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Expert insight on health, performance, longevity, critical thinking, and pursuing excellence. Dr. Peter Attia (Stanford/Hopkins/NIH-trained MD) talks with leaders in their fields.

The Peter Attia Drive Peter Attia, MD

    • Gesundheit und Fitness
    • 4,7 • 145 Bewertungen

Expert insight on health, performance, longevity, critical thinking, and pursuing excellence. Dr. Peter Attia (Stanford/Hopkins/NIH-trained MD) talks with leaders in their fields.

    Liquid biopsies for early cancer detection, the role of epigenetics in aging, and the future of aging research | Alex Aravanis, M.D., Ph.D.

    Liquid biopsies for early cancer detection, the role of epigenetics in aging, and the future of aging research | Alex Aravanis, M.D., Ph.D.

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    Alex Aravanis is a leader in research and development of technologies and clinical tests utilizing the latest tools in DNA analysis and data science. In this episode, Alex delves into two interconnected topics: liquid biopsies and epigenetics. He begins by tracing the trajectory of genome sequencing and tumor sequencing, setting the stage for a detailed exploration of liquid biopsies as an early cancer detection method. The discussion encompasses key concepts such as cell-free DNA, DNA methylation, sensitivity, specificity, and the predictive values associated with liquid biopsies. Transitioning to epigenetics, Alex examines the intricate interplay of DNA methylation and aging biology and explores the possibility of using cellular reprogramming to reverse epigenetic changes that occur with aging.
    We discuss:
    Alex’s background in applying engineering to problems in medicine [3:15]; A primer on human genetics, and the history and current landscape of DNA sequencing [11:00]; The advent and evolution of liquid biopsies for early detection of cancer [23:15]; The role of cell-free DNA in cancer detection: how incidental findings in non-invasive prenatal testing led to the development of liquid biopsies [40:15]; The development of a universal blood test for cancer detection and a discussion of specificity of tests [46:00]; Advancements in cell-free DNA analysis and development of a multi-cancer screening test at GRAIL [51:00]; DNA methylation explained [58:15]; Optimizing cancer detection with methylation analysis of cfDNA in small blood samples [1:02:45]; The importance of understanding sensitivity, specificity, positive predictive value, and negative predictive value in cancer screening [1:08:00]; The performance of the GRAIL Galleri test and its ability to detect various types and stages of cancer [1:21:00]; Do early cancer detection methods, like liquid biopsies, translate to improvement in overall survival? [1:27:45]; The role of epigenetics in aging [1:39:30]; How cell-free DNA methylation patterns can help identify a cancer’s tissue of origin [1:45:30]; Cellular and epigenetic reprogramming and other exciting work in the field of aging [1:52:30]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

    • 2 Std 5 Min.
    AMA #56: Cancer screening: pros and cons, screening options, interpreting results, and more

    AMA #56: Cancer screening: pros and cons, screening options, interpreting results, and more

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    In this “Ask Me Anything” (AMA) episode, the conversation focuses on cancer screening, a topic often shrouded in confusion yet crucial to understand given that early identification of a cancer is an essential part of survival strategy. Peter examines the arguments both for and against cancer screening, including addressing why some trials may show no benefit to screening. He then delves into the various screening modalities available for different cancers, highlights the pros and cons associated with each, and explains how to interpret the results. Additionally, Peter provides guidance for navigating outside of the relatively narrow and confined screening guidelines for various types of screening tests.
    If you’re not a subscriber and are listening on a podcast player, you’ll only be able to hear a preview of the AMA. If you’re a subscriber, you can now listen to this full episode on your private RSS feed or our website at the AMA #56 show notes page. If you are not a subscriber, you can learn more about the subscriber benefits here.
    We discuss:
    Why understanding cancer screening is crucial [2:45]; The prevalence of cancer diagnosis and mortality rates [4:30]; Why cancer screening and early detection is such an important part of the strategy to survive a cancer diagnosis [11:00]; Data on how cancer screening impacts survivability of cancer [16:30]; Inconsistencies between cancer screening trials regarding benefits to survival rates [25:45]; What are some of the reasons why clinical trials don’t always improve cancer-specific mortality? [30:15]; What are the arguments against population-level cancer screening? [42:00]; Cancer screening outside the recommended guidelines: risks and benefits, interpreting results, and other considerations [46:00]; Understanding sensitivity and specificity when reviewing screening results [52:30]; Risks and complications associated with colonoscopies [55:45]; Cancer screening modalities: options for cancer screening both within standard recommendations and beyond [58:30]; The strengths and limitations of various types of cancer screening [1:02:15]; Understanding positive and negative predictive value using sensitivity, specificity, and pretest probability [1:11:45]; Factors that influence an individual's pretest probability of cancer [1:13:45]; How to interpret cancer screening results [1:18:15]; The importance of having an advocate when considering out-of-guideline cancer screening tests [1:23:30]; How stacking multiple cancer screening modalities can decrease the risk of false positives [1:29:30]; Advice and guidance for making decisions related to cancer screening [1:31:15]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

    • 20 Min.
    The impact of gratitude, serving others, embracing mortality, and living intentionally | Walter Green

    The impact of gratitude, serving others, embracing mortality, and living intentionally | Walter Green

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    Walter Green is a remarkable philanthropist, mentor, author of This Is the Moment!, and founder of the impactful “Say It Now” movement. In this episode, Walter delves into the unique insights gained from his challenging upbringing, discusses embracing mortality, and highlights the mindset of “finishing strong.” He shares insights on intentionality, thinking in reverse, saying “no,” prioritizing relationships, and the essence of focusing on others. The conversation focuses on the “Say It Now” movement, which stresses the importance of expressing sentiments to loved ones well before the end of life.
    We discuss:
    How Peter and Walter met through Ric Elias [2:45]; The unique perspectives and life lessons provided by Walter’s challenging childhood [5:30]; Walter’s harrowing experience with a sudden mental breakdown and his subsequent recovery with the help of therapy [11:15]; A diverse professional journey ending in great success [18:15]; The birth of a movement: celebrating friendships through public tributes and expressing gratitude to those who have shaped your life’s journey [22:30]; Intentionality, thinking in reverse, saying “no”, and other guiding principles for Walter [30:00]; Walter’s global journey of gratitude on his 70th birthday: visiting friends and creating memorable experiences [39:15]; The profound impact of acknowledging and expressing gratitude for the people who contribute to our lives [46:15]; The key elements for creating meaningful connections and cultivating deep, authentic friendships [52:15]; The “Say It Now” movement: the inspiration behind the remarkably impactful initiative [58:30]; What “finishing strong” means to Walter [1:07:30]; Finding peace at the end of life through expressing gratitude and finding purpose in serving others [1:16:00]; Resources to learn about “Say It Now” [1:26:15]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

    • 1 Std. 32 Min.
    Lower back pain: causes, treatment, and prevention of lower back injuries and pain | Stuart McGill, Ph.D.

    Lower back pain: causes, treatment, and prevention of lower back injuries and pain | Stuart McGill, Ph.D.

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    Stuart McGill is a distinguished professor emeritus at the University of Waterloo and the chief scientific officer at Backfitpro Inc. where he specializes in evaluating complex cases of lower back pain from across the globe. In this episode, Stuart engages in a deep exploration of lower back pain, starting with the anatomy of the lower back, the workings of the spine, the pathophysiology of back pain, and areas of vulnerability. He challenges the concept of nonspecific back pain, emphasizing the importance of finding a causal relationship between injury and pain. Stuart highlights compelling case studies of the successful treatment of complex cases of lower back pain, reinforcing his conviction that nobody needs to suffer endlessly. He also covers the importance of strength and stability, shares his favorite exercises to prescribe to patients, and provides invaluable advice for maintaining a healthy spine.
    We discuss:
    Peter’s experience with debilitating back pain [3:30]; Anatomy of the back: spine, discs, facet joints, and common pain points [14:45]; Lower back injuries and pain: acute vs. chronic, impact of disc damage, microfractures, and more [24:45]; Why the majority of back injuries happen around the L4, L5, and S1 joints [31:00]; How the spine responds to forces like bending and loading, and how it adapts do different athletic activities [36:15]; The pathology of bulging discs [43:15]; The pathophysiology of Peter’s back pain, injuries from excessive loading, immune response to back injuries, muscle relaxers, and more [46:00]; The three most important exercises Stuart prescribes, how he assesses patients, and the importance of tailored exercises based on individual needs and body types [56:15]; The significance of strength and stability in preventing injuries and preserving longevity [1:08:15]; Stuart’s take on squats and deadlifting: potential risks, alternatives, and importance of correct movement patterns [1:19:30]; Helping patients with psychological trauma from lower back pain by empowering them with the understanding of the mechanical aspects of their pain [1:30:00]; Empowering patients through education and understanding of their pain through Stuart’s clinic and work through BackFitPro [1:39:00]; When surgical interventions may be appropriate, and “virtual surgery” as an alternative [1:46:45]; Weakness, nerve pain, and stenosis: treatments, surgical considerations, and more [1:55:30]; Tarlov cysts: treatment and surgical considerations [2:00:15]; The evolution of patient assessments and the limitations of MRI [2:02:15]; Pain relief related to stiffness and muscle bulk through training [2:07:00]; Advice for the young person on how to keep a healthy spine [2:14:15]; Resources for individuals dealing with lower back pain [2:25:30]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

    • 2 Std 35 Min.
    Journal club with Andrew Huberman: the impact of light exposure on mental health and an immunotherapy breakthrough for cancer treatment

    Journal club with Andrew Huberman: the impact of light exposure on mental health and an immunotherapy breakthrough for cancer treatment

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    Andrew Huberman, professor of neurobiology at Stanford University and host of the Huberman Lab podcast, returns for another special journal club episode. Andrew introduces an observational study investigating the influence of light exposure on circadian clock regulation and its link to mental health, while Peter covers a phase III clinical trial employing immune checkpoint inhibitors for the treatment of metastatic cancer. They delve into the essential findings of their respective papers, elucidate the reasons for their enthusiasm, and tackle potential limitations and unanswered questions. Additionally, they provide valuable insights into their approaches for comprehending research studies, aiding listeners in independently navigating this process.
    We discuss:
    The intricate relationship between light exposure, circadian rhythms, and mental health [3:30]; The importance of low solar angle sunlight, and other types of light needed for optimal mental and physical health [12:00]; Promising new lightbulb technology that simulates low solar angle sunlight [17:45]; The significance of both darkness and the need for direct light exposure to the eyes, specifically [20:00]; Some tips and advice regarding optimizing light exposure, blue blockers, and effects on circadian rhythm [22:15]; Andrew presents a paper which suggests avoiding light at night and seeking light during the day is associated with better mental health [25:45]; Examining the data: the negative impact of increasing nighttime light exposure and the positive effects of daytime light exposure [34:30]; Statistical analysis: the importance of focusing not only on statistical significance but also clinical relevance, power analysis, error bar range, and more [45:45]; Takeaways from the study of daytime and nighttime light exposure [49:45]; The practicalities of minimizing light exposure and screen time at night, the use of sleep trackers, and overall challenge of modern, indoor lifestyles [55:15]; Potential limitations of the light exposure study, reverse causality, and the complex interplay of variables in epidemiological studies [1:06:00]; A tangent on diet soda and sugar substitutes as an example of reverse causality [1:13:15]; Andrew and Peter’s take on the causality vs. correlation of light exposure to mental health, the damage of circadian disruption, and the interpretation of observational data [1:17:30]; A primer on the immune system as background for the paper Peter chose [1:25:00]; Background on cancer: causes, how it evades the immune system, and the logic behind immune checkpoint inhibitor therapy [1:35:45]; Peter presents a paper on immune checkpoint inhibitor therapy in cancer patients [1:50:15]; Unpacking the results of the checkpoint inhibitor trial [1:59:45]; Other noteworthy observations, including the differing results between males and females [2:15:30]; Adverse effects resulting from treatment with an immune checkpoint inhibitor targeting CTLA-4 [2:20:00]; Why melanoma is especially responsive to immunotherapy, and the remarkable success story of immunotherapy for pancreatic cancer [2:25:15]; Why immunotherapy may be the most important hope we have for treating cancer [2:35:30]; Avoiding melanoma: the sunscreen debate, sunburn as the biggest risk factor, and more [2:38:45]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

    • 2 Std 46 Min.
    AMA #55: Exercise: longevity-focused training, goal setting, improving deficiencies, managing emotional stress, and more

    AMA #55: Exercise: longevity-focused training, goal setting, improving deficiencies, managing emotional stress, and more

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    In this “Ask Me Anything” (AMA) episode, Peter delves into the crucial topic of exercise, starting with the importance of having a goal in training, including how and why Peter uses the goal of training for the “Centenarian Decathlon” when structuring his training plans. Peter elaborates on how to identify deficient areas within the four pillars of exercise and guides listeners on incorporating periodization training for optimal improvement and training variety. The episode explores diverse case studies, offering insights into tailored workouts for individuals of various training backgrounds, from seasoned enthusiasts to complete beginners. Additionally, Peter tackles the universal issue of emotional stress and its impact on training, as well as how exercise can help manage stress and how to determine when training should be adjusted during a high-stress period.
    If you’re not a subscriber and are listening on a podcast player, you’ll only be able to hear a preview of the AMA. If you’re a subscriber, you can now listen to this full episode on your private RSS feed or our website at the AMA #55 show notes page. If you are not a subscriber, you can learn more about the subscriber benefits here.
    We discuss:
    Overview of exercise topics [2:15]; Importance of training with a goal in mind, the Centenarian Decathlon, and the natural decline of fitness with age [4:00]; The four pillars of exercise [12:15]; Measuring peak aerobic output with VO2max, and the importance of VO2max as a predictor of longevity [16:45]; Measuring aerobic efficiency with zone 2 [25:45]; Measuring and tracking muscle mass and strength [27:30]; Case study of a fit person with a neglected pillar: why adding more training volume may not the best strategy [30:30]; Periodization training: what it is and why it is beneficial [36:15]; Periodization case study: high cardio fitness, lacking muscle and strength [40:00]; Periodization case study: adequate muscle, low cardio fitness [44:45]; Case study: significant improvement needed across all exercise pillars [48:45]; Best ways to do zone 2 exercise and how to use relative perceived exertion (RPE) to find your zone 2 level [56:30]; How the body responds to physical and emotional stress, its impact on training, and the consequences of chronic stress [1:01:00]; The difference between “good” stress and “bad” or chronic stress [1:10:30]; The complex relationship between exercise and stress, and the importance of adjusting exercise goals during high-stress periods [1:13:30]; Clues that stress may be impacting your training [1:19:15]; The use of wearables and devices for tracking trends and making decisions related to training [1:21:00]; Parting thoughts regarding the importance of exercise for longevity and stress management [1:32:00]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

    • 21 Min.

Kundenrezensionen

4,7 von 5
145 Bewertungen

145 Bewertungen

Ingmeister K ,

Challenge your views on diet, medicine, exercise and more

Every episode let’s me learn a ton of new things in a wide variety of topics centered around longevity. Peter gives us insights into experts and pioneers from the fields of medicine, nutrition, exercise and so much more, all rooted in science. Prepare to have your mind blown!

Moorfuss ,

Brilliant content but far to lengthy

Frankly I'm torn about this one. He has great guests and very valuable learnings from the front of medical progress. However there is far too much chitchat. He's probably copying the style of Ferris. I just don't have enough hours in the day to listen to all the podcasts that I love. I've already stopped listening to Ferriss with few exceptions. Hope that Peter will change his style to a more focused approach

Diesdas-dieseLeier ,

Perfect Mix

This podcast is suited for everyone! The mix of broad easy to understand explanations and in depth data analysis just makes you want more! The best first step to a healthier and more fulfilled life
Thanks to the whole team that makes this possible.

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