PsyQ

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Kanal • 5 Sendungen

Medizin

Medizin

16. März
Wissenschaft

Wissenschaft

Wöchentlich
Medizin

Medizin

22.06.2025
Medizin

Medizin

30.06.2025
Medizin

Medizin

22.06.2025

30.06.2025

Chapter 15 - Psychosis

This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit upathak.substack.com

30.06.2025

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21 Min.
02.09.2025

Managing Racist Patient Behavior in Psychiatric Settings - PsyQ Episode 18

How should psychiatrists respond when patients use racist language or refuse care based on a clinician’s identity? In this episode, we translate the NEJM five-factor framework into psychiatry’s day-to-day reality—balancing EMTALA obligations and patient autonomy with Title VII protections and clinician well-being—and turn it into practical playbooks for the ED, inpatient units, and clinic. We cover rapid triage in emergencies, capacity and intent assessment (illness-driven vs. bigotry), boundary-setting scripts, when (and when not) to accommodate, safe transfer options, documentation, debriefing, and institution-level policies (codes of conduct, bystander support, reporting pathways). Pearls focus on protecting staff while ensuring care, distinguishing culturally appropriate concordance from prejudice, and leading post-incident team recovery—so trainees can respond clearly, ethically, and confidently. This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit upathak.substack.com

02.09.2025

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24 Min.
15.06.2025

Focused Ultrasound and the Future of Mood Disorders - PsyQ Episode 8

This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit upathak.substack.com

15.06.2025

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19 Min.
30.06.2025

The Bipolar Blueprint: Translating Genetic Discoveries into Clinical Care - PsyQ Episode 9

We dive into two landmark studies that have dramatically expanded the genetic map of bipolar disorder, identifying nearly 300 risk loci from over 150,000 patients. We explore the game-changing discovery of the AKAP11 gene, which provides a direct molecular link to lithium's mechanism, and unpack the complex genetic architecture that both unites and separates bipolar disorder from schizophrenia and its own subtypes. Finally, we translate these complex findings into clinical practice, discussing the current role of pharmacogenetic testing, how to counsel families about genetic risk, and what the future of precision psychiatry for bipolar disorder might look like. Sources: Mullins, N. et al. (2021). Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology. Nature Genetics, 53, 817-829. O'Connell, K.S. et al. (2025). Genomics yields biological and phenotypic insights into bipolar disorder. Nature, 639, 968-975. This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit upathak.substack.com

30.06.2025

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18 Min.
11.08.2025

The Dopamine Dialogues: Combining D2 Full and Partial Agonists - PsyQ Episode 15

Combining aripiprazole and haloperidol presents a clinical and pharmacological puzzle. On one hand, you have haloperidol, a potent D₂ antagonist that fully blocks dopamine; on the other, aripiprazole, a partial agonist with high affinity that displaces the antagonist only to provide a weaker signal. This interplay can be dangerous, potentially triggering a "dopamine supersensitivity psychosis" in a brain already adapted to chronic blockade, leading to a sudden worsening of symptoms. Yet, this same mechanism can be harnessed to treat stubborn side effects like hyperprolactinemia, making it a tempting strategy. In this episode of PsyQ, we dissect the competing pharmacology, review the conflicting case literature—from successful augmentation to severe relapse—and provide evidence-based, practical guidance on how to navigate this combination. Join us for a deep dive into this double-edged sword of psychopharmacology, equipping you with the knowledge to proceed with caution and confidence. This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit upathak.substack.com

11.08.2025

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15 Min.
29.09.2025

Profit Over Patients: Private Equity in Psychiatry - PsyQ Episode 22

In this episode, we dissect the alarming 75.6% rise in private equity (PE) ownership of US psychiatric hospitals and unpack the central paradox from a landmark 2025 JAMA Psychiatry study: how do these facilities operate with significantly fewer nurses and social workers, yet report better outcomes on official quality metrics like restraint use and readmissions? We deconstruct this quality illusion, revealing how self-reported data, administrative gaming, and the strategic "cream-skimming" of less-ill patients can mask the erosion of care. Drawing stark warnings from the devastating impact of PE in other sectors—where the model is linked to increased patient mortality—we provide a critical guide for clinicians to navigate a healthcare landscape where the pursuit of profit often conflicts with the mission of healing. This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit upathak.substack.com

29.09.2025

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17 Min.
15.09.2025

The CATIE-AD Trial: A Cognitive Cost for Calm? - PsyQ Episode 20

This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit upathak.substack.com

15.09.2025

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19 Min.
30.06.2025

Chapter 11 - Novel Drug Therapeutics

This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit upathak.substack.com

30.06.2025

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25 Min.
02.06.2025

ADHD Treatment Over the Long Term: The MTA Study - PsyQ Episode 6

In this episode we explore the landmark MTA study, unraveling its insights into ADHD treatment from childhood to adulthood. We'll cover the initial trial's findings on medication and combined therapy, then trace how these effects evolved, highlighting the surprising persistence of impairment compared to peers and the nuanced impact of long-term stimulant use on height versus symptoms. This episode offers essential clinical pearls, emphasizing individualized, quality care, the chronic nature of ADHD, and the importance of addressing comorbidities. Studies Referenced in this Episode: The MTA at 8 Years: Prospective Follow-Up of Children Treated for Combined Type ADHD in a Multisite Study Multimodal Interventions Are More Effective in Improving Core Symptoms in Children With ADHD A 14-Month Randomized Clinical Trial of Treatment Strategies for Attention-Deficit/Hyperactivity Disorder Young adult outcomes in the follow-up of the Multimodal Treatment Study of Attention-Deficit/Hyperactivity Disorder: symptom persistence, source discrepancy and height Suppression This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit upathak.substack.com

02.06.2025

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26 Min.
22.06.2025

Chapter 15 - Sleep

This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit upathak.substack.com

22.06.2025

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39 Min.

This is a channel featuring multiple psychiatric knowledge podcasts for trainees and clinicians. Content is AI generated, please consult original literature for the most up to date and accurate information. This content is for educational purposes only and is in no way commercialized.