The Pharm So Hard Emergency Medicine & Hospital Pharmacy Podcast

Jimmy Pruitt, PharmD, BCPS, BCCCP, BCEMP

The Pharm So Hard Podcast is a show focused primarily on emergency medicine and hospital pharmacy related topics. Episodes range from 5-30 minutes depending on the topic and guest speakers. The goal is to disseminate information in bite-sized episodes from experts in the field of acute care and hospital pharmacy sub-specialties.

  1. 10 OCT

    Episode 126. Part 2 – Loop There It Is! Navigating Diuretics, Resistance, and Heart Failure Therapies

    Picking up right where Part 1 left off, this episode zeroes in on the practical, high-stakes side of inpatient heart failure management. Dr. Cait Kulig returns to unpack key adverse effects of diuresis, strategies to overcome diuretic resistance, and how to approach add-ons, IV vasoactive agents, and inotropes. Jimmy and Cait also dive into the impact of acute decompensated heart failure on pharmacokinetics, diuretic selection, and guideline-directed therapy across HFrEF and HFpEF—including tips for transitioning to ARNIs and remembering what really matters during inpatient optimization. Whether you're adjusting diuretics or making big-picture decisions, this episode will help you level up your heart failure confidence.

    50 min

  2. 10 OCT

    Episode 125. Part 1 – Loop There It Is! Mastering the Foundations of Heart Failure

    In Part 1 of this two-part masterclass on acute heart failure, host Jimmy Pruitt, PharmD, BCPS, BCCCP, BCEMP, teams up with Cait E. Kulig, PharmD, HF-Cert, clinical cardiology expert and creator of CAR Rx Explain, to unpack the fundamentals of heart failure in a way that finally clicks. From defining heart failure and understanding ejection fraction to breaking down volume status and the Forrester plot, this episode delivers clear, memorable teaching pearls for any pharmacist working with cardiac patients. Learn when to hold GDMT, how to think through diuretic strategies, and what questions you should be asking your patients on admission. This is heart failure demystified—through the lens of real-world clinical decision-making. 💡 Up next in Part 2: We pick up with the adverse reactions of diuresis, dive into overcoming diuretic resistance, and discuss IV vasoactives, GDMT classes, and more.

    35 min

  3. 13 MAY

    Episode 124. Minor Hemorrhages, Major Questions: To Reverse or Not to Reverse in Minor TICH

    In Episode 124 of The Pharm So Hard Podcast, host Jimmy Pruitt, PharmD, BCPS, BCCCP, BCEMP, explores the ongoing debate around anticoagulation reversal in patients with minor traumatic intracranial hemorrhage (TICH). Highlighting a recent multicenter study, Jimmy breaks down the data, challenges current guideline-driven practices, and raises critical questions about risk, patient selection, and clinical judgment. Tune in for a nuanced discussion that could reshape how we approach minor TICH in the emergency department.

    7 min

  4. 4 ABR

    Episode 123. Unveiling SEMP: A New Era in Emergency Medicine Pharmacy

    In this episode of The Pharm So Hard Podcast, host Jimmy Pruitt, PharmD, BCPS, BCCCP, BCEMP, introduces the Society of Emergency Medicine Pharmacists (SEMP), a newly established organization dedicated to advancing the practice of emergency medicine pharmacy. Jimmy discusses SEMP's mission to optimize pharmacotherapeutic care in emergency departments through practice improvement, education, advocacy, research, and international collaboration. He highlights the importance of creating a unified global community for emergency medicine pharmacists and explores how SEMP aims to provide tailored support and resources for practitioners in this dynamic field. Tune in to learn how SEMP plans to shape the future of emergency medicine pharmacy and how you can get involved.​

    28 min

  5. 26 FEB

    Episode 122. SGLT2 Inhibitors in the ICU - Are We Missing an Opportunity?

    In this episode of The Pharm So Hard Emergency Medicine Podcast, host Jimmy Pruitt, PharmD, BCPS, BCCCP, BCEMP, explores the potential of SGLT2 inhibitors in critically ill patients with guest Daniella Abi Kheir, PharmD. Traditionally viewed as diabetes medications, SGLT2 inhibitors are now gaining attention for their pleiotropic effects, including cardiovascular, renal, and anti-inflammatory benefits. Together, Jimmy and Daniella dive into the DEFENDER trial, the first study to evaluate SGLT2 inhibitors in ICU patients with acute organ dysfunction. They break down the study design, key findings, and practical implications for managing critically ill patients. Could these drugs help prevent renal replacement therapy or improve outcomes in septic patients? The episode also tackles potential safety concerns, including DKA and altered absorption in critically ill populations, while offering actionable insights for clinicians considering SGLT2 inhibitors in the ICU. Tune in for an evidence-based discussion packed with clinical pearls and takeaways.

    27 min

  6. 5 FEB

    Episode 121. Journavix: A New Era in Non-Opioid Pain Management?

    In this episode of The Pharm So Hard Emergency Medicine Podcast, host Jimmy Pruitt, PharmD, BCPS, BCCCP, BCEMP, is joined by William Amarquaye, PharmD, to discuss Journavix, the first non-opioid pill approved for moderate to severe acute pain in over 20 years. They break down its mechanism as a NAV1.8 sodium channel blocker, compare it to existing analgesics, and analyze clinical trial data on its efficacy and safety. The conversation also tackles key considerations like side effects, drug interactions, and cost implications for real-world use.

    11 min

  7. 29 ENE

    Episode 120. Ketamine for Benzodiazepine-Resistant Status Epilepticus – A Game-Changer?

    Episode 120. Ketamine for Benzodiazepine-Resistant Status Epilepticus – A Game-Changer? In this episode of The Pharm So Hard Emergency Medicine Podcast, host Jimmy Pruitt, PharmD, BCPS, BCCCP, BCEMP dives deep into an exciting new study exploring ketamine as a rescue agent for benzodiazepine-resistant status epilepticus. Traditionally, managing refractory seizures often requires intubation, high-dose propofol, or other antiepileptics. But could ketamine provide rapid and effective seizure control in these critical moments? Jimmy discusses key findings from the study, practical implications for the ED, and how this data could influence your choice of induction agents during intubation. Plus, he shares valuable clinical pearls and caveats when considering ketamine use in different patient populations.   00:00 Introduction 02:16 The Clinical Dilemma: Benzodiazepine-Resistant Status Epilepticus 03:39 Introducing the Study: Ketamine as a Rescue Drug 05:16 Key Findings: Rapid Seizure Termination 06:05 Safety and Dosing Insights 06:42 Clinical Implications: Ketamine in ED Practice 07:05 Caveats and Patient Populations 07:55 Conclusion

    11 min

  8. 08/12/2024

    Episode 119. Cephalosporins for Pyelonephritis: Insights from the COPY-ED Study

    In Episode 119 of The Pharm So Hard Emergency Medicine Podcast, Jimmy Pruitt, PharmD, BCPS, BCCCP, BCEMP, dives into the COPY-ED study, which explores cephalosporins as a viable option for treating outpatient pyelonephritis. Jimmy challenges the fluoroquinolone-dominant narrative, breaks down the study’s methods and results, and highlights the implications for emergency medicine pharmacists.

    36 min
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The Pharm So Hard Podcast is a show focused primarily on emergency medicine and hospital pharmacy related topics. Episodes range from 5-30 minutes depending on the topic and guest speakers. The goal is to disseminate information in bite-sized episodes from experts in the field of acute care and hospital pharmacy sub-specialties.

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