Metascience Matters

Randy Ellis
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I'm Randy Ellis, a computational biologist and neuroscientist who cares about metascience, reproducibility, and rigor in science. I started Metascience Matters because I believe science communication can be improved across the board for all fields of science, but most especially for the field of science dedicated to studying science itself.

Episodios

  1. 23 ENE

    Esketamine for depression, registered reports, and alcohol use disorder | Metascience Matters #2

    Florian Naudet is a Professor of Therapeutics at Rennes University. As a metascientist and psychiatrist, his research interests lie in developing and evaluating methodological solutions to treatment assessment, primarily but not exclusively for mental health conditions. His work has also made inroads to quantifying and understanding research waste and the prevalence of substandard data-sharing practices. CONTACT RANDY: Feedback: metasciencematters@gmail.com EPISODE LINKS: Efficacy and safety of esketamine for “treatment resistant depression”: registered report for a systematic review with an individual patient data meta-analysis of randomized, double-blind, placebo-controlled trials https://link.springer.com/article/10.... Vibration of effects from diverse inclusion/exclusion criteria and analytical choices: 9216 different ways to perform an indirect comparison meta-analysis https://link.springer.com/article/10.... Pharmageddon (book) https://davidhealy.org/pharmageddon-i... A manifesto for reproducible science https://www.nature.com/articles/s4156... Using reporting guidelines to improve the reproducibility of cooking Christmas tree meringues: the “People tasting trees” cluster-randomised controlled trial https://pmc.ncbi.nlm.nih.gov/articles... OUTLINE: 0:00 - Introduction 0:36 - Florian's origin story as a psychiatrist and metascientist 4:46 - How Florian became interested in metascience 11:55 - Systematic review of clinical trials of Esketamine for depression 28:45 - Publishing this study as a registered report 40:49 - Vibration-of-effects analysis of double-blind randomized controlled trials assessing nalmefene and/or naltrexone for treating alcohol use disorders 59:58 - Advice for listeners interested in pursuing research like Florian's 1:03:38 - Outro

    1 h y 4 min

  2. 15/12/2025

    Exposomics, Vibration-of-Effects, and the Future of AI in Health | Metascience Matters #1

    Chirag Patel is an Associate Professor of Biomedical Informatics at Harvard Medical School, renowned for his expertise in using computational methods to understand human health and disease from high-throughput data streams. He specializes in understanding the role in the intersection of genetics and environmental exposures (the exposome) in human health, as well as various disease areas such as diabetes, cardiovascular disease, and Alzheimer’s disease. CONTACT RANDY: Feedback: metasciencematters@gmail.com EPISODE LINKS: Chirag’s Lab: https://www.chiragjpgroup.org/ TEDx talk on the exposome:    • Exposome: decoding human health and diseas...   OUTLINE: 0:00 - Introduction 0:37 - How do you decide what to work on? 1:57 - Where does metascience fit into your work? 3:57 - Vibration-of-effects analysis 6:41 - How does VoE change how we see existing scientific work? 9:22 - The biggest challenges in the replication crisis within biomedical informatics 11:48 - Environment-wide association study of Type 2 diabetes 15:04 - The exposome 17:30 - Policy vs. precision medicine applications of the exposome 20:09 - The patient exposome 22:38 - HBA1C for diabetes as a bridge to the exposome 23:54 - Broader metascientific issues of the exposome 25:01 - The effects of extreme weather events on human health 29:35 - AI for biomedical informatics, the exposome, metascience 31:19 - Advice for listeners interested in pursuing research like Chirag’s 32:53 - Outro

    33 min
  • 2 episodios

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I'm Randy Ellis, a computational biologist and neuroscientist who cares about metascience, reproducibility, and rigor in science. I started Metascience Matters because I believe science communication can be improved across the board for all fields of science, but most especially for the field of science dedicated to studying science itself.

Información

  • Creador
    Randy Ellis
  • Años de actividad
    2025 - 2026
  • Episodios
    2
  • Clasificación
    Apto
  • Copyright
    © Randy Ellis
  • Mostrar sitio web
    Metascience Matters