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29. jan.
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17.12.2025
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24.01.2022
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10.05.2022
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Hver anden måned

29. JAN.

Celebrating 101 episodes of Healio Rheuminations with Dr. Leonard Calabrese

To celebrate 101 episodes, I sit with Leonard H. Calabrese, DO, to discuss his unique career in Rheumatology, spanning immunology, HIV, MECFS, IRES, CNS vasculitis and more. We also discuss how medical history shaped our careers. · Intro 0:12 · Welcome Leonard H. Calabrese, DO 3:11 · A quick friendship begins over medical history 4:14 · How Healio Rheuminations began and where the show is now 5:38 · How Dr. Calabrese got interested in medical history 7:11 · Serotherapy 10:52 · Why patients get certain diseases 12:33 · Dr. Calabrese's career trajectory 14:43 · One day in 1981… 17:52 · A few things happened in the 90's 20:20 · Tell us about CNS vasculitis 21:53 · Don't be afraid to reinvent yourself 24:30 · Checkpoint inhibitors 25:09 · How do you keep up? 26:43 · Placebo science 28:25 · Do you think we'll ever be able to answer where diseases come from? 29:33 · Thank you, Dr. Calabrese 31:01 · Thanks for listening 31:26 We'd love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum.

29. jan.

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32 min.
07.11.2019

all CAPS: A Story of Ice and Fire - Part 1

This first episode delves into the clinical aspects of the Cryopyrin-Associated Periodic Syndromes and includes some helpful tips for sorting out some of the autoinflammatory diseases in the spectrum. Intro :10 Cryopyrin-Associated Periodic Syndromes (CAPS) :25 Outline of Part 1 2:25 What is CAPS? 3:12 Case #1 – a 25-year-old female with urticaria after cold exposure 4:25 Case #2 – a 55-year-old female with progressive deafness 5:45 The index case of familial cold autoinflammatory syndrome 9:00 The final disease in the spectrum 11:00 A lot of names for the same disease 13:50 Genetics prove these three diseases are in the same spectrum 14:22 Over 100 mutations have been found to-date 16:31 Let's talk about mosaicism 17:03 Disease characteristics of CAPS 18:15 Neutrophilic infiltrate in chronic urticaria vs. CAPS 20:00 Schnitzler syndrome 20:45 Sensorineural hearing loss 21:58 Joint pain 24:10 Complication: Amyloidosis 25:29 These diseases were very debilitating 28:38 Episode recap 29:46 Part 2 sneak peek 30:38 Come say hi at ACR! 30:51 We'd love to hear from you! Send your comments/questions to rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum References: Ahmadi N, et al. Otolaryngol Head Neck Surg. 2011;145:295-302. Aksentijevich I, et al. Arthritis Rheum. 2002;46:3340-3348. Alecu M, et al. Romanian Journal of Morphology and Embryology = Revue Roumaine de Morphologie et Embryologie. 2015;56:7-14. Hassink SG, Goldsmith DP. Arthritis Rheum. 1983;26:668–673. Hoffman HM, et al. Nat Genet. 2001;29:301-305. Hoffman HM, et al. J Allergy Clin Immunol. 2001;108:615-620. Kile RM, Rusk HA. JAMA. 1940;114:1067-1068. Levy R, et al. Ann Rheum Dis. 2015;74:2043-2049. Marzano AV, et al. Clin Exp Rheumatol. 2018;36 Suppl 110:32-38. Muckle TJ, Wells M. Q J Med. 1962;31:235-248. Prieur AM, Griscelli C. Rev Rhum Mal Osteoartic. 1980;47:645–649. Tran TA. Open Access Rheumatol. 2017;9:123-129.

07.11.2019

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32 min.
25.11.2025

The history of giant cell arteritis: Infections, injections and the man who couldn't wear a hat

What does a goiter and syphilis have in common with the first descriptions of giant cell arteritis? Join us as we dive into the history of the most common type of vasculitis! Intro 0:13 GCA at ACR 2025 00:30 How Brown has approached framing this episode 1:01 A primer leading us to GCA 3:15 Let's get to the story 4:02 The man who couldn't wear a hat 4:57 Dr. Bayard Horton's 7:40 A tangent on cluster headaches 8:27 Let's get back to GCA 13:16 The first temporal artery biopsy 14:28 Vision loss and other puzzle pieces of GCA 16:27 What about jaw claudication? 21:15 Could GCA be transmissible? Injecting ground temporal arteries into healthy volunteers 24:13 Oxygen? Histamines? Adrenal cortical extract? Looking for GCA treatments 26:55 Steroids and GCA 28:40 A quote from the 1959 Mayo Clinic Board of Governors 32:24 Extracranial involvement in GCA 33:24 When did we recognize aorta involvement? Syphilis enters the picture 35:08 A recap of the history of GCA 41:25 Thanks for listening 42:19 We'd love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum. References: Boes CJ, Cephalalgia. 2007;doi:10.1111/j.1468-2982.2007.01238.x Cummer CL, et al. JAMA. 1912;doi:10.1001/jama.1912.04270080101004 Horton BT, Proc Cent SOC Clin Res. 1946 Sproul EE, et al. Am J Pathol. 1937;PMID: 19970328 Disclosures: Brown reports no relevant financial disclosures.

25.11.2025

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43 min.
30.05.2025

History of polymyalgia rheumatica: The origin of the pain & link to giant cell arteritis

In this episode, we dive into the history of polymyalgia rheumatica, how it was discovered and its link to giant cell arteritis. Intro 0:01 In this episode 0:10 What is polymyalgia rheumatica (PMR)? 0:24 The history of PMR 02:12 PMR in the 1950s: A formally recognized disease 04:52 What was probably PMR in the 1880s 06:27 Naming PMR: Senile rheumatic gout 07:26 1957: The witch's shot and finally landing on polymyalgia rheumatica 08:30 Where is PMR coming from? 14:42 Injecting joins with saline 16:39 A biopsy study in 1964 19:54 Technetium bone scintigraphy in 1971 and bone scan history 23:01 First look at a PMR ultrasound in 1993 27:00 1997: First use of MRI on PMR patients in Italy 27:49 Going back to 1962: PMRs association with giant cell arteritis 30:40 A paper on muscular involvement in giant cell arteritis: 80-year-old 'robust' partially blind seaman 32:15 First systematic approach: The link between PMR and giant cell arteritis 35:14 80 cases of PMR 38:13 Swedish autopsy studies 41:07 Introduction of advanced imaging in the 1990s 42:40 Summing up PMR through the decades 43:28 That is the end! 45:25 Thanks for listening 45:50 We'd love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum. References: Bruk MI. Ann Rheum Dis. 1967;doi:10.1136/ard.26.2.103. Cantini F, et al. J Rheumatol. 2001;28(5):1049-55. De Miguel E, et al. Rheumatology (Oxford). 2024;doi:10.1093/rheumatology/kead189. Dixon AS, et al. Ann Rheum Dis. 1966;doi:10.1136/ard.25.3.203. Hamrin B, et al. Ann Rheum Dis. 1968;doi:10.1136/ard.27.5.397. Salvarani C, et al. Ann Intern Med. 1997;doi:10.7326/0003-4819-127-1-199707010-00005. Shah S, et al. Rheumatology (Oxford). 2025;doi:10.1093/rheumatology/keae569. Disclosures: Brown reports no relevant financial disclosures.

30.05.2025

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46 min.
29.09.2025

Don't forget the toes: Managing patients with ANCA vasculitis

Active or not active, that is the question. In this week's episode we interview Alexandra Villa-Forte, MD, MPH, a staff physician in the Center for Vasculitis Care and Research at Cleveland Clinic and a leading vasculitis expert, on a pragmatic approach to recognizing disease activity in patients with ANCA vasculitis. · Intro 0:01 · Welcome Alexandra Villa-Forte, MD, MPH 0:10 · Dr. Brown sketches a potential patient that may be seen in practice 0:40 · How are you monitoring patients' kidneys? 1:28 · How reliable are 'no casts' results in urinalysis tests? 4:15 · What is happening in the glomeruli? 5:23 · The importance of monitoring the urinalysis of patients with ANCA vasculitis 7:06 · Symptoms to watch for when tapering off medications 7:43 · Different scenarios with lung symptoms 9:35 · Evaluating patients with GPA; looking at the nose, ear and sinuses 12:20 · Neurologic symptoms in ANCA vasculitis 14:24 · Laboratory monitoring 15:52 · Should ANCA titers be a part of routine vasculitis monitoring? 17:05 · What is your approach using PJP prophylaxis in ANCA-associated vasculitis? 18:05 Thank you, Dr. Villa-Forte! 20:25 We'd love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum. Disclosures: Brown reports no relevant financial disclosures. Healio was unable to confirm relevant financial disclosures for Villa-Forte at the time of publication.

29.09.2025

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22 min.
19.09.2025

Healio Community Book Club: A conversation between Leonard Calabrese, DO and Eric Topol, MD, author of Super Agers

This special edition episode features the latest installment of Healio Community's book club. Physician author Eric Topol, MD, discusses his book, Super Agers: An Evidence-Based Approach to Longevity, a guide to the science of living a long life free of debilitating diseases with Leonard H. Calabrese, DO, chief medical editor of Healio Rheumatology. · Intro by Adam J. Brown, MD 0:01 · A warm welcome by Leonard H. Calabrese, DO 0:47 · Introducing Eric Topol, MD 1:12 · "Deep Medicine: How Artificial Intelligence Can Make Healthcare Human Again" but did you think it would happen this fast? 1:54 · Let's get into "Super Agers" 3:46 · What's killing most people? 6:33 · An evidence-based treatise on healthy aging 9:42 · The role of immune health in longevity 12:55 · What's next on the horizon? 16:14 · A candle in the dark 19:40 · Minimizing the risk of getting old while you age 22:14 · The influence of health behaviors on immunologic wellness 25:15 · The hot issues: GLP-1's 26:28 · A new world for immunology 31:50 · Thank you, Dr. Topol 33:09 · Thanks for listening 33:57 Don't miss out! To engage in future conversations like this with physician authors on Healio Community, register here. We'd love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum. Disclosures: No products or companies that would require financial disclosure are mentioned in this episode.

19.09.2025

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34 min.
24.10.2024

The Story of the Flu Vaccine (Re-Release)

It's that time of year again, everyone rolling up their sleeves to get a flu shot. This throwback episode dives into the history of the struggles pinning down the causative agent of flu and the journey to the vaccine! Intro 0:40 In this episode 1:11 The history of the flu: 1892 1:41 What do we know about viruses? 6:29 Rabies and dead virus 11:17 A Sickness in the Serum, Part 2 14:43 1918 16:44 Vaccines and trials 19:13 Pig influenza 23:12 Influenza: a filterable agent we can't see 27:01 The trials of 1942 33:02 PS: 1918 influenza 38:57 Thanks for listening 47:42 Disclosures: Brown reports no relevant financial disclosures. We'd love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum. References: Hicks DJ, et al. Clin Exp Immunol. 2012;doi:10.1111/j.1365-2249.2012.04592.x. Rosenau MJ. Experiments Upon Volunteers to Determine the Cause and Mode of Spread of Influenza, Boston, November and December, 1918. https://quod.lib.umich.edu/f/flu/3750flu.0016.573. Published February 1921. Accessed December 6, 2023. Rosenau MJ, et al. JAMA. 1925;doi:10.1001/jama.1925.02670070040019. Taubenberger JK, et al. Antivir Ther. 2007;12(4 Pt B):581-91. Tobin J. The first flu shot. https://heritage.umich.edu/stories/the-first-flu-shot/. Accessed December 6, 2023.

24.10.2024

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48 min.
08.03.2019

Trials and Tribulations of Tumor Necrosis Factor, Part 1

In Part 1, we look at the original studies that led to the discovery of TNF in two separate labs where researchers were looking for two completely different things. We'll learn how these discoveries then fueled the use of TNF in the failed trials as an anti-cancer agent, and the eventual development of antibody therapy against TNF in septic shock. Intro :11 The origins of this episode and what we'll cover here and in Part 2 :18 What Part 1 will cover 2:01 Early cytokine research in general codiscovery of TNF TNF as anticancer agent TNF's role in cachexia trials of anti-TNF in the setting of septic shock What part 2 will cover 2:59 TNF's role in rheumatoid arthritis TNF in the late 1800s 3:18 Lipopolysaccharide from gram-negative bacteria is first isolated and discovered 8:16 Fast forward to the 1960s, enter Memorial Sloan Kettering Cancer Center 9:08 Anthony Cerami studies cachexin in his Rockefeller lab 11:10 Focus on cachexia 12:27 Late 1980s: TNF is produced and given to humans using recombinant technology 20:01 Studies of TNF in patients with various types of cancer 20:48 High doses seem to induce shock-like illness 21:38 TNF-secreting tumor is created and tested 25:21 Some take away 26:12 Studying TNF led to the discovery that it's associated with shock 26:33 Money pours into research on blocking TNF 27:00 A look at studies of TNF in infection 27:22 Study of TNF in sepsis 30:20 Let's talk about anti-TNF and what it's doing 34:00 Studies of anti-TNF in humans 36:00 Rat and baboon studies don't always correlate with humans 40:25 Episode recap 40:45 Stay tuned for Part 2 42:20 Follow us on Twitter @HRheuminations and leave us a review in iTunes 42:50 We'd love to hear from you! Send your comments/questions to rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum References: Beutler B, et al. Science. 1985;229:869–871. Blick M, et al. Cancer Research. 1987;47:2986-2989. Carswell E, Williamson B. Cancer Imm. 2012;12:4. Feldman M. Nat Rev Immunol. 2002;2:364-371. Fong Y, et al. J Exp Med. 1989;170:1627-1633. Kawakami M. Mol Med. 2014;doi:10.2119/molmed.2014.00177. Lv S, et al. Int J Clin Pract. 2014;68:520-528. Marks JD, et al. Am Rev Respir Dis. 1990;141:94-97. McCarthy EF. Iowa Orthop J. 2006;26:154-158. Michi HR, et al. N Engl J Med. 1988;318:1481-1486. Oliff A. Cell. 1988;54:141-142. Opal SM, et al. J Infect Dis. 1990;161:1148-1152. Qui P, et al. Expert Opin Investig Drugs. 2011;20:1555-1564. Tracey KJ, et al. Nature. 1987;330:662-4. Waage A, et al. Lancet. 1987;1:355-7.

08.03.2019

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43 min.
31.07.2018

A Diagnosis Divided

A young woman presents with migraine-like headaches, black spots in her vision and emotional lability. Think you know the diagnosis? You may be surprised – this medical mystery is not what it seems. In this episode, learn more about this rare diagnosis, and gain clinical insight from neurologist Devon Conway, MD, and ophthalmologist Arthi Venkat, MD. Intro :11 A 24-year-old woman presents with gradual worsening of a migraine-like headache accompanied by nausea :22 Description of symptoms :37 ER visit 1:23 Onset of new symptoms 1:44 Second ER visit 2:11 Outpatient MRI findings 2:28 Lumbar puncture findings 2:50 Patient is admitted to hospital 3:52 Second MRI findings 4:16 Ophthalmology consult and results of fluorescein angiography 4:46 Audiogram is ordered 5:17 Case summary 5:40 What is the most likely diagnosis? 6:05 Triad of Susac syndrome 6:27 Remember: This is not a vasculitis 7:11 History of Susac syndrome 7:40 CNS manifestations of the Susac triad 8:27 Consult with Devon Conway, MD 10:13 Flare signals for non-radiologists/neurologists 11:05 Anything specific that says "demyelinating" on MRI? 13:35 Distinguishing the lesions in this case from those of MS 15:36 Neurology work-up approach to this type of case 16:28 The utility of lumbar puncture in this situation 18:05 About ADEM (acute disseminated encephalomyelitis) 21:06 Ocular manifestations of Susac syndrome 22:26 Consult with Arthi Venkat, MD 23:17 Ophthalmology differential in a patient with intermittent vision loss in various fields of vision 23:55 Overview of branch retinal artery occlusions 25:22 Difference between branch retinal artery occlusions and other ophthalmologic presentations common to rheumatologists 27:51 How the ophthalmologic exam helps differentiate MS from Susac syndrome 30:07 Overview of sensorineural hearing loss in Susac syndrome 34:09 Do we know for sure this is an autoimmune disease? 34:59 Aggressive immunosuppression seems to halt the progression of disease 35:34 What are treatment options? 35:42 What do we know about long-term outcomes? 36:31 Who takes care of these patients? 37:29 Treatment, outcome of this patient 38:07 Episode/case summary 38:20 Devon Conway, MD, is a staff neurologist at Cleveland Clinic's Mellen Center for Multiple Sclerosis. Arthi Venkat, MD, is a retinal and uveitis specialist at Cole Eye Institute at Cleveland Clinic. We'd love to hear from you! Send your comments/questions to rheuminationspodcast@healio.com. References: Aubart-Cohen F, et al. Medicine (Baltimore). 2007;86:93-102. Greco A, et al. Autoimmun Rev. 2014;13:814-821. Rennebohm RM, et al. Int J Stroke. 2018;doi:10.1177/1747493017751737.

31.07.2018

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41 min.
05.10.2018

The History of Gout, Part 1

Do you know the etymology of the word "gout," or how a simple microscope aided in the identification of tophi? Join me as I explore the history of this inflammatory arthritis and highlight the important scientists who shaped the modern era of gout. Intro :10 What to expect in Part 2 :48 A question: Which urate-lowering therapy was made for an expressly different reason than to treat gout? 1:34 The first modern description of gout 1:54 Let's go back to the Greeks 3:05 Why is it called "gout?" 3:06 An anecdote from medical school 4:13 Hippocrates' words of wisdom on gout 4:58 First century AD: Gout is linked with excessive eating and drinking 6:01 Things get muddled 6:20 1683: The modern era of gout is described 6:42 "Gout Perspectives" published in The Lancet in 2018 7:06 Self-taught Dutch scientist, Antony van Leeuwenhoek, pioneers the microscope and identifies tophi 8:29 Swedish chemist Carl Wilhelm Scheele discovers uric acid 11:38 William Hyde Wollaston tests tophi and discovers it's full of uric acid 12:57 Emperor of uric acid, Alfred Baring Garrod, associates elevated serum uric acid with gout 13:48 If anyone knows how the thread test works, please email me 14:58 He theorized that uric acid causes gout 15:37 A look back at what we know 16:09 What we don't know: What's in the joints of patients with acute gout? 16:22 Stay tuned for The History of Gout, Part 2 16:34 We'd love to hear from you! Send your comments/questions to rheuminationspodcast@healio.com. References: Barnett R. Lancet. 2018;391:2595. Faires JS, Mccarty DJ. Lancet. 1962;280:682-685. Kippen I, et al. Ann Rheum Dis. 1974;33:391-396. Marson P, Pasero G. Reumatismo. 2011;63:199-206. Mccarty DJ, Hollander JL. Ann Intern Med. 1961;54:452-460. Nuki G, Simkin PA. Arthritis Res Ther. 2006;doi: 10.1186/ar1906. Rundles RW. Arch Intern Med. 1985;145:1492-1503. Shyambhavee, Behera BK. J Pharmacol Clin Toxicol. 2017;5:1098. Storey GD. Rheumatology. 2001;40:1189-1190. West JB. Am J Physiol Lung Cell Mol Physiol. 2014;doi:10.1152/ajplung.00223.2014.

05.10.2018

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17 min.

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