Inside Modern Biotech

Biotechnologyguy: Shubham Thorat
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A podcast exploring the tools, technologies and breakthroughs reshaping biology. Each episode dives into one powerful concept—like CRISPR, CAR-T, AlphaFold or mRNA vaccines breaking it down in simple but scientifically solid language for students, researchers and curious minds. From gene editing and synthetic biology to AI in drug discovery, Inside Modern Biotech takes you from the lab bench to real-world impact.

Episodes

  1. 08/12/2025

    Lipid Nanoparticles: Delivering the Future

    Lipid nanoparticles made headlines as the delivery vehicle behind COVID-19 mRNA vaccines, but their story goes far beyond the pandemic. Join us as we explore how these microscopic fat bubbles are transforming medicine from gene therapy and cancer treatment to the next generation of vaccines. We’ll break down the science, meet the researchers pushing boundaries, and discover why these nanoscale couriers might be the key to treating diseases once thought incurable.

    14 min

  2. 02/12/2025

    AlphaFold: When AI Teaches Us Protein Structure

    In this episode of Inside Modern Biotech, we dive into how AI is transforming protein science through tools like AlphaFold and AlphaFold 3. We’ll explore how these models can “fold” proteins in silicon from just their amino acid sequence, what that means for understanding disease, and how it’s speeding up drug discovery and protein design. From basic folding concepts to real-world applications in the lab, this episode is your guided tour of the AI revolution in structural biology.

    14 min

  3. 01/12/2025

    CRISPR CAS9: The molecular scissors

    CRISPR-Cas9 is a gene-editing system adapted from a bacterial immune defense that lets scientists cut and rewrite DNA at precise locations using a programmable guide RNA and the Cas9 “molecular scissors.” Once Cas9 makes a break in the DNA, the cell’s own repair machinery either stitches it back together in an error-prone way (knocking genes out) or uses a supplied template to make precise changes. On top of classic Cas9, newer tools like base editors and prime editors can rewrite single letters or small stretches of DNA without making full double-strand breaks. This toolkit has completely changed biology: it’s now routine to switch genes on or off, build disease models, engineer crops and livestock, and run massive genetic screens. In medicine, CRISPR has moved from the lab to the clinic, with a focus on somatic (non-heritable) edits delivered either ex vivo (cells edited outside the body and reinfused) or in vivo (directly into patients, often via lipid nanoparticles or viral vectors). Safety issues—off-target edits, complex DNA rearrangements, immune reactions, and delivery-related toxicity—are active areas of research and regulation. Headline CRISPR treatments so far: Casgevy (exa-cel) – first approved CRISPR therapy (US, UK, others) for sickle cell disease and β-thalassemia, by editing blood stem cells ex vivo to turn back on fetal hemoglobin.NTLA-2001 – in vivo CRISPR knock-out of the TTR gene for transthyretin amyloidosis; showed huge TTR reductions but is now under FDA clinical hold after a serious liver toxicity case.EDIT-101 – subretinal CRISPR for an inherited blindness (LCA10), with many participants showing meaningful vision improvements.Custom CPS1 base-editing therapy – a one-off CRISPR base-editing treatment designed for a single baby with a lethal metabolic disorder.Cardiovascular base editing (e.g., VERVE-101, ANGPTL3 programs) – one-time in vivo edits in the liver to permanently lower LDL and triglycerides.CRISPR-engineered immune cells – T cells with PD-1 knocked out or multiplex-edited CAR-T cells for cancer immunotherapy. At the same time, the controversial case of gene-edited babies (germline CCR5 edits) has led to strong global consensus that heritable embryo editing is off-limits for now, while carefully regulated somatic CRISPR therapies continue to expand.

    17 min
  • 3 Episodes

About

A podcast exploring the tools, technologies and breakthroughs reshaping biology. Each episode dives into one powerful concept—like CRISPR, CAR-T, AlphaFold or mRNA vaccines breaking it down in simple but scientifically solid language for students, researchers and curious minds. From gene editing and synthetic biology to AI in drug discovery, Inside Modern Biotech takes you from the lab bench to real-world impact.

Information

  • Creator
    Biotechnologyguy: Shubham Thorat
  • Years Active
    2K
  • Episodes
    3
  • Rating
    Clean
  • Copyright
    © Biotechnologyguy: Shubham Thorat
  • Show Website
    Inside Modern Biotech