59 episodios

Promoting strategies to increase healthspan, well-being, cognitive and physical performance through deeper understandings of biology.

FoundMyFitness Rhonda Patrick, Ph.D.

    • Medicina
    • 5.0 • 2 valoraciones

Promoting strategies to increase healthspan, well-being, cognitive and physical performance through deeper understandings of biology.

    Dr. Steve Horvath on epigenetic aging to predict healthspan: the DNA PhenoAge and GrimAge clocks

    Dr. Steve Horvath on epigenetic aging to predict healthspan: the DNA PhenoAge and GrimAge clocks

    Consistent patterns of age-based alterations in DNA methylation can be harnessed to estimate age, serving as a sort of "clock," the premise of which is truly remarkable: Predict a person's age (or even lifespan), based on chemical modifications to their DNA that reflect the biological life history of the organism. Dr. Steve Horvath has analyzed large data sets of DNA methylation profiles to derive an algorithm that accurately predicts a person's chronological age across multiple cells, tissues, and organs, and even mammalian species. He built on this algorithm to develop second-generation clocks that could predict time-to-death among people of the same chronological age, as well as lifespan and healthspan.
    In this episode, Dr. Steven Horvath describes epigenetic clocks and their role in predicting – and possibly slowing – aging.
    Get this show's notes, timeline, and transcript: https://www.foundmyfitness.com/episodes/steve-horvath
    Dr. Horvath's faculty bio page: https://ph.ucla.edu/faculty/horvath
    Dr. Horvath's Wikipedia page: https://en.wikipedia.org/wiki/Steve_Horvath
    Dr. Rhonda Patrick's 3-minute video crash course in epigenetics: https://www.foundmyfitness.com/episodes/epigenetic-clock
    The FoundMyFitness overview article of epigenetic clocks: https://www.foundmyfitness.com/topics/epigenetic-clocks

    • 1h 33 min
    Q&A with Dr. Jed Fahey on Sulforaphane, Moringa and Chemoprotection

    Q&A with Dr. Jed Fahey on Sulforaphane, Moringa and Chemoprotection

    In this special two-hour Q&A episode with Dr. Jed Fahey, a world-leading expert on the science of chemoprotection and, in particular, sulforaphane, we discuss many of the listener-submitted questions from the hundreds of live event participants.
    Get the full timeline and show notes.
    Listen to learn Dr. Fahey's thoughts on…
    00:07:19 - The minimum daily dose of sulforaphane that elicits beneficial health effects 00:12:04 - Why gauging the amount of sulforaphane in foods presents challenges 00:17:37 - Workarounds to enhance the sulforaphane in cooked foods 00:23:38 - How often to consume broccoli sprouts and how long their effects last 00:39:28 - The effects of sulforaphane on glutathione production in the brain 00:43:12 - The effects of sulforaphane on cancer 01:17:26 - Alternatives to sprouts, such as supplements (and which ones Dr. Fahey recommends) 01:33:08 - Safety concerns regarding sulforaphane In this episode, Dr. Fahey mentions the following companies, websites, and supplements:
    Brassica Protection Products Cullman Chemoprotection Center Crucera SGS® (Thorne) Oncoplex® (Xymogen) Avmacol® Vision Defense® (Swanson) MaxN-Fuze® MitoCORE® (Ortho Molecular Products) Extra resources
    Learn how to sprout at home safely by downloading the 15-page sprouting guide developed with Dr. Fahey.
    Sign-up to participate in the live every-single-month Q&A series by becoming a FoundMyFitness premium member.

    • 1h 56 min
    Dr. Giselle Petzinger on Exercise for Parkinson's Disease

    Dr. Giselle Petzinger on Exercise for Parkinson's Disease

    Giselle Petzinger, MD, an associate professor of Neurology at the University of Southern California and today’s guest, studies the extensive effects of how different types of exercise, in particular skill-based exercise, can affect the clinical outcome for people with Parkinson’s disease.
    Dr. Petzinger's work focuses on understanding how to promote brain repair after injury, particularly in the context of Parkinson's disease. She is currently investigating ways to enhance neuroplasticity in a preclinical model of the disease. She has examined the role of exercise in Parkinson's disease, with emphasis on how different types of exercise affect distinct regions of the brain. Her work has implications for improving the quality of life of patients diagnosed with the neurological disorder — a condition for which there is no cure.
    In this episode, we discuss...
    00:06:57 - What is Parkinson’s disease? 00:11:57 - How symptoms of Parkinson’s disease generally only appear when ~50% of dopamine-secreting neurons in substantia nigra are lost. 1 00:14:57 - How other circuits in the brain can compensate for the loss of function of the substantia nigra. 00:18:37 - Prevalence and hereditary risk factors of Parkinson’s disease. 00:21:25 - How epidemiological studies have linked increased Parkinson’s disease risk with exposure to pesticides, herbicides, solvents, and certain heavy metals such as manganese. 1 00:26:57 - How exercise can lower the risk of developing Parkinson’s disease. 1 2 3 00:35:38 - How skill-based exercise, such as yoga, Tai chi, boxing, tango or skateboarding may play a special role in ameliorating some of the effects of the disease by driving circuit-specific effects, by creating top-down cognitive challenge for skills involved in a patient's movement through space. 00:47:49 - How serum BDNF significantly increases in Parkinson’s patients after 1 month of treadmill exercise and why this might mean better cognitive function. 1 2 00:58:33 - How treadmill exercise with heart rate 80-85% maximum for at least 3x per week slowed the progression of Parkinson’s disease symptoms. 1 01:01:31 - Why exercise may not fully replace the use of medications. 01:09:58 - How the omega-3 fatty acid DHA has some preclinical evidence suggesting it may reduce motor-symptoms and dyskinesia in Parkinson’s disease. 1 2 3 4 01:12:12 - How patients with Parkinson’s disease have higher levels of inflammatory biomarkers and how this might contribute to the disease. 1 Click here to get this episode's show notes and transcript
    Get early access with the premium members early access podcast feed, monthly Q&A sessions, an exclusive bi-weekly science digest email, and more! Click here to get started.

    • 1h 18 min
    Aliquot #3: Q&A Mashup - Fasting

    Aliquot #3: Q&A Mashup - Fasting

    Get a sample of our new premium member's content, known as Aliquots, by listening to this in-depth Q&A mashup on Fasting.
    What's an aliquot, you may ask? Aliquots are special, curated segments prepared and distributed to premium members via the premium members podcast feed.
    This collection of clips covers a range of topics related to fasting, including associated mechanisms of healthspan and longevity, purported health benefits, and when and how to break the fast.
    Episode Highlights
    00:01:36 - Fasting mimicking diet, the ketogenic diet and autoimmune diseases
    00:13:42 - Spermidine is a fasting mimetic compound
    00:16:51 - Aerobic exercises in a fasting state induces autophagy quicker than in a fed state.
    00:25:15 - Intermittent fasting, prolonged fasting and healthspan. 00:28:02 - What we know about the minimal fasting time it takes to induce autophagy and apoptosis.
    00:33:35 - Comparing and contrasting a ketogenic diet with prolonged fasting.
    00:37:33 - Rhonda compares the rejuvenation effect of time-restricted eating vs prolonged fasting vs fasting mimicking diet.
    00:41:16 - Rhonda's thoughts on coffee breaking a fast.
    00:52:29 - Supplements and other medications outside of a time-restricted eating window.
    01:01:28 - Differences between a fasting-mimicking diet vs a water-only fast. Learn more about our premium podcast feed The Aliquot by clicking here.
    Learn more about premium membership benefits by clicking here.

    • 28 min
    Aliquot #2: Q&A Mashup - Sauna

    Aliquot #2: Q&A Mashup - Sauna

    Get a sample of our new premium member's content, known as Aliquots, by listening to this in-depth Q&A mashup on Sauna use.
    What's an aliquot, you may ask? Aliquots are special, curated segments prepared and distributed to premium members via the premium members podcast feed.
    This collection of clips covers some of the many health benefits associated with sauna use, including heat shock protein activation, cardiovascular health, muscle mass preservation, and more.
    Episode Highlights
    00:07:00 - What are the effects of sauna and hot baths on heat shock proteins and the immune system?
    00:16:14 - What are your recommendations for infrared sauna temperature and time?
    00:24:03 - At what temperature and how long do you need to stay in the sauna to activate heat shock proteins?
    00:26:50 - Does sauna use promote excretion of heavy metals such as arsenic? 00:29:12 - Are there ways of mimicking sauna use without regular access to a sauna?
    00:33:55 - If compounds such as metformin, resveratrol and vitamin E counteract exercise-induced hormesis, would this be true for other stressors such as the sauna, fasting, broccoli sprouts, polyphenols?
    00:37:06 - How does fasting affect human growth hormone and IGF-1 in respect to muscle mass?
    00:43:30 - Can saunas be used during fasting to preserve more muscle and increase fat burning?
    00:45:50 - Can saunas be used to treat headaches? Learn more about our premium podcast feed The Aliquot by clicking here.
    Learn more about premium membership benefits by clicking here.

    • 18 min
    Aliquot #1: Q&A Mashup - Pregnancy and child development

    Aliquot #1: Q&A Mashup - Pregnancy and child development

    Get a sample of our new premium member's content, known as Aliquots, by listening to this in-depth Q&A mashup on pregnancy and child development.
    What's an aliquot, you may ask? Aliquots are special, curated segments prepared and distributed to premium members via the premium members podcast feed.
    This particular collection of segments covers every single major discussion of pregnancy and child development spanning years of members-only Q&As.

    Just for a few examples, it covers...
    My pre-pregnancy regimen, including diet, exercise, vitamins and sleep Nutrition for babies and toddlers to maximize brain development and growth Extra precautions that I took during my pregnancy And much, much more! Learn more about our premium podcast feed The Aliquot by clicking here.
    Learn more about premium membership benefits by clicking here.

    • 24 min

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