit by going to fatty15.com DAVE and using code DAVE at checkout  - Omni-Biotic | Discover your formula at OmnibioticLife.com. Take 20% off your first order with code ASPREY.  Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.  New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.  Keywords: testosterone therapy, hormone replacement therapy, HRT for women, weekly testosterone injections, scream cream, compounded testosterone cream, vasodilation, AFib hormones, heart arrhythmia, menopause symptoms, thyroid vs testosterone, mitochondria quantum biology, biohacking, Dave Asprey, autism superpowers, cancer protocols, serrapeptase, nattokinase, peptides longevity, cyclical ketosis, carnivore diet, Gabby Reece, longevity for women, anti-aging hormones  Resources:    • Learn More About The Hamilton House At: https://hamiltonhouse.co/  • Watch Gabby’s Podcast At: https://www.youtube.com/@GabbyReece  • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/   • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.    • Danger Coffee: https://dangercoffee.com/discount/dave15?  • My Daily Supplements: SuppGrade Labs (15% Off)     • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)     • Dave Asprey’s BEYOND Conference: https://beyondconference.com     • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated    • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/   • Upgrade Labs: https://upgradelabs.com     Timestamps:   00:00 – Trailer  00:52 – Gabby Interviews Dave  02:58 – Fatherhood and Teenagers  12:25 – Autism and Superpowers  17:02 – Quantum Biology & Biohacking  24:03 – Autism Epidemic and Hope  35:01 – Joe Rogan Feud  48:04 – Death, Immortality, Living to 180  56:24 – The Four F's Framework  1:04:55 – Cancer Prevention and Detection  1:18:20 – Travel Biohacking Tips  1:31:46 – Nothing You Can't Hack  1:41:23 – Peptides Deep Dive  1:52:33 – The Human Upgrade Podcast Starts  1:59:35 – Advice at Eighteen  2:10:03 – Fame and Holding Back  2:22:44 – Hormone Replacement Therapy  2:31:31 – Pursuit Over Happiness  2:43:02 – Advice for Tall Women  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    Scream Cream and Weekly Injections (Double Episode) | Gabby Reece
  8. 16 Aug

    It's Weird, But It Turns On Your Anti-Aging Switch

    Save Up To $600: SUNLIGHTEN.COM/DAVE Try TrueDark glasses: https://truedark.com Try Danger Coffee: https://dangercoffee.com/discount/davetube Try Suppgrade Labs: https://shopsuppgradelabs.com/ Most people see chronic fatigue and brain fog as permanent conditions caused by getting older, but this video cuts through that misconception by explaining that these symptoms are actually the direct result of damaged mitochondria piling up inside your cells because a specific longevity switch called mitophagy has been turned off. You'll also learn: Why mitophagy, not aging, controls fatigue and brain fogHow damaged mitochondria pile up when this switch turns offThe early signs your mitophagy switch is underperformingWhat actually flips mitophagy back on Try Danger Creatine: https://dangercoffee.com/products/danger-creatine Try TrueDark glasses: https://truedark.com Try Danger Coffee: https://dangercoffee.com/discount/davetube Try Suppgrade Labs: https://shopsuppgradelabs.com/ Thank you to our sponsors! PredictiveMind™ | Get your Brain Pattern Mapping report at predictivemind.io/dave and use code DAVE for 10% off.Viome | Check it out at viome.com and use code 16DAVE for 16% off. It’s time to stop guessing and start knowing your body.iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE Timestamps: 00:00 – The Longevity Switch 00:59 – Mitochondria: Power Plants 02:14 – What Is Mitophagy 04:05 – How Stress Blocks It 05:36 – Exercise Extremes 07:29 – NAD+ and Silent Damage 08:59 – Reversing It: Fasting 10:27 – REHIT and Cold Exposure 12:02 – The Supplement Stack Connect with Dave Asprey! Website: https://daveasprey.com TikTok: https://www.tiktok.com/@daveaspreyofficial Instagram: https://www.instagram.com/dave.asprey/ Facebook: https://www.facebook.com/Daveaspreyofficial/ X: https://x.com/daveasprey YouTube: https://www.youtube.com/c/daveaspreybpr The Human Upgrade Podcast: https://www.instagram.com/ TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/ Dave Asprey’s BEYOND Conference: https://beyondconference.com/ Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15 Upgrade Labs: https://upgradelabs.com 40 Years of Zen: https://40yearsofzen.com See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    It's Weird, But It Turns On Your Anti-Aging Switch

About

For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization. Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more. This isn’t just self-improvement - it’s human enhancement backed by data. Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life. Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.

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