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The Life Scientific

Professor Jim Al-Khalili talks to leading scientists about their life and work, finding out what inspires and motivates them and asking what their discoveries might do for us in the future

  1. 7 AVR. • ACCÈS ANTICIPÉ POUR LES PERSONNES ABONNÉES

    Jim Ashworth-Beaumont on how a near-fatal accident made him a better clinician

    It's a rare thing to encounter a medical specialist who has experience of his field from the expert and the patient perspective - but not unheard of... Jim Ashworth-Beaumont is an orthotist and prosthetist who spent years helping people adapt to life with artificial limbs and musculoskeletal supports, before a near-fatal accident left him relying on both. This twist of fate might have derailed many - but Jim drew on reserves of resilience and determination forged long before his accident; initially in the army, then by returning to education to earn the qualifications he missed out on as a youngster. He put himself through night school before earning a place to study Prosthetics and Orthotics at the University of Strathclyde. Later, while working at London’s Royal National Orthopaedic Hospital, Jim completed a Master’s in Neurorehabilitation, and a PhD in Health Studies – driven by a fascination with how the human body adapts under pressure. But in 2020, while training for a triathlon, Jim was involved in a catastrophic cycling accident that nearly killed him - and cost him an arm. He tells Jim Al-Khalili how the incident gave him a whole new insight into his patients’ experience and made him more determined than ever to achieve his goals. Presented by Jim Al-Khalili Produced by Lucy Taylor A BBC Studios production for Radio 4

    28 min
  2. 09/12/2025

    Pierre Friedlingstein on carbon’s pivotal role in climate change

    The COP30 climate summit is taking place in the Brazilian city of Belém, a gateway to the Amazon rainforest, which continues to face widespread deforestation. We all know that our climate is changing and that we are largely responsible for this, but we can’t tackle the problem unless we understand what’s going on. One scientist who’s done more than most to rectify this is Professor Pierre Friedlingstein. He’s a prominent climate scientist and Chair in Mathematical Modelling of the Climate System at Exeter University. His models have transformed our understanding of climate change, revealing a complex dynamical system with carbon at its centre, cycling between the atmosphere, oceans and land, to directly influence the level of carbon dioxide in the atmosphere. Pierre is actively involved in assessing the state of our climate through the Intergovernmental Panel on Climate Change and, as director of the Global Carbon Budget, estimates the remaining amount of carbon dioxide that can be emitted before we breach our global climate targets. It’s the ultimate test of effective climate action and the latest annual update will be released at COP. Pierre explains how we can all play our part to reduce carbon emissions, and he practises what he preaches - he won’t be flying to COP this year so as to minimise his own carbon footprint. Presented by Jim Al-Khalili Produced by Beth Eastwood Executive Producer: Alexandra Feachem A BBC Studios Production

    28 min
  3. 18/11/2025

    AP De Silva on building molecular fluorescence sensors for healthcare

    From humble beginnings in his native Sri Lanka, to a more than 40 year academic career at Queen’s University Belfast, Prof. AP (Amilra Prasanna) De Silva’s research into molecular photosensors has led to a pioneering career in that’s evolved from chemistry to medical diagnostics on one hand, to information processing on the other. Prof. De Silva challenged cultural expectations and overcame the lack of opportunities in chemistry that were available in Sri Lanka in the early 1970s. He first moved to Belfast to pursue research in photochemistry at Queen’s University. Inspired by his grandmother’s struggle with high blood pressure he engineered a unique sodium photosensor by marrying fluorescent molecules with chemical receptors. As a result of his international collaborations, a commercial, portable sensor was developed to detect salts and minerals in the blood. Its speed of analysis has since saved countless lives and improved healthcare around the world. AP talks to Jim Al-Khalili about his passion for engineering molecules and how his photochemical innovations have since crossed into computer science. They’ve been developed to perform molecular computations far inside the human body - where silicon microchips fear to tread. A new deeper understanding of life inside our tissues and cells beckons. Presented by Jim Al-Khalili Produced by Adrian Washbourne Executive Producer: Alexandra Feachem A BBC Studios Production

    28 min

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Professor Jim Al-Khalili talks to leading scientists about their life and work, finding out what inspires and motivates them and asking what their discoveries might do for us in the future

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