Bench Boost by Inorganic Ventures

Inorganic Ventures

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Join our host and Inorganic Ventures Technical Director, Mike Booth, as he sparks insightful conversations with our panel of experts in Bench Boost, your go-to podcast for analytical chemistry enthusiasts. Together, they explore the realm of ICP, sharing tips and tricks and diving deep into all things analytical chemistry.

vor 1 Tag

CCVs & ICVs

Send us Fan Mail This week on Bench Boost Mike explains two key ICP-OES/ICP-MS quality control samples: the Initial Calibration Verification (ICV) and Continuing Calibration Verification (CCV). The ICV is run after calibration and before samples to confirm the calibration worked. The CCV is run periodically during the batch to confirm the calibration remains valid as drift, clogging, cone buildup, washout, or other issues occur. This episode concludes with reviewing how to troubleshoot ICV or CCV failures.

9 Min.
9. Juni

Elevated ICP-OES Backgrounds

Send us Fan Mail This week Mike discusses elevated backgrounds in ICP-OES when analyzing high total dissolved solids (TDS) samples such as brines, digests, excipients, salts, and starting materials. TDS increases free electron density in the plasma, producing Bremsstrahlung (braking) radiation and recombination radiation, which raise a broad continuum background across the spectrum. The elevated background degrades signal-to-noise, increases blank standard deviation, and worsens detection limits, especially for elements with poor ICP-OES sensitivity. Mitigation approaches include dilution, matrix-matched calibration or standard additions when dilution isn’t feasible.

9 Min.
2. Juni

Conductivity Tips and Tricks

Send us Fan Mail Join Mike this week on Bench Boost as he explores the basics of conductivity measurements. We review the theory of how conductivity is dependent on ion concentration, charge, and mobility. He describes how contact probes work, emphasizing the cell constant and how proper probe selection to avoid poor sensitivity or signal saturation. Temperature is highlighted as a major variable, often ~2–3% per °C. Lastly we cover calibration using NIST-traceable KCl standards, and how calibrating near the sample range and controlling errors can lead to accurate and reliable data.

9 Min.
26. Mai

Titrations and USP 541

Send us Fan Mail This week on Bench Boost we discuss titration techniques based on USP 541 and the Inorganic Venture's Titration Tips and Tricks guide. Mike explains the difference between equivalence point and observed endpoint and how key performance factors can include using the correct glassware, appropriate techniques, and thorough cleaning of burettes. We also cover the correct way to read a meniscus, and how optimizing sample size can prevent poor replicate agreement and high result variability.

11 Min.
20. Mai

pH and USP 791

Send us Fan Mail This week on Bench Boost Mike explains why accurate pH measurement is more complex than it appears, highlighting the effects from temperature, ionic strength, calibration technique, probe condition, and sample chemistry. He reviews pH theory of hydrogen ion activity (not just concentration) and the logarithmic meaning of pH changes, then describes how a pH probe functions as an electrochemical cell. He details temperature impacts on solution pH and electrode response (Nernst slope), notes automatic temperature compensation limits, summarizes USP calibration buffers and allowable uncertainty.

11 Min.
13. Mai

Common Tips for Analyzing Low Concentrations

Send us Fan Mail This week on Bench Boost Mike shares practical tips for analyzing pharmaceutical samples at low concentrations for USP 232 elemental impurities, emphasizing that high dilution makes small contamination or carryover issues critical. He advises minimizing contamination through careful container selection (avoiding glass and using acid-leached LDPE or leached polypropylene), and outlines a typical leaching process using dilute nitric acid for seven days. He also stresses using high-purity acids (ppb/ppt grade) and method blanks to monitor impurities. For trace measurements, he recommends tightening calibration ranges with more points near the LOD/LOQ, managing washout by running blanks before/after calibration and throughout batches, using appropriate internal standards to correct drift or suppression, recalibrating about every 20 samples, and understanding signal-to-noise requirements for LOD and LOQ.

11 Min.
5. Mai

The J Value

Send us Fan Mail This week Mike and Ashley explain the J value used in pharmaceutical elemental impurity testing to relate typical ICP concentration units to permitted daily exposure (PDE) limits reported in micrograms per day under USP and ICH Q3D. They describe how J value accounts for both sample dilution factor and maximum daily dose, making results comparable to PDE requirements. They recommend preparing method standards at PDE limits for the relevant administration route and diluting to match the J calculation for method validation.

7 Min.
28. Apr.

Pharma Elemental Analysis Overview

Send us Fan Mail This week Mike & Ashley review the standardized methods for elemental impurity analysis in pharmaceuticals: ICH Q3D, USP , and USP . ICH Q3D provides guidelines for testing up to 24 elements and emphasizes risk assessment but not detailed testing calculations; USP sets elemental impurity limits; and USP addresses sample preparation and analysis and relies on ICH Q3D concepts such as “J” concentrations (to be covered next week). They explain risk assessment factors (element, route of administration, intentional addition, and screened materials) and outline element classes. They also discuss sample types (APIs, drug products, excipients) and how early screening can reduce final testing needs.

8 Min.

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Join our host and Inorganic Ventures Technical Director, Mike Booth, as he sparks insightful conversations with our panel of experts in Bench Boost, your go-to podcast for analytical chemistry enthusiasts. Together, they explore the realm of ICP, sharing tips and tricks and diving deep into all things analytical chemistry.

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Inorganic Ventures
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2023 - 2026
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Bench Boost by Inorganic Ventures