Science (Video)

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  1. vor 3 Tagen ·  Video

    Inflammatory Memory in Human Hematopoietic Stem Cells as a Driver of Clonal Selection in Aging and Cancer

    Hematopoietic stem cells make blood across the lifespan, but they do not all behave the same way. Stephanie Xie, Ph.D., Scientist at Princess Margaret Cancer Centre, University of Toronto, examines how these rare cells self-renew, differentiate, and respond to inflammatory stress, asking whether differences in the stem cell pool help explain why aging affects people so differently. Xie identifies two hematopoietic stem cell subsets, including one that retains inflammatory memory after stress recovery, and connects this state to aging, clonal hematopoiesis, sickle cell disease, post-COVID recovery, and mortality risk markers in blood. Her research also raises questions about whether targeting the inflammatory environment, including through GLP-1 receptor agonists or metformin, could help mitigate clonal hematopoiesis. Understanding these patterns could clarify how inflammation shapes blood production, cancer risk, and immune health over time. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 41406]

    59 Min.

  2. 12. Juni ·  Video

    Gene Therapies and Rare Disease - Medicine Informing Novel Discoveries (MIND)

    Rare disease research is creating new paths for diagnosis, treatment, and broader medical discovery. Gene therapy can repair or replace faulty genes, and work on cystinosis has led to a stem cell platform now being applied to Danon disease, Sanfilippo syndrome C, Friedreich’s ataxia, and Alzheimer’s research. Funding programs support gene therapy, clinical trials, and new platform approaches for rare diseases. CAR-T cell research is also advancing treatment possibilities for pediatric brain tumors, including early results in children with DIPG and diffuse midline glioma. A patient advocate shares her daughter’s diagnostic odyssey and treatment for TUBB4A leukodystrophy. Together, these stories show why rare disease research matters beyond rarity. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 41402]

    51 Min.

  3. 8. Juni ·  Video

    Ethical Sourcing in Health Data Supply Chains: Considerations for ML/AI Training

    Health data affects artificial intelligence in important ways. Camille Nebeker, Ed.D., M.S., UC San Diego, explains why ethically sourced data is foundational to building trustworthy, AI-ready health data repositories. Nebeker examines how ethical sourcing applies across the full data lifecycle, including consent, governance, transparency, data quality, privacy, stewardship, and community engagement. She also shows how ideas from supply chain management and value sensitive design help teams identify ethical tensions and improve decision-making. This work helps explain why ethics cannot be added at the end of AI development and points toward more accountable data practices that support public trust and stronger downstream performance. Series: "Exploring Ethics" [Science] [Show ID: 41368]

    24 Min.

  4. 5. Juni ·  Video

    Stem-Cell Aging and Pathways to Precancer Evolution

    Pre-cancer and cancer can begin when stressed blood-forming stem cells lose their normal controls. Catriona Jamieson, M.D., Ph.D., UC San Diego, explains how inflammation-linked editing enzymes, repetitive elements in the genome, and stem cell stress shape the progression from myeloproliferative neoplasms to acute myeloid leukemia. Jamison examines how spaceflight accelerates stem cell aging, how some astronauts mobilize a resilient regenerative stem cell population, and how tumor organoids in space help reveal drug responses by activating the enzyme ADAR1. This work helps explain how cancer starts, why it can return, and how space-based research may speed the development of therapies that stop malignant stem cells before disease advances. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 41473]

    22 Min.

  5. 30. Mai ·  Video

    From Electronic Health Records to Space Medicine: Building the Future of Space Healthcare

    Space healthcare depends on connected health data that can follow people wherever care happens. Peter DeVault, Epic, explains how electronic health record tools built for hospitals, labs, and patients can also support healthcare in space. DeVault describes patient-facing tools like MyChart, interoperability across health systems, structured genomics and pharmacogenomics in the patient record, and Cosmos, Epic’s patient data aggregation platform with about 300 million longitudinal records. He also examines AI capabilities that can generate possible future health scenarios and expand to telemetry and molecular data collected before, during, and after a mission. This work helps explain how records, data sharing, and predictive tools could support astronaut health and resilience and why those capabilities may be necessary for the future of space medicine. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 41481]

    12 Min.

  6. 25. Mai ·  Video

    From Orbital Experiments to Curing Earthling Diseases: How Space-Enabled Biotechnology is Advancing Neuroscience on Earth

    Brain aging and disease research can gain new insights from space. Aline M.A. Martins, Ph.D., UC San Diego, explains how neuroscience studies in space use brain organoids, proteomics, and single-cell analysis to understand cognition decline, space-induced neurosenescence, and disease-related changes. Martins examines molecular markers of senescence, mitochondrial impairment, and neuroinflammation in organoid models, including Rett syndrome, while also comparing how space affects organoids of different ages. She shows that space can accelerate aging-related changes and affect cell types differently, helping clarify how space biology may speed drug discovery and reveal biomarkers for disease. This work helps explain how space research can inform treatments on Earth and points toward faster preclinical testing and broader understanding of brain disease. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 41478]

    10 Min.

  7. 23. Mai ·  Video

    Climate Faith and Collective Responsibility with Bill McKibben

    Environmentalist and author Bill McKibben has helped shape how the world understands climate change. In this conversation with Marco Werman, host of The World, McKibben offers a clear-eyed look at the climate crisis and the solutions that could help reduce the damage of a warming planet. As part of the Burke Lectureship at UC San Diego, McKibben also explores the moral and spiritual questions at the heart of climate change. More than three decades after The End of Nature brought climate change to a broad audience, his work continues to connect science, ethics, and grassroots action, including the global climate campaign 350.org and the fossil fuel divestment movement. Series: "Burke Lectureship on Religion and Society" [Humanities] [Science] [Show ID: 41265]

    1 Std. 27 Min.

  8. 22. Mai ·  Video

    Extreme Events in California’s Changing Climate

    How does global warming connect to the extreme weather people experience close to home? Drawing on the work of the Weather Extremes and Climate Impacts Analytics group, Sasha Gershunov of Scripps Institution of Oceanography outlines the accelerating warming trend, the role of fossil fuels and carbon dioxide, and the greenhouse effect, and how it relates to extreme weather. He also traces key milestones in climate science, including the long-term carbon dioxide measurements begun by Charles David Keeling. The discussion then turns to how climate change may affect heat waves, floods, droughts, storms, wildfires, and sea level rise. Series: "Osher UC San Diego Distinguished Lecture Series" [Science] [Show ID: 41412]

    1 Std. 5 Min.
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