The Evidence Based Rheumatology Podcast

Michael Putman
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A weekly podcast for physicians interested in evidence based medicine and rheumatology. Find the papers at ebrheum.com

  1. 24. Juli

    E138: Dapirolizumab for SLE (PHOENYCS-GO)

    A new therapy for SLE! This one is a CD40-CD40L blocker, which has some nice new-things to inhibit. The study itself was a qualified success and the podcast got a bit more rant-y than it should have been, but hopefully you get a kick out of it.  Paper: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)00691-4/fulltext

  2. 29. Juni

    E137: Obexelimab in IgG4-RD (INDIGO)

    Another day, another B cell drug. This one adds an interesting option for IgG4-RD, offering a "maybe less efficacious maybe less toxic" pathway. I could see folks being excited for this, especially in a disease where non-scary-manifestations are relatively common.  Also, check out boardsbank.com!  Paper: https://www.nejm.org/doi/full/10.1056/NEJMoa2601337

  3. 15. Juni

    E136: Secukinumab in PMR (REPLENISH)

    Big trial this week in the NEJM investigating the IL17 inhibitor secukinumab in PMR. Well worth a read, I would bet on FDA approval in the near future. Some interesting tidbits and of course a weird safety thing we now have to grapple with.  Be sure to go to boardsbank.com! Free rheumatology board review, >1000 questions!  Paper: https://www.nejm.org/doi/full/10.1056/NEJMoa2602567

  4. 30. Apr.

    E135: IL17 and a GLP1?

    Really interesting study this week comparing the IL17 inhibitor ixekizumab WITH the GLP1 inhibitor tirzepatide to ixekizumab alone. Raises some interesting questions about what worked here and whether or not it matters how it worked.    Paper: https://acrjournals.onlinelibrary.wiley.com/doi/10.1002/art.70134 Newsletter: http://autoimmunedevreport.com/

  5. 17. Apr.

    E134: Brepocitinib in Dermatomyositis (VALOR)

    Great trial this week looking at brepocitinib in dermatomyositis. Looks like a winner, expect it will be approved. Where it fits in our approach to IIM is an open question, but nice to have another option.  Study: https://www.nejm.org/doi/10.1056/NEJMoa2503531 JC Companion: https://autoimmunedevreport.substack.com/

  6. 19. März

    E133: Obinutuzumab for SLE (ALLEGORY)

    Good RCT this week, investigating the CD20 B cell inhibitor obinutuzumab for SLE. Sign up for my newsletter if you would like to have a read-along companion piece!    Paper: https://www.nejm.org/doi/full/10.1056/NEJMoa2516150 Landing Page: https://ebrheum.com/ Substack: https://autoimmunedevreport.substack.com/

  7. 5. März

    E132: Romosozumab vs teriparatide for osteoproosis (STRUCTURE)

    Quick podcast this week about a nifty head to head study that I had previously missed. Worth reading if - like me - you're still trying to figure out how the heck to manage osteoporosis.  Paper: https://pubmed.ncbi.nlm.nih.gov/28755782/

  8. 21. Jan.

    E131: A Sham-Controlled Sham of a Trial: RESET-RA

    Today I cover the recent publication of the RESET-RA study, which evaluated vagal nerve stimulation to treat rheumatoid arthritis. Have a listen in full, but let me be clear upfront: I do not think this works and will not be referring any patients to receive it. This will forever be my pivotal example of the effect of unblinding, but would love to hear if you think different!    Paper: https://www.nature.com/articles/s41591-025-04114-7 Supplement (see S4): https://www.nature.com/articles/s41591-025-04114-7#Sec27

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A weekly podcast for physicians interested in evidence based medicine and rheumatology. Find the papers at ebrheum.com

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  • Erstellt von
    Michael Putman
  • Jahre aktiv
    2025 - 2026
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    100
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