The Metabolic Link Dr. Dominic D'Agostino PhD, Dr. Angela Poff PhD, and Victoria Field

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In this episode, recorded at Metabolic Health Summit 2024, Dr. Richard Johnson dives into the groundbreaking research that has uncovered the central role of fructose in driving the epidemics of obesity, diabetes, and a wide range of other metabolic diseases.

Dr. Johnson presents compelling evidence that fructose, a seemingly innocuous sugar, is in fact a key trigger for activating a powerful biological survival switch. This switch, evolved in nature to help animals prepare for times of scarcity, is now being inadvertently activated in humans by our modern high-carbohydrate, high-sugar diets.

Through detailed scientific explanation and insightful case studies, Dr. Johnson illuminates how fructose's unique metabolic effects - including its ability to lower ATP levels, induce leptin resistance, and promote fat storage - are the driving forces behind the rise of metabolic syndrome and its associated conditions.

Equally important, Dr. Johnson offers practical dietary recommendations and strategies to help individuals navigate this complex landscape, emphasizing the importance of reducing sugar, refined carbs, and processed foods, while embracing a low-carb, nutrient-dense approach.

This eye-opening episode is a must-listen for anyone seeking to understand the root causes of the metabolic health crisis and learn evidence-based solutions to reclaim their wellbeing.

Special thanks to our sponsors:

Genova Connect, powered by Genova Diagnostics, offers easy access to advanced lab tests, covering key health areas like metabolic health, nutrition, gut health, immune function, and hormones. Receive 15% off any of their tests with code metaboliclink: http://gdx.net/themetaboliclink

LMNT, a zero-sugar electrolyte drink mix free of artificial colors and dodgy ingredients. Get a free LMNT Sample Pack with any drink mix purchase at: drinkLMNT.com/MetabolicLink 


In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!

You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel, Apple, Google, Spotify, Amazon Music, and Buzzsprout.

Thanks for listening! Follow us on social media @metabolichealthsummit for the latest science on metabolic health and therapy. Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

In this episode of The Metabolic Link, Victoria Field, Dr. Dominic D'Agostino, and Dr. Angela Poff dive into a fascinating new paper that compares the metabolic and immune impacts of ketogenic and vegan diets in humans.
The study, titled “Differential Peripheral Immune Signatures Elicited by Vegan Versus Ketogenic Diets in Humans” takes a deep dive into the multi-omic effects of these two very different dietary approaches. The researchers found that just two weeks on a ketogenic diet significantly enhanced markers of adaptive immunity, while the vegan diet was associated with increased innate immune function.
The hosts unpack these findings, discussing the potential mechanisms behind the divergent immune signatures, the limitations of the short-term study design, and the need for further research.
They also highlight the importance of carefully standardizing the macronutrient and micronutrient compositions of the dietary interventions to isolate the key drivers of the observed changes.
Overall, this episode provides a thought-provoking look at the profound impacts that diet can have on the functioning of our immune system, setting the stage for future studies exploring the therapeutic potential of nutritional approaches.
This episode is sponsored by Genova Diagnostics. Genova has been researching and refining precision health testing for decades. It's that experience that has allowed them to create comprehensive assessments that shed light on your individual health status and make recommendations for changes that will bring your wellness into focus.
Genova Connect, powered by Genova Diagnostics, offers easy access to advanced lab tests, covering key health areas like metabolic health, nutrition, gut health, immune function, and hormones. Through Genova Connect, anyone can gain insights into their health and find ways to improve their well-being. Learn more at https://gdx.net/themetaboliclink
As mentioned in the introduction, you can watch the free virtual masterclass co-hosted Genova Diagnostics and Metabolic Health Summit showcasing some of the world-leading experts in metabolic health here
In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!

You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel, Apple, Google, Spotify, Amazon Music, and Buzzsprout.

Thanks for listening! Follow us on social media @metabolichealthsummit for the latest science on metabolic health and therapy. Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

The following Metabolic Link episode was originally filmed at Metabolic Health Summit 2024 and we're excited to share it with you today in its entirety! In this presentation, Dr. Andy Galpin, a human performance scientist, shares his insights on utilizing scientific principles, specifically the 'Biomolecular Athlete' concept, to achieve athletic excellence. He emphasizes the importance of individualized strategies that consider sleep, diet, stress, respiratory rates, and blood chemistry.
The discussion then progresses to the groundbreaking future of human performance, including the use of digital twins for simulating and optimizing individual health outcomes, and the exploration of advanced technologies such as in-mouth sensors, full-body MRI, shoe sole force plates, and markerless motion capture.
Case studies are presented to illustrate the successful application of these innovative approaches, showcasing the potential for precision and customization in coaching for optimal health and performance.
This talk is sponsored by Genova Diagnostics. Genova has been researching and refining precision health testing for decades. It's that experience that has allowed them to create comprehensive assessments that shed light on your individual health status and make recommendations for changes that will bring your wellness into focus.

Genova Connect, powered by Genova Diagnostics, offers easy access to advanced lab tests, covering key health areas like metabolic health, nutrition, gut health, immune function, and hormones. Through Genova Connect, anyone can gain insights into their health and find ways to improve their well-being. Learn more at gdx.net/themetaboliclink

As mentioned in the introduction, you can watch this free virtual masterclass co-hosted Genova Diagnostics and Metabolic Health Summit showcasing some of the world-leading experts in metabolic health.


In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!

You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel, Apple, Google, Spotify, Amazon Music, and Buzzsprout.

Thanks for listening! Follow us on social media @metabolichealthsummit for the latest science on metabolic health and therapy. Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

This week’s episode of The Metabolic Link features an illuminating sit-down interview with Dr. Jeff Volek, a professor at The Ohio State University. With a PhD in Kinesiology specializing in exercise and nutrition science from Penn State University, Dr. Volek has performed cutting edge research on how humans adapt to diets restricted in carbohydrates with a dual focus on clinical and performance applications of nutritional ketosis. His scholarly work includes more than 300 peer-reviewed scientific manuscripts and five books, including a New York Times Best Seller.
In this wide-ranging interview, we cover:
💡 Unexpected normalization of muscle glycogen on ketogenic diets
💡 Muscle production of beta-hydroxybutyrate as an alternative fuel and cellular NAD+ source
💡 The emerging science on improved function of a heart muscle fueled by ketones
💡 Revisiting the FASTER study: Fitness, Aging, Stress & TBI Exposure Repository
💡 Ketogenic diets to enhance military resilience under high-stress conditions
💡 Targeting diabetic complications - studies that show hard outcomes are needed to change policy
💡 Educating physicians on therapeutic nutrition - the value of credible science-based platforms
💡 Helping address the epidemics of obesity, diabetes, and metabolic disease through lifestyle change
Watch the  video version on our Metabolic Health Summit YouTube channel. If you enjoy The Metabolic Link, make sure you sign-up for The Metabolic Link: Private Feed for access to exclusive Q&As, presentations, and interviews from world-renowned metabolic health experts. You gain access a member of The Metabolic Initiative and can listen in from your favorite podcast player. Claim your 7-day trial here.
In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!

You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel, Apple, Google, Spotify, Amazon Music, and Buzzsprout.

Thanks for listening! Follow us on social media @metabolichealthsummit for the latest science on metabolic health and therapy. Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

This week's episode of The Metabolic Link features a full presentation from Metabolic Health Summit 2024. Dr. Ben Bikman, professor at Brigham Young University, dives deep into the intricacies of fat and its relationship to metabolic health.
This is the full presentation he delivered at Metabolic Health Summit 2024 in Clearwater Beach, Florida. In it he shares his expertise on the link between body fat, insulin resistance, and chronic diseases such as obesity and diabetes. Throughout this talk, he covers:

💡 The role of insulin in regulating obesity and diabetes, and its direct correlation with maintaining fat mass.
💡 Understanding the concept of the personal fat threshold and how it differs among individuals, leading to insulin resistance when exceeded.
💡 Why studying weight gain provides crucial insights into the mechanisms of obesity, rather than merely focusing on weight loss.
💡 The paradox of hyperplasia and its unexpected role in improving insulin sensitivity.
💡 How exercise influences fat cell behavior through hormonal signals, particularly insulin.
If you enjoy this episode, it is just one of 30 fascinating presentations captured at Metabolic Health Summit 2024. You can still get on-demand access and watch all the action just like you were there in-person. But the doors close on February 29th! Go to metabolichealthsummit.com to get your virtual pass now.
In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!

You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel, Apple, Google, Spotify, Amazon Music, and Buzzsprout.

Thanks for listening! Follow us on social media @metabolichealthsummit for the latest science on metabolic health and therapy. Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

This week’s episode of The Metabolic Link features an illuminating sit-down interview with Dr. Georgia Ede, a Harvard-trained psychiatrist specializing in nutrition science and brain metabolism. With over 25 years of clinical experience, including 12 years as a college psychiatrist and nutrition consultant at Smith College and Harvard University Health Services, Dr. Ede was the first to offer students nutrition-based approaches as an alternative to psychiatric medications. She speaks internationally about using dietary therapies for psychiatric disorders, co-authored the first inpatient study of the ketogenic diet for treatment-resistant mental illness, and developed the first accredited course on ketogenic diets for mental health practitioners. Her new book Change Your Diet, Change Your Mind was published in January 2024.
In this wide-ranging interview, we cover:
Implementing a therapeutic ketogenic diet in Dr. Ede’s clinical practice and the mental health benefits observedThe critical role of ketones in alleviating cerebral glucose hypometabolismWhy metabolic health forms the foundation for optimal mental healthThe lack of practical nutrition education in medical training and why it mattersAlzheimer’s disease as a metabolic disorderThe importance of insulin levels, not just glucose, for gauging metabolic healthWatch the full episode on our Metabolic Health Summit YouTube channel and be sure to catch Dr. Ede on The Metabolic Psychiatry Panel featuring Dr. Chris Palmer, Dr. Iain Campbell, and Matt Baszucki. On-Demand access closes on Friday, February 16th so don't wait! Get your virtual pass at metabolichealthsummit.com.
Also be sure to catch Dr. Ede on March 6th where she'll be joining us for a live Q&A on The Metabolic Initiative. We’ll be exploring ketogenic therapy for mental health. Register to join us here.


In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!

You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel, Apple, Google, Spotify, Amazon Music, and Buzzsprout.

Thanks for listening! Follow us on social media @metabolichealthsummit for the latest science on metabolic health and therapy. Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.