This Week in Virology Vincent Racaniello

In his weekly clinical update, Dr. Griffin begins with discussing if the antibiotic neomycin is really a pan-antiviral countermeasure, then reviews the recent statistics on SARS-CoV-2 infection before deep diving into if shedding and the rapid antigen test results correlate, the guidelines for spring administration of COVID vaccines boosters, whether COVID booster associates with the long COVID prevalence, discusses the emergency use application of a pre-exposure prophylactic, revised guidelines for how to treat respiratory viral infection guidelines by the CDC, the caveats for improper use of antibiotics to treat SARS-CoV-2 (a viral infection), continues to dispel the myth of viral rebound, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, if administration of an anti-immunoglobulin E monoclonal antibody can be used for COVID-19 treatment, if inhibiting T-cell activation will reduce secretion and production of inflammatory cytokines including IL-6, if changes in the gut microbiome associate with post -acute COVID-19 syndrome, and the pulmonary and neurologic determinants of long COVID-19 such as the presence of neurofilament light chain in plasma. For more information about this body of work, listen to TWiV 1088. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Intranasal antibiotic evokes antiviral response (PNAS) COVID-19 national trend (CDC) COVID-19 deaths (CDC) SARS-CoV-2 shedding vs rapid antigen test performance (MMWR) Spring vaccineadvice (CIDRAP) Older adult spring booster available (CDC) Advisory committee for immunization practices slides (CDC) Advisory committee for immunization practices spring 2024 COVID-19 boosters (CDC) COVID-19 booster take: cross-sectional study (Vaccine) EUA for pemgarda (FDA) CDC Quarantine guidelines (CDC) NIH COVID-19 treatment guidelines (NIH) Infectious Disease Society guidelines for treatment and management (IDSociety) Overuse ofantibiotics for COVID-19: a viral disease (European Society of Clinical Microbiology and Infectious Diseases) Can you believe that antibiotics are ineffective against a viral illness (NKT Institute) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (IDSociety) Outpatient treatment with concomitant vaccine-boosted convalescent plasma (mBio) Updated respiratory virus guidances (CDC) What do when your heathcare provider is infected with SARS-CoV-2 (CDC) Managing healthcare staffing shortages (CDC) Steroids,dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org) Immunologic antiviral therapy with omalizumab (OFID) Abatacept pharmacokinetics and exposure response (JAMA Network Open) Long COVID evidence based review TWiV shout out (TWiV 1088) Gut microbiome and post-acute COVID-19 syndrome, ugh? (Cell Host and Microbe) Pulmonary long COVID (JCI Insight) Neurofilament light chain in long COVID019 neurocognitive symptoms (Molecular Psychiatry) Contribute to our Floating Doctors fundraiser Letters read on TWiV 1110 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV reviews avian H5N1 influenza virus in the US, measles at highest levels in England, positive selection underlies repeated knockout of ORF8 in SARS-CoV-2 evolution, and cross-species spill-over potential of the H9N2 bat influenza A virus. Hosts: Vincent Racaniello, Dickson Despommier, and Alan Dove Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) The New City by Dickson Despommier (blog post) International Conference on Pandemic Preparedness Bird flu in humans (NY Times) H5N1 genome sequences (USDA) Measles cases and outbreaks (CDC) Latest measles statistics (UK) Positive selection underlies ORF8 loss (Nat Comm) Spillover potential of bat H9N2 influenza virus (Nat Comm) Letters read on TWiV 1109 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Journey to the Andromeda Galaxy, Highest jump in human history Alan – What Does a Scientist Look Like? photo gallery by Nature, and public display in London Vincent – The Campus-Left Occupation That Broke Higher Education, I’m a Columbia Professor. The Protests on my Campus are not Justice Listener Picks David – Blue Angels unbelievable footage Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of measles, and H51 influenza infection of birds, poultry and cows before and SARS-CoV-2 circulation, before discussing if the original monovalent SARS-CoV-2 vaccine was effective in children and adolescents, how to use words to properly describe respiratory pathogens the guidelines for spring administration of COVID vaccines boosters, discusses the emergency use application of a pre-exposure prophylactic, revised guidelines for how to treat respiratory viral infection guidelines by the CDC, continues to dispel the myth of viral rebound, revised guidelines SARS-CoV-2 treatment and how to treat respiratory viral infections, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, if administration of remdesivir reduces mortality, long COVID, persistence of virus infection during long COVID and it prevalence. For more information about this body of work, listen to TWiV 1088. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Measles tracking (CDC) Cows, chickens and birds H5N1….oh, my (USDA) Evolution of circulating H5N1 (CIDRAP) COVID-19 national trend (CDC) COVID-19 deaths (CDC) Original monovalent mRNA vaccine effectiveness in children and adolescents (MMWR) Updated terminology for pathogens transmitted through the air (WHO) Are these really better definitions for pathogens transmitted through the air (NY Times) Pharmaceuticals for diseases spread through the air (Reuters) Older adult spring booster available (CDC) Advisory committee for immunization practices slides (CDC) Advisory committee for immunization practices spring 2024 COVID-19 boosters (CDC) EUA for pemgarda (FDA) CDC Quarantine guidelines (CDC) NIH COVID-19 treatment guidelines (NIH) Infectious Disease Society guidelines for treatment and management (IDSociety) WHO vs national guidelines for COVID-19 therapeutics (BMJ) COVID-19 and the bay of pigs (UNC) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (IDSociety) Outpatient treatment with concomitant vaccine-boosted convalescent plasma (mBio) Updated respiratory virus guidances (CDC) What do when your heathcare provider is infected with SARS-CoV-2 (CDC) Managing healthcare staffing shortages (CDC) Steroids,dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org) Remdesivir associated with reduced mortality of hospitalized oxygenated patients (OFID) Long COVID evidence based review TWiV shout out (TWiV 1088) Long COVID prevalence among adults (MMWR) Persistence of SARS-CoV-2 infection (Lancet Infectious Diseases) More questions, new answers long COVID (Lancet Infectious Diseases) Contribute to our ASTMH fundraiser at PWB Letters read on TWiV 1108 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

It has been a long time since TWiV has released an all listener email episode, and if you have been waiting for one, then this episode is for you! (and everyone else of course). Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) The New City by Dickson Despommier (blog post) International Conference on Pandemic Preparedness Letters read on TWiV 1107 Timestamps by Jolene. Thanks! Weekly Picks Brianne – Cats Are Perfect. An Evolutionary Biologist Explains Why Alan – Bardcore music by Hildegard von Blingin’ Vincent – A quote from Georgia O’Keefe: “I think it’s so foolish for people to want to be happy. Happy is so momentary – you’re happy for an instant and then you start thinking again. Interest is the most important thing in life; happiness is temporary, but interest is continuous”. From the dailyphilosopher Listener Picks Julia – Recent success in troubleshooting autoclave challenges Charmaine – Viruses, myelin, the evolution of complex life, and the Fermi paradox Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of measles, potential risk factors for severe disease following influenza infection before and SARS-CoV-2 circulation, before discussing if SARS-CoV-2 infection impacts sperm fertility, the guidelines for spring administration of COVID vaccines boosters, discusses the emergency use application of a pre-exposure prophylactic. revised guidelines for how to treat respiratory viral infection guidelines by the CDC,continues to dispel the myth of viral rebound, revised guidelines SARS-CoV-2 treatment and how to treat respiratory viral infections, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, and long COVID. For more information about this body of work, For more information about this body of work, listen to TWiV 1088. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Measles tracking (CDC) Influenza risk factors for potential severe outcomes (OFID) COVID-19 national trend (CDC) Does SARS-CoV-2 infection influence sperm quality (Scientific Reports) Spring COVID-19 booster recommendations (CIDRAP) Older adult spring booster available (CDC) Advisory committee for immunization practices slides (CDC) Advisory committee for immunization practices spring 2024 COVID-19 boosters (CDC) Slide 19 (CDC) EUA for pemgarda (FDA) CDC Quarantine guidelines (CDC) NIH COVID-19 treatment guidelines (NIH) Infectious Disease Society guidelines for treatment and management (IDSociety) Nirmatrelvir for vaccinated or unvaccinated COVID-19 patients (NEJM) Nirmatrelvir/ritonavir vs. remdesivir for treatment of high risk outpatients (Therapeutic Advances in Infectious Disease) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (IDSociety) Outpatient treatment with concomitant vaccine-boosted convalescent plasma (mBio) Updated respiratory virus guidances (CDC) What do when your heathcare provider is infected with SARS-CoV-2 (CDC) Managing healthcare staffing shortages (CDC) Steroids,dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org) Long COVID evidence based review TWiV shout out (TWiV 1088) Contribute to our ASTMH fundraiser at PWB Letters read on TWiV 1106 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV reviews influenza H5N1 in North American cows and in birds throughout New York City, polio health emergency extended, ChatGPT to control vaccine hesitancy, increasing viral hepatitis worldwide, dengue public health alert in Puerto Rico, cherry trees drowning in Washington DC, death of iron lung Paul, origin and dispersal history of hepatitis B virus in Eastern Eurasia, and antibody-independent protection against heterologous SARS-CoV-2 challenge. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) The New City by Dickson Despommier (blog post) Navigating the U.S. Immigration System webinar International Conferene on Pandemic Preparedness Avian influenza in dairy cows North Carolina and South Dakota H5N1 clade 2.3.4.4 Pathogenic flu throughout NYC Polio from Afghanistan to Pakistan extending public health emergency CHAT GPT to combat vaccine hesitancy Viral hepatitis worldwide Dengue public health alert in Puerto Rico Cherry trees being drowned by water level rise in DC Paul in iron lung dies (NPR) Hepatitis B virus in Eastern Eurasia (Nat Comm) Antibody-independent protection against heterologous SARS-CoV-2 (Nature) Timestamps by Jolene. Thanks! Weekly Picks Brianne – Do Other Planets Have Solar Eclipses? Kathy – Radcliffe Wave and Mt. Etna smoke rings with video Rich – Spongy Oak Apple Gall Wasp (Amphibolips confluenta) Life cycle; Gall formation Alan – Rogue attempt to clone giant sheep for captive hunting Vincent – The Scientists Rock. Literally. Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv