Peptides Explained

John Garrett

Peptides Explained breaks down the most talked-about peptides and GLP-1 medications in health, fitness, and longevity — including semaglutide, tirzepatide, BPC-157, TB-500, and more. Hosted by Registered Nurse John Garrett, this podcast explains how these compounds work, why they’re popular, what the research shows, and the real risks and side effects — all in plain language. No bro science. No hype. Just clear, foundational education. For informational purposes only. Not medical advice. For Research Peptides; Offlinepeptides.com/ref/johngarrett/ https://www.skool.com/peptides-explained-15

  1. DSIP Explained: The Sleep Peptide That Science Still Can't Explain

    16 hr ago

    DSIP Explained: The Sleep Peptide That Science Still Can't Explain

    Description Can a tiny peptide discovered nearly 50 years ago hold the key to better sleep? In this episode of Peptides Explained, we explore Delta Sleep-Inducing Peptide (DSIP)—one of the most mysterious compounds in peptide research. Unlike many peptides discussed today, DSIP has no confirmed receptor, conflicting clinical data, and decades of unanswered questions. In this episode you'll learn: ✔️ What DSIP is✔️ How sleep is biologically regulated✔️ The fascinating history of DSIP's discovery in the 1970s✔️ Proposed mechanisms involving GABA, serotonin, dopamine, and the HPA axis✔️ Human and animal research findings✔️ Potential side effects and safety considerations✔️ Why DSIP is not FDA approved and why no major medical organization recommends it for insomnia or other sleep disorders This podcast is intended for educational purposes only and is not medical advice. 🌐 Peptide Solutionshttps://peptide-solutions.info 🧬 Research Peptides (Affiliate Partner)PeptidesExplained.info/OfflinePeptides If you use my affiliate link, I may receive a commission at no additional cost to you. 📧 N=1: Your Real-World Results Have you researched DSIP? Send a 2–3 minute video describing your experience to: john@peptidesexplained.info You may be featured in a future episode. #DSIP #SleepPeptide #Peptides #SleepScience #Insomnia #Longevity #PeptidesExplained #SleepResearch #Neuroscience #Biohacking

    8 min
  2. 5-Amino-1MQ Explained: NNMT, NAD⁺, and Fat Cell Metabolism

    2 days ago

    5-Amino-1MQ Explained: NNMT, NAD⁺, and Fat Cell Metabolism

    5-Amino-1MQ is often talked about in peptide circles, but it is not actually a peptide. It is a small-molecule NNMT inhibitor being studied for its potential role in nicotinamide metabolism, NAD⁺ biology, methylation, fat-cell function, insulin sensitivity, and liver metabolism. In this episode, John Garrett breaks down the proposed mechanism behind 5-Amino-1MQ, why people are discussing it for fat loss and body composition, and what the current research actually shows. The data is interesting, especially in preclinical studies involving adipocytes, diet-induced obese mice, glucose tolerance, insulin sensitivity, and fatty liver markers. But the human clinical evidence is still limited, and 5-Amino-1MQ is not FDA-approved for fat loss, obesity, metabolic disease, longevity, or body composition. This episode takes a balanced look at the science, the grey-market reality, and how to think about emerging metabolic compounds responsibly. This podcast is for informational purposes only and is not medical advice. Always consult a licensed healthcare professional before considering any therapy. Peptides Explained is powered by Peptide Solutions. Peptides Explained is also an affiliate partner with Offline Peptides. If you use my link, I may earn a commission at no additional cost to you. Offline Peptides affiliate link:https://offlinepeptides.com/ref/JohnGarrett/ Podcast website:https://peptidesexplained.info Peptide Solutions:https://peptide-solutions.info

    29 min
  3. BPC-157 & TB-500 for Dogs: Healing, Recovery & the Science | Veterinary Series Ep. 1

    5 days ago

    BPC-157 & TB-500 for Dogs: Healing, Recovery & the Science | Veterinary Series Ep. 1

    BPC-157 & TB-500 for Dogs: Healing, Recovery & the Current Science Welcome to Episode 1 of the Peptides Explained Veterinary Series. In this episode, we examine two of the most talked-about peptides in regenerative veterinary medicine—BPC-157 and TB-500. We'll discuss what researchers currently know about these experimental peptides, why they're generating interest among veterinarians and dog owners, how they may influence tendon, ligament, muscle, and connective tissue repair, and where the evidence remains limited. Whether you own an active family pet, a hunting dog, an agility competitor, or a working K9, this episode provides a balanced look at the science while separating evidence from online speculation. Educational only. BPC-157 and TB-500 are experimental compounds and are not FDA-approved veterinary medications. Learn more at https://peptide-solutions.info Peptides Explained is an affiliate partner with Offline Peptides. If you use my link, I may earn a commission at no additional cost to you. https://offlinepeptides.com/ref/JohnGarrett/ Have a real-world experience using peptides with your dog? Send a 2–3 minute horizontal video to john@peptidesexplained.info for a chance to be featured in our "N=1: Your Real-World Results" segment.

    22 min
  4. I Asked ChatGPT to Build the Ultimate Peptide Stack... Here's What It Chose

    1 Jul

    I Asked ChatGPT to Build the Ultimate Peptide Stack... Here's What It Chose

    I asked ChatGPT a simple question... and the answer surprised me. For Research Grade Peptides, check out Offline Peptides 🌐 ⁠OfflinePeptides.com/Ref/JohnGarrett⁠ If ChatGPT were a 47-year-old peptide researcher who needed to lose 40 pounds, had a nagging knee injury, wanted to preserve muscle, improve energy, and had an unlimited budget, what peptide stack would it choose? Instead of recommending every popular peptide on the market, it built a surprisingly logical plan focused on solving the biggest problems first. In this episode of Peptides Explained, we break down the science and reasoning behind each selection: RetatrutideBPC-157TB-500TesamorelinMOTS-cGHK-CuWe also discuss why several well-known peptides didn't make the list, why ChatGPT preferred individual peptides over a Glow Stack, and how prioritizing your biggest health challenge may be more important than simply taking more compounds. This episode is an educational thought experiment—not medical advice—and is designed to spark discussion about peptide science, mechanisms, and evidence. Powered by Peptide Solutions Looking for peptide education, research resources, or provider-guided peptide options? 🌐 https://peptide-solutions.info For Research Grade Peptides, check out Offline Peptides 🌐 OfflinePeptides.com/Ref/JohnGarrett Affiliate Disclosure: Peptides Explained is an affiliate partner with OfflinePeptides.com. If you choose to use my affiliate link, I may earn a commission at no additional cost to you.

    13 min
  5. Epitalon Explained: The Science of Telomeres, Aging & Longevity

    29 Jun

    Epitalon Explained: The Science of Telomeres, Aging & Longevity

    Can a peptide actually slow the aging process? In this episode of Peptides Explained, we take a deep dive into Epitalon—one of the most talked-about peptides in longevity medicine. You'll learn: What Epitalon is and where it came from How telomeres and telomerase work Why the pineal gland may play a role in aging What the human and animal research actually shows Why activating telomerase is both exciting and scientifically complex The current FDA and regulatory status of Epitalon The difference between promising mechanisms and proven clinical outcomes Rather than relying on hype, we examine the available evidence and discuss what researchers know—and just as importantly, what they still don't know. New Segment – N=1: Your Real-World Results Have you used Epitalon or another peptide we've covered on the show? I'd love to feature your experience in a future episode. Record a 2–3 minute video sharing:• Which peptide you used• Why you decided to try it• Your results—positive, negative, or somewhere in between• Anything you learned along the way Email your video to: john@peptidesexplained.info Your experience may be featured in an upcoming N=1: Your Real-World Results segment. This podcast is for educational purposes only and is not medical advice.

    13 min
  6. SS-31 Explained: The FDA-Approved Mitochondrial Peptide

    24 Jun

    SS-31 Explained: The FDA-Approved Mitochondrial Peptide

    SS-31 (Elamipretide) may be one of the most fascinating peptides ever developed. Unlike most peptides that work by activating receptors on the surface of cells, SS-31 targets the mitochondria—the cellular power plants responsible for producing energy. In this episode of Peptides Explained, we break down: ✅ What mitochondria actually do✅ The role of cardiolipin in cellular energy production✅ How SS-31 works biologically✅ Why SS-31 received FDA Accelerated Approval in 2025✅ What Barth Syndrome is✅ The latest human clinical data✅ How SS-31 compares with MOTS-c✅ Whether repairing mitochondria before metabolic optimization makes biological sense We'll separate proven science from speculation and discuss what remains investigational. This podcast is for informational purposes only and is not medical advice. Support the Show Peptides Explained is an affiliate partner with OfflinePeptides.com. If you use my link, I may earn a commission at no additional cost to you. https://offlinepeptides.com/ref/JohnGarrett/ For peptide education, provider resources, and information about compounded peptide options through licensed providers: https://peptide-solutions.info #PeptidesExplained #SS31 #Elamipretide #Forzinity #BarthSyndrome #Mitochondria #Longevity #MOTSc #Peptides

    15 min
  7. Peptide Math Explained: Dose, Volume, Concentration & Reconstitution

    22 Jun

    Peptide Math Explained: Dose, Volume, Concentration & Reconstitution

    Most peptide users understand what peptide they want to use, but many struggle with the math behind vial size, reconstitution, concentration, units, volume, and medication calculations. In this episode of Peptides Explained, we break down the fundamentals of peptide math in plain English. You'll learn the difference between total vial contents and dose, what reconstitution actually means, why concentration matters, how syringe units can create confusion, and the medication calculation formula used throughout healthcare. Whether you're interested in GLP-1 medications, growth hormone secretagogues, BPC-157, TB-500, Tesamorelin, or other peptides, these mathematical principles apply across the board. Topics Covered:• Vial Size vs. Dose• Reconstitution Explained• Concentration Made Simple• Units vs. Volume• The D ÷ H × V Medication Calculation Formula• Common Mistakes Peptide Users Make This podcast is for informational and educational purposes only and is not medical advice. Support the Show: Visit Peptide Solutions:https://peptide-solutions.info Peptides Explained is an affiliate partner with OfflinePeptides.com. If you use my link, I may earn a commission at no additional cost to you. https://offlinepeptides.com/ref/JohnGarrett/

    13 min
  8. Melanotan I, Melanotan II & PT-141 Explained: The Tanning Peptides That Changed Sexual Medicine

    17 Jun

    Melanotan I, Melanotan II & PT-141 Explained: The Tanning Peptides That Changed Sexual Medicine

    What do tanning peptides have to do with sexual medicine? More than you might think. In this episode of Peptides Explained, we explore the fascinating science behind Melanotan I, Melanotan II, and PT-141 (Bremelanotide). What began as research into skin pigmentation and UV protection unexpectedly led to the development of an FDA-approved medication for hypoactive sexual desire disorder. You'll learn: • How the melanocortin system works• The role of alpha-MSH in pigmentation and physiology• The differences between Melanotan I and Melanotan II• Why Melanotan II became known for effects beyond tanning• How PT-141 was developed from Melanotan II research• The clinical data behind pigmentation and sexual function• Potential side effects and safety considerations• The current regulatory status of these compounds Whether you're interested in peptide science, dermatology, sexual health, or drug development, this episode highlights one of the most unexpected stories in modern peptide research. This podcast is for informational purposes only and is not medical advice. Learn more at:📍 Peptide-Solutions.info Research Peptide Affiliate Partner:📍 https://offlinepeptides.com/ref/JohnGarrett/ Affiliate Disclosure: Peptides Explained is an affiliate partner with OfflinePeptides.com. If you use my link, I may earn a commission at no additional cost to you. #PeptidesExplained #Melanotan #Melanotan2 #Melanotan1 #PT141 #Bremelanotide #PeptideTherapy #Longevity #HealthPodcast #MedicalScience

    10 min
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About

Peptides Explained breaks down the most talked-about peptides and GLP-1 medications in health, fitness, and longevity — including semaglutide, tirzepatide, BPC-157, TB-500, and more. Hosted by Registered Nurse John Garrett, this podcast explains how these compounds work, why they’re popular, what the research shows, and the real risks and side effects — all in plain language. No bro science. No hype. Just clear, foundational education. For informational purposes only. Not medical advice. For Research Peptides; Offlinepeptides.com/ref/johngarrett/ https://www.skool.com/peptides-explained-15

Information

  • Creator
    John Garrett
  • Years Active
    2k
  • Episodes
    30
  • Rating
    Clean
  • Copyright
    © John Garrett
  • Show Website
    Peptides Explained

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