Hart2Heart with Dr. Mike Hart

Dr. Mike Hart
  • 5.0 (1)
  • Medicine
  • Fortnightly

Hart2Heart is the show where Dr. Mike Hart breaks down evidence-based health, longevity, performance, and modern medicine without the fluff. Each episode explores practical, evidence-based strategies for improving your life, including hormone health, peptides, sleep optimization, nutrition, supplements, exercise, sunlight, psychedelics, and smarter medication use. The goal is simple: help you understand what actually works so you can make better decisions for your health. The show also looks at the bigger picture, including how public health policy and politics influence personal well-being, and what you can do to take back control. If you want clear, actionable, no-BS conversations about living healthier, performing better, and thinking for yourself, this podcast is for you.

  1. 23 hr ago

    #244 Dr. Amanda Kahn on Peptides, Skincare, Hair Growth, GLP-1 Microdosing, and Preventive Screening

    Dr. Amanda Kahn joins Dr. Mike Hart to explore the role of peptides, regenerative medicine, and emerging longevity treatments in improving health and recovery. She discusses her clinical experience with BPC-157 for soft tissue injuries, pain, and inflammation, while addressing its limitations, potential safety concerns, and the importance of informed consent. The conversation covers practical anti-aging skincare strategies, including retinoids, vitamin C, and GHK-Cu, along with approaches to hair loss involving nutritional deficiencies and minoxidil. Kahn also explains why she favors tirzepatide among GLP-1 medications, explores potential benefits beyond weight loss, and discusses strategies for preserving muscle during treatment. Additional topics include peptides for sleep, the limitations of biological age testing, and her experience identifying an unexpected thymic carcinoma through whole-body MRI screening. Dr. Amanda Kahn is a primary care physician and internist whose work focuses on personalized medicine, preventive healthcare, and helping patients optimize their health as they age. Drawing on her background in internal medicine and experience across multiple medical specialties, she takes a comprehensive approach to patient care that considers metabolic health, hormonal balance, nutritional status, and the interconnected systems of the body. Through laboratory testing, biomarker monitoring, individualized treatment plans, and ongoing patient evaluation, she works to identify underlying health concerns rather than simply addressing isolated symptoms. Her approach emphasizes informed decision-making, careful consideration of emerging therapies, and combining conventional medical care with proactive strategies to support long-term health and quality of life.   Dr. Amanda Kahn's Official Website — Dr. Amanda Kahn, MD https://www.dramandakahn.com/home BPC-157 Peptide Safety Information — U.S. Food and Drug Administration (FDA) https://www.fda.gov/drugs/human-drug-compounding/certain-bulk-drug-substances-use-compounding-may-present-significant-safety-risks Anthelios Mineral Tinted Sunscreen SPF 50 — La Roche-Posay https://www.laroche-posay.us/our-products/sunscreen/tinted-sunscreen/anthelios-mineral-tinted-sunscreen-for-face-spf-50-883140020899.html C E Ferulic Vitamin C Serum — SkinCeuticals https://www.skinceuticals.com/skincare/vitamin-c-serums/c-e-ferulic-with-15-l-ascorbic-acid/S17.html Retinoids and Retinol for Skin Aging — American Academy of Dermatology https://www.aad.org/public/everyday-care/skin-care-secrets/anti-aging/retinoid-retinol/ GHK-Cu Copper Peptide Research — L. Pickart and colleagues, National Library of Medicine https://pubmed.ncbi.nlm.nih.gov/29986520/ Luminette 3 Light Therapy Glasses — Luminette https://myluminette.com/en-us/products/luminette-3 Lipstick on the Rim Podcast with Dr. Amanda Kahn — Molly Sims and Emese Gormley https://www.iheart.com/podcast/867-lipstick-on-the-rim-82212151/episode/from-vogue-to-elle-shes-the-343396422/ Minoxidil and Hair Loss Treatment — American Academy of Dermatology https://www.aad.org/public/diseases/hair-loss/treatment/diagnosis-treat Latisse for Eyelash Growth — American Academy of Ophthalmology https://www.aao.org/eye-health/drugs/latisse-for-eyelash-growth PP405 Experimental Hair Loss Treatment — Pelage Pharmaceuticals https://pelagepharma.com/our-program/ Mounjaro and Zepbound (Tirzepatide) — Eli Lilly and Company https://tirzepatide.lilly.com/ Eight Sleep Pod 6 — Eight Sleep https://www.eightsleep.com/ BedJet 3 Climate Comfort Sleep System — BedJet https://bedjet.com/products/bedjet-3-climate-comfort-system-with-biorhythm-sleep-technology Whole-Body MRI Screening Guidance — American College of Radiology https://www.acr.org/News-and-Publications/Media-Center/2023/ACR-Statement-on-Screening-Total-Body-MRI Urolithin A and Mitochondrial Health Research — A. Singh and colleagues, National Library of Medicine https://pubmed.ncbi.nlm.nih.gov/35584623/ Longevity Docs Physician Network — Dr. David Luu, Founder https://longevitydocs.org/pages/about   Show Notes   00:00 Welcome to the Hart2Heart Podcast 00:40 BPC 157 Injury Uses 03:06 Dosing and Injection 07:17 Limits and Nerve Pain 10:42 TB4 Pairing Debate 12:20 KPV and Gut Peptides 14:12 Drug Interactions and PCP Lens 17:35 Cancer Risk Concerns 18:11 Skincare Routine Basics 23:19 Retinoids and Tolerance 26:17 Vitamin C and Ferulic 28:50 GHK Copper Peptide 34:25 Simple Routine and Supplements 39:16 Antioxidants And NAD 41:23 Micronutrients And Hormones 42:32 Sunlight Without Damage 43:57 Hair Growth Protocols 45:28 Minoxidil And New Drugs 49:55 GLP1 Favorites And Safety 54:43 Tirzepatide Dosing Strategy 58:37 Peptides And Sleep Tech 01:03:05 MRI And Longevity Picks 01:07:17 Supplements Nootropics Wrap   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance.   This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary.   Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being.   Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen).   If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

  2. 22 Oct

    #243 Dr. Jess on Blood Sugar, Cortisol, Gut-Histamine Issues, Mold, and Environmental Toxins

    Dr. Mike Hart sits down with Dr. Jessica Peatross to explore the overlooked factors that may contribute to unexplained health symptoms, from blood sugar fluctuations that resemble anxiety to disrupted cortisol rhythms that affect sleep and energy. They discuss how meal timing, fasting, and hormone balance influence overall well-being, along with the relationship between gut health, histamine intolerance, and mast cell activation syndrome (MCAS). Dr. Jess explains why she questions conventional food sensitivity testing, how she evaluates potential liver dysfunction and mold exposure, and why certain probiotics and supplements may not work for everyone. The conversation also covers environmental toxins, breast implant illness, genetic variations such as MTHFR and COMT, and the importance of tailoring health interventions to individual needs. Dr. Jessica Peatross, also known as Dr. Jess, is a medical doctor and former hospitalist who spent nearly seven years practicing conventional medicine before transitioning toward a more holistic, individualized approach to patient care. Her work focuses on identifying underlying contributors to chronic health concerns through detailed patient histories, symptom patterns, laboratory assessments, and personalized treatment strategies. She emphasizes nervous system regulation, nutritional support, and understanding how environmental and biological factors influence individual health responses. Beyond her clinical practice, she shares educational content through her Wellness+ platform and serves as a supplement formulator for Aegis Formulas. Her philosophy encourages patients to look beyond symptom management while recognizing the essential role of conventional medicine, particularly in emergencies.   Dr. Jess MD (Official Website & Consultations) — Dr. Jessica Peatross https://drjess.health/ WellnessPlus (Health Education Platform) — Dr. Jessica Peatross https://wellnessplus.com/ Aegis Formulas (Supplement Company) — Dr. Jessica Peatross https://shop.aegisformulas.com/ TUDCA Max (Liver & Bile Support) — Aegis Formulas https://shop.aegisformulas.com/products/tudca-max Total Tox Binder — Aegis Formulas https://shop.aegisformulas.com/products/total-tox-binder DUTCH Cortisol Awakening Response Test — Precision Analytical https://dutchtest.com/product-information-sheets/cortisol-awakening-response-car-information-sheet Hormone Zoomer (Hormone Testing) — Vibrant Wellness https://vibrant-wellness.com/tests/hormone-zoomer Environmental Relative Moldiness Index (ERMI) — U.S. Environmental Protection Agency https://www.epa.gov/air-research/environmental-relative-moldiness-index-ermi Urine Mycotoxin Testing Information — Centers for Disease Control and Prevention https://www.cdc.gov/mmwr/preview/mmwrhtml/mm6406a7.htm Dr. Jess MD (Instagram) — Dr. Jessica Peatross https://www.instagram.com/dr.jess.md/ Dr. Jessica Peatross (YouTube) — Dr. Jessica Peatross https://www.youtube.com/@DoctorJessMD   Show Notes   00:00 Welcome to the Hart2Heart Podcast 00:32 Meet Dr Jess Journey 03:36 Panic Or Blood Sugar 04:30 Protein Fiber Meal Timing 06:12 Fasting Women Hormones 08:32 Waking At Three AM 09:39 Cortisol Melatonin Testing 12:13 Liver Stagnation Clues 14:03 TUDCA Bile Brain Benefits 16:00 Adrenal Fatigue Explained 16:59 Hormones DHEA Testosterone 18:57 Mast Cell Activation Basics 20:43 Treating Histamine Flares 23:37 Sudden Food Reactions 24:39 Peptides For Gut Repair 25:34 Oral Peptides Reality Check 27:17 Gut Brain Mood Connection 29:05 Probiotics Ferments Fiber 30:39 Food Sensitivity Tests Myth 33:18 Mold Symptoms And Diagnosis 36:08 Mold Detox Order Operations 38:33 Binders Sauna Detox Tips 40:10 Everyday Carcinogen Exposures 41:41 Breast Implant Illness Genes 44:32 MTHFR Overmethylation Pitfalls 46:16 Rapid Fire Final Questions 49:05 Closing Where To Find Dr Jess   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance.   This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary.   Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being.   Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen).   If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

  3. 15 Oct

    #242 Hair Loss Treatments: Minoxidil, Topical Dutasteride, Microneedling, and PRP/Placental Exosomes

    In this solo Hart2Heart Podcast episode (focused on male androgenetic alopecia), Dr. Mike Hart reviews hair-loss treatments, emphasizing that regrowth is harder if follicles are gone after 12–18 months. He highlights minoxidil (topical or oral), noting similar efficacy between 2.5 mg and 5 mg oral dosing, comparable results between oral 5 mg and topical 5% twice daily, and that adding 0.01% tretinoin may allow once-daily topical use; combining oral and topical is unstudied but not necessarily dangerous. He advises avoiding systemic DHT blockers due to side effects, favoring 0.05% topical dutasteride for minimal blood DHT reduction, and recommends weekly microneedling (~0.75 mm) without applying products immediately after. As growth-factor adjuncts, he prioritizes PRP or placental exosomes, discusses limited evidence for ketoconazole shampoo and copper peptides, warns DHT-derived anabolic steroids won't be helped by dutasteride, and reviews emerging anti-androgen options and their systemic-risk concerns.   Oral vs. Topical Minoxidil for Hair Loss — Mariana Alvares Penha et al., JAMA Dermatology https://pubmed.ncbi.nlm.nih.gov/38598226/ Minoxidil and Tretinoin Combination Treatment — Hyo Seung Shin et al., American Journal of Clinical Dermatology https://pubmed.ncbi.nlm.nih.gov/17902730/ Topical Dutasteride 0.05% for Male Pattern Hair Loss — Veerendra Kumar Panuganti et al., Cureus https://pubmed.ncbi.nlm.nih.gov/40909044/ Ketoconazole 2% Shampoo for Hair Loss (Nizoral) — C. Piérard-Franchimont et al., Dermatology https://pubmed.ncbi.nlm.nih.gov/9669136/ Microneedling for Hair Regrowth — Rachita Dhurat et al., International Journal of Trichology https://pubmed.ncbi.nlm.nih.gov/23960389/ Platelet-Rich Plasma (PRP) for Hair Loss — C. Donnelly et al., Journal of Cosmetic Dermatology https://pubmed.ncbi.nlm.nih.gov/38284294/ Exosomes for Hair Regeneration — Mohammed A. Al Ameer et al., Clinical, Cosmetic and Investigational Dermatology https://pubmed.ncbi.nlm.nih.gov/40955427/ AHK-Cu Copper Peptide and Hair Growth Research — Hyun Keol Pyo et al., Archives of Pharmacal Research https://pubmed.ncbi.nlm.nih.gov/17703734/ Emerging Hair Loss Treatments: Clascoterone and Pyrilutamide — Shivali Devjani et al., Drugs https://pubmed.ncbi.nlm.nih.gov/37166619/ GT20029: Emerging Hair Loss Treatment — Ruiming Hu et al., Journal of Dermatological Treatment https://pubmed.ncbi.nlm.nih.gov/41328006/   Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:34 Podcast Intro and Scope 01:56 Realistic Regrowth Expectations 02:47 Minoxidil Dosing and Use 07:23 Topical Dutasteride Strategy 11:26 Adjunct Shampoo Option 12:16 Microneedling Done Right 14:55 PRP and Exosomes Boosters 16:47 Copper Peptides Hype Check 19:05 Other Add Ons and Big Four Recap 20:16 Steroids and DHT Reality 22:32 Future Anti Androgen Treatments 28:12 Wrap Up and Final Takeaways   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

  4. 8 Oct

    #241 Decriminalization, Healthcare, and the Future of Medicine with Dr. Ira Price

    Dr. Mike Hart and Dr. Ira Price explore how medicine is adapting as patients gain greater access to emerging treatments, health information, and tools once limited to physicians. They discuss unapproved peptides and GLP-1 drugs, the growing shift toward personalized and patient-centered care, and the challenges doctors face when evidence and regulation lag behind real-world use. The conversation expands into Canada's opioid crisis, drug decriminalization, fentanyl and medetomidine contamination, emergency-room strain, physician burnout, and broader problems within the Canadian healthcare system. They also examine medical cannabis, CBD and lesser-known cannabinoids, psychedelic medicine, sleep, longevity, and the importance of balancing individual choice with evidence, clinical judgment, and responsible medical guidance. Dr. Ira Price is an emergency physician, sports medicine specialist, and longtime cannabinoid-medicine practitioner whose work sits at the intersection of acute care, emerging therapeutics, and patient-centered medicine. Over nearly two decades working with cannabinoids and years on the front lines of emergency care, he has developed a strong focus on helping patients navigate treatments that often move faster than traditional medical guidelines. His approach emphasizes collaboration rather than gatekeeping, encouraging physicians to remain lifelong learners while helping patients critically evaluate evidence, understand risks and benefits, and make more informed decisions about their health. He brings a practical perspective shaped by emergency medicine, sports medicine, cannabinoid research and clinical practice, and firsthand experience with the evolving challenges facing modern healthcare.   Medical Cannabis or Cannabinoids for Chronic Non-Cancer and Cancer Related Pain — Li Wang et al., including Dr. Ira Price / The BMJ H2H 241 IRA PRICE TRANSCRIPT BMJ https://www.bmj.com/content/374/bmj.n1034 Therapeutic Potential of Cannabidiol (CBD) in Anxiety Disorders: A Systematic Review and Meta-Analysis — Kevin Han, Jia-Yu Wang, Peng-Yun Wang & Yue-Chu-Han Peng H2H 241 IRA PRICE TRANSCRIPT PubMed https://pubmed.ncbi.nlm.nih.gov/38924898/ EPIDIOLEX (Cannabidiol) — Jazz Pharmaceuticals H2H 241 IRA PRICE TRANSCRIPT EPIDIOLEX.com https://www.epidiolex.com/what-is-epidiolex Acute Effects of Cannabigerol on Anxiety, Stress, and Mood — Carrie Cuttler, Amanda Stueber, Ziva D. Cooper & Ethan Russo / Scientific Reports H2H 241 IRA PRICE TRANSCRIPT PubMed https://pubmed.ncbi.nlm.nih.gov/39003387/ CBD and THCV in Patients With Type 2 Diabetes — Khalid A. Jadoon et al. / Diabetes Care H2H 241 IRA PRICE TRANSCRIPT PubMed https://pubmed.ncbi.nlm.nih.gov/27573936/ Dependence Potential and Acute Toxicity of Psychoactive Substances — Robert S. Gable / American Journal of Drug and Alcohol Abuse H2H 241 IRA PRICE TRANSCRIPT PubMed https://pubmed.ncbi.nlm.nih.gov/8213692/ Tru Niagen / Nicotinamide Riboside (NR) — Niagen Bioscience / Dr. Charles Brenner H2H 241 IRA PRICE TRANSCRIPT Tru Niagen https://www.truniagen.com/pages/our-story Oura Ring Sleep Tracking — Oura Health H2H 241 IRA PRICE TRANSCRIPT Oura Support https://support.ouraring.com/hc/en-us/articles/11752397946003-Sleep-Stages   Show Notes 00:00 Welcome to the Hart2Heart Podcast 02:04 Peptides Are Everywhere 04:01 GLP-1s Disrupt Weight Loss 08:02 Metformin Longevity Debate 10:41 Doctors Handling Unapproved GLPs 17:17 Patient Power And Education 21:31 Misinformation And Collaboration 25:02 Canadian Drug Policy Overhaul 31:37 Fentanyl Lacing Medetomidine 36:23 Why Healthcare Is Failing 41:01 ER Burnout And Wellness 43:17 Physician Self Care 43:39 Residency Grind Reality 44:23 Fixing Resident Hours 45:34 ER Career Longevity 47:05 Private Healthcare Debate 51:07 Immigration System Strain 53:24 CBD Hype vs Evidence 56:53 CBD Dosing and Cost 01:00:39 Buspirone and Psychedelics 01:08:24 Underrated Cannabinoids 01:12:54 Cannabis Sleep and REM 01:19:03 Cannabis Risks and Alcohol 01:24:47 Closing Thoughts   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

  5. 1 Oct

    #240 Dr. Spencer Nadolsky on Repatha, ApoB Targets, and What Actually Matters in Lipidology

    Dr. Mike Hart sits down with lipidologist Dr. Spencer Nadolsky for a practical discussion on cardiovascular prevention, cholesterol management, and metabolic health. They break down how to interpret ApoB, LDL, HDL, triglycerides, and Lp(a), when cholesterol-lowering medications may make sense, and why long-term exposure matters when thinking about heart disease risk. The conversation also explores statins, PCSK9 inhibitors, plaque progression, supplements, insulin resistance, and the evolving role of GLP-1 medications in obesity treatment and long-term cardiometabolic health. Dr. Spencer Nadolsky is a physician specializing in obesity medicine, lipidology, and cardiometabolic health, with a strong focus on preventing chronic disease before it develops. His approach combines evidence-based medicine with individualized risk assessment, helping patients make sense of cholesterol, metabolic health, body weight, medications, and lifestyle without relying on one-size-fits-all recommendations. Known for translating complex medical research into practical guidance, he emphasizes sustainable health decisions, meaningful clinical outcomes, and finding the balance between being proactive about longevity and becoming overly consumed by it.   SAMSON Trial: Statin, Placebo, and No Treatment — James P. Howard et al. / Imperial College London https://pubmed.ncbi.nlm.nih.gov/34531021/   Multi-Ethnic Study of Atherosclerosis (MESA) — National Heart, Lung, and Blood Institute / NIH https://www.nhlbi.nih.gov/science/multi-ethnic-study-atherosclerosis-mesa   Framingham Heart Study Offspring Cohort — National Heart, Lung, and Blood Institute / BioLINCC https://biolincc.nhlbi.nih.gov/studies/framoffspring/   Repatha (Evolocumab) — Amgen https://www.repatha.com/resources-and-support   Ezetimibe — Mark Cuban Cost Plus Drug Company https://www.costplusdrugs.com/medications/ezetimibe-10mg-tablet/   Rosuvastatin — Mark Cuban Cost Plus Drug Company https://www.costplusdrugs.com/medications/rosuvastatin-10mg-tablet/   Psyllium Fiber / Metamucil — Procter & Gamble / Metamucil https://www.metamucil.com/en-us/articles/psyllium-fiber/psyllium-fiber-in-metamucil   Docs Who Lift Podcast — Dr. Spencer Nadolsky & Dr. Karl Nadolsky https://docswholift.com/podcast/   Vineyard — Dr. Spencer Nadolsky https://joinvineyard.com/   Dr. Spencer Nadolsky on Instagram — Dr. Spencer Nadolsky https://www.instagram.com/drnadolsky/   Dr. Spencer Nadolsky on X — Dr. Spencer Nadolsky https://x.com/DrNadolsky Show Notes   00:00 Welcome to the Hart2Heart Podcast 00:29 Reconnecting And Lipids Focus 00:46 Why Switch To Repatha 02:42 Diet Limits And ApoB Goals 04:03 Ezetimibe And Statin Rationale 05:07 Family History Wake Up Call 06:26 Nocebo And Cleaner PCSK9 10:31 Lp Little A Not A Factor 11:47 Oura Ring And Biohacker Stress 13:33 Dropping Pitavastatin And CoQ10 17:20 Bempedoic Acid And Combo Therapy 20:18 LDL ApoB Discordance Explained 23:37 How Low Is Too Low 26:10 Optimal Targets And When To Start 29:13 Can Ultra Low Prevent Plaque 31:09 Why People Ignore Cholesterol 32:23 Can Plaque Regress 33:16 Vitamin K2 Reality Check 34:00 Mechanisms vs Outcomes 34:58 Lp(a) Drug Disappointment 37:08 How to Use Lp(a) 40:23 HDL Myths Explained 43:11 Triglycerides and Insulin 45:35 Oxidized LDL and NMR 47:33 Supplements That Matter 48:51 Berberine Benefits and Risks 51:50 GLP-1 Stacking Debate 56:41 Microdosing and Plateaus 59:34 Longevity and Alcohol Effects 01:00:36 Future of Anti Obesity Drugs 01:02:00 Wrap Up and Where to Find   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

  6. 24 Sept

    #239 Oral Peptides: How They Work Without Entering the Bloodstream

    Dr. Mike Hart discusses how oral peptides can still have biological effects despite limited or no systemic absorption, using examples including KPV, BPC-157, linaclotide (Constella), oral semaglutide, and cyclosporine. He explains protein digestion into dipeptides/tripeptides and the PEPT1 transporter that moves some small peptides into enterocytes for local cellular effects, noting that KPV can act in intestinal cells without entering circulation and that carnosine is another PEPT1-absorbed example. He outlines multiple local mechanisms (acting in the gut lumen, on the enterocyte surface, inside enterocytes, and in nearby gut tissue) and contrasts these with systemic absorption examples like semaglutide formulated with SNAC (only 0.4–1% reaches blood yet remains effective) and cyclosporine's unusual properties. He notes exceptions like glutathione and discusses theories for BPC-157's oral effects, emphasizing regulated products and upcoming discussion on GLP-1s and obesity with Dr. Spencer Nadolsky.   LINZESS (Linaclotide) Prescribing Information — DailyMed, U.S. National Library of Medicine (dailymed.nlm.nih.gov) https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=linaclotide PepT1-Mediated Tripeptide KPV Uptake Reduces Intestinal Inflammation — Gastroenterology / PubMed, U.S. National Library of Medicine (PubMed) https://pubmed.ncbi.nlm.nih.gov/18061177/ The Oligopeptide Transporter PEPT1 in Human Intestine — PubMed, U.S. National Library of Medicine (PubMed) https://pubmed.ncbi.nlm.nih.gov/9207295/ Oral Semaglutide (RYBELSUS) Prescribing Information — Novo Nordisk / DailyMed, U.S. National Library of Medicine (DailyMed) https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=27f15fac-7d98-4114-a2ec-92494a91da98 Transcellular Stomach Absorption of Oral Semaglutide With SNAC — Science Translational Medicine / PubMed (PubMed) https://pubmed.ncbi.nlm.nih.gov/30429357/ BPC-157 Oral Administration and Gastrointestinal Healing Research — University of Zagreb / PubMed (PubMed) https://pubmed.ncbi.nlm.nih.gov/18818478/ Cyclosporine Oral Prescribing Information — DailyMed, U.S. National Library of Medicine (DailyMed) https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=bfca7088-fe93-abb9-3ec3-e6f5710a69c6   Show Notes   00:00 Welcome to the Hart2Heart Podcast 00:52 Oral Peptides Mythbusting 02:37 Protein Digestion Basics 03:31 PEPT1 Absorption Pathway 04:39 KPV and Carnosine Examples 06:12 Glutathione Exception 07:38 Garden Hose Local Actions 08:26 Linaclotide IBS Mechanism 09:37 Four Local Action Sites 11:25 SNAC Enables Blood Levels 13:26 Cyclosporine Oral Exception 14:35 Other Minor Pathways 15:43 BPC 157 Oral Mystery 18:10 Wrap Up and Safety Notes 19:57 Closing and Next Episode   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

  7. 17 Sept

    #238 The Science of Hormones: Birth Control, HRT, and Thyroid with Dr. Masghati

    In this episode, Dr. Mike Hart and OB-GYN Dr. Salome Masghati examine how common hormone interventions can affect women far beyond pregnancy prevention or symptom relief. They discuss the risks and tradeoffs of different birth control options, possible effects on mood, libido, testosterone, and attraction, and why individual responses can vary significantly. The conversation then explores when to consider HRT, the roles of estrogen, progesterone, and testosterone, thyroid testing beyond TSH, and how shifting hormones may contribute to mast cell symptoms during perimenopause. The episode provides a practical framework for making more informed and personalized decisions about hormone care. Dr. Salome Masghati is a board-certified OB-GYN and functional gynecologist whose work focuses on individualized hormone care for women throughout their reproductive years, perimenopause, and menopause. Her approach combines symptoms, menstrual patterns, comprehensive laboratory testing, metabolic markers, and treatment response to understand each patient's complete health picture rather than relying on a single test or standardized protocol. She works with bioidentical and rhythmic hormone strategies, thyroid care, sexual wellness, and root-cause assessment, emphasizing informed choices, careful monitoring, and helping patients move beyond temporary symptom control toward better long-term health and function.   Dr. Salome Masghati Official Website — Dr. Salome Masghati, Precision Gynecology https://drsalomemasghati.com/ Dr. Salome Masghati on Instagram — Dr. Salome Masghati https://www.instagram.com/drsalomemasghatimd/ This Is Your Brain on Birth Control — Dr. Sarah E. Hill https://www.sarahehill.com/books/your-brain-on-birth-control/ Women's Health Initiative — National Heart, Lung, and Blood Institute, NIH https://www.nhlbi.nih.gov/science/womens-health-initiative-whi 2022 Hormone Therapy Position Statement — The North American Menopause Society https://menopause.org/wp-content/uploads/professional/nams-2022-hormone-therapy-position-statement.pdf Mortality Associated With Hormone Replacement Therapy — Shelley R. Salpeter et al. https://pubmed.ncbi.nlm.nih.gov/15209595/ Oral Contraceptives, SHBG, and Androgen Levels — Claudia Panzer et al. https://pubmed.ncbi.nlm.nih.gov/16409223/ Hormonal Contraceptive Discontinuation and Relationship Satisfaction — V. Michelle Russell et al. https://pubmed.ncbi.nlm.nih.gov/25404285/ Progestogen Use and Intracranial Meningioma Risk — Léa Hoisnard et al., The BMJ https://www.bmj.com/content/384/bmj-2023-078078 Physiologic Hormone Restoration Therapy — Women's Hormone Network https://womenshormonenetwork.org/traditional-versus-pr/ GlycanAge Biological Age Test — GlycanAge https://glycanage.com/   Show Notes   00:00 Welcome to the Hart2Heart Podcast 01:00 Birth Control Safety Overview 02:07 SHBG Testosterone Libido Risks 04:19 SSRIs And Sexual Side Effects 05:26 Depo Shot Meningioma Concerns 09:07 Choosing Alternatives And Counseling 12:40 Attraction Changes And Partner Choice 15:20 Doctor Personal Story Coming Off 19:15 Menopause HRT Fear And WHI 22:00 Estrogen Window For Heart Brain 24:12 HRT Longevity And Start Age 30:41 Testosterone For Women Benefits 33:06 Rhythmic Hormone Dosing Explained 35:30 Cycle-Based GLP-1 Dosing 37:12 Evidence for Rhythmic HRT 39:32 Hormone Cycling and Cancer Risk 41:13 Why Most Doctors Don't 42:58 Libido and Orgasm Tools 46:59 Thyroid Labs Beyond TSH 50:26 Thyroid Antibodies Strategy 54:59 Staying on HRT for Life 58:21 Bioidentical Hormone Choices 01:00:53 Progesterone Delivery Debate 01:02:50 Mast Cell Activation Explained 01:07:28 Wrap-Up and Where to Follow   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

  8. 10 Sept

    #237 Oral Health, Blood Pressure, and Better Hygiene: Dr. Eilon on Toothpaste, Mouthwash, and Whitening

    Dr. Mike Hart sits down with Dr. Ilon Choai to unpack everyday dental habits and the connection between oral and overall health. They discuss choosing toothpaste, fluoride versus nano-hydroxyapatite, and how mouthwash may affect the oral microbiome. Dr. Choai shares his approach to brushing, flossing, tongue scraping, and managing dietary acid exposure, while explaining teeth-whitening options, addressing root canal concerns, and outlining what to consider before getting veneers. Dr. Ilon Choai is a practicing dentist, the creator of NOBS oral care products, and a co-host of Down to Health. His work emphasizes preventive dentistry, patient education, and helping people build habits they can maintain beyond the dental chair. Known online as @thenobsdentist, he encourages informed conversations about dental products and treatment choices. His approach combines clinical care with an interest in moving dentistry beyond "drill, fill, and bill" toward a more integrated role in whole-body health.   NOBS Toothpaste Tablets — NOBS https://nobsroutines.com/products/nobs-toothpaste-tablets NOBS Herbal Mouthwash — NOBS https://nobsroutines.com/products/nobs-herbal-mouthwash Atomic Habits — James Clear https://jamesclear.com/atomic-habits Root Canal Discussion: "Is This Procedure Really Causing Cancer?" — Down to Health, featuring Dr. Valerie Kanter https://music.youtube.com/podcast/Vn-SH7qbvkw Relative Dentin Abrasivity (RDA) Explained — American Dental Association https://www.ada.org/resources/ada-library/oral-health-topics/toothpastes   Show Notes 00:00 Welcome to the Hart2Heart Podcast 01:08 Why Oral Health Matters 04:35 Choosing The Right Toothpaste 09:15 Why Whitening Toothpaste Fails 13:58 Key Toothpaste Ingredients 22:49 Hydroxyapatite And Fluoride 28:31 Electric Brushes And Technique 30:56 Waterpik Versus Flossing 34:32 Mouthwash Myths And Safer Picks 40:24 Acidic Mouthwash Risks 41:00 Tongue Scraping Basics 44:21 Nighttime Snacking Rules 45:48 Carbonated Drinks and pH 47:43 Mouth Breathing and Dry Mouth 50:39 Teeth Whitening Science 54:00 Whitening Options and Longevity 01:00:25 Dental Cleaning Ingredients 01:01:54 Fillings Materials and Safety 01:06:53 Root Canals Mythbusting 01:11:34 Veneers Hype and Downsides 01:16:37 Gum Disease and Heart Health 01:20:19 Ideal Oral Hygiene Plan 01:24:10 Where to Find NOBS   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

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About

Hart2Heart is the show where Dr. Mike Hart breaks down evidence-based health, longevity, performance, and modern medicine without the fluff. Each episode explores practical, evidence-based strategies for improving your life, including hormone health, peptides, sleep optimization, nutrition, supplements, exercise, sunlight, psychedelics, and smarter medication use. The goal is simple: help you understand what actually works so you can make better decisions for your health. The show also looks at the bigger picture, including how public health policy and politics influence personal well-being, and what you can do to take back control. If you want clear, actionable, no-BS conversations about living healthier, performing better, and thinking for yourself, this podcast is for you.

Information

  • Creator
    Dr. Mike Hart
  • Years Active
    2020 - 2026
  • Episodes
    240
  • Rating
    Explicit
  • Copyright
    © Copyright 2023 | Upfire Digital LLC
  • Show Website
    Hart2Heart with Dr. Mike Hart

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