Base to Base Biotech

Jim Cornall

The Base to Base Biotech podcast is a weekly look at what's happening in the world of biotech, with interviews with biotech leaders around the world. Whether it's a new drug, cutting-edge technology, product launches, new technology, major finding announcement or clinical trial results, Base to Base Biotech keeps you informed. The podcast is hosted by former biotech editor and broadcaster, the award-winning media veteran Jim Cornall. Base to Base is an Ayr Coastal Media Ltd production.

  1. Base to Base biotech podcast 40: Anchored immunotherapy, and healing the skin

    19/12/2025

    Base to Base biotech podcast 40: Anchored immunotherapy, and healing the skin

    This week, we’re talking about skin and wounds, with Ned Swanson, president and chief medical officer at PolarityBio, and Nikolai Sopko, chief operating officer, chief scientific officer and director at PolarityBio; and we discuss anchored immunotherapy with Howard Kaufman, CEO of Ankyra Therapeutics. 04:03 Ankyra Therapeutics 34:31 PolarityBio Anchored immunotherapies Ankyra Therapeutics, based in Cambridge, Massachusetts, develops anchored immunotherapies that tether cytokines at the injection site to stimulate local immune responses while limiting systemic toxicity. The company’s technology is designed to unlock cytokines that have historically been limited by safety concerns. Its lead programme, ANK‑101 (tolododekin alfa), is an anchored IL‑12 construct. Early trials have demonstrated safety and local immune activation, and the company is now testing the drug in combination with checkpoint inhibitors for non‑small cell lung cancer. The platform is modular, allowing other immune payloads to be developed using the same anchoring chemistry. Ankyra recently began dosing patients in its phase 1b LANTERN trial, combining ANK‑101 with PD‑1/PD‑L1 inhibitors in non‑small cell lung cancer. The science of skin Utah-headquartered PolarityBio focuses on regenerative skin therapies for chronic wounds. Its flagship product, SkinTE, is an autologous heterogeneous skin construct designed to restore functional skin architecture in Wagner Grade 1 diabetic foot ulcers. The company’s development strategy centres on pivotal trials to demonstrate healing rates, durability, and safety, with regulatory and reimbursement pathways treated as critical for adoption. SkinTE has Breakthrough Therapy designation from the FDA. PolarityBio recently announced completion of its pivotal phase III trial, with final results expected in early 2026. To get in touch with guest suggestions, or to sponsor or advertise on the podcast, please email jim@deeptechdigest.com

    1h 10m
  2. Base to Base biotech podcast 39: Gene therapy for eye problems, GAIA, and separation science

    12/12/2025

    Base to Base biotech podcast 39: Gene therapy for eye problems, GAIA, and separation science

    This week, we have conversations with Jakob Andersson, vice president of engineering at Anaphora and founder and chairman of GAIA; Coave Therapeutics’ CEO Rodolphe Clerval; and MOBILion Systems’ CEO, Melissa Sherman. Times: 03:13 Coave Therapeutics 24:43 GAIA Conference 36:55 MOBILion Systems Genetic medicine for ophthalmology Coave Therapeutics is a Paris‑based biotechnology company focused on developing genetic medicines using its ALIGATER platform. The company has pioneered ligand‑conjugated AAV vectors, enabling precision capsids that are highly tissue‑specific, safer, and more effective. In October 2025, Coave presented data at the European Society of Gene and Cell Therapy Congress in Seville, demonstrating the superiority of its lead suprachoroidal capsid, coAAV‑SCS‑01. The vector showed up to 26‑fold improved performance in targeting retinal cells compared to other capsids. This work supports the company’s focus on treatments for retinal vascular diseases. Coave also recently announced the nomination of its lead gene therapy programme, CoTx‑101, for conditions such as wet age‑related macular degeneration and diabetic macular oedema. Delivered via an in‑office suprachoroidal procedure, CoTx‑101 aims to provide durable vision gains. Artificial intelligence and the GAIA Conference Jakob Andersson is the vice president of engineering at Swedish company Anaphora, a company active in artificial intelligence and complex systems. He is also the founder and chairman of the Gothenburg Artificial Intelligence Alliance (GAIA), a non‑profit association established in 2018 to promote interest in AI, machine learning, and data science in the Gothenburg region. GAIA hosts the annual GAIA Conference, which has become a recognised event for researchers, developers, and industry leaders to share advances in artificial intelligence. At the 2025 GAIA Conference, Andersson delivered the opening remarks, outlining the state of AI and expectations for the future. The conference continues to attract international participation, with sessions ranging from lightning talks to open discussions shaped by attendees. Separation science MOBILion Systems is a US‑based company specialising in separation science and advanced proteomics technologies. Its proprietary platforms, including MOBIE and BILLIE, are designed to improve ion mobility and mass spectrometry workflows, enabling deeper proteome coverage and faster analysis. The company has gained recognition for its innovations in parallel accumulation mobility aligned fragmentation (PAMAF), a technique that enhances sensitivity and throughput in proteomics and multi‑omics research. In November 2025, MOBILion presented transformative advances in proteomics at the HUPO World Congress in Toronto. Its CTO, Daniel DeBord, highlighted how PAMAF technology delivers near‑complete ion utilisation, improving analysis of post‑translational modifications and proteoforms. To get in touch with guest suggestions, or to sponsor or advertise on the podcast, please email jim@deeptechdigest.com

    1h 6m
  3. Base to Base biotech podcast 38: Obesity, life sciences in the Netherlands, and killing cancer cells

    05/12/2025

    Base to Base biotech podcast 38: Obesity, life sciences in the Netherlands, and killing cancer cells

    This week, we have conversations with Sjanna Bosma, international relations officer at Health Holland; Mark Bagnall, CEO of Phenomix; and PDS Biotechnology CEO Frank Bedu-Addo. 04:17 Phenomix 32:53 Health Holland 44:02 PDS Biotechnology Phenomix takes on obesity Phenomix Sciences is a biotechnology company focused on precision obesity medicine. The firm has developed the MyPhenome test, a saliva‑based assay that uses machine‑learning algorithms and genetic risk scores to classify obesity phenotypes and predict treatment outcomes. The company positions itself as the first commercial precision obesity medicine biotech, aiming to improve patient stratification and guide therapeutic decisions for obesity management. Its work is closely tied to the Mayo Clinic, where co‑founder Andres Acosta has led much of the underlying research. Recent studies have expanded the evidence base for MyPhenome, particularly in relation to GLP‑1 receptor agonists such as semaglutide and liraglutide. At Obesity Week 2025, Phenomix presented data showing the test’s ability to predict weight‑loss response across diverse patient populations, including those who had undergone bariatric surgery. PDS Biotechnology harnesses immune system to kill cancer cells PDS Biotechnology is a late‑stage immunotherapy company in New Jersey. It develops novel treatments that harness the immune system to target and kill cancer cells, with its lead candidate PDS0101 designed for HPV16‑positive cancers. The company’s pipeline is based on its Versamune platform, which is intended to activate both CD4+ helper and CD8+ killer T cells to generate durable anti‑tumour responses. PDS Biotech has advanced multiple clinical programmes, with head and neck cancer as a primary focus. PDS0101 could become a new immunotherapy option for patients with HPV‑related cancers, addressing a significant unmet medical need. The Netherlands life sciences industry The Dutch life sciences industry was represented at the Nordic Life Science Days in Gothenburg. Health Holland, the public‑private partnership that promotes the Dutch life sciences and health sector, coordinated the Dutch Lounge at the event. This brought together biotech, medtech, and contract research organizations from the Netherlands, highlighting the country’s strengths in innovation, collaboration, and international partnerships. The Netherlands has established itself as a hub for advanced therapies, biopharma, and medical technologies. At NLS Days, more than 30 Dutch companies emphasised their expertise in areas such as cell and gene therapy, diagnostics, and digital health. The event provided opportunities to showcase collaborations with Scandinavian partners and explore new avenues into the Nordic market. The Netherlands continues to develop international cooperation and attract investment into the life sciences sector and continues to position itself as a leading European life sciences hub, leveraging events like NLS Days to build visibility and connect with key stakeholders across the region. To get in touch with guest suggestions, or to sponsor or advertise on the podcast, please email jim@deeptechdigest.com

    1h 19m
  4. 28/11/2025

    Base to Base biotech podcast 37: Life Sciences in Flanders, AI and drug discovery, and healthcare investment

    This week, we have conversations with Jérôme Van Biervliet, chair of the board of Flanders life sciences body Biovia and managing director at VIB; Sylvain Sachot, partner at Asabys Partners; and Jonas Béal, head of science strategy, R&D, at Owkin. 03:32 Owkin 27:42 Biovia/VIB 38:06 Asabys Partners Biovia/VIB Biovia has emerged as a new health innovation cluster in the Belgian region of Flanders, created through the merger of flanders.bio and MEDVIA. The organisation brings together more than 450 members across biotech, medtech, and digital health, with a focus on unmet medical needs and value‑based healthcare. It positions itself as a spearhead cluster supported by Flanders Innovation & Entrepreneurship (VLAIO). In July 2025, Biovia launched its second funding call of the year, offering €8m in non‑dilutive support for consortia projects. Biovia’s broader vision is framed around “One Health,” emphasizing the interdependence of human and planetary health. This approach is intended to break down silos between sectors and align with EU priorities for sustainable healthcare innovation. VIB (Vlaams Instituut voor Biotechnologie) is a research institute founded by the Flemish government in 1995. Its main objective is to strengthen Flemish life sciences research and to turn the results into new economic growth. Asabys Partners Asabys Partners is a Barcelona‑based venture capital firm specialising in healthcare investments. The firm manages funds focused on biotech, medtech, and digital health, and has steadily expanded its portfolio through both direct investments and strategic partnerships. In September 2025, Asabys led a €10m extension of SafeHeal’s oversubscribed Series C financing round. The funding is intended to accelerate commercialization of Colovac, a medical device designed as an alternative to temporary stoma in colorectal cancer surgery. In early October, Asabys integrated Aliath Bioventures into its platform, boosting assets under management from €300m to more than €400m. The integration strengthens its position in European life sciences investment and sets a trajectory toward building a €1bn platform by 2030. Owkin Owkin is a French‑based biotech company focused on applying artificial intelligence to clinical research and drug development. Founded in 2016, it has built a platform that combines machine learning with multi‑modal biomedical data, aiming to accelerate discovery and improve trial efficiency. Its work spans oncology, cardiovascular disease, and immunology, with a focus on predictive modelling and biomarker identification. The company’s core product, Owkin K, functions as an AI copilot for biology. It is designed to integrate genomic, imaging, and clinical data to help researchers uncover mechanisms of disease and optimize trial design. By embedding AI into the research process, Owkin positions itself as a bridge between raw health data and actionable therapeutic insights. Owkin has established partnerships with major pharmaceutical companies including Bristol Myers Squibb, Sanofi, and Merck, as well as collaborations with European cancer centres and teaching hospitals. To get in touch with guest suggestions, or to sponsor or advertise on the podcast, please email jim@deeptechdigest.com

    1h 5m
  5. 21/11/2025

    Base to Base biotech podcast 36: Life science in Gothenburg, Charcot-Marie-Tooth disease and Ultrasound AI

    This week, we have conversations with Robert Bunn, founder and president of Ultrasound AI; Laura MacNeill, CEO of the Charcot Marie Tooth Research Foundation; and Iris Örhn, investment advisor at Business Region Göteborg. 03:00 Ultrasound AI 30:19 Business Region Gothenburg 39:35 CMTRF Business Region Gothenburg Business Region Gothenburg (BRG) is the regional development agency for western Sweden, tasked with driving growth and innovation across key sectors, including life sciences. Its work spans business support, investment promotion, and cluster development. Gothenburg has more than 600 life science companies with around 11,000 employees, creating a strong ecosystem for biotech, medtech, and pharma. This is reinforced by BRG’s efforts to attract global investors. The recent NLS Days event, held in Gothenburg for the first time, highlighted the city’s growing influence. It featured the launch of SwedenBIO’s updated pipeline report, which tracks more than 500 active drug development projects across the country. BRG focuses on infrastructure and innovation platforms such as GoCo Health Innovation City, aiming to strengthen the city’s role in precision medicine, digital health, and advanced therapies. These efforts reflect a long-term strategy to ensure the region remains globally competitive in life sciences. Ultrasound AI Ultrasound AI is a US technology company specialising in artificial intelligence solutions for ultrasound diagnostics, with a focus on improving accuracy in pregnancy-related diagnostics. Its technology is designed to predict gestational age and identify risks such as preterm birth with precision, reducing uncertainty in care for premature babies. By analysing image data alone, the platform aims to support clinicians in making faster, more reliable decisions at the point of care. Ultrasound AI recently expanded its portfolio, securing additional patents that cover predictive algorithms for obstetric and cardiovascular applications. These developments build on earlier work in gestational age estimation and preterm birth prediction, areas where AI-driven tools are gaining traction in clinical practice. The company’s technology integrates into existing ultrasound systems, making adoption practical for hospitals and clinics. As demand for point-of-care diagnostics rises, Ultrasound AI’s approach reflects a broader shift toward data-driven healthcare. Charcot-Marie-Tooth Research Foundation (CMTRF) The Charcot-Marie-Tooth Research Foundation (CMTRF) is a non-profit organisation dedicated to accelerating the development of treatments for Charcot-Marie-Tooth disease, a group of inherited neuropathies affecting peripheral nerves. CMTRF focuses on funding research that moves promising therapies from the laboratory into clinical trials, bridging the gap between discovery and delivery. It has recently advanced several projects aimed at addressing different genetic subtypes of CMT. These include preclinical studies on gene therapy and small-molecule approaches, as well as partnerships with biotech firms to support early-stage drug development. The foundation prioritises collaboration with academic researchers and industry partners to maximise impact and shorten timelines for therapeutic breakthroughs. To get in touch with guest suggestions, or to sponsor or advertise on the podcast, please email jim@deeptechdigest.com

    1h 17m
  6. Base to Base biotech podcast 35: Gothenburg Tech Week, osteoarthritis and respiratory virus infections

    14/11/2025

    Base to Base biotech podcast 35: Gothenburg Tech Week, osteoarthritis and respiratory virus infections

    This week, we have conversations with Malin Kjällström, Gothenburg Tech Week Press and partnerships lead; Eliot Forster the CEO of Levicept; and Christophe Demaison, CEO of ENA Respiratory. Gothenburg Tech Week Gothenburg Tech Week is western Sweden’s largest technology event, held annually across multiple venues in the city. The 2025 edition ran from October 14–16, with a programme that includes startup and investor matchmaking, thematic forums, and partner showcases. The event covers a wide range of topics, including AI, life sciences, and sustainable technologies. Sessions are hosted at The Yard, World of Volvo, and other partner locations, with activities designed to connect regional innovation with international networks. Gothenburg Tech Week has established itself as a meeting place for entrepreneurs, investors, and innovators in Northern Europe. The event provides a platform for new ideas, collaborations, and opportunities, reinforcing Gothenburg’s role as a hub for technology and innovation. Levicept Levicept is a biotechnology company based in Sandwich in the UK. It is developing LEVI‑04, a therapy for osteoarthritis and the associated pain that targets the neurotrophin‑3 pathway. The programme is intended as a non‑opioid alternative for chronic pain management. The company originated from research at Pfizer’s former R&D site in Kent, where founder Simon Westbrook spun out the programme to continue development independently. In June 2025, Levicept presented new data from its large‑scale phase II trial at the European Congress of Rheumatology (EULAR) in Barcelona. The study enrolled more than 500 patients with knee osteoarthritis and demonstrated clinically meaningful improvements in pain and function. Levicept is advancing preparations for late‑stage clinical trials. ENA Respiratory ENA Respiratory is a clinical‑stage pharmaceutical company headquartered in Melbourne, Australia. It develops antiviral host defence enhancers for the prevention of complications from respiratory viral infections. Its lead product, INNA‑051, is a nasal spray designed for weekly self‑administration. INNA‑051 works by priming innate immune responses at the entry site of respiratory viruses in the upper airways. This mechanism accelerates viral clearance and reduces dissemination to the lungs. The product is being evaluated in clinical studies for safety and efficacy. Last month, ENA Respiratory raised $34m in a Series B funding round to support the development of INNA‑051. To get in touch with guest suggestions, or to sponsor or advertise on the podcast, please email jim@deeptechdigest.com

    51 min
  7. Base to Base biotech podcast 34: World Immunization Day and infertility

    07/11/2025

    Base to Base biotech podcast 34: World Immunization Day and infertility

    It’s World Immunization Day on Monday, so we had a chat with Geovax chairman, president and CEO David Dodd, and in our other conversation, we talked about infertility, with Igyxos Biotherapeutics’ chief medical officer Elke Bestel. Challenging infertility Igyxos Biotherapeutics is a French biotechnology company founded in 2017 and based in Nouzilly, France. The company focuses exclusively on infertility, developing monoclonal antibody‑based therapeutics designed to enhance the activity of gonadotropins, the hormones central to reproduction. Its lead program involves a first‑in‑class antibody that potentiates follicle stimulating hormone (FSH), aiming to improve the effectiveness of fertility treatments for both men and women. Igyxos brings together a small team of scientific experts and has raised venture capital to support its research. The company’s approach is intended to overcome limitations of current infertility treatments, which often have modest success rates. By targeting hormonal pathways directly, Igyxos aims to deliver more reliable outcomes for patients. In October 2025, Igyxos announced it had secured a €5.7m grant from the French government under the France 2030 program. The non‑dilutive funding will support phase 2 clinical trials of its lead antibody, IGX12, across France and Europe. World Immunization Day World Immunization Day is observed annually on November 10 to raise awareness of the importance of vaccines in preventing disease and protecting public health. The day emphasizes that immunization is one of the most effective and cost‑efficient health interventions, preventing millions of deaths each year. The observance highlights both the successes of global vaccination campaigns and the challenges that remain, including plateaued coverage rates and disruptions caused by the covid‑19 pandemic. It underscores the role of vaccines in combating infectious diseases, reducing antibiotic resistance, and strengthening community health worldwide. GeoVax Labs, Inc. is a US‑based, clinical‑stage biotechnology company founded in 2001 and headquartered in Atlanta, Georgia. The company develops vaccines and immunotherapies for infectious diseases and cancers, using proprietary Modified Vaccinia Ankara (MVA) vector technology to generate virus‑like particles in vivo. GeoVax’s pipeline includes candidates for covid‑19, Mpox, Ebola, Zika, malaria, and haemorrhagic fever viruses, as well as immunotherapies for solid tumours. Its lead clinical programme, GEO‑CM04S1, is a next‑generation covid‑19 vaccine designed to provide broader and more durable protection, particularly for immunocompromised patients. In late October 2025, GeoVax highlighted phase 2 clinical data for GEO‑CM04S1, showing robust T‑cell responses and cross‑variant durability. The company linked these findings to new Infectious Diseases Society of America (IDSA) guidance emphasising the need for tailored vaccines for immunocompromised populations. To get in touch with guest suggestions, or to sponsor or advertise on the podcast, please email jim@deeptechdigest.com

    1h 2m
  8. Base to Base biotech podcast 33: Pain relief, fungi and psychedelics

    31/10/2025

    Base to Base biotech podcast 33: Pain relief, fungi and psychedelics

    This week, we have conversations with Cosmo Feilding Mellen, CEO of Beckley Psytech; Sirli Rosenvald, CEO of Estonian company Funki, and Per von Mentzer, CEO of Swedish company PharmNovo. We spoke with Funki at Life Sciences Baltics in Vilnius, Lithuania, recently, and with von Mentzer at NLS Days in Gothenburg. Taking on pain PharmNovo AB is a biotechnology company headquartered at Medicon Village in Lund, Sweden. Founded in 2008, it specialises in the development of novel treatments for neuropathic pain, a condition that affects millions of patients worldwide and remains difficult to manage. The company’s lead candidate, PN6047, is a selective delta opioid receptor agonist. Preclinical studies have indicated analgesic effects without the tolerance and dependency risks associated with traditional opioids. PN6047 has progressed into Phase II clinical trials, marking a significant step in evaluating its safety and efficacy in patients. PharmNovo conducts its clinical programme across European trial sites, with a focus on peripheral neuropathic pain indications such as diabetic neuropathy and post‑surgical nerve injury. Data from these studies will inform the design of later‑stage trials and determine the potential pathway toward regulatory approval. Funki fungi Funki is an Estonian food biotech company developing fungi‑based proteins as alternatives to meat and fish. The company combines food science with product development to create sustainable foods that replicate the taste and texture of conventional protein sources. Its work gained international recognition as a finalist in the XPrize “Feed the Next Billion” competition, where it presented a salmon analogue made from pea protein and fungi. This project highlighted both technical capability and consumer‑oriented design. Funki’s research and production efforts are part of a wider European movement to diversify protein supply chains and reduce the environmental impact of food systems. Psychedelics take a leap forward Beckley Psytech is a UK‑based biotechnology company developing psychedelic‑derived medicines for serious mental health conditions. Its lead programme, BPL‑003, is an intranasal formulation of 5‑MeO‑DMT designed for the treatment of treatment‑resistant depression (TRD). The company is also advancing ELE‑101, an intravenous psilocin candidate, for major depressive disorder and alcohol use disorder. Clinical progress has been significant. Phase IIb trials of BPL‑003 met primary and secondary endpoints, showing rapid and durable reductions in depressive symptoms. On the back of these results, the U.S. FDA granted Breakthrough Therapy designation in October 2025, expediting the path toward phase III trials. ELE‑101 is in earlier‑stage studies, with recruitment completed for initial safety and efficacy assessments. By targeting conditions such as TRD — where existing therapies often fail — Beckley Psytech is addressing one of the most urgent gaps in psychiatry. Its strategy combines short‑acting psychedelic compounds with controlled delivery methods, aiming to make treatments both clinically effective and practical within healthcare systems. To get in touch with guest suggestions, or to sponsor or advertise on the podcast, please email jim@deeptechdigest.com

    59 min

About

The Base to Base Biotech podcast is a weekly look at what's happening in the world of biotech, with interviews with biotech leaders around the world. Whether it's a new drug, cutting-edge technology, product launches, new technology, major finding announcement or clinical trial results, Base to Base Biotech keeps you informed. The podcast is hosted by former biotech editor and broadcaster, the award-winning media veteran Jim Cornall. Base to Base is an Ayr Coastal Media Ltd production.