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Dementia Researcher

A biweekly podcast for early career researchers, bringing together fantastic guests to discuss their research, careers + much more. Dedicated to sharing the science, encouraging collaborations, attracting more people to the field of Alzheimer's and other dementias research, and supporting those already here to succeed. Brought to you by https://www.dementiaresearcher.nihr.ac.uk at University College London, in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia - everything you need, all in one place. supporting early career researchers across the world Register today to recieve weekly bulletins, with news, funding opportunities, jobs, and events.

  1. The B-Sides - Dr Carla Abdelnour

    vor 10 Std. • Nur Abonnent:innen

    The B-Sides - Dr Carla Abdelnour

    Same researchers, different track. The B Sides is the bonus series from Dementia Researcher, available exclusively for our YouTube and Apple Podcasts subscribers. Recorded alongside our main episodes, these shows provide a more personal conversation about the twists, motivations, habits, and moments that shape a life in research. In this episode, Adam Smith is joined by Dr Carla Abdelnour, fresh from recording our main ISTAART Relay discussion on the Clinical Trials Advancement and Methods PIA. In this B-Sides conversation, Carla reflects on the curiosity that first drew her towards biology, neurology and the brain, and how working with patients continues to shape the questions she asks as a researcher. She talks about joining the European Dementia with Lewy Bodies Consortium, the value of being in the right place at the right time, and why patient conversations are such a rich source of research ideas. Carla also shares her love of music, fashion and fabric, before recalling a powerful experience as a medical student in Venezuela that still motivates her to do work that feels meaningful for society. -- Follow us on social media: https://www.instagram.com/dementia_researcher/ https://www.facebook.com/Dementia.Researcher/ https://www.twitter.com/demrescommunity https://www.linkedin.com/company/dementia-researcher https://bsky.app/profile/dementiaresearcher.bsky.social -- Download and Register with our Community App: https://www.onelink.to/dementiaresearcher Leave us a tip: https://dementia-researcher.captivate.fm/support

    27 Min.
  2. Relay Podcast - Clinical Trials Advancement and Methods PIA 2026

    vor 1 Tag ·  Video

    Relay Podcast - Clinical Trials Advancement and Methods PIA 2026

    Welcome to the seventh season of the Dementia Researcher X ISTAART PIA Relay Podcast. Across six episodes, leading early career and senior researchers hand the mic from one ISTAART PIA to the next, giving you an honest, peer-to-peer tour of where dementia research is actually heading, from wearables and biomarkers to policy and trial design, in the run-up to AAIC. Series closer, and the relay comes full circle: Carla Abdelnour, who hosted episode one, returns as the guest. Carla is a clinician scientist in Barcelona and incoming Chair of the ISTAART Clinical Trials Advancement and Methods PIA, working on mixed neurodegenerative disease, particularly Lewy body and Alzheimer's pathology together. With host Sindhuja Tirumalai Govindarajan she explains why co-pathology is so common and what it means for treatment: does someone with both alpha-synuclein and Alzheimer's pathology respond to an anti-amyloid drug the same way as someone without? They discuss why she leans on fluid biomarkers, the wish for a synuclein PET tracer, and how trials might stratify or include people by co-pathology. Carla makes a useful point for anyone designing research, that clinical trial methods translate straight to observational studies, and previews the CTAM PIA's AAIC programme, including a panel and featured session on global representation in trials. Takeaways Mixed pathology is common, and co-occurring alpha-synuclein and Alzheimer's pathology may change how people respond to treatment.Trials could stratify or include people by co-pathology, but alpha-synuclein is currently detectable only in CSF, which limits that.Fluid biomarkers offer the specificity to track different proteinopathies and, potentially, response to treatment.Clinical trial design transfers straight to observational research: the same inclusion criteria, outcomes and sample-size thinking.Global representation in trials is a live priority, with a CTAM panel launching at AAIC. -- The Alzheimer’s Association International Society to Advance Alzheimer’s Research and Treatment (ISTAART) convenes the global Alzheimer’s and dementia science community. Members share knowledge, fuel collaboration and advance research to find more effective ways to detect, treat and prevent Alzheimer’s and other dementias. Professional Interest Areas (PIA) are an assembly of ISTAART members with common subspecialties or interests. There are currently 30 PIAs covering a wide range of interests and fields, from Neuroimaging to Diversity and Disparities and everything in between. Find out more at https://istaart.alz.org/ -- A transcript of this show, links and show notes and profile on all our guests are available on our website at https://www.dementiaresearcher.nihr.ac.uk. If you prefer to watch rather than listen, you will find a video version of this podcast on Apple Podcasts, YouTube, and on our website. Leave us a tip: https://dementia-researcher.captivate.fm/support Follow us on social media: https://www.instagram.com/dementia_researcher/ https://www.facebook.com/Dementia.Researcher/https://www.twitter.com/demrescommunityhttps://www.linkedin.com/company/dementia-researcher https://bsky.app/profile/dementiaresearcher.bsky.social Download and Register with our Community App: https://www.onelink.to/dementiaresearcher We gratefully acknowledge the support of our funders: Alzheimer’s Association, Race Against Dementia, Alzheimer’s Research UK, Alzheimer’s Society, and the National Institute for Health and Care Research. The views and opinions expressed by guests in this podcast are their own and do not necessarily reflect those of the producers, funders, or sponsors. Subscribe to our sister show 'Dementia Researcher The Blogs': https://podfollow.com/dementia-researcher-blogs

    33 Min.
  3. The B-Sides - Dr Sindhuja Govindarajan

    vor 1 Tag • Nur Abonnent:innen

    The B-Sides - Dr Sindhuja Govindarajan

    Same researchers, different track. The B Sides is the bonus series from Dementia Researcher, available exclusively for our YouTube and Apple Podcasts subscribers. Recorded alongside our main episodes, these shows provide a more personal conversation about the twists, motivations, habits, and moments that shape a life in research. In this episode, Adam Smith is joined by Dr Sindhuja Govindarajan, fresh from recording our main ISTAART Relay podcast. In this B-Sides conversation, Sindhuja reflects on the winding route that took her from biomedical engineering into neuroimaging, brain health and dementia research. She talks about learning to handle difficult feedback, the conference conversations that helped her think differently about sharing science, and how research careers often look very different from the outside than they do once you are living them. Sindhuja also shares why researchers should not wait for a perfect moment to build a life beyond work, and recalls the advice that helped her recognise the value of the skills she already had. -- Follow us on social media: https://www.instagram.com/dementia_researcher/ https://www.facebook.com/Dementia.Researcher/ https://www.twitter.com/demrescommunity https://www.linkedin.com/company/dementia-researcher https://bsky.app/profile/dementiaresearcher.bsky.social -- Download and Register with our Community App: https://www.onelink.to/dementiaresearcher Leave us a tip: https://dementia-researcher.captivate.fm/support

    38 Min.
  4. Relay Podcast - PIA to Elevate Early Career Researchers

    vor 2 Tagen ·  Video

    Relay Podcast - PIA to Elevate Early Career Researchers

    Welcome to the seventh season of the Dementia Researcher X ISTAART PIA Relay Podcast. Across six episodes, leading early career and senior researchers hand the mic from one ISTAART PIA to the next, giving you an honest, peer-to-peer tour of where dementia research is actually heading, from wearables and biomarkers to policy and trial design, in the run-up to AAIC. Most people with hypertension after 50 never develop dementia, so what separates those who do? That is the question driving Dr Sindhuja Tirumalai Govindarajan, a neuroimaging researcher and outgoing Chair of the ISTAART PEERs PIA, recorded as she moves from a postdoc at the University of Pennsylvania to an assistant professorship at the Karolinska Institute. With host Dr Joe Kane she explains how machine learning on tens of thousands of MRI scans can pick up subtle brain changes years before symptoms, and why scans from different scanners have to be harmonised first. The conversation then turns to PEERs itself, a PIA built not around one research area but around early career researchers everywhere, and the work of levelling opportunity across borders through local routes like Neuroscience Next, WYLD and INTERDEM Academy. Sindhuja runs through the PIA's AAIC workshops, from narrative CVs to social bingo for ECRs, and closes with practical advice on getting people involved: make the ask specific. Takeaways Machine learning on large MRI datasets can detect brain changes years before any cognitive symptoms show.Scans from different scanners must be harmonised first, stripping out machine noise so only the biology remains.PEERs exists to level opportunity for early career researchers wherever they are, across every research area.Local routes such as Neuroscience Next, WYLD and INTERDEM Academy widen access for those who cannot get to the big conference.Interest among ECRs is common but clarity often is not, so make the ask specific and people will step up. -- The Alzheimer’s Association International Society to Advance Alzheimer’s Research and Treatment (ISTAART) convenes the global Alzheimer’s and dementia science community. Members share knowledge, fuel collaboration and advance research to find more effective ways to detect, treat and prevent Alzheimer’s and other dementias. Professional Interest Areas (PIA) are an assembly of ISTAART members with common subspecialties or interests. There are currently 30 PIAs covering a wide range of interests and fields, from Neuroimaging to Diversity and Disparities and everything in between. Find out more at https://istaart.alz.org/ -- A transcript of this show, links and show notes and profile on all our guests are available on our website at https://www.dementiaresearcher.nihr.ac.uk. If you prefer to watch rather than listen, you will find a video version of this podcast on Apple Podcasts, YouTube, and on our website. Leave us a tip: https://dementia-researcher.captivate.fm/support Follow us on social media: https://www.instagram.com/dementia_researcher/ https://www.facebook.com/Dementia.Researcher/https://www.twitter.com/demrescommunityhttps://www.linkedin.com/company/dementia-researcher https://bsky.app/profile/dementiaresearcher.bsky.social Download and Register with our Community App: https://www.onelink.to/dementiaresearcher We gratefully acknowledge the support of our funders: Alzheimer’s Association, Race Against Dementia, Alzheimer’s Research UK, Alzheimer’s Society, and the National Institute for Health and Care Research. The views and opinions expressed by guests in this podcast are their own and do not necessarily reflect those of the producers, funders, or sponsors. Subscribe to our sister show 'Dementia Researcher The Blogs': https://podfollow.com/dementia-researcher-blogs

    33 Min.
  5. The B-Sides - Dr Joe Kane

    vor 2 Tagen • Nur Abonnent:innen

    The B-Sides - Dr Joe Kane

    Same researchers, different track. The B Sides is the bonus series from Dementia Researcher, available exclusively for our YouTube and Apple Podcasts subscribers. Recorded alongside our main episodes, these shows provide a more personal conversation about the twists, motivations, habits, and moments that shape a life in research. In this episode, Adam Smith is joined by Dr Joe Kane, fresh from recording our main ISTAART Relay discussion on Lewy body dementia. In this B-Sides conversation, Joe reflects on how he “meandered” into a clinical academic career, balancing psychiatry, research and the patient stories that keep him connected to the work. He talks about the guilt and privilege that can come with stepping between clinical practice and research, the value of asking questions and reaching out to corresponding authors, and a collaboration that began with a simple email about prescribing trends in Northern Ireland. Joe also shares the working habit he has had to rethink — late-night productivity — and recalls an early Lewy body dementia conference moment that nearly sent him home, but instead helped him see the kind of researcher he wanted to become. -- Follow us on social media: https://www.instagram.com/dementia_researcher/ https://www.facebook.com/Dementia.Researcher/ https://www.twitter.com/demrescommunity https://www.linkedin.com/company/dementia-researcher https://bsky.app/profile/dementiaresearcher.bsky.social -- Download and Register with our Community App: https://www.onelink.to/dementiaresearcher Leave us a tip: https://dementia-researcher.captivate.fm/support

    32 Min.
  6. Relay Podcast - Lewy Body Dementias PIA

    vor 3 Tagen ·  Video

    Relay Podcast - Lewy Body Dementias PIA

    Welcome to the seventh season of the Dementia Researcher X ISTAART PIA Relay Podcast. Across six episodes, leading early career and senior researchers hand the mic from one ISTAART PIA to the next, giving you an honest, peer-to-peer tour of where dementia research is actually heading, from wearables and biomarkers to policy and trial design, in the run-up to AAIC. Lewy body pathology shows up in roughly 30% of the brains of people who had dementia, yet it gets diagnosed in only about 5% of cases. Closing that gap has shaped much of Dr Joe Kane's career. Joe is a geriatric psychiatrist at Queen's University Belfast and outgoing Chair of the ISTAART Lewy Body Dementias PIA, and with host Dr Patrick Lao he traces his work from the Diamond Lewy programme to consensus diagnostic guidelines built by Delphi process. They discuss the symptoms clinicians often miss because they don't think to ask, from constipation to loss of smell, the cardiac scans and seed amplification assays now detecting pathology in CSF and even skin, and the TOP HAT trial repurposing an anti-sickness drug for hallucinations. Joe makes the case for a Lewy body specific rating scale, explains why the prodrome may be psychiatric or delirium rather than cognitive, and runs through the PIA's biggest AAIC programme in years, including a PIA Day panel on seed amplification assays. Takeaways Lewy body dementia is heavily underdiagnosed: pathology appears in about 30% of brains but is diagnosed in around 5%.Much of the disease shows outside the brain, in constipation, blood pressure and smell, so it gets missed if nobody asks.Seed amplification assays, now usable on CSF and even a small skin biopsy, are changing how the pathology is detected.Trials can fail on the wrong yardstick, which is why the PIA is building a Lewy body specific rating scale.The prodrome is not only cognitive; the first sign can be depression, psychosis or delirium, and those gaps need data. -- The Alzheimer’s Association International Society to Advance Alzheimer’s Research and Treatment (ISTAART) convenes the global Alzheimer’s and dementia science community. Members share knowledge, fuel collaboration and advance research to find more effective ways to detect, treat and prevent Alzheimer’s and other dementias. Professional Interest Areas (PIA) are an assembly of ISTAART members with common subspecialties or interests. There are currently 30 PIAs covering a wide range of interests and fields, from Neuroimaging to Diversity and Disparities and everything in between. Find out more at https://istaart.alz.org/ -- A transcript of this show, links and show notes and profile on all our guests are available on our website at https://www.dementiaresearcher.nihr.ac.uk. If you prefer to watch rather than listen, you will find a video version of this podcast on Apple Podcasts, YouTube, and on our website. Leave us a tip: https://dementia-researcher.captivate.fm/support Follow us on social media: https://www.instagram.com/dementia_researcher/ https://www.facebook.com/Dementia.Researcher/https://www.twitter.com/demrescommunityhttps://www.linkedin.com/company/dementia-researcher https://bsky.app/profile/dementiaresearcher.bsky.social Download and Register with our Community App: https://www.onelink.to/dementiaresearcher We gratefully acknowledge the support of our funders: Alzheimer’s Association, Race Against Dementia, Alzheimer’s Research UK, Alzheimer’s Society, and the National Institute for Health and Care Research. The views and opinions expressed by guests in this podcast are their own and do not necessarily reflect those of the producers, funders, or sponsors. Subscribe to our sister show 'Dementia Researcher The Blogs': https://podfollow.com/dementia-researcher-blogs

    37 Min.
  7. The B-Sides - Dr Patrick Lao

    vor 3 Tagen • Nur Abonnent:innen

    The B-Sides - Dr Patrick Lao

    Same researchers, different track. The B Sides is the bonus series from Dementia Researcher, available exclusively for our YouTube and Apple Podcasts subscribers. Recorded alongside our main episodes, these shows provide a more personal conversation about the twists, motivations, habits, and moments that shape a life in research. In this episode, Adam Smith is joined by Dr Patrick Lao, fresh from recording our main ISTAART Relay discussion on the Down Syndrome and Alzheimer’s Disease PIA. In this B-Sides conversation, Patrick reflects on how his path from biology and physics into medical physics, neuroimaging and Alzheimer’s research was shaped by curiosity, timing and a growing sense of purpose. He talks about the mentor advice that stayed with him before a major AAIC presentation, why some of his best ideas arrive on his commute, and the challenge of explaining a research career that spans biomarkers, brain imaging, vascular disease, Alzheimer’s and Down syndrome. Patrick also shares a very memorable conference networking mix-up involving the WRAP study, rap music, and an elevator conversation he has never quite forgotten. -- Follow us on social media: https://www.instagram.com/dementia_researcher/ https://www.facebook.com/Dementia.Researcher/ https://www.twitter.com/demrescommunity https://www.linkedin.com/company/dementia-researcher https://bsky.app/profile/dementiaresearcher.bsky.social -- Download and Register with our Community App: https://www.onelink.to/dementiaresearcher Leave us a tip: https://dementia-researcher.captivate.fm/support

    22 Min.
  8. Relay Podcast - Down Syndrome and Alzheimer's Disease PIA

    vor 4 Tagen ·  Video

    Relay Podcast - Down Syndrome and Alzheimer's Disease PIA

    Welcome to the seventh season of the Dementia Researcher X ISTAART PIA Relay Podcast. Across six episodes, leading early career and senior researchers hand the mic from one ISTAART PIA to the next, giving you an honest, peer-to-peer tour of where dementia research is actually heading, from wearables and biomarkers to policy and trial design, in the run-up to AAIC. Almost everyone born with Down syndrome overproduces the amyloid precursor protein from birth, which makes it one of the clearest natural windows we have into how Alzheimer's begins. Dr Patrick Lao, Assistant Professor at Columbia and Programmes Chair of the ISTAART Down Syndrome and Alzheimer's Disease PIA, comes from a medical physics background and uses multimodal neuroimaging to map the disease across its genetic and sporadic forms. With host Lillian Morgado, he explains amyloid and tau PET, Thal phases and Braak staging, and how chronological age can stand in for disease stage in this population, with a typical symptom onset around 54. They talk about why people with Down syndrome were long left out of anti-amyloid trials and how that is now changing, and the risk and resilience research asking why some people fall off the expected timeline. Patrick also previews the PIA's AAIC PIA Day session on returning results, plus the separate DSAD/ADAD conference coming to London next year. Takeaways Genetic forms of Alzheimer's, including Down syndrome, let researchers study the earliest disease pathways before symptoms appear.In Down syndrome, chronological age can approximate disease stage, with symptoms typically expected around age 54.Imaging shows where amyloid and tau sit in the brain, the spatial detail a blood test cannot give.People with Down syndrome were historically excluded from anti-amyloid trials; that is shifting, with a lecanemab safety extension now underway.Not everyone follows the population timeline, and risk and resilience work asks what pushes onset earlier or later. -- The Alzheimer’s Association International Society to Advance Alzheimer’s Research and Treatment (ISTAART) convenes the global Alzheimer’s and dementia science community. Members share knowledge, fuel collaboration and advance research to find more effective ways to detect, treat and prevent Alzheimer’s and other dementias. Professional Interest Areas (PIA) are an assembly of ISTAART members with common subspecialties or interests. There are currently 30 PIAs covering a wide range of interests and fields, from Neuroimaging to Diversity and Disparities and everything in between. Find out more at https://istaart.alz.org/ -- A transcript of this show, links and show notes and profile on all our guests are available on our website at https://www.dementiaresearcher.nihr.ac.uk. If you prefer to watch rather than listen, you will find a video version of this podcast on Apple Podcasts, YouTube, and on our website. Leave us a tip: https://dementia-researcher.captivate.fm/support Follow us on social media: https://www.instagram.com/dementia_researcher/ https://www.facebook.com/Dementia.Researcher/https://www.twitter.com/demrescommunityhttps://www.linkedin.com/company/dementia-researcher https://bsky.app/profile/dementiaresearcher.bsky.social Download and Register with our Community App: https://www.onelink.to/dementiaresearcher We gratefully acknowledge the support of our funders: Alzheimer’s Association, Race Against Dementia, Alzheimer’s Research UK, Alzheimer’s Society, and the National Institute for Health and Care Research. The views and opinions expressed by guests in this podcast are their own and do not necessarily reflect those of the producers, funders, or sponsors. Subscribe to our sister show 'Dementia Researcher The Blogs': https://podfollow.com/dementia-researcher-blogs

    32 Min.
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A biweekly podcast for early career researchers, bringing together fantastic guests to discuss their research, careers + much more. Dedicated to sharing the science, encouraging collaborations, attracting more people to the field of Alzheimer's and other dementias research, and supporting those already here to succeed. Brought to you by https://www.dementiaresearcher.nihr.ac.uk at University College London, in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia - everything you need, all in one place. supporting early career researchers across the world Register today to recieve weekly bulletins, with news, funding opportunities, jobs, and events.

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